Category: 54773-19-2

Some common heterocyclic compound, 54773-19-2, name is 1,2-Dichloro-3-(trifluoromethyl)benzene, molecular formula is C7H3Cl2F3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: chlorides-buliding-blocks

500.0 g (2.28 mol, 1.0 eq) of 2,3-dichlorotrifluoromethylbenzene and 50.0 g (0.06 mol, 2.5 mol %) of aqueous 50% CYPHOS (tetradecyltri-n-butylphosphonium chloride) solution are initially charged under nitrogen and heated to 80 C. 990.0 g (2.96 mol, 1.3 eq) of 21% aqueous sodium thiomethoxide solution is metered in at 80 C. over 2 h and the mixture is further stirred at 80 C. for 4 h. The organic phase is drained off and the aqueous phase is extracted with 300 ml of toluene. The combined organic phases are combined and concentrated at 40 C./50 mbar. The residue is distilled under a reduced pressure of 10 mbar. This gives 361 g of a colourless liquid (b.p. 104 C./10 mbar) in a yield of 70%. 1H-NMR (CDCl3, 400 MHz) delta (ppm)=7.67 (dd, J=8.1, 1.3 Hz, 1H), 7.64 (dd. J=8.0, 1.3 Hz, 1H), 7.38 (td, J=8.0, 0.8 Hz, 1H), 2.42 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 54773-19-2, its application will become more common.

Reference:
Patent; Bayer CropScience Aktiengesellschaft; GALLENKAMP, Daniel; FORD, Mark James; US2019/233382; (2019); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 54773-19-2, name is 1,2-Dichloro-3-(trifluoromethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H3Cl2F3

EXAMPLE 5 Preparation of Compound No. 5 (Reaction (a)) A mixture of 1,2-dichloro-3-(trifluoromethyl)benzene (21.5 g), N-[(+-)-2-(4-hydroxyphenoxy)propionyl]isoxazolidine (23.7 g) which was prepared as in Example 3, anhydrous potassium carbonate (14.5 g) and dimethylsulfoxide (200 ml) was stirred at 130 C. for 3 hours. After the mixture was cooled, water and benzene were added thereto to form two layers. The organic layer thus separated was washed with 1 N aqueous sodium hydroxide solution and then with water and dried over anhydrous sodium sulfate. Removal of the solvent by a distillation in vacuo gave N-[(+-)-2-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]propionyl]isoxazolidine (39.9 g) as a pale brown crystalline solid. Recrystallization from a mixture of n-hexane and ethyl acetate afforded a white crystalline solid. m.p. 66.5-67.5 C.

The synthetic route of 1,2-Dichloro-3-(trifluoromethyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hokko Chemical Industry Co., Ltd.; US4447259; (1984); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 54773-19-2,Some common heterocyclic compound, 54773-19-2, name is 1,2-Dichloro-3-(trifluoromethyl)benzene, molecular formula is C7H3Cl2F3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2,3-dichlorobenzotrifluoride 215 g (1.00 mol) of the compound of the formula (II), anhydrous potassium fluoride 140 g (2.41 mol), sulfolane 2000 mL,10 g of tetraphenylphosphonium bromide was introduced into the autoclave in batches, and the temperature was raised to 250-300 C for 20 hours under stirring. After cooling, the formed potassium chloride and excess potassium fluoride were removed by filtration.The filtrate is rectified, and a fraction of 112 C to 119 C is collected to obtain a compound of formula (III) 2,3-difluorobenzotrifluoride; The residue is further subjected to rectification to collect a fraction of 145 C – 151 C to obtain a by-product 2-fluoro-3-chlorobenzotrifluoride; the by-product can be recycled.The average yield of 2,3-difluorobenzotrifluoride, which is a continuous preparation of the compound of formula (III) after application, is 87.6%.

The synthetic route of 54773-19-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Zheng Rong Pharmaceutical And Chemical Co., Ltd.; Chen Zhengwei; Xiao Tao; Zhu Jiahao; Yu Chuanzong; Dai Jianxin; (13 pag.)CN104693080; (2016); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics