Elslager, Edward F. published the artcileAntimalarial drugs. 34. Synthesis of 5,5′-[[3-(dimethylamino)propyl]imino]bis[3-(trichloromethyl)-1,2,4-thiadiazole] and related thiadiazoles as antimalarial agents, Related Products of chlorides-buliding-blocks, the main research area is antimalarial thiadiazole derivative.
The condensation of 5-chloro-3-(trichloromethyl)-1,2,4-thiadiazole with N,N-dimethyl-1,3-propanediamine gave 5-[[3-(dimethylamino)propyl]-amino]-3-(trichloromethyl)-1,2,4-thiadiazole and 5,5′-[[3-(dimethylamino)propyl]imino]bis[3-(trichloromethyl)-1,2,-4-thiadiazole] (I), together with 5,5′-[(3-methyl[3-(trichloromethyl)-1,2,4-thiadiazole-5-yl]amino]propyl)imino]bis[3-(trichloromethyl)-1,2,4-thiadiazole] which was formed by a displacement of the distal methyl group of I. The antimalarial activity of I prompted the preparation of 5-amino-3-(trichloromethyl, methyl, and 3,4-dichlorophenyl)-1,2,-4-thiadiazoles and 5,5′-[[(dialkylamino)alkyl]imino]bis[3-(trichloromethyl, methyl, and 3,4-dichlorophenyl)-1,2,4-thiadiazoles] from an amine and the requisite 5-chloro-3-substituted-1,2,4-thiadiazoles, which were prepared from the appropriate amidine and trichloromethylsulfenyl chloride. 5-[3-[(Diethylamino)methyl]-p-anisidino]-3-(trichloromethyl)-1,2,-4-thiadiazole was active against a chloroquine-resistant line of Plasmodium berghei in the mouse. Structure-activity relations against P. berghei in mice and P. gallinaceum in chicks are discussed.
Journal of Heterocyclic Chemistry published new progress about Antimalarials. 50292-25-6 belongs to class chlorides-buliding-blocks, name is 3,4-Dichlorobenzene-1-carboximidamide hydrochloride, and the molecular formula is C7H7Cl3N2, Related Products of chlorides-buliding-blocks.
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