Category: 54453-94-0

The author of 《5-alkyl-1,3-oxazole derivatives of 6-amino-nicotinic acids as alkyl ester bioisosteres are antagonists of the P2Y12 receptor [Erratum to document cited in CA160:125148]》 were Bach, Peter; Bostroem, Jonas; Brickmann, Kay; Burgess, Laurence E.; Clarke, David; Groneberg, Robert D.; Harvey, Darren M.; Laird, Ellen R.; O’Sullivan, Michael; Zetterberg, Fredrik. And the article was published in Future Medicinal Chemistry in 2014. Computed Properties of C10H12ClNO2 The author mentioned the following in the article:

On page 2037, the author affiliations were incorrect; the corrected affiliations are given. On pages 2051 and 2052, Tables 3 and 4, resp., were incomplete; the corrected tables are given. In addition to this study using Ethyl 6-chloro-2,4-dimethylnicotinate, there are many other studies that have used Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0Computed Properties of C10H12ClNO2) was used in this study.

Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Computed Properties of C10H12ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《New compounds obtained by direct condensation of 2-halopyridines with benzo-1,2,3-triazole》 were Nantka-Namirski, Pawel; Kalinowski, Jerzy. And the article was published in Acta Poloniae Pharmaceutica in 1974. SDS of cas: 54453-94-0 The author mentioned the following in the article:

1-(2-Pyridyl)-1,2,3-benzotriazoles I (R = H, Me; R1 = H, NO2, CN, CO2H, CO2Et; R2 = H, Et, Me, NO2, NH2, CN, CO2H, CO2Et; R3 = H, NO2) were prepared in 33-84% yield by fusing 1,2,3-benzotriazole with the appropriately substituted 2-chloroor 2-bromopyridine at 140-80°. II and III were isolated as byproducts in the preparation of I (R = R1 = R3 = H, R2 = NO2). A detailed discussion of the NMR spectra was presented. The experimental process involved the reaction of Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0SDS of cas: 54453-94-0)

Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 54453-94-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication》 were Skerlj, Renato; Bridger, Gary; Zhou, Yuanxi; Bourque, Elyse; McEachern, Ernest; Langille, Jonathan; Harwig, Curtis; Veale, Duane; Yang, Wen; Li, Tongshong; Zhu, Yongbao; Bey, Michael; Baird, Ian; Sartori, Michael; Metz, Markus; Mosi, Renee; Nelson, Kim; Bodart, Veronique; Wong, Rebecca; Fricker, Simon; MacFarland, Ron; Huskens, Dana; Schols, Dominique. And the article was published in Bioorganic & Medicinal Chemistry Letters in 2011. Reference of Ethyl 6-chloro-2,4-dimethylnicotinate The author mentioned the following in the article:

A series of CCR5 antagonists, e.g. I, were optimized for potent inhibition of R5 HIV-1 replication in peripheral blood mononuclear cells. Compounds that met acceptable ADME criteria, selectivity, human plasma protein binding, potency shift in the presence of α-glycoprotein were evaluated in rat and dog pharmacokinetics. In the experimental materials used by the author, we found Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0Reference of Ethyl 6-chloro-2,4-dimethylnicotinate)

Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Reference of Ethyl 6-chloro-2,4-dimethylnicotinate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication》 were Skerlj, Renato; Bridger, Gary; Zhou, Yuanxi; Bourque, Elyse; McEachern, Ernest; Langille, Jonathan; Harwig, Curtis; Veale, Duane; Yang, Wen; Li, Tongshong; Zhu, Yongbao; Bey, Michael; Baird, Ian; Sartori, Michael; Metz, Markus; Mosi, Renee; Nelson, Kim; Bodart, Veronique; Wong, Rebecca; Fricker, Simon; MacFarland, Ron; Huskens, Dana; Schols, Dominique. And the article was published in Bioorganic & Medicinal Chemistry Letters in 2011. Reference of Ethyl 6-chloro-2,4-dimethylnicotinate The author mentioned the following in the article:

A series of CCR5 antagonists, e.g. I, were optimized for potent inhibition of R5 HIV-1 replication in peripheral blood mononuclear cells. Compounds that met acceptable ADME criteria, selectivity, human plasma protein binding, potency shift in the presence of α-glycoprotein were evaluated in rat and dog pharmacokinetics. In the experimental materials used by the author, we found Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0Reference of Ethyl 6-chloro-2,4-dimethylnicotinate)

Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Reference of Ethyl 6-chloro-2,4-dimethylnicotinate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lemoine, Remy C.; Petersen, Ann C.; Setti, Lina; Wanner, Jutta; Jekle, Andreas; Heilek, Gabrielle; deRosier, Andre; Ji, Changhua; Berry, Pamela; Rotstein, David published an article on January 15 ,2010. The article was titled 《Evaluation of secondary amide replacements in a series of CCR5 antagonists as a means to increase intrinsic membrane permeability. Part 1: Optimization of gem-disubstituted azacycles》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.SDS of cas: 54453-94-0 The information in the text is summarized as follows:

Replacement of a secondary amide with an N-acyl or N-sulfonyl gem-disubstituted azacyle in a series of CCR5 antagonists led to the identification of compounds with excellent in vitro HIV antiviral activity and increased intrinsic membrane permeability. The experimental process involved the reaction of Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0SDS of cas: 54453-94-0)

Ethyl 6-chloro-2,4-dimethylnicotinate(cas: 54453-94-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 54453-94-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics