Category: 5344-49-0

Symmetrical biaryls from diazotized amines. Scope of the reaction. Unsymmetrical biaryls was written by Atkinson, Edward R.;Morgan, C. R.;Warren, H. H.;Manning, T. J.. And the article was included in Journal of the American Chemical Society in 1945.Recommanded Product: 5344-49-0 This article mentions the following:

The reducing agent was prepared by-reducing Cu₂SO₄ in NH₄OH with NH₂OH; the exptl. conditions were those reported in C.A. 35, 2879.8. The yields of R₂ and (:NR)₂ are given (%), as well as other products isolated. PhNH₂, small, 45, ROH; o-MeC₆H₄NH₂, 0, 45, ROH, RCl; m-MeC₆H₄NH₂, 0, 27, ROH; p-MeC₆H₄NH₂, 0, 50, ROH, RCl; o-O₂NC₆H₄NH₂, 45, 3, RCl (14%); m-O₂NC₆H₄NH₂, 45, 3, RCl (13%); p-O₂NC₆H₄Me (at 30-5掳), 12, small, RCl (14%); 2,6-Me(O₂N)C₆H₃NH₂, 24, 16; 2,4-isomer, 31, -; 2,4-O₂N(MeO)C₆H₃NH₂, 64, small; p-HOC₆H₄NH₂, 0, 45; p-AcNHC₆H₄NH₂, 0, 28; o-H₂NC₆H₄CO₂H, 85-90, 0, RNHR; 4,2-Cl(H₂N)C₆H₃CO₂H, 75, 0, RX, R₂O, ROH; 5-Cl isomer, 50, 0, RX, ROH; 6-Cl isomer, 80, 0; 3,5,2-Cl₂(H₂N)C₆H₂CO₂H, 50, 0, RCl, RNH₂; 3,5,2-Br₂(H₂N)C₆H₂CO₂H, 40, 0, RCl, RNH₂; 2,4-H₂N(O₂N)C₆H₃CO₂H, 61, -; 6-NO₂ isomer, 40, -, RCl; m-H₂NC₆H₄CO₂H, 0, 31, RCl; p-isomer, 0, 35; o-H₂NC₆H₄SO₃H gives 20% of (2-C₆H₄SO₃H)₂; aminonaphthalenecarboxylic acid gives high yields of R₂. A mixture of the diazo solutions from 10 g. of 3,5,2-Cl₂(H₂N)C₆H₂CO₂H and 10 g. of o-H₂NC₆H₄CO₂H gives 2 g. of 4,4′,6,6′-tetrachlorodiphenic acid and 0.5 g. of 4,6-dichlorodiphenic acid (II), m. 216-17掳. II (0.3 g.) and 2 g. concentrated H₂SO₄, heated 10 min. at 150掳 and for 2 days at 80掳, give 2,4-dichlorofluorenone-5-carboxylic acid (III), yellow, m. 240-2掳. The formation of III is a convenient method for estimating II in a mixture of diphenic acid and its tetra-Cl derivative A mixture of the diazo solutions from o-O₂NC₆H₄NH₂ and o-H₂NC₆H₄CO₂H gives the same reduction products as are obtained from their reduction sep. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Recommanded Product: 5344-49-0).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 5344-49-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chemometric analysis of substituent effects. VI. A study of ortho effect in dissociation of 2,6-disubstituted benzoic acids was written by Kulhanek, Jiri;Pytela, Oldrich. And the article was included in Collection of Czechoslovak Chemical Communications in 1995.Application of 5344-49-0 This article mentions the following:

Ten 2,6-disubstituted benzoic acids have been synthesized containing all possible combinations of the following substituents: CH₃, OCH₃, cl, and NO₂. The dissociation constants of these acids have been measured by potentiometric titration in methanol, acetone, DMSO, DMF, acetonitrile, pyridine, and 1,2-dichloroethane. The exptl. data obtained together with the pK values of 2-substituted benzoic acids in the same solvents have been analyzed from the point of view of ortho effect and additivity of disubstitution. The mutual interaction between substituents was found to represent only 0.12% of the variability due to substitution and to contribute to the overall variability of data less than the interaction between the substituent and solvent by a factor of about 13. The anal. of data by the method of multiple linear regression revealed a contribution of steric effects beside the effects transmitted through the aromatic skeleton. The 2- and 6-substituents effects are additive within the validity of the Hammett equation,a nd an addition of a multiplicative term describing interactions between the substituents is statistically insignificant. Nonlinear regression has been adopted in the additive model with multiplicative term to find the inner substituent constants including all the effects of substituents from ortho position: the term describing the interaction between 2- and 6-substituents is statistically insignificant in this model. An application of the method of conjugated deviations revealed two statistically significant latent variables. The first one explains 91.5% of the variability of data and is connected with the substituent effects transmitted through the aromatic skeleton. The second one explains 7.5% of variability of data and predominantly reflects the steric effects of substituents. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Application of 5344-49-0).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 5344-49-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Acyl/aroyl Meldrum’s acid as an enol surrogate for the direct organocatalytic synthesis of 伪,尾-unsaturated ketones was written by Khopade, Tushar M.;Warghude, Prakash K.;Mete, Trimbak B.;Bhat, Ramakrishna G.. And the article was included in Tetrahedron Letters in 2019.Reference of 5344-49-0 This article mentions the following:

The operationally simple, robust and straightforward organocatalytic protocol is developed for the synthesis of E-selective 伪,尾-unsaturated ketones. The method utilizes simple and easily accessible starting materials such as Meldrum’s acid, carboxylic acid, aldehyde and simple bifunctional amine catalyst. The tandem organocatalytic process utilizes acyl/aroyl Meldrum’s acid as an enol surrogate for the effective Doebner-Knoevenagel type condensation reactions. A wide variety of aldehydes, carboxylic acids and base sensitive functional groups are well tolerated under the mild reaction conditions. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Reference of 5344-49-0).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 5344-49-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Studies on structures and pKa values of benzoic acid derivatives was written by Qi, Yu-hua;Xu, Lu;Zhang, Qing-you. And the article was included in Jisuanji Yu Yingyong Huaxue in 2002.Category: chlorides-buliding-blocks This article mentions the following:

The topol. indexes were used in the QSPR studies of the structures of benzoic acid derivatives and their pK_a values. The orthogonal method is performed for selection of the variables. Satisfactory results were achieved. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Category: chlorides-buliding-blocks).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nitro and nitroamino derivatives of o-chlorobenzoic acid was written by Goldstein, Henri;Preitner, Gaston. And the article was included in Helvetica Chimica Acta in 1944.Category: chlorides-buliding-blocks This article mentions the following:

It has been shown that nitration of 2,5-Cl(AcNH)C₆H₃CO₂H gives 2,5,6-Cl(AcNH) (O₂N)C₆H₂CO₂H (I) (C. A. 32, 2521.2). I (1.08 g.) in 10 cc. absolute alc. and 0.6 cc. concentrated H₂SO₄ at -10° was treated with 1.1 g. of iso-AmNO₂ at 0° for 1 h. The reaction product was refluxed for 1 h. in the presence of a trace of Zn and worked up, yielding 0.32 g. (30%) of 2,6-Cl(O₂N)C₆H₃CO₂H, m. 163°, identical with the compound obtained by Lehmstedt and Schrader by the oxidation of 2,6-Cl(O₂N)C₆H₃Me (C. A. 31, 4670.7), transformed by refluxing with SOCl₂ to 6-nitro-2-chlorobenzoyl chloride, m. 32-4°, b_12-13 160°; Me ester, m. 94-5°; Et ester, m. 49-50°; amide, C₇H₅ClN₂O₃, m. 186-7°; anilide, m. 176-7°. The nitration of 2,5-Cl(AcNH)C₆H₃Me (prepared by the chlorination of 18 g. m-MeC₆H₄NHAc) in a mixture of 18 cc. HNO₃ (d. 1.40) and 18 cc. HNO₃ (d. 1.52) below 15° for 2 h. yielded 4.0-4.5 g. of 4-nitro-5-acetamido-2-chlorotoluene (II), m. 113°, and a small amount of the isomeric 6-nitro-5-acetamido-2-chlorotoluene (IIa), m. 152-3° (from alc.). Oxidation of 1.15 g. II in 100 cc. H₂O containing 2 g. MgSO₄ at 100° by addition of 3 g. KMnO₄ in 60 cc. H₂O for 3 h. and recrystallization of the product from AcOH produced 0.5 g. of 4-nitro-5-acetamido-2-chlorobenzoic acid, m. 214°, saponified to the corresponding 4-nitro-5-amino-2-chlorobenzoic acid, m. 239-40° (decomposition). A similar oxidation of IIa gave I, saponified to the corresponding 2,5,6-Cl(H₂N) (O₂N)C₆H₂CO₂H. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Category: chlorides-buliding-blocks).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Evaluation of 4-(4-Fluorobenzyl)piperazin-1-yl]-Based Compounds as Competitive Tyrosinase Inhibitors Endowed with Antimelanogenic Effects was written by Mirabile, Salvatore;Vittorio, Serena;Paola Germano, Maria;Adornato, Ilenia;Ielo, Laura;Rapisarda, Antonio;Gitto, Rosaria;Pintus, Francesca;Fais, Antonella;De Luca, Laura. And the article was included in ChemMedChem in 2021.Electric Literature of C7H4ClNO4 This article mentions the following:

There is a considerable attention for the development of inhibitors of tyrosinase (TYR) as therapeutic strategy for the treatment of hyperpigmentation disorders in humans. Continuing in our efforts to identify TYR inhibitors, we describe the design, synthesis and pharmacophore exploration of new small mols. structurally characterized by the presence of the 4-fluorobenzylpiperazine moiety as key pharmacophoric feature for the inhibition of TYR from Agaricus bisporus (AbTYR). Our investigations resulted in the discovery of the competitive inhibitor [4-(4-fluorobenzyl)piperazin-1-yl]-(3-chloro-2-nitro-phenyl)methanone 26 (I, IC₅₀=0.18μM) that proved to be ∼100-fold more active than reference compound kojic acid (IC₅₀=17.76μM). Notably, compound 26 exerted antimelanogenic effect on B16F10 cells in absence of cytotoxicity. Docking anal. suggested its binding mode into AbTYR and into modelled human TYR. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Electric Literature of C7H4ClNO4).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics