Category: 53250-84-3

4,4-Disubstituted cyclohexylamine based CCR5 chemokine receptor antagonists as anti-HIV-1 agents was written by Duan, Maosheng;Aquino, Christopher;Dorsey, George F.;Ferris, Robert;Kazmierski, Wieslaw M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Recommanded Product: 53250-84-3 The following contents are mentioned in the article:

A series of 4,4-disubstituted cyclohexylamine based CCR5 antagonists has been designed and synthesized. The prepared derivatives contain arylsulfonamides and differentially linked (benzimidazolyl)azabicyclooctane moieties. Their antiviral structure-activity relationship has been extensively explored, and compound I was found to be most potent of the antagonists studied. This study involved multiple reactions and reactants, such as 2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3Recommanded Product: 53250-84-3).

2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 53250-84-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Potential antitumor agents. 14. Acridylmethanesulfonanilides was written by Cain, Bruce F.;Seelye, Ralph N.;Atwell, Graham J.. And the article was included in Journal of Medicinal Chemistry in 1974.Safety of 2-Chloro-4-sulfamoylbenzoic acid The following contents are mentioned in the article:

A series of 74 structural variants of 4′-(9-acridinylamino)methanesulfonanilide hydrochloride (I) [35440-46-1] was prepared by coupling of the appropriate chloroheterocycle with a p-aminosulfonanilide. In tests in mice, 13 compounds provided some indefinite survivors of i.p. inoculation of L 1210 leukemia. Activity in relation to structure and lipophilicity was discussed. This study involved multiple reactions and reactants, such as 2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3Safety of 2-Chloro-4-sulfamoylbenzoic acid).

2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 2-Chloro-4-sulfamoylbenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway was written by Castanedo, Georgette M.;Wang, Shumei;Robarge, Kirk D.;Blackwood, Elizabeth;Burdick, Daniel;Chang, Christine;Dijkgraaf, Gerrit J. P.;Gould, Stephen;Gunzner, Janet;Guichert, Oivin;Halladay, Jason;Khojasteh, Cyrus;Lee, Leslie;Marsters, James C. Jr.;Murray, Lesley;Peterson, David;Plise, Emile;Salphati, Laurent;de Sauvage, Frederic J.;Wong, Susan;Sutherlin, Daniel P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.COA of Formula: C7H6ClNO4S The following contents are mentioned in the article:

Potent and efficacious inhibitors of the hedgehog pathway for the treatment of cancer have been prepared using the 2-pyridyl biphenyl amide scaffold common to the clin. lead GDC-0449. Analogs with polar groups in the para-position of the aryl amide ring optimized potency, had minimal CYP inhibition, and possessed good exposure in rats. Compounds 9d and 14f potently inhibited hedgehog signaling as measured by Gli1 mRNA and were found to be equivalent or more potent than GDC-0449, resp., when studied in a Ptch^+/- medulloblastoma allograft model, i.e., highly dependent on hedgehog signaling. This study involved multiple reactions and reactants, such as 2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3COA of Formula: C7H6ClNO4S).

2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C7H6ClNO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rational Design of Potent Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase was written by Chong, Pek;Sebahar, Paul;Youngman, Michael;Garrido, Dulce;Zhang, Huichang;Stewart, Eugene L.;Nolte, Robert T.;Wang, Liping;Ferris, Robert G.;Edelstein, Mark;Weaver, Kurt;Mathis, Amanda;Peat, Andrew. And the article was included in Journal of Medicinal Chemistry in 2012.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

A new series of non-nucleoside reverse transcriptase inhibitors based on an imidazole-amide biarylether scaffold has been identified and shown to possess potent antiviral activity against HIV-1, including the NNRTI-resistant Y188L mutated virus. X-ray crystallog. of inhibitors bound to reverse transcriptase, including a structure of the Y188L RT protein, was used extensively to help identify and optimize the key hydrogen-bonding motif. This led directly to the design of compound (I) that exhibits remarkable antiviral activity (EC₅₀ < 1 nM) against a wide range of NNRTI-resistant viruses and a favorable pharmacokinetic profile across multiple species. This study involved multiple reactions and reactants, such as 2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3Category: chlorides-buliding-blocks).

2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Acridine derivatives as antimalarials. II was written by Basu, U. P.;Das-Gupta, S. J.. And the article was included in Journal of the Indian Chemical Society in 1939.Recommanded Product: 53250-84-3 The following contents are mentioned in the article:

2-Chloro-4-sulfonamidotoluene (I), m. 121-3°, was prepared by reacting o-chlorotoluene and chlorosulfonic acid (1:5) at a low temperature and finishing the reaction by heating the mixture at 60° for 2 hrs., cooling over ice and treating with NH₄OH. Oxidation of I with 10% KMnO₄ gave 2-chloro-4-sulfonamidobenzoic acid (II), m. 198-9°. A mixture of II (2.3 g.), 1.2 g. p-anisidine, 1.4 g. anhydrous K₂CO₃, 0.1 g. Cu powder and 25 cc. AmOH was refluxed for 5 hrs. to give 5-sulfonamido-4′-methoxydiphenylamine-2-carboxylic acid (III), m. 242°. III, heated at 100° for 2 hrs. with excess POCl₃ gave 2-sulfonamido-5-chloro-7-methoxyacridine (IV), m. 240°. IV (1 g.) was dissolved in PhOH and heated with 0.7 g. δ-diethylamino-α-methylbutylamine for 1 hr. The reaction mixture was poured into NaOH solution and extracted with Et₂O to give 2-sulfonamido-7-methoxy-5-(ω-diethylaminoisoamyl)aminoacridine, m. 115-20°. Similarly IV with δ-diethylaminobutylamine in PhOH gave 2-sulfonamido-7-methoxy-5-(δ-diethylaminobutyl)aminoacridine, m. 110-5°. Using similar technics the following were prepared: 2-chloro-5-sulfonamidobenzoic acid, m. 217-19°; 2-chloro-5-sulfondiethylamidobenzoic acid, m. 147°; 2-chloro-5-sulfonphenylamidobenzoic acid, m. 194-5°; 4-sulfonamido-4′-methoxydiphenylamine-2-carboxylic acid, m. 239-40°; 4-sulfondiethylamido-4′-methoxydiphenylamine-2-carboxylic acid, m. 170-1°; 4-sulfonphenylamido-4′-methoxydiphenylamine-2-carboxylic acid, m. 233°; 3-sulfonamido-3-chloro-7-methoxyacridine, m. above 230° (decomposition); 3-sulfondiethylamido-5-chloro-7-methoxyacridine, m. 184-6°; 3-sulfonphenylamido-5-chloro-7-methoxyacridine, m. 207-8°; 3-sulfonamido-7-methoxy-5-(ω-diethylaminoisoamyl)aminoacridine, m. 135° (indefinite); 3-sulfonamido-7-methoxy-5-(δ-diethylaminobutyl)aminoacridine, m. 138° (indefinite); 3-sulfondiethylamido-7-methoxy-5-(ω-diethylaminoisoamyl)aminoacridine, m. 105-10°; 3-sulfophenylamido-7-methoxy-5-(ω-diethylaminobutyl)aminoacridine, m. 100-5°; 5-chloro-4′-sulfonamidodiphenylamine-4-carboxylic acid, m. 207°; 5-chloro-4′-acetylaminodiphenylamine-2-carboxylic acid, m. 287-8°; 2,5-dichloro-7-acetylaminoacridine, m. 242-3°; 2-chloro-7-aminoacridone, m. 250° (decomposition). This study involved multiple reactions and reactants, such as 2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3Recommanded Product: 53250-84-3).

2-Chloro-4-sulfamoylbenzoic acid (cas: 53250-84-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 53250-84-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics