Related Products of 553-82-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 553-82-2, name is 2,4-Dichloro-1-methoxybenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To synthesize compound 96, to 2,4-dichloroanisole (5 mL, 36 mmol) in THF (22 mL) at -78 C. was added 2.5 M nBuLi (17 mL, 43 mmol) keeping the temperature below -65 C. After 30 min, the reaction was poured into frozen (-78 C.) trimethylborate (14 mL, 215 mmol) followed by another portion of trimethylborate (10 mL, 90 mmol) and allowed to warm to room temperature over 16 h. The solid suspension was poured into a 1 N HCl aqueous solution and stirred for 1 h. The suspension was filtered to give 3.6 g (46%) of a white solid contaminated most likely with B(OH)4. A second batch of crystals formed which were collected as an off-white solid that was compound 96 (5.8 g, 74%). 1H NMR DMSO-d6: delta 8.53 (s, 2H), 7.29 (d, J=8.8 Hz, 1H), 7.06 (d, J=8.8 Hz, 1H), 3.83 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dichloro-1-methoxybenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TargeGen, Inc.; US2005/245524; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics