Category: 57017-95-5

3,4,5-Trisubstituted isoxazoles as novel PPAR未 agonists. Part 2 was written by Epple, Robert;Azimioara, Mihai;Russo, Ross;Xie, Yongping;Wang, Xing;Cow, Christopher;Wityak, John;Karanewsky, Don;Bursulaya, Badry;Kreusch, Andreas;Tuntland, Tove;Gerken, Andrea;Iskandar, Maya;Saez, Enrique;Martin Seidel, H.;Tian, Shin-Shay. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Application In Synthesis of Methyl 3-chloro-4-hydroxyphenylacetate This article mentions the following:

A series of PPAR未-selective agonists was investigated and optimized for a favorable in vivo pharmacokinetic profile. Isoxazole LCI765 (I) was a potent and selective PPAR未 agonist with good in vivo PK properties in mouse (C_max = 5.1 渭M, t_1/2 = 3.1 h). LCI765 regulated expression of genes involved in energy homeostasis in relevant tissues when dosed orally in C57BL6 mice. A co-crystal structure of compound LCI765 and the LBD of PPAR未 is discussed. In the experiment, the researchers used many compounds, for example, Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5Application In Synthesis of Methyl 3-chloro-4-hydroxyphenylacetate).

Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of Methyl 3-chloro-4-hydroxyphenylacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and Synthesis of a Screening Library Using the Natural Product Scaffold 3-Chloro-4-hydroxyphenylacetic Acid was written by Kumar, Rohitesh;Sadowski, Martin C.;Levrier, Claire;Nelson, Colleen C.;Jones, Amy J.;Holleran, John P.;Avery, Vicky M.;Healy, Peter C.;Davis, Rohan A.. And the article was included in Journal of Natural Products in 2015.Quality Control of Methyl 3-chloro-4-hydroxyphenylacetate This article mentions the following:

The fungal metabolite 3-chloro-4-hydroxyphenylacetic acid (I) was utilized in the generation of a unique drug-like screening library using parallel solution-phase synthesis. A 20-membered amide library, II (R = CH₂CH₂CHMe₂, morpholinoethyl, CH₂CH₂NMe₂, etc.), III (R¹, R² = H, F, R³ = H, Br, Cl, F), and IV, was generated by first converting I to Me (3-chloro-4-hydroxyphenyl)acetate, then reacting this scaffold with a diverse series of primary amines via a solvent-free aminolysis procedure. The structures of the synthetic analogs II, III, and IV were elucidated by spectroscopic data anal. The structures of compounds III (R¹ = F, R² = R³ = H), IV (R¹ = R² = H, R³ = F), and the hydrate of II (R = CH₂CH₂NMe₂) were confirmed by single X-ray crystallog. anal. All compounds were evaluated for cytotoxicity against a human prostate cancer cell line (LNCaP) and for antiparasitic activity toward Trypanosoma brucei brucei and Plasmodium falciparum and showed no significant activity at 10 渭M. The library was also tested for effects on the lipid content of LNCaP and PC-3 prostate cancer cells, and it was demonstrated that the fluorobenzyl analogs IV (R¹ = R² = H, R³ = F; R¹ = R³ = H, R² = F; R¹ = F, R² = R³ = H) significantly reduced cellular phospholipid and neutral lipid levels. In the experiment, the researchers used many compounds, for example, Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5Quality Control of Methyl 3-chloro-4-hydroxyphenylacetate).

Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of Methyl 3-chloro-4-hydroxyphenylacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Highly twisted adamantyl arotinoids: Synthesis, antiproliferative effects and RXR transactivation profiles was written by Perez-Rodriguez, Santiago;Ortiz, Maria A.;Pereira, Raquel;Rodriguez-Barrios, Fatima;de Lera, Angel R.;Piedrafita, F. Javier. And the article was included in European Journal of Medicinal Chemistry in 2009.COA of Formula: C9H9ClO3 This article mentions the following:

I (R = H, MeOCH₂CH₂OCH₂; R¹ = R² = H; R¹R² = CH:CH) and II (R = H, MeOCH₂CH₂OCH₂) are prepared as novel adamantyl biaryl arotinoids with decreased binding to retinoic acid receptors but with anticancer activity (by selective induction of apoptosis in cancer cells). I and II are prepared using Suzuki coupling reactions of an adamantylphenylboronic acid with a trifloxyphenylacetate, a trifloxycinnamate, and a trifloxynaphthoate. I (R = H, MeOCH₂CH₂OCH₂; R¹ = R² = H; R¹R² = CH:CH) show significant antiproliferative activity in several human cancer cell lines, with the anticancer activity correlated to the induction of apoptosis as measured by caspase activity. I (R = H, MeOCH₂CH₂OCH₂; R¹ = R² = H; R¹R² = CH:CH), while devoid of retinoic acid receptor binding capacity, transactivate the retinoid X receptor 伪. In the experiment, the researchers used many compounds, for example, Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5COA of Formula: C9H9ClO3).

Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C9H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Highly twisted adamantyl arotinoids: Synthesis, antiproliferative effects and RXR transactivation profiles was written by Perez-Rodriguez, Santiago;Ortiz, Maria A.;Pereira, Raquel;Rodriguez-Barrios, Fatima;de Lera, Angel R.;Piedrafita, F. Javier. And the article was included in European Journal of Medicinal Chemistry in 2009.COA of Formula: C9H9ClO3 This article mentions the following:

I (R = H, MeOCH₂CH₂OCH₂; R¹ = R² = H; R¹R² = CH:CH) and II (R = H, MeOCH₂CH₂OCH₂) are prepared as novel adamantyl biaryl arotinoids with decreased binding to retinoic acid receptors but with anticancer activity (by selective induction of apoptosis in cancer cells). I and II are prepared using Suzuki coupling reactions of an adamantylphenylboronic acid with a trifloxyphenylacetate, a trifloxycinnamate, and a trifloxynaphthoate. I (R = H, MeOCH₂CH₂OCH₂; R¹ = R² = H; R¹R² = CH:CH) show significant antiproliferative activity in several human cancer cell lines, with the anticancer activity correlated to the induction of apoptosis as measured by caspase activity. I (R = H, MeOCH₂CH₂OCH₂; R¹ = R² = H; R¹R² = CH:CH), while devoid of retinoic acid receptor binding capacity, transactivate the retinoid X receptor α. In the experiment, the researchers used many compounds, for example, Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5COA of Formula: C9H9ClO3).

Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C9H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists was written by Epple, Robert;Russo, Ross;Azimioara, Mihai;Cow, Christopher;Xie, Yongping;Wang, Xing;Wityak, John;Karanewsky, Don;Gerken, Andrea;Iskandar, Maya;Saez, Enrique;Seidel, H. Martin;Tian, Shin-Shay. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Reference of 57017-95-5 This article mentions the following:

The authors report the identification of a novel series of trisubstituted isoxazoles as PPAR activators from a high-throughput screen. A series of structural optimizations led to improved efficacy and excellent functional receptor selectivity for PPARδ. The isoxazoles represent a series of agonists which display a scaffold that lies outside the typical PPAR agonist motif. In the experiment, the researchers used many compounds, for example, Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5Reference of 57017-95-5).

Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 57017-95-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery and optimization of efficacious neutral 4-amino-6-biphenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one diacylglycerol acyl transferase-1 (DGAT1) inhibitors was written by Goldberg, Frederick W.;Birch, Alan M.;Leach, Andrew G.;Groombridge, Sam D.;Snelson, Wendy L.;Gutierrez, Pablo Morentin;Hammond, Clare D.;Birtles, Susan;Buckett, Linda K.. And the article was included in MedChemComm in 2013.Computed Properties of C9H9ClO3 This article mentions the following:

A series of neutral DGAT1 inhibitors with good potency and pharmacokinetics (PK) has been designed by modification of an acidic startpoint. This was achieved by selecting the acid with the highest ligand lipophilicity efficiency (LLE) and replacing the acid with neutral isosteres. PK properties (F_abs) were then improved by removing the sidechain to reduce mol. weight and polar surface area (PSA). Compound 13 has shown good cross-species PK, with pre-clin. efficacy and PK/PD relationships comparable to those previously described for acidic inhibitors. In the experiment, the researchers used many compounds, for example, Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5Computed Properties of C9H9ClO3).

Methyl 3-chloro-4-hydroxyphenylacetate (cas: 57017-95-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C9H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics