Category: 51419-59-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51419-59-1, name is p-Tolylmethanesulfonyl chloride, A new synthetic method of this compound is introduced below., Recommanded Product: p-Tolylmethanesulfonyl chloride

6-Amino-1-allyl-3,4-dihydro-2 (1H)-quinolinone was prepared in the same manner as in Steps 1.1, 1.2 and 1.3 of Example 1, except that 3-bromopropene was used instead of 3-iodopropane. 1.01 g (5 mmol) of 6-amino-1-allyl-3,4-dihydro-2 (1H)-quinolinone and 1.23 g (6 mmol) of 4-methyl benzylsulfonyl chloride were added into 30 mL of DMF, and 2.01 g (15 mmol) of potassium carbonate was added as an acid-binding agent. The reaction was maintained at room temperature and stirred for 16 hours. After the reaction was completed, ice water was added, and extracted with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate and concentrated. The crude product was subjected to silica gel column chromatography to give 1.36 g of the compound 130925 as a pale yellow solid, with a yield of 73%. 1H NMR (400 MHz, CDCl3): delta 7.22-6.93 (m, 7H), 5.91-5.83 (m, 1H), 5.25-5.13 (dd, 2H), 4.54 (s, 2H), 4.27 (d, 2H), 2.89 (t, 2H), 2.68 (t, 2H), 2.32 (s, 3H) ppm.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES; ZHU, Jiankang; CAO, Minjie; ZHANG, Yulu; LIU, Xue; (56 pag.)US2018/360039; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 51419-59-1, name is p-Tolylmethanesulfonyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51419-59-1, HPLC of Formula: C8H9ClO2S

The product of step (v) (360 mg) was dissolved in DCM (5 ml), this was followed by addition of a solution of NaHCO3 (218 mg) in water (5 ml). (4-methylphenyl)methane sulfonyl chloride (280 mg) was added portionwise and stirred for 1 day, then additional NaHCO3 and sulfonyl chloride were added and stirred for 3 days overall. The reaction was diluted with water and extracted with DCM (.x.3). The combined organic layers were washed (brine), dried (MgSO4) then concentrated under reduced pressure to give the sub-title compound as a pale yellow oil, yield 210 mg.MS: ESI(+ve) 479 (M+H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, p-Tolylmethanesulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; US2008/255150; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics