Category: 56961-77-4

56961-77-4, name is 1-Bromo-2,3-dichlorobenzene, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 56961-77-4

Under a nitrogen atmosphere, and added at 90 will have the N 1 , the N 1 , theN 3 – triphenyl benzene-1,3-diamine (51.7g), 1- bromo-2,3-dichlorobenzene ( 35.0g), Pd-132 (0.6g ), NaOtBu (22.4g) and xylene (350ml) was stirred for 2 hours the flask washeated. The reaction mixture was cooled until room temperature, water and ethyl acetateto carry out a liquid. Then, the use of silica gel column chromatography (eluent:toluene / heptane = 5/5 (volume ratio)) to be purified, thereby obtaining the N 1 -(2,3-dichlorophenyl) -N 1 , the N 3 , the N 3 – triphenyl benzene-1,3-diamine (61.8g).

Statistics shows that 56961-77-4 is playing an increasingly important role. we look forward to future research findings about 1-Bromo-2,3-dichlorobenzene.

Reference:
Patent; Kwansei Gakuin School Corporation; Tian, Shanzuoci; Zhong, Zhongzongyiliang; Zhong, Daoguiyi; Ping, Jingdagui; Xiao, Yeyangping; Zhi, Lianyizhi; Ni, Jingping; Song, Xiawusi; Sheng, Tianlizhao; (405 pag.)CN105431439; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 56961-77-4, name is 1-Bromo-2,3-dichlorobenzene, molecular formula is C6H3BrCl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 56961-77-4

EXAMPLE 10 6-(2,3-Dichlorophenyl)-1,2-dihydro-2,2,4-trimethylquinoline (Compound 109, structure 4 of Scheme II, where R1 =2,3-dichlorophenyl) This compound was prepared according to General Method 2 (EXAMPLE 9). From Compound 9 (68.0 mg, 0.21 mmol) and commercially available 2,3-dichlorobromobenzene (40.1 mg, 0.18 mmol, Lancaster) was obtained a crude product which was isolated and purified by reverse phase HPLC (ODS column, 97% methanol/water, 3.0 mL/min) to afford 20 mg (29%) of Compound 109. Data for Compound 109: 1 H NMR (400 MHz, CDCl3) 7.39 (dd, J=8, 1.6, 1H), 7.19 (dd, J=16, 8, 1H), 7.23 (dd, J=4, 1.6, 1H), 7.11 (d, J=1.6, 1H), 7.05 (dd, J=8, 1.6, 1H), 6.46 (d, J=8, 1H), 5.34 (s, 1H), 3.82 (br s, 1H), 1.99 (s, 3H), 1.32 (s, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 56961-77-4, its application will become more common.

Reference:
Patent; Ligand Pharmaceuticals Incorporated; US5688810; (1997); A;; ; Patent; Ligand Pharmaceuticals Incorporated; US5696127; (1997); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

56961-77-4, A common compound: 56961-77-4, name is 1-Bromo-2,3-dichlorobenzene, belongs to chlorides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

After dissolving 10 g (44 mmol) of 1-bromo-2,3-dichlorobenzene [1-bromo-2,3-dichlorobenzene] in 100 mL of toluene, diphenylamine (2.1eq, 92mmol), sodium t-butok Side [sodium t-butoxide] (2.7eq, 120mmol), BTP (Bis (tri-tert-butylphosphine) palladium (0)) (10mol%) was added and stirred under reflux for 3 hours to prepare intermediate 2 (2-chloro-N1, N1, N3, N3-tetraphenylbenzene-1,3-diamine) was synthesized. The obtained intermediate 2 was purified by column chromatography.Intermediate 2: m / z = 446.15 (C30H23ClN2)Yield = 15g (75.8%), Purity = 99.5%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2,3-dichlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LG Chem, Ltd.; Lee Gi-gon; Seo Sang-deok; Keum Su-jeong; Kim Myeong-gon; Kim Gyeong-hui; Lee Dong-hun; Park Tae-yun; Kim Dong-heon; Lee U-cheol; (46 pag.)KR2020/4248; (2020); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The chemical industry reduces the impact on the environment during synthesis 56961-77-4, name is 1-Bromo-2,3-dichlorobenzene, I believe this compound will play a more active role in future production and life. 56961-77-4

Example 1 1- (2, 3-DICHLOROPHENYL)- [1, 4] diazepine (starting material) 2.25 g (10 MMOL) 1-bromo-2, 3-dichloro-benzene was dissolved in dry toluene (50 ml), 2.3 (11 MMOL) of [1, 4] diazepine-1-carboxylic acid tert-butylester was added followed by 0.2 g BINAP (2,2-bis (diphenylphosphino)-1, 1′-binaphtyl), 85 mg tris (DIBENZYLIDENEACETONE) dipalladium (0) and 1.2 g (12MMOL) SODIUM-TERT-BUTOXYDE. The reaction mixture was refluxed for eight hours and filtered. The organic layer was washed with water, dried and evaporated in vacuo. The residue was purified by chromatography and deprotected at 10 C using 20 ML ETHYLACETATE saturated with gaseous hydrochloric acid, the precipitate was filtered giving 2.1 g (yield : 75 %) hydrochloride salt of the title compound, melting at 182-3 C.

The chemical industry reduces the impact on the environment during synthesis 56961-77-4. I believe this compound will play a more active role in future production and life.

Reference:
Patent; RICHTER GEDEON VEGYESZETI GYAR RT.; WO2005/12266; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

56961-77-4, These common heterocyclic compound, 56961-77-4, name is 1-Bromo-2,3-dichlorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-bromo-2,3-dichlorobenzene (15.0 g, 66.4 mmol) and aniline (12.7 g, 136.1 mmol) were added to toluene in a three-necked flask. Dissolved in 450ml sodium tert-butoxide (9.6g, 99.6mmol), bis (tri-tert-butylphosphine) palladium (0) (0.7 g, 1.3 mmol) was added thereto, followed by stirring for 6 hours under reflux conditions under argon atmosphere. After the reaction was completed, the reaction mixture was cooled to room temperature, H 2 O was added thereto, and the reaction solution was transferred to a separatory funnel to extract. The extract was dried over MgSO 4, concentrated and the sample was purified by silica gel column chromatography to give 14.7 g of intermediate A-1. (Yield 75%)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 56961-77-4.

Reference:
Patent; LG Chem, Ltd.; Seo Sang-deok; Park Tae-yun; Lee Dong-hun; (32 pag.)KR2019/141620; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding some certain compound to certain chemical reactions, such as: 56961-77-4, name is 1-Bromo-2,3-dichlorobenzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56961-77-4. 56961-77-4

1 15 g of 1 -Bromo-2,3-dichlorobenzene was dissolved in 470 g of toluene and the solution was cooled down to -10C. Then a 20% THF solution of isopropylmagnesium chloride (309 g) was added over 30 min and the reaction mixture was stirred 1 hour at -10C. Freshly distilled cyclopentadiene (44.5 g, 1 .3 eq) was added over 10 min. After one hour stirring at ambient temperature, the mixture was heated to reflux. When the conversion was completed, the reaction mixture was filtered off and washed twice with toluene. The mother liquor was evaporated and 106 g of brown crude oil was obtained (yield: 91 .5%. The material can be purified by distillation or by CC (silica gel, eluant: Hept TBME 19/1 ).1H-NMR (400 MHz, CDCI3): delta = 7.08-6.97 (m, 3H, Ar-H); 7.00-6.96 (m, 2H, Vinyl-H); 4.32- 4.31 (m, 1 H); 4.09-4.08 (m, 1 H); 2.46 (dt, J = 7.5 Hz, 1 .5 Hz, 1 H); 2.41 (dt, J = 7.0 Hz, 1 .5 Hz, 1 H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1-Bromo-2,3-dichlorobenzene.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; DUMEUNIER, Raphael; SCHLETH, Florian; VETTIGER, Thomas; ROMMEL, Michael; TRAH, Stephan; WO2011/131545; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics