Category: 52927-98-7

Petigara, R. B. published the artcileNovel polycyclic heterocycles. XI. Synthesis of 11,12-dihydropyrido[2,1-b][1,3]benzodiazepines, 6H-pyrido[1,2-c][1,3,5]benzoxadiazepines, and 6H-pyrido[1,2-c][1,3,5]benzothiadiazepines, Category: chlorides-buliding-blocks, the main research area is cyclization iminobromoanilinomethylpyridine; pyridobenzodiazepine; pyridobenzoxadiazepine; pyridobenzothiadiazepine; pyridine imino bromoanilinomethyl cyclization.

An unusually facile dehydrobromination, involving the ortho Br atom and the NH proton of the iminopyridines I (X = CH2, O, S, R = H, Cl) gave the 11,12-dihydropyrido[2,1-b] [1,3]benzodiazepines II (X = CH2), 6H-pyrido[1,2-c] [1,3,5]benzoxadiazepines II (X = O), and 6H-pyrido-[1,2-c] [1,3,5]benzothiadiazepines II (X = S). These cyclizations required a base, e.g., potassium carbonate, and a catalyst, e.g., copper bronze. The reactions occurred in methanol or propanol at reflux, either under anhydrous conditions or in the presence of large amounts of water.

Journal of Heterocyclic Chemistry published new progress about Cyclization. 52927-98-7 belongs to class chlorides-buliding-blocks, name is 2-Bromo-1-(2-bromoethyl)-4-chlorobenzene, and the molecular formula is C8H7Br2Cl, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 52927-98-7, The chemical industry reduces the impact on the environment during synthesis 52927-98-7, name is 2-Bromo-1-(2-bromoethyl)-4-chlorobenzene, I believe this compound will play a more active role in future production and life.

Step 2: 2-Bromo-4-chloro-l-{2-[(4-methoxybenzyl)sulfanyl]ethyl}benzene4-({[2-(2-bromo-4- chlorophenyl)ethyl]sulfanyl}methyl)phenyl methyl ether [00343] To a solution of 2-biOmo- l -(2-bromoethyl)-4-chlorobenzene (2.47 g, 8.28 mmol) and p- methoxy-a-toluenethiol ( 1.3262 mL, 9.5190 mmol) in dimethyl sulfoxide (6.00 mL, 84.5 mmol) was added potassium carbonate (2.2880 g, 16.555 mmol) and the reaction was stirred at rt for 72 h. The reaction was quenched by pouring into 40ml water, the layers were separated, and the aqueous layer was extracted 2 x 15ml DCM. The combined organic layers were concentrated and purified by flash column (80g, eluent 0- 15% EtOAc in hexane for 15 min) to give 1.95g (64%) of title compound. NMR (400 MHz, Chloroform-d) delta 7.48 (s, 1 H), 7.23 – 7.13 (m, 3H), 7.06 (d, J = 8.2 Hz, 1 H), 6.80 (d, J = 8.5 Hz, 2H), 3.75 (s, 3H), 3.64 (s, 2H), 2.93 – 2.79 (t, J = 7.3 Hz, 2H), 2.65 – 2.51 (t, J = 7.3 Hz, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-(2-bromoethyl)-4-chlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DUFFEY, Matthew O.; ENGLAND, Dylan; FREEZE, Scott; HU, Zhigen; LANGSTON, Steven, P.; MCINTYRE, Charles; MIZUTANI, Hirotake; ONO, Koji; XU, He; (684 pag.)WO2016/4136; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics