Category: 5781-53-3

In 2022,Ye, Cheng; Tong, Weiqi; Wu, Fan published an article in Synthesis. The title of the article was 《Nickel-Catalyzed Reductive Cross-Coupling of Oxalates Derived from α-Hydroxy Carbonyls with Vinyl Bromides》.Computed Properties of C3H3ClO3 The author mentioned the following in the article:

A nickel-catalyzed cross-electrophile coupling was disclosed in which a range of vinyl bromides were utilized as electrophiles with oxalates derived from α-hydroxy carbonyls as precursors to carbonyl radical coupling partners. This method was compatible with a broad range of functional groups, providing a complementary solution for the construction of β,γ-unsaturated carbonyl compounds The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Computed Properties of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Computed Properties of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 5781-53-3In 2021 ,《Zn-Mediated Hydrodeoxygenation of Tertiary Alkyl Oxalates》 was published in Synlett. The article was written by Ye, Yang; Ma, Guobin; Yao, Ken; Gong, Hegui. The article contains the following contents:

A general, mild, and scalable method for hydrodeoxygenation of readily accessible tertiary alkyl oxalates by Zn/silane under Ni-catalyzed conditions was described. The reduction method was suitable for an array of structural motifs derived from tertiary alcs. that beared diverse functional groups, included the synthesis of a key intermediate en route to estrone. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Related Products of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Related Products of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《A H2O2-responsive boron dipyrromethene-based photosensitizer for imaging-guided photodynamic therapy》 were Wang, Zhi-Wei; Su, Dan; Li, Xiao-Qiang; Cao, Jing-Jing; Yang, De-Chao; Liu, Jian-Yong. And the article was published in Molecules in 2019. Application In Synthesis of Methyl 2-chloro-2-oxoacetate The author mentioned the following in the article:

In this study, we demonstrate a novel H2O2 activatable photosensitizer (compound 7) which contains a diiodo distyryl boron dipyrromethene (BODIPY) core and an arylboronate group that quenches the excited state of the BODIPY dye by photoinduced electron transfer (PET). The BODIPY-based photosensitizer is highly soluble and remains nonaggregated in DMSO (DMSO) as shown by the intense and sharp Q-band absorption (707 nm). As expected, compound 7 exhibits negligible fluorescence emission and singlet oxygen generation efficiency. However, upon interaction with H2O2, both the fluorescence emission and singlet oxygen production of the photosensitizer can be restored in phosphate buffered saline (PBS) solution and PBS buffer solution containing 20% DMSO as a result of the cleavage of the arylboronate group. Due to the higher concentration of H2O2 in cancer cells, compound 7 even with low concentration is particularly sensitive to human cervical carcinoma (HeLa) cells (IC50 = 0.95μM) but hardly damage human embryonic lung fibroblast (HELF) cells. The results above suggest that this novel BODIPY derivative is a promising candidate for fluorescence imaging-guided photodynamic cancer therapy. In addition to this study using Methyl 2-chloro-2-oxoacetate, there are many other studies that have used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application In Synthesis of Methyl 2-chloro-2-oxoacetate) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Application In Synthesis of Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Iron-Catalyzed Reductive Vinylation of Tertiary Alkyl Oxalates with Activated Vinyl Halides》 was written by Ye, Yang; Chen, Haifeng; Yao, Ken; Gong, Hegui. Quality Control of Methyl 2-chloro-2-oxoacetate And the article was included in Organic Letters in 2020. The article conveys some information:

Herein a rare and efficient method for the creation of vinylated all carbon quaternary centers via Fe-catalyzed cross-electrophile coupling of vinyl halides with tertiary alkyl Me oxalates was reported. The reaction displayed excellent functional group tolerance and broad substrate scope, which allowed cascade radical cyclization and vinylation to afford complex bicyclic and spiral structural motifs, e.g., I and II. The reaction proceeded via tertiary alkyl radicals, and the putative vinyl-Br/Fe complexation appeared to be crucial for activating the alkene and enabling a possibly concerted radical addition/C-Fe forming process. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Quality Control of Methyl 2-chloro-2-oxoacetate)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Quality Control of Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Selective, Intermolecular Alkylarylation of Alkenes via Photoredox/Nickel Dual Catalysis》 were Guo, Lei; Tu, Hai-Yong; Zhu, Shengqing; Chu, Lingling. And the article was published in Organic Letters in 2019. Category: chlorides-buliding-blocks The author mentioned the following in the article:

A regioselective, intermol. 1,2-alkylarylation of alkenes with aryl halides and alkyl oxalates has been developed via photoredox/nickel dual catalysis. This dual-catalytic protocol involves a radical relay process, where radical addition is followed by a nickel-assisted coupling, forging two consecutive C-C bonds in a single operation. The mild and redox-neutral conditions allow for good compatibility in the scope of olefins, (hetero)aryl halides, as well as alkyl oxalates. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Category: chlorides-buliding-blocks)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Molecules included an article by Meuser, Megan E.; Rashad, Adel A.; Ozorowski, Gabriel; Dick, Alexej; Ward, Andrew B.; Cocklin, Simon. HPLC of Formula: 5781-53-3. The article was titled 《Field-based affinity optimization of a novel azabicyclohexane scaffold HIV-1 entry inhibitor》. The information in the text is summarized as follows:

Small-mol. HIV-1 entry inhibitors are an extremely attractive therapeutic modality. We have previously demonstrated that the entry inhibitor class can be optimized by using computational means to identify and extend the chemotypes available. Here we demonstrate unique and differential effects of previously published antiviral compounds on the gross structure of the HIV-1 Env complex, with an azabicyclohexane scaffolded inhibitor having a pos. effect on glycoprotein thermostability. We demonstrate that modification of the methyltriazole-azaindole headgroup of these entry inhibitors directly effects the potency of the compounds, and substitution of the methyltriazole with an amine-oxadiazole increases the affinity of the compound 1000-fold over parental by improving the on-rate kinetic parameter. These findings support the continuing exploration of compounds that shift the conformational equilibrium of HIV-1 Env as a novel strategy to improve future inhibitor and vaccine design efforts. The experimental part of the paper was very detailed, including the reaction process of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3HPLC of Formula: 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.HPLC of Formula: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 5781-53-3In 2020 ,《Facile Access to 1,4-Disubstituted Pyrrolo[1,2-a]pyrazines from α-Aminoacetonitriles》 appeared in Synthesis. The author of the article were Karmakar, Ananta; Ramalingam, Sridharan; Basha, Mushkin; Indasi, Gopi Kumar; Belema, Makonen; Meanwell, Nicholas A.; Dhar, T. G. Murali; Rampulla, Richard; Mathur, Arvind; Gupta, Anuradha; Gupta, Arun Kumar. The article conveys some information:

An efficient and practical synthetic protocol for synthesis of 1,4-disubstituted pyrrolo[1,2-a]pyrazine derivatives I (R = Ph, pyridin-3-yl, cyclohexyl, t-Bu, etc.) that originate from α-substituted pyrroloacetonitriles II (R1 = H) which, in turn, are readily available from aryl and alkyl aldehydes RCHO is described . The α-pyrroloacetonitriles II were subjected to a Friedel-Crafts acylation with Me chlorooxoacetate followed by reduction of the nitrile group under Pd-catalyzed hydrogenation conditions and finally aromatization with DDQ leading to the desired pyrrolo[1,2-a]pyrazine derivatives I. This method was generalized and successfully applied to various substrates. The developed protocol provides direct and convenient access to 1,4-disubstituted ring systems in moderate to good overall yields (51-68%) without the need for purification of the intermediates II (R1 = 2-methoxy-2-oxoacetyl). Further functionalization via the stepwise halogenation (bromination, iodination) and nitration was also demonstrated. In addition, the potential of the ester functionality for elaboration was demonstrated by manipulating into heterocyclic ring systems, exemplified by conversion into 2-(4-phenylpyrrolo[1,2-a]pyrazin-1-yl)benzo[d]oxazole.Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application of 5781-53-3) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Application of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Zhao, Shizhen; Wang, Le; Wang, Jie; Wang, Chenwei; Zheng, Shaowei; Fu, Yajie; Li, Yunfu; Chen, Wei-Dong; Hou, Ruifang; Yang, Dongbin; Wang, Yan-Dong published an article in RSC Advances. The title of the article was 《Design, synthesis and evaluation of 3-phenoxypyrazine-2-carboxamide derivatives as potent TGR5 agonists》.HPLC of Formula: 5781-53-3 The author mentioned the following in the article:

TGR5 is emerging as an important and promising target for the treatment of non-alc. steatohepatitis, type 2 diabetes mellitus (T2DM), and obesity. A series of novel 3-phenoxypyrazine-2-carboxamide derivatives were designed, synthesized and evaluated in vitro and in vivo. The most potent compounds 18g and 18k exhibited excellent hTGR5 agonist activity, which was superior to those of the reference drug INT-777. In addition, compound 18k could significantly reduce blood glucose levels in C57 BL/6 mice and stimulate GLP-1 secretion in NCI-H716 cells and C57 BL/6 mice. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3HPLC of Formula: 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.HPLC of Formula: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cheng, Fei; Chen, Tao; Huang, Yin-Qiu; Li, Jia-Wei; Zhou, Chen; Xiao, Xiao; Chen, Fen-Er published an article in 2022. The article was titled 《Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters》, and you may find the article in Organic Letters.Synthetic Route of C3H3ClO3 The information in the text is summarized as follows:

Authors have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale. In the experimental materials used by the author, we found Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Synthetic Route of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Synthetic Route of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: Methyl 2-chloro-2-oxoacetateIn 2019 ,《Ni-Catalyzed Reductive C-O Bond Arylation of Oxalates Derived from α-Hydroxy Esters with Aryl Halides》 was published in Organic Letters. The article was written by Gao, Mengyu; Sun, Deli; Gong, Hegui. The article contains the following contents:

A Ni-catalyzed reductive cross-coupling of α-hydroxycarbonyl compounds modified with oxalyl groups and aryl halides has been developed that furnishes α-aryl esters under mild conditions and tolerates a variety of functionalized aryl halides bearing electron-withdrawing and -donating groups. This work highlights C-O bond fragmentation on secondary alkyl carbon centers that generates α-carbonyl radicals.Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Name: Methyl 2-chloro-2-oxoacetate) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Name: Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics