Category: 5781-53-3

In 2022,Ji, Dong-Sheng; Liang, Hui; Yang, Kai-Xuan; Feng, Zhi-Tao; Luo, Yong-Chun; Xu, Guo-Qiang; Gu, Yucheng; Xu, Peng-Fei published an article in Chemical Science. The title of the article was 《Solvent directed chemically divergent synthesis of β-lactams and α-amino acid derivatives with chiral isothiourea》.HPLC of Formula: 5781-53-3 The author mentioned the following in the article:

A protocol for the chem. divergent synthesis of β-lactams I (R1 = Ph, 3-ClC6H4, 2-thienyl, etc.; R2 = Ph, 1-naphthyl, 3-thienyl, 3-indolyl, etc.; R3 = Me, Et, PhCH2) and α-amino esters II with isothiourea catalysis by switching solvents has been developed. The stereospecific Mannich reaction occurring between imines III and zwitterionic enolate intermediates, generated from the catalyst and perfluorophenyl esters IV, followed by intramol. lactamization afforded β-lactams I when dichloromethane and acetonitrile were used as solvents. However, when EtOH was used as the solvent, the intermediates underwent an intermol. esterification reaction, and α-amino acid derivatives II were produced. Detailed mechanistic experiments were conducted to prove that these two kinds of products came from the same intermediates. Furthermore, chem. diversified transformations of β-lactam and α-amino acid derivatives were achieved. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3HPLC of Formula: 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.HPLC of Formula: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Chen, Jian-Qiang; Tu, Xiaodong; Qin, Binyan; Huang, Shaoxin; Zhang, Jun; Wu, Jie published an article in Organic Letters. The title of the article was 《Synthesis of Ester-Substituted Indolo[2,1-a]isoquinolines via Photocatalyzed Alkoxycarbonylation/Cyclization Reactions》.SDS of cas: 5781-53-3 The author mentioned the following in the article:

A direct alkoxycarbonylation/cyclization reaction is accomplished under visible light-induced photoredox catalysis. With this approach, a variety of ester-substituted indolo[2,1-a]isoquinolines are prepared in good to excellent yields. It is worth noting that this method not only can afford the synthesis of indolo[2,1-a]isoquinolines but also can provide an alternative route for generating complex target structures bearing carboxylic esters.Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3SDS of cas: 5781-53-3) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.SDS of cas: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Bhunia, Subhajit; De, Subhadip; Ma, Dawei published an article in Organic Letters. The title of the article was 《Room Temperature Cu-Catalyzed N-Arylation of Oxazolidinones and Amides with (Hetero)Aryl Iodides》.Reference of Methyl 2-chloro-2-oxoacetate The author mentioned the following in the article:

N,N’-Bis(pyridin-2-ylmethyl)oxalamide (BPMO) was found to be an apposite promoter for the Cu-catalyzed N-arylation of oxazolidinones and primary and secondary amides with (hetero)aryl iodides at room temperature Excellent chemoselectivity reached between aryl iodides and aryl bromides, and a wide range of functional groups tolerated the reaction conditions, which led to the formation of greatly diverse N-arylation products. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Reference of Methyl 2-chloro-2-oxoacetate)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Reference of Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Weiss, Alexander K. H.; Wurzer, Richard; Klapec, Patrycia; Eder, Manuel Philip; Loeffler, Johannes R.; von Grafenstein, Susanne; Monteleone, Stefania; Liedl, Klaus R.; Jansen-Duerr, Pidder; Gstach, Hubert published an article in 2021. The article was titled 《Inhibitors of Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1)》, and you may find the article in Molecules.SDS of cas: 5781-53-3 The information in the text is summarized as follows:

FAH domain containing protein 1 (FAHD1) acts as oxaloacetate decarboxylase in mitochondria, contributing to the regulation of the tricarboxylic acid cycle. Guided by a high-resolution X-ray structure of FAHD1 liganded by oxalate, the enzymic mechanism of substrate processing is analyzed in detail. Taking the chem. features of the FAHD1 substrate oxaloacetate into account, the potential inhibitor structures are deduced. The synthesis of drug-like scaffolds afforded first-generation FAHD1-inhibitors with activities in the low micromolar IC50 range. The investigations disclosed structures competing with the substrate for binding to the metal cofactor, as well as scaffolds, which may have a novel binding mode to FAHD1. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3SDS of cas: 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.SDS of cas: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Collin, Diego E.; Kovacic, Kristina; Light, Mark E.; Linclau, Bruno published their research in Organic Letters in 2021. The article was titled 《Synthesis of Ortho-Functionalized 1,4-Cubanedicarboxylate Derivatives through Photochemical Chlorocarbonylation》.Electric Literature of C3H3ClO3 The article contains the following contents:

Here a practical procedure for a direct radical-mediated chlorocarbonylation process initially reported by Bashir-Hashemi, to access a range of 2-substituted 1,4-cubanedicarboxylic ester derivatives was reported. A subsequent regioselective ester hydrolysis to give fully differentiated 1,2,4-trisubstituted cubanes was demonstrated. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Electric Literature of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Electric Literature of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gediya, Shweta K.; Vyas, Vijyesh K.; Clarkson, Guy J.; Wills, Martin published an article in 2021. The article was titled 《Asymmetric Transfer Hydrogenation of α-Keto Amides; Highly Enantioselective Formation of Malic Acid Diamides and α-Hydroxyamides》, and you may find the article in Organic Letters.Computed Properties of C3H3ClO3 The information in the text is summarized as follows:

The asym. transfer hydrogenation (ATH) of α-keto-1,4-diamides using a tethered Ru/TsDPEN catalyst was achieved in high ee. Studies on derivatives identified the structural elements which led to the highest enantioselectivities in the products. The α-keto-amide reduction products were converted to a range of synthetically valuable derivatives In the experimental materials used by the author, we found Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Computed Properties of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Computed Properties of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Placais, Clotilde; Donnard, Morgan; Panossian, Armen; Vors, Jean-Pierre; Bernier, David; Pazenok, Sergii; Leroux, Frederic R. published their research in Organic Letters in 2021. The article was titled 《Synthesis of 3-Amino-5-fluoroalkylfurans by Intramolecular Cyclization》.Synthetic Route of C3H3ClO3 The article contains the following contents:

A synthesis to access rarely described 3-amino-5-fluoroalkylfurans has been developed by cyclization of easily accessible fluorovinamides. This method is rapid and simple and affords the desired furans as hydrochloride salts in quant. or nearly quant. yields. It is compatible with four different fluorinated groups (-CF3, -CF2CF3, -CHF2, and -CF2Cl) and a wide range of substituents on the amine. The experimental part of the paper was very detailed, including the reaction process of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Synthetic Route of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Synthetic Route of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Sheng, Cheng; Ling, Zheng; Luo, Yicong; Zhang, Wanbin published an article in Nature Communications. The title of the article was 《Cu-Catalyzed asymmetric addition of alcohols to β,γ-alkynyl-α-imino esters for the construction of linear chiral N,O-ketals》.Computed Properties of C3H3ClO3 The author mentioned the following in the article:

Herein, a Cu-catalyzed asym. addition of alcs. to β,γ-alkynyl-α-imino esters was developed under mild conditions, providing the corresponding linear chiral N,O-ketals I [R1 = n-Bu, Ph, 2-thienyl, etc.; R2 = Me, Et, n-Pr, n-Bu; R3 = Me, Et, cyclobutyl, Bn, etc.] with up to 96% ee. The method tolerated some variation in the β,γ-alkynyl-α-imino esters and alc. scope, including some glucose and natural amino acid derivatives Computational results indicated that the Boc group of the substrates assist in the extraction of hydrogen atoms from the alcs. to promote the addition reactions. These products could be synthesized on a gram-scale and can be used in several transformations. This asym. addition system provided an efficient, mild, gram-scale, and transition-metal-catalyzed synthesis of linear chiral N,O-ketals. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Computed Properties of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Computed Properties of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Straccia C., Vianni G.; Lugo, Pedro L.; Rivela, Cynthia B.; Blanco, Maria B.; Wiesen, Peter; Teruel, Mariano A. published an article in 2021. The article was titled 《OH-initiated degradation of methyl 2-chloroacetoacetate and ethyl 2-chloroacetoacetate: Kinetics, products and mechanisms at 298 K and atmospheric pressure》, and you may find the article in Chemosphere.Application of 5781-53-3 The information in the text is summarized as follows:

Rate coefficients for the gas-phase reactions of OH radicals with CH3C(O)CHClC(O)OCH3 (k1) and CH3C(O)CHClC(O)OCH2CH3 (k2) were measured using the relative technique with different reference compounds The experiments were performed at (298 ± 2) K and 750 Torr of nitrogen or synthetic air by in situ FTIR spectroscopy and GC-FID chromatog. The following rate coefficients (in units of cm3mol.-1 s-1) were obtained: k1FTIR= (2.70 ± 0.51) x 10-11; k1GC-FID= (2.30 ± 0.71) x 10-11 and k2FTIR= (3.37 ± 0.62) x 10-11; k2GC-FID= (3.26 ± 0.85) x 10-11. This work reports the first kinetic study for the reactions of OH radicals with the mentioned chloroacetoacetates. Addnl., product studies are reported in similar conditions of the kinetic experiments Acetic acid, acetaldehyde, formyl chloride, and Me 2-chloro-2-oxoacetate were pos. identified and quantified as degradation products. According to the identified products, atm. chem. mechanisms were proposed. The environmental implications of these reactions were assessed by the tropospheric lifetimes calculations of the title chloroesters. Significant average ozone production of 4.16 ppm for CH3C(O)CHClC(O)OCH3 and 5.98 ppm for CH3C(O)CHClC(O)OCH2CH3, resp. were calculated In the experimental materials used by the author, we found Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Application of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sharland, Jack C.; Wei, Bo; Hardee, David J.; Hodges, Timothy R.; Gong, Wei; Voight, Eric A.; Davies, Huw M. L. published their research in Chemical Science in 2021. The article was titled 《Asymmetric synthesis of pharmaceutically relevant 1-aryl-2-heteroaryl- and 1,2-diheteroarylcyclopropane-1-carboxylates》.Formula: C3H3ClO3 The article contains the following contents:

This study described general methods for the enantioselective syntheses of pharmaceutically relevant 1-aryl-2-heteroaryl- and 1,2-diheteroarylcyclopropane-1-carboxylates through dirhodium tetracarboxylate-catalyzed asym. cyclopropanation of vinyl heterocycles with aryldiazoacetates. The reactions were highly diastereoselective and high asym. induction could be achieved using either (R)-pantolactone as a chiral auxiliary or chiral dirhodium tetracarboxylate catalysts. For meta- or para-substituted aryl- or heteroaryldiazoacetates the optimum catalyst was Rh2(R-p-Ph-TPCP)4. In the case of ortho-substituted aryl- or heteroaryldiazoacetates, the optimum catalyst was Rh2(R-TPPTTL)4. For a highly enantioselective reaction with the ortho-substituted substrates, 2-chloropyridine was required as an additive in the presence of either mol. sieves or 1,1,1,3,3,3-hexafluoroisopropanol (HFIP). Under the optimized conditions, the cyclopropanation could be conducted in the presence of a variety of heterocycles, such as pyridines, pyrazines, quinolines, indoles, oxadiazoles, thiophenes and pyrazoles. The results came from multiple reactions, including the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Formula: C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Formula: C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics