Category: 5153-70-8

Hu, Cui-Xia; Chen, Lin; Hu, Di; Song, Xue; Chen, Zhi-Chao; Du, Wei; Chen, Ying-Chun published the artcile< Construction of Enantioenriched 9H-Fluorene Frameworks via a Cascade Reaction Involving Remote Vinylogous Dynamic Kinetic Resolution>, Electric Literature of 5153-70-8, the main research area is fluorene enantioselective preparation dicyanoolefin indanone cyclization dynamic kinetic resolution; dicyanoolefin indanone addition cascade cyclization dynamic kinetic resolution.

The benzylic C-H group of α,α-dicyanoolefins from 3-substituted 1-indanones could be significantly activated via transmission along the aromatic system, thus enabling dynamic kinetic resolution via a traditional reversible deprotonation-protonation process. Enantioenriched 9-substituted 9H-fluorene frameworks were finally constructed through an asym. vinylogous Michael addition to nitroolefins, followed by a cascade cyclization and oxidative aromatization process, under the catalysis of a chiral bifunctional thiourea-tertiary amine.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (cyano). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Electric Literature of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Jinjin; Chang, Dan; Xiao, Fuhong; Deng, Guo-Jun published the artcile< Three-Component Ordered Annulation of Amines, Ketones, and Nitrovinylarenes: Access to Fused Pyrroles and Substituted Indoles under Metal-Free Conditions>, Category: chlorides-buliding-blocks, the main research area is fused pyrrole indole preparation; cyclocondensation cyclic ketone amine nitrostyrene; cyclohexanone arylamine nitrostyrene cyclocondensation aerobic aromatization iodine catalyst.

Ketones, primary amines such as aniline, and β-nitrostyrenes such as (E)-PhCH:CHNO2 underwent cyclocondensation reactions in toluene at 150° to yield fused pyrroles such as I [R = Me, Et, n-Pr, BuCH2, t-Bu, EtCMe2, Ph, 4-HOC6H4, EtO2C, AcNH, BocNH; X = (CH2)n, CHR, Me2C; n = 1, 2, 3, 7]. Thermal cyclocondensation of cyclohexanones, arylamines, and nitrostyrenes followed by aromatization with O2 and DMSO in the presence of I2 yielded indoles in 50-75% yields.

Journal of Organic Chemistry published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bharathi Priya, Velumani; Ramya, Subramani; Uthayanila, Selvarasu; Karthikeyan, Parasuraman published the artcile< A development of a reusable copper supported imidazolium functionalized ionic liquid catalyzed asymmetric Michael addition reaction>, Computed Properties of 5153-70-8, the main research area is cyclohexanone nitrostyrene copper ionic liquid enantioselective Michael addition; nitro phenylethyl cyclohexanone preparation green chem.

An eco-friendly copper supported Imidazolium functionalized ionic liquid [[Gmim]Cl-Cu (II)] was used as green catalyst in solvent free asym. Michael addition at 25°C. This technique covers simplified product isolation, high conversion and catalyst recycling.

Journal of the Indian Chemical Society published new progress about Cyclohexanones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Computed Properties of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bolous, Mina; Arumugam, Natarajan; Almansour, Abdulrahman I.; Suresh Kumar, Raju; Maruoka, Keiji; Antharam, Vijay C.; Thangamani, Shankar published the artcile< Broad-spectrum antifungal activity of spirooxindolo-pyrrolidine tethered indole/imidazole hybrid heterocycles against fungal pathogens>, Safety of (E)-1-Chloro-4-(2-nitrovinyl)benzene, the main research area is spirooxindole pyrrolidine indole imidazole hybrid antifungal; 1,3-Dipolar cycloaddition; Antifungal agent; Candida; Cryptococcus; Fungi; Ionic liquids; Minimum inhibitory concentration (MIC); Spirooxindolo-pyrrolidine tethered indole/imidazole; Toxicity.

Invasive fungal infections are one of the leading causes of nosocomial bloodstream infections with a limited treatment option. A series of derivatized spirooxindolo-pyrrolidine tethered indole and imidazole heterocyclic hybrids have been synthesized, and their antifungal activity against fungal strains were determined Here we characterize the antifungal activity of a specific spirooxindolo-pyrrolidine hybrid, dubbed compound 9c (I), a spirooxindolo-pyrrolidine tethered imidazole synthesized with a 2-chloro and trifluoromethoxy substituent. The compound 9c exhibited no cytotoxicity against mammalian cell line at concentrations that inhibited fungal strains. Compound 9c also significantly inhibited the fungal hyphae and biofilm formation. Our results indicate that spirooxindolo-pyrrolidine heterocyclic hybrids potentially represent a broad class of chem. agents with promising antifungal potential.

Bioorganic & Medicinal Chemistry Letters published new progress about 1,3-Dipolar cycloaddition reaction, regioselective. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Safety of (E)-1-Chloro-4-(2-nitrovinyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shim, Jae Ho; Ahn, Byung Kook; Lee, Ji Yeon; Kim, Hyeon Soo; Ha, Deok-Chan published the artcile< Organocatalysis for the Asymmetric Michael Addition of Cycloketones and α, β-Unsaturated Nitroalkenes>, SDS of cas: 5153-70-8, the main research area is nitroalkene cycloketone Michael addition organocatalyst enantioselectivity diastereoselectivity.

Michael addition is one of the most important carbon-carbon bond formation reactions. In this study, an (R, R)-1,2-diphenylethylenediamine (DPEN)-based thiourea organocatalyst was applied to the asym. Michael addition of nitroalkenes and cycloketones to produce a chiral product. The primary amine moiety in DPEN reacts with the ketone to form an enamine and is activated through the hydrogen bond formation between the nitro group in the α, β-unsaturated nitroalkene and thiourea. Here, the aim was to obtain an asym. Michael product through the 1,4-addition of the enamine to an alkene to form a new carbon-carbon bond. As a result, the primary amine of the chiral diamine was converted into an enamine. The reaction proceeded with a relatively high level of enantioselectivity achieved using double activation through the hydrogen bonding of the nitro group and thiourea. Michael products with high levels of enantioselectivity (76-99% syn ee) and diastereoselectivity (syn/anti = 9/1) were obtained with yields in the range of 88-99% depending on the ketone.

Catalysts published new progress about Free energy. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, SDS of cas: 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Garcia-Monzon, Irma; Borges-Gonzalez, Jorge; Martin, Tomas published the artcile< Solid-Supported Tetrahydropyran-Based Hybrid Dipeptide Catalysts for Michael Addition of Aldehydes to Nitrostyrenes>, Computed Properties of 5153-70-8, the main research area is tetrahydropyran dipeptide catalyst solid support aldehyde nitrostyrene michael addition.

The heterogenization of homogeneous catalysts onto a solid support is a step towards a more sustainable chem. The recovery and reuse of catalysts is extremely important from a practical, economic and environmental point of view. In this regards, we report a series of polymer-supported tetrahydropyran-based hybrid dipeptides that serve as active catalysts for the enantioselective Michael addition of aldehydes to β-nitrostyrenes. These supported catalysts have been designed considering the optimal anchor position and orientation between the catalyst and the solid support. Addnl., the influence of the linker length on the catalytic efficiency was studied. The catalysts allowed the transformation of a variety of substrates in 76-98% yield and with 94-97% enantiomeric excess. Detailed deactivation studies have provided important information, which allows to increase the useful life of these immobilized catalysts.

Advanced Synthesis & Catalysis published new progress about Asymmetric catalysis. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Computed Properties of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

do Carmo, Lucas F.; Silva, Simone C.; Machado, Matheus V.; Prata, Paloma S.; Junior, Alberto Wisniewski; Vidal, Diogo M.; Villar, Jose Augusto F. P. published the artcile< The role of L-proline and co-catalysts in the enantioselectivity of OXA-Michael-Henry reactions>, Application In Synthesis of 5153-70-8, the main research area is nitrophenyl chromene preparation enantioselective; salicylaldehyde nitrostyrene Michael Henry tandem proline catalyst.

In this work, a study of the OXA-Michael-Henry reactions between salicylaldehyde and β-nitrostyrenes 2-R1-3-R2-4-R3C6H2CH=CHNO2 (R1 = R2 = H, R3 = Cl; R1 = R2 = H, R3 = Br; R1 = R2 = 2,3-Cl2, R3 = H, etc.), catalyzed by proline derivatives e.g., L-proline was described. The corresponding (R)-3-nitro-2-phenyl-2H-chromenes I were obtained in 55% enantiomeric excess (ee, 20 mol% L-proline) and 70% ee (stoichiometric amount) employing Ti(OiPr)4 as Lewis acid. Despite the ee obtained, this result represents the highest enantioselectivity obtained in this reaction. Therefore, this work demonstrated that it is possible to obtain considerable enantiomeric excesses in OXA-Michael-Henry reactions using L-proline, an inexpensive and accessible amino acid.

Journal of the Brazilian Chemical Society published new progress about Benzopyrans Role: SPN (Synthetic Preparation), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Application In Synthesis of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Vishe, Mahesh; Johnston, Jeffrey N. published the artcile< The inverted ketene synthon: a double umpolung approach to enantioselective β2,3-amino amide synthesis>, Name: (E)-1-Chloro-4-(2-nitrovinyl)benzene, the main research area is amino amide synthesis enantioselective diastereoselective; oxime preparation reduction; dinitro alkane preparation amine umpolung; ethane nitro styrene Michael addition enantioselective.

A stereocontrolled synthesis of β2,3-amino amides I [R = Me, Ph, 4-MeC6H4; R1 = Ph, 4-MeOC6H4; R2 = Ac, Cbz, Fmoc] was reported. Innovation was encapsulated by the first use of nitroalkenes to achieve double umpolung in enantioselective β2,3-amino amide synthesis. Step economy was also fulfilled by the use of umpolung Amide Synthesis (UmAS) in the second step, delivering the amide product without intermediacy of a carboxylic acid or activated derivative Molybdenum oxide-mediated hydride reduction provided the anti-β2,3-amino amides I with high selectivity.

Chemical Science published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Name: (E)-1-Chloro-4-(2-nitrovinyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Afanasyev, Oleg I.; Kliuev, Fedor S.; Tsygankov, Alexey A.; Nelyubina, Yulia V.; Gutsul, Evgenii; Novikov, Valentin V.; Chusov, Denis published the artcile< Fluoride Additive as a Simple Tool to Qualitatively Improve Performance of Nickel-Catalyzed Asymmetric Michael Addition of Malonates to Nitroolefins>, COA of Formula: C8H6ClNO2, the main research area is nitroalkene dialkyl malonate nickel catalyst enantioselective Michael addition; dialkylnitroethylmalonate preparation.

Described that simple in-situ addition of the fluoride source to the asym. organometallic catalyst was improved not only activity but also enantioselectivity. Bromide-nickel diimine complexes were found to catalyze asym. Michael addition in low yields and ee, but activation with fluoride leads to a significant improvement in catalyst performance. The developed approach were applied to prepare several enantioenriched GABA analogs.

Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, COA of Formula: C8H6ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mohr, Lisa-Marie; Bauer, Andreas; Jandl, Christian; Bach, Thorsten published the artcile< Visible light-mediated intermolecular [2 + 2] photocycloaddition of 1-aryl-2-nitroethenes and olefins>, Synthetic Route of 5153-70-8, the main research area is aryl cyclobutane preparation intermol photocycloaddition arylnitroethene olefin.

Despite the importance of cyclobutanes there are not many direct [2 + 2] photocycloaddition reactions which can be performed with visible light in the absence of a catalyst. A notable exception is the reaction of 1-aryl-2-nitroethenes and olefins which can be performed at a wavelength of λ = 419 nm or λ = 424 nm in CH2Cl2 as the solvent. In the present study, a total of 15 1-aryl-2-nitroethenes were found to undergo a [2 + 2] photocycloaddition with 2,3-dimethyl-2-butene (28-86% yield) and a set of 12 olefins was studied in their photocycloaddition to 1-phenyl-2-nitroethene (37-88% yield). All mechanistic results are in agreement with a triplet reaction pathway and with the intermediacy of a 1,4-diradical.

Organic & Biomolecular Chemistry published new progress about [2+2] Photocycloaddition reaction. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Synthetic Route of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics