Category: 56966-48-4

The author of 《Constitution of the Naphthols AS and their bases》 were Semard, Andre. And the article was published in Teintex in 1939. Reference of 2-Amino-2,4-dichlorodiphenyl ether The author mentioned the following in the article:

Thirty-one different AS couplings have been put on the market by several countries. Their constitutions have been explained in the references furnished in this article. S. would add the following compounds to the above lists: Naphthol AS-LC (2,5-dimethoxy-4-chloroanilide of 2-hydroxy-3-naphthoic acid (I)); Cibanaphthol RPH (p-phenetide of I); Cibanaphthol RT (p-toluide of I); Naphthol AS-SG (p-aniside of 3′-hydroxy-2′-carboxy-7,8-benzocarbazole (II); Naphthol AS-SR (o-methyl-p-aniside of II); Naphthol AS-LB (p-chloroanilide of 7-hydroxy-6-carboxycarbazole) ; Naphthol AS-BT (2,5-dimethoxyanilide of 6-hydroxy-7-carboxybiphenylene oxide); Naphthol AS-L3G (2-methoxy-5-methyl-4-chloroanilide of terephthalylethanoic acid (III)); Naphthol AS-LG (2,4-dimethoxy-5-chloroanilide of III); Red FG base (4-chloro-2-aminodiphenyl oxide); Scarlet Ciba IV base (2-amino-2′,4-dichlorodiphenyl oxide); Red FR base (4,4′-dichloro-2-aminodiphenyl oxide); Scarlet LG base [1-methoxy-2-amino-4-(benzylsulfonyl)benzene]; Red GTR base [1-methoxy-2-amino-4-(ethylsulfonyl)benzene]; Bordeaux Ciba III base (4-amino-3-methoxyazobenzene); Corinthe LB base (1-benzoylamino-2-methoxy-4-amino-5-chlorobenzene); Blue RR base (5-amino-2-benzoylamino-1,4-dimethoxybenzene); Blue BB base (5-amino-2-benzoylamino-1,4-diethoxybenzene); Violet Ciba III base [1-amino-2,5-dimethoxy-4-(tolylacetylamino)benzene]; and Brown B base [o-chloro-p-nitro-p’-amino-o’-(cresol methyl ether)azobenzene].2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Reference of 2-Amino-2,4-dichlorodiphenyl ether) was used in this study.

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Reference of 2-Amino-2,4-dichlorodiphenyl ether

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 1957,Yakugaku Zasshi included an article by Matsuura, Shin; Matsuura, Akira. Recommanded Product: 56966-48-4. The article was titled 《Synthesis of 2′-hydroxy-3′ (and 5′)-acetyl-4,4′-dimethoxychalcone》. The information in the text is summarized as follows:

2,4-HO(MeO)C6H3COCH:CH6C6H4OMe-4 (I) (2.8 g.), 1 g. AcCl,40 ml. PhNO2, and 1.5 g. AlCl3, let stand 2 days, let stand 2 days with an addnl. 1 g. AlCl3 the product decomposed with HCl, steam distilled, the residue extracted with C6H6, the C6H6 removed, and the residue in 150 ml. EtOH evaporated to one-half separated 0.48 g. 3′-Ac derivative (II) of I, needles, m. 145.5°. The above reaction at 15° yielded 0.3 g. 5′-Ac derivative (III) of I, needles, m. 171.5°. Reaction of 5 g. 2,4-AcO(MeO)C6H3COCH: CHC6H4OMe-4 (IV), 4 g. AlCl3, and 50 ml. PhNO2 yielded 0.1 g. II, m. 145.5°. Condensation of 1 g. 2,4-diacetyl-resorcinol mono-Me ether and 1 g. p-MeOC6H6CHO (V) in 10 ml. EtOH and 4 ml. 50% KOH gave 1.6 g. 2′-hydroxy-3′-( 4-methoxycinnamoyl)-4,4′-dimethoxychalcone (VI), needles, m. 171° (from dilute AcOH). Condensation of 0.1 g. II and 0.2 g. V in 5 ml. EtOH and 1 g. 50% KOH yielded 0.07 g. VI, m. 171°. Similarly, 0.1 g. III and 0.5 g. V in 5 ml. EtOH and 1 g. 50% KOH gave 0.12 g. 2′-hydroxy-4,4′-dimethoxy-5′-(4-methoxycinnamoyl)chalcone, m. 190°. The experimental process involved the reaction of 2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Recommanded Product: 56966-48-4)

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Recommanded Product: 56966-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 1954,Nippon Kagaku Zasshi included an article by Yamashiro, Seishi; Matsueda, Sumu. Application of 56966-48-4. The article was titled 《Chlorodiphenylene oxides. I. Synthesis of 1,6- and 2,6-dichlorodiphenylene oxides》. The information in the text is summarized as follows:

2,6-Dichlorodiphenylene oxide, m. 149°, has been synthesized from 2,6-diaminodiphenylene oxide sulfate by the Sandmeyer method in 40.5% yield. o-Chlorophenol (25 g.) and 11 g. KOH melted, treated with 37 g. 2,5-Cl2C6H3NO2, and heated 7 hrs. at 170-80° yielded 35 g. 2-nitro-2′,4-dichlorodiphenyl ether (I), m. 62°. I was converted to the corresponding 2-amino compound (II), m. 167° by action of SnCl2-HCl in MeOH in 95% yield. Direct chlorination of II by addition of a CCl4 solution of Cl afforded 1,6-dichlorodiphenylene oxide, m. 135°, 7.7% yield, and 2-hydroxy-2′,4-dichlorodiphenyl ether, m. 66° 7.5% yield. The results came from multiple reactions, including the reaction of 2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Application of 56966-48-4)

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application of 56966-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Desai, C. K.; Desai, K. R. published an article in High Performance Polymers. The title of the article was 《Azo dyes based on 2-naphthol-formaldehyde oligomer》.Safety of 2-Amino-2,4-dichlorodiphenyl ether The author mentioned the following in the article:

A series of new oligomeric disperse dyes were prepared by coupling various diazonium salts of aniline ethers to a 2-naphthol-formaldehyde oligomer. They were characterized in terms of their softening points, color, solubility, and IR and UV-visible spectral studies. The structural property relationships were discussed. Application to polyester and nylon resulted in yellow, orange, and pink-to-red shades having good to excellent light- and washfastness properties. In addition to this study using 2-Amino-2,4-dichlorodiphenyl ether, there are many other studies that have used 2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Safety of 2-Amino-2,4-dichlorodiphenyl ether) was used in this study.

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Safety of 2-Amino-2,4-dichlorodiphenyl ether

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gonzalez-Bello, C.; Castedo, L. published an article in Science of Synthesis. The title of the article was 《Product class: monohydric phenol, and corresponding phenolates – synthesis by rearrangement》.Related Products of 56966-48-4 The author mentioned the following in the article:

A review of methods to prepare monohydric phenols and corresponding phenolates by rearrangement. The experimental part of the paper was very detailed, including the reaction process of 2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Related Products of 56966-48-4)

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Related Products of 56966-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2003,Jingxi Yu Zhuanyong Huaxuepin included an article by Hua, Yuxia; Jiao, Xiaoyun; Yu, Lixin; Zhu, Sicheng; Zou, Zhichen. Safety of 2-Amino-2,4-dichlorodiphenyl ether. The article was titled 《Study on the bactericides of polychlorophenoxylphenols》. The information in the text is summarized as follows:

Nine polychlorophenoxylphenols were synthesized from chlorophenols and chloronitrobenzenes and their bactericidal activities were tested against Staphylococcus aureus and Escherichia coli. In the part of experimental materials, we found many familiar compounds, such as 2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Safety of 2-Amino-2,4-dichlorodiphenyl ether)

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Safety of 2-Amino-2,4-dichlorodiphenyl ether

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 56966-48-4On May 4, 1984 ,《The Halogen-activated Smiles rearrangement. 2》 appeared in Journal of Organic Chemistry. The author of the article were Schmidt, Diane M.; Bonvicino, Guido E.. The article conveys some information:

The cyclization of diaryl ethers I (R = H, R1 = Cl; R = Cl, R1 = H) with K2CO3/DMF gave phenoxazines II via the Smiles-rearranged intermediates III. III, isolated as the betaines, were cyclized to II. In the part of experimental materials, we found many familiar compounds, such as 2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Application of 56966-48-4)

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Application of 56966-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ma, Menglin; Xiang, Feng; Xin, Ying; Wang, Yuliang; Chen, Shuhua published their research in Sichuan Daxue Xuebao, Ziran Kexueban on February 29 ,2004. The article was titled 《Studies on synthesis of halogenated hydroxyl diphenyl ethers》.Reference of 2-Amino-2,4-dichlorodiphenyl ether The article contains the following contents:

Hydroxydiphenyl ethers were synthesized from halogenated phenol and dinitrochlorobenzene via modified Williamson etherification, reduction and diazotization. The modified Williamson etherification was performed by melting in a solvent free system to prepare substituted nitro-diphenyl ethers. The process for hydrolyzation of diazonium salt was improved by adjusting the acidity of the reaction. In the experiment, the researchers used many compounds, for example, 2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Reference of 2-Amino-2,4-dichlorodiphenyl ether)

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Reference of 2-Amino-2,4-dichlorodiphenyl ether

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 1950,Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science included an article by Barry, Vincent C.; Belton, J. G.; Conalty, M. L.; O’Rourke, L.; Twomey, D.. Safety of 2-Amino-2,4-dichlorodiphenyl ether. The article was titled 《Antituberculous substances. VII. Derivatives of diphenyl ether》. The information in the text is summarized as follows:

An attempt is made to relate antitubercular activity to chem. structure among Ph2O derivatives The dilution which completely inhibits the growth of Mycobacterium tuberculosis for 6 wk was determined in each case. The compounds tested and their effective dilution (in the presence and in the absence of blood serum, resp.) are given as follows: Ph2O, -, 1000. Derivatives containing 1 solubilizing group: 4-H2N, -, 35,000; 4-HO, -, 100,000; 4-HO2C, -, <5,000; 4-HO3S, -, <1,000; 4-guanyl, 10,000, 25,000; and 2-H2N, -, 10,000. Derivatives containing 1 halogen atom: 4-chloro-4'-amino, 10,000, 200,000; 2-chloro-4'-amino, -, 250,000; 2-chloro-4-amino, 10,000, 250,000; 2-chloro-4'-guanyl, 10,000, 50,000; 2-chloro-4-guanyl, 25,000, 25,000; 4-chloro-4'-guanyl, 50,000, 150,000; 4-chloro-4'-hydroxy, -, 300,000; 4-chloro-4'-carboxy, -, 50,000; 4,4'-diguanyl, 1,000, 10,000; 2-chloro-4,4'-diguanyl, 10,000, 25,000; 4-chloro-2'-amino, -, 10,000; and 4-chloro-2',4'-diamino, -, 10,000. Dihalogenated derivatives: 2,4'-dichloro-4-guanyl, 50,000, 100,000; 2,4-dibromo-4'-amino, -, 400,000; 2,4-dichloro-4'-amino, 10,000, 600,000; 4-amino-2,4'-dichloro, 25,000, 1,000,000; 4-amino-2,2'-dichloro, 10,000, 400,000; 2-amino-2',4-dichloro, -, 100,000; 2-amino-4,4'-dichloro, 10,000, 150,000; 4-amino-2',4'-dichloro, 5,000, 400,000; and 2,3-diiodo-4-amino, -, 600,000. Trihalogenated derivatives: 2,2-diiodo-4-amino-4'-chloro, 25,000, 1,000,000; 2,4,5-trichloro-4'-amino, 50,000, 500,000; 2,4,6-trichloro-4'-amino, 25,000, 500,000; 2,4,5-trichloro-4'-hydroxy, -, 400,000; 2,4,5-trichloro-2',4'-diamino, -, 25,000; 2,2',4-trichloro-4'-amino, 10,000, 1,000,000. Miscellaneous derivatives and other compounds: 3,4-dimethyl-4'-amino, 10,000, 50,000; 2-chloro-4-isobutyl-4'-amino, 10,000, 750,000; 3,5-dimethyl-4-chloro-4'-amino, 25,000, 500,000; 2-methyl-4-amino-4'-chloro, -, 300,000; 2-amino-4-methyl-2'-bromo, -, 25,000; 2-bromo-4-methyl-2'-amino, -, 25,000; 2-amino-4-nitro-4'-chloro, 5,000, 10,000; 2,2',4,5-tetrachloro-4'-amino-, 25,000, 1,000,000; 4,4'-diamino, -, 1,000; 4-amino-4'-hydroxy, 10,000, 50,000; 4-amino-4'-carboxy, -, 5,000; and 4-nitro-4'-carboxy, -, 25,000; 2-hydroxy-4-aminobenzoic acid (PAS), 200, 300; sulphetrone, <1000, <1000; and streptomycin, 500,000, 1,000,000. Similar tests were run to determine the dilution needed to inhibit growth of M. smegmatus for 6 days and data are given. The most active compounds are those in which the hydrophilic group occupies the para position to the O bridge and its basic or acidic character is not significant. A grouping which possesses high water solubility depresses biol. activity, as when 2 HO, 2 H2N, or 2 guanyl groups are present. Introduction of 1 or 2 Cl substituents increases the antitubercular activity; further halogenation has little addnl. effect. The greatest activity is shown by compounds in which the halogens are shared by both Bz nuclei. Compounds which most strongly depress O uptake of yeast cells have the highest antitubercular activity. All of the Ph2O derivatives tested required a dilution of 50,000 or less in the presence of serum (in vivo) as compared to an active dilution of 1:500,000 for streptomycin.2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4Safety of 2-Amino-2,4-dichlorodiphenyl ether) was used in this study.

2-Amino-2,4-dichlorodiphenyl ether(cas: 56966-48-4) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Safety of 2-Amino-2,4-dichlorodiphenyl ether

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics