Category: 5153-70-8

Sousa-Brito, Hellida Larissa; Arruda-Barbosa, Loeste; Vasconcelos-Silva, Alfredo Augusto; Gonzaga-Costa, Karoline; Duarte, Gloria Pinto; Borges, Rosivaldo Santos; Magalhaes, Pedro Jorge Caldas; Lahlou, Saad published the artcile< Vasorelaxant effect of trans-4-chloro-β-nitrostyrene, a synthetic nitroderivative, in rat thoracic aorta>, Product Details of C8H6ClNO2, the main research area is trans chloro nitrostyrene vasorelaxant thoracic aorta structure activity relationship; IP3 receptors; calcium influx; endothelium-independent vasorelaxation; ryanodine-sensitive Ca2+ channels; trans-4-chloro-β-nitrostyrene.

Previously, we showed that 1-nitro-2-phenylethene, a nitrostyrene derivative of 1-nitro-2-phenylethane, induced vasorelaxant effects in rat aorta preparations Here, we studied mechanisms underlying the vasorelaxant effects of its structural analog, trans-4-chloro-β-nitrostyrene (T4CN), in rat aortic rings. Increasing concentrations of T4CN (0.54-544.69μM) fully and similarly relaxed contractions induced by phenylephrine (PHE, 1μM) or KCl (60 mM) in endothelium-intact aortic rings with IC50 values of 66.74 [59.66-89.04] and 79.41 [39.92-158.01] μM, resp. In both electromech. and pharmacomech. couplings, the vasorelaxant effects of T4CN remained unaltered by endothelium removal, as evidenced by the IC50 values (108.35 [56.49-207.78] and 65.92 [39.72-109.40] μM, resp.). Pretreatment of endothelium-intact preparations with L-NAME, ODQ, glibenclamide, or TEA did not change the vasorelaxant effect of T4CN. Under Ca2+-free conditions, T4CN significantly reduced the phasic contractions induced by caffeine or PHE, as well as the contractions due to exogenous CaCl2 in aortic preparations stimulated with PHE (in the presence of verapamil). These results suggest that in rat aortic rings, T4CN induced vasorelaxation independently from the activation of soluble guanylate cyclase/cGMP pathway, an effect that may be related to the electrophilicity of the substituted chloro-nitrostyrene. This vasorelaxation seems to involve inhibition of both calcium influx from the extracellular milieu and calcium mobilization from intracellular stores mediated by IP3 receptors and by ryanodine-sensitive Ca2+ channels.

Fundamental & Clinical Pharmacology published new progress about Arterial endothelium, thoracic aorta endothelium. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Product Details of C8H6ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Schnitzer, Tobias; Wennemers, Helma published the artcile< Deactivation of Secondary Amine Catalysts via Aldol Reaction-Amine Catalysis under Solvent-Free Conditions>, Recommanded Product: (E)-1-Chloro-4-(2-nitrovinyl)benzene, the main research area is secondary amine catalyst deactivation aldol reaction; solvent free enantioselective conjugate addition.

Despite intense interest in amine-catalyzed stereoselective reactions, high catalyst loadings of ≥10 mol % are still common and either due to low reactivity or catalyst deactivation. Yet, few deactivation pathways are well understood. Here, we unraveled the deactivation of secondary amines by undesired aldol reaction. Mechanistic studies with peptide and prolinol silyl ether catalysts showed the generality of this so-far underappreciated catalyst deactivation pathway. The insights enabled conjugate addition reactions between aldehydes and nitroolefins on a multigram scale in the absence of solvent-conditions that are attractive as environmentally benign processes-with excellent product yields and stereoselectivities in the presence of as little as 0.1 mol % of a chemoselective peptidic catalyst.

Journal of Organic Chemistry published new progress about Addition reaction kinetics. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Recommanded Product: (E)-1-Chloro-4-(2-nitrovinyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Xia; Wang, Zhifang; Sun, Jiaxing; Gao, Jia; Zhao, Yu; Cheng, Peng; Aguila, Briana; Ma, Shengqian; Chen, Yao; Zhang, Zhenjie published the artcile< Squaramide-decorated covalent organic framework as a new platform for biomimetic hydrogen-bonding organocatalysis>, Electric Literature of 5153-70-8, the main research area is squarine covalent organic framework michael addition catalyst.

A squaramide-decorated COF was synthesized and used as a highly efficient heterogeneous catalyst for hydrogen-bonding organocatalysis as exemplified in the context of catalyzing Michael addition reactions under mild conditions. Our work lays a foundation for the development of functional COFs as a new platform for biomimetic organocatalysis.

Chemical Communications (Cambridge, United Kingdom) published new progress about Covalent organic frameworks. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Electric Literature of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Jian-Cheng; Kan, Xuan; Shang, Jin-Yan; Qiao, Hua; Dong, Yu-Bin published the artcile< Catalytic Asymmetric Synthesis of Chiral Covalent Organic Frameworks from Prochiral Monomers for Heterogeneous Asymmetric Catalysis>, Electric Literature of 5153-70-8, the main research area is catalytic asym chiral covalent organic framework prochiral monomer catalysis.

Direct synthesis, postsynthetic modification, and chiral induction have been recognized as three powerful methods to synthesize chiral covalent organic frameworks (CCOFs). However, catalytic asym. methodol., as the most important and effective synthetic approach to access chiral organics, has not been enabled for CCOFs synthesis thus far. Herein we report, for the first time, the construction of CCOFs from prochiral monomers via catalytic asym. polymerization The obtained propargylamine-linked CCOFs can be the highly reusable chiral catalysts to promote asym. Michael addition reactions. The concept of catalytic asym. polymerization might open a new route for constructing the CCOFs that are not possible with the existing CCOF synthetic methods.

Journal of the American Chemical Society published new progress about Asymmetric catalysis. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Electric Literature of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Owolabi, Isiaka Alade; Chennapuram, Madhu; Seki, Chigusa; Okuyama, Yuko; Kwon, Eunsang; Uwai, Koji; Tokiwa, Michio; Takeshita, Mitsuhiro; Nakano, Hiroto published the artcile< Amino Amide Organocatalysts for Asymmetric Michael Addition of β-Keto Esters with β-Nitroolefins>, Product Details of C8H6ClNO2, the main research area is nitroolefin keto ester enantioselective Michael addition amino amide organocatalyst.

Asym. Michael addition of β-keto esters with trans-β-nitroolefins using chiral amino amide organocatalyst was tried and afforded synthetically useful chiral Michael adducts in both excellent chem. yields (up to 99%) and stereoselectivities (up to dr. 99:1, up to 98% ee).

Bulletin of the Chemical Society of Japan published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Product Details of C8H6ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jao, Tsung-Jung; Akula, Pavan Sudheer; Hong, Bor-Cherng; Lee, Gene-Hsiang published the artcile< Catalytic 1,2-Rearrangements: Organocatalyzed Michael/Semi-Pinacol-like Rearrangement Cascade of 1,3-Diones and Nitroolefins>, Application of C8H6ClNO2, the main research area is phenylnitroalkane preparation; dicarbonylalkyl compound nitroalkene Michael semipinacol rearrangement cascade organocatalyst.

New types of organocatalytic 1,2-rearrangements, which resemble the Smiles-like or semi-pinacol-like rearrangement, of Michael adducts of 1,3-dicarbonyl-2-alkyl compounds and nitroalkenes have been realized. Unlike the well-known conjugate addition, the reaction affords the 1-phenyl-1-nitroalkanes via unprecedented rearrangement and cascade reactions. Structures of the appropriate products were unambiguously characterized by X-ray crystallog.

Organic Letters published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent) (alkyl). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Application of C8H6ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mahato, Chandan K.; Mukherjee, Sayan; Kundu, Mrinalkanti; Vallapure, Virbhadra P.; Pramanik, Animesh published the artcile< Asymmetric 1,4-Michael Addition in Aqueous Medium Using Hydrophobic Chiral Organocatalysts>, Related Products of 5153-70-8, the main research area is proline organocatalyst asym Michael water green solvent.

Organic transformations exclusively in water as an environmentally friendly and safe medium have drawn significant interest in the recent years. Moreover, transition metal-free synthesis of enantiopure mols. in water will have a great deal of attention as the system will mimic the natural enzymic reactions. In this work, a new set of proline-derived hydrophobic organocatalysts have been synthesized and utilized for asym. Michael reactions in water as the sole reaction medium. Among the various catalysts screened, the catalyst 1 is indeed efficient for stereoselective 1,4-conjugated Michael additions (dr: >97:3, ee up to >99.9%) resulting in high chem. yields (up to 95%) in a very short reaction time (1 h) at room temperature This methodol. provides a robust, green, and convenient protocol and can thus be an important addition to the arsenal of the asym. Michael addition reaction. Upon successful implementation, the present strategy also led to the formation of an optically active octahydroindole, the key component found in many natural products.

Journal of Organic Chemistry published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Related Products of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mishra, Aniket; Bhowmik, Arup; Samanta, Siddhartha; Sarkar, Writhabrata; Das, Sumit; Deb, Indubhusan published the artcile< Diastereoselective Spirocyclization of Benzoxazines with Nitroalkenes via Rhodium-Catalyzed C-H Functionalization/Annulation Cascade under Mild Conditions>, Computed Properties of 5153-70-8, the main research area is tetrahydrospirobenzooxazineindene diastereoselective preparation; benzoxazine nitroalkene diastereoselective spirocyclization rhodium catalyst.

A Rh(III)-catalyzed [3 + 2] annulation of benzoxazines with nitroolefins that proceeds via redox-neutral C-H functionalization has been demonstrated, leading to the novel class of spirocycles in a single step. The construction of three continuous stereogenic centers has been achieved starting from easily accessible achiral substrates in an atom-efficient manner under mild reaction conditions. A broad range of pharmaceutically relevant nitro substituted spirocyclic 2,3-dihydro-1,4-benzoxazine derivatives has been synthesized in good to excellent yields with high diastereoselectivity.

Organic Letters published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Computed Properties of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Akutsu, Hiroshi; Nakashima, Kosuke; Hirashima, Shin-ichi; Matsumoto, Hikari; Koseki, Yuji; Miura, Tsuyoshi published the artcile< Highly efficient asymmetric conjugate addition of 5-benzylfurfurals to nitroalkenes using a thiourea organocatalyst>, Name: (E)-1-Chloro-4-(2-nitrovinyl)benzene, the main research area is nitroalkene benzyl furfural thiourea organocatalyst Michael reaction; phenyl nitropropyl furancarbaldehyde enantioselective diastereoselective regioselective preparation.

The asym. direct bisvinylogous conjugate addition of 5-benzylfurfural derivatives to nitroalkenes using a thiourea organocatalyst resulted in a corresponding ε-regioselective addition products in high yields and up to 95% enantiomeric excess.

Tetrahedron published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Name: (E)-1-Chloro-4-(2-nitrovinyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Borges-Gonzalez, Jorge; Garcia-Monzon, Irma; Martin, Tomas published the artcile< Conformational Control of Tetrahydropyran-based Hybrid Dipeptide Catalysts Improves Activity and Stereoselectivity>, Category: chlorides-buliding-blocks, the main research area is aldehyde nitrostyrene dipeptide catalyst enantioselective diastereoselective Michael addition; nitro phenyl alkanal preparation.

It was demonstrated as to how carbohydrates can be used as conformational control units of organocatalysts to tune their catalytic properties was introduced. New hybrid dipeptide-like organocatalysts based on ζ-sugar aminoacids and proline were prepared and tested for the asym. Michael addition of aldehydes to β-nitrostyrenes. Taking full advantage of the modular nature of the carbohydrate motif, both reactivity and stereoselectivity were significantly improved. By simple structural changes, such as the elimination of the methoxy group in the C4 position of the tetrahydropyran ring, we obtained two complementary catalysts that allow accessed to both enantiomers of the γ-nitroaldehydes with excellent yields, diastereoselectivity and enantiomeric excesses between 97 and 99%, using a catalytic load even below 1 mol%.

Advanced Synthesis & Catalysis published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics