Category: 5335-05-07 00:00:00

Kinetics of hydrolysis of 伪-chloroalkyl benzoates was written by Euranto, Erkki K.;Yrjana, Torsti. And the article was included in Suomen Kemistilehti B in 1965.Electric Literature of C8H7ClO2 This article mentions the following:

The kinetics of the hydrolysis of chloromethyl benzoate (I) and 伪-chloroethyl benzoate (II) in dioxane-water mixtures was investigated. The main reaction in both cases was a nucleophilic displacement of the Cl, which took place by the unimol. S_N1 mechanism in the case of II and by the bimol. S_N2 mechanism in the case of I as indicated by the approx. 100 times higher rate of hydrolysis of II, by the different solvent and salt effects, and by the values of the Arrhenius parameters. For 75% dioxane-water at 25掳, E₀ for the uncatalyzed hydrolysis was 22.00 卤 0.008 and 20.20 卤 0.20 kcal./mole for I and II, resp. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Electric Literature of C8H7ClO2).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C8H7ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors was written by Crocetti, Letizia;Bartolucci, Gianluca;Cilibrizzi, Agostino;Giovannoni, Maria Paola;Guerrini, Gabriella;Iacovone, Antonella;Menicatti, Marta;Schepetkin, Igor A.;Khlebnikov, Andrei I.;Quinn, Mark T.;Vergelli, Claudia. And the article was included in Chemistry Central Journal in 2017.Recommanded Product: 5335-05-7 This article mentions the following:

The synthesis of new thiazol-2-(3H)-ones as an elaboration of potent HNE inhibitors with an isoxazol-5-(2H)-one scaffold that recently identified was described. Two-dimensional NMR spectroscopic techniques and tandem mass spectrometry allowed correct assignment of the structure for final compounds arising from both tautomers of the thiazol-2-(3H)-one nucleus (N-3 of the thiazol-2-(3H)-one and 3-OH of the thiazole). All new compounds were tested as HNE inhibitors and no activity was found at the highest concentration used (40 渭M), demonstrating that the thiazol-2-(3H)-one was not a good scaffold for HNE inhibitors. Mol. modeling experiments indicated that the low-energy pose might limit the nucleophilic attack on the endocyclic carbonyl group of the thiazolone-based compounds by HNE catalytic Ser195, in contrast to isoxazol-5-(2H)-one analogs. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Recommanded Product: 5335-05-7).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 5335-05-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel synthesis with the participation of organozinc compounds. XII. Interaction of organozinc compounds with chloromethyl benzoate was written by Lapkin, I. I.;Belykh, Z. D.;Kozlova, L. S.;Fotin, V. V.. And the article was included in Zhurnal Organicheskoi Khimii in 1972.Application In Synthesis of Chloromethyl benzoate This article mentions the following:

Treatment of PhCO2CH2Cl with RCH(ZnBr)CO2R1 in absolute Et2O containing HgCl2 gave esters, PhC(OH)(OCH2CHRCO2R1)CHRCO2R1 (I, R, R1, and % yield given): Me, Me2CHCH2, 66; Et, Me, 72; Et, Et, 80; Et, Me2CH, 59; Et, Bu, 78; Et, Me2CHCH2, 72; Et, pentyl, 57. I readily dehydrated to give PhC(OCH2CHRCO2R1):CRCO2R1 (R, R1, and % yield given): Me2CH, Et, 86; Me2CH, Pr, 80; Me2CH, Bu, 84; Me2CH, Me2CHCH2, 76; Me2CH, pentyl, 86; Me2CH, hexyl, 86. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Application In Synthesis of Chloromethyl benzoate).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of Chloromethyl benzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and bioactivation of bis(aroyloxymethyl) and mono(aroyloxymethyl) esters of benzylphosphonate and phosphonoacetate was written by Thomson, William;Nicholls, Dave;Mitchell, Antony G.;Corner, Julie A.;Irwin, William J.;Freeman, Sally. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1993.Computed Properties of C8H7ClO2 This article mentions the following:

The bis(aroyloxymethyl) esters of benzylphosphonate, I (X = Ph, Ar = Ph, 2-MeC₆H₄ or 2,4,6-Me₃C₆H₂), and methoxycarbonylmethylphosphonate, I (X = MeO₂C, Ar = Ph, 2-MeC₆H₄ or 2,4,6-Me₃C₆H₂), have been prepared by reaction of 2 equivalent of the appropriate aroyloxymethyl iodide with the disilver salt of either benzylphosphonate or methoxycarbonylmethylphosphonate. The cyclohexylammonium salts of the mono(aroyloxymethyl) esters of benzylphosphonate, II (Ar = Ph, 2-MeC₆H₄ or 2,4,6-Me₃C₆H₂, M⁺ = C₆H₁₁NH₃⁺), were prepared by reaction of silver benzyl benzylphosphonate with the appropriate aroyloxymethyl iodide, with subsequent hydrogenolysis to remove the P-OCH₂Ph group. The bis(aroyloxymethyl) esters I (X = Ph or MeO₂C, Ar = Ph, 2-MeC₆H₄ or 2,4,6-Me₃C₆H₂) and the mono(aroyloxymethyl) salts II (Ar = Ph, 2-MeC₆H₄ or 2,4,6-Me₃C₆H₂, M⁺ = C₆H₁₁NH₃⁺) were stable towards chem. hydrolysis at 37掳 at physiol. pH. In the presence of porcine liver carboxyesterase, the bis(aroyloxymethyl) esters of benzylphosphonate I (X = Ph, Ar = Ph or 2-MeC₆H₄) degraded to the mono(aroyloxymethyl) esters II (Ar = Ph or 2-MeC₆H₄), which showed slow hydrolysis to benzylphosphonate. For the bis(aroyloxymethyl) esters of methoxycarbonylmethylphosphonate I (X = MeO₂C, Ar = Ph or 2-MeC₆H₄) there was competition between the esterase-catalyzed hydrolyses of the aroyloxymethyl and methoxycarbonyl groups. For the triester I (X = MeO₂C, Ar = 2,4,6-Me₃C₆H₂) cleavage of the methoxycarbonyl group was observed; hydrolysis of the sterically hindered 2,4,6-trimethylbenzoyl group was not detected for any compound In regard to aiding charged drug transport across biol. membranes, the authors conclude that, unless a very slow release of parent drug is required, the aroyloxymethyl prodrug approach tested here does not offer any apparent advantage over acyloxymethyl or 4-acyloxybenzyl esters already described for several drugs containing phospho groups. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Computed Properties of C8H7ClO2).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C8H7ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics