Category: 5781-53-3

The author of 《Photoredox-catalyzed deoxyfluorination of activated alcohols with Selectfluor》 were Gonzalez-Esguevillas, Maria; Miro, Javier; Jeffrey, Jenna L.; MacMillan, David W. C.. And the article was published in Tetrahedron in 2019. Computed Properties of C3H3ClO3 The author mentioned the following in the article:

A new visible-light photoredox catalyzed method was disclosed for the deoxyfluorination of alcs. via their corresponding oxalates, which were readily accessible in a single step and could be use without purification This radical-mediated C-F coupling was capable of fluorinating secondary and tertiary alcs. efficiently, complementing previously reported nucleophilic deoxyfluorination protocols. From a mechanistic perspective, this strategy constitute a distinct approach to the deoxyfluorination of alcs., employing an electrophilic fluorine source. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Computed Properties of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Computed Properties of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ji, Mingjuan; Xu, Liang; Luo, Xiangxiang; Jiang, Minghui; Wang, Siyu; Chen, Jian-Qiang; Wu, Jie published an article in 2021. The article was titled 《Alkoxycarbonyl radicals from alkyloxalyl chlorides: photoinduced synthesis of isoquinolinediones under visible light irradiation》, and you may find the article in Organic Chemistry Frontiers.Product Details of 5781-53-3 The information in the text is summarized as follows:

Alkyloxalyl chlorides, generated from alcs. and oxalyl chlorides, were used as alkoxycarbonyl radicals in the reaction of N-acryloyl benzamides under photocatalysis at room temperature This approach could be compatible with a variety of alc.-containing pharmaceutically active compounds under visible light irradiation A variety of isoquinoline-1,3(2H,4H)-diones I [R = Me, Et, hexadecyl, etc.; R1 = H, 6-Me, 6-F, etc.; R2 = Me, cyclohexyl, Bn, etc.; R3 = Me, Ph, Bn] were prepared in moderate to good yields. The experimental part of the paper was very detailed, including the reaction process of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Product Details of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Product Details of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Access to polyfunctionalized carbazoles through π-extension of 2-methyl-3-oxoacetate indoles》 were Guo, Yingying; Wang, Zhoulu; Zhu, Ying; Zhang, Qiaochu; Wei, Donghui; Liu, Xiang; Fu, Zhenqian. And the article was published in Organic Chemistry Frontiers in 2019. SDS of cas: 5781-53-3 The author mentioned the following in the article:

An efficient and direct strategy for the synthesis of polyfunctionalized carbazoles I [R1 = H, 2-Me, 3-Cl, etc.; R2 = Me, Et, Bn, etc.; R3 = H, 8-OMe, 9,10-di-Br; X = NTs, NSO2Ph, O, S] and II [R4 = H, 2-Me, 3-Cl, 2-NO2; R5 = OMe, OEt, OBn; X = NTs, NSO2Ph, S] was developed via formal [4 + 2] annulation of 2-methyl-3-oxoacetate indoles with naphthalene-1,4-dione or dialkyl acetylene dicarboxylate in acceptable to excellent yields. This reaction featured H2O as the only byproduct, broad substrate scope and proceeded under mild conditions. In addition to this study using Methyl 2-chloro-2-oxoacetate, there are many other studies that have used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3SDS of cas: 5781-53-3) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.SDS of cas: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Application of high-throughput competition experiments in the development of aspartate-directed site-selective modification of tyrosine residues in peptides》 was written by Chinn, Alex J.; Hwang, Jaeyeon; Kim, Byoungmoo; Parish, Craig A.; Krska, Shane W.; Miller, Scott J.. Recommanded Product: 5781-53-3 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

Herein we report a Cu-catalyzed, site-selective functionalization of peptides that employs an aspartic acid (Asp) as a native directing motif, which directs the site of O-arylation at a proximal tyrosine (Tyr) residue. Through a series of competition studies conducted in high-throughput reaction arrays, effective conditions were identified that gave high selectivity for the proximal Tyr in Asp-directed Tyr modification. Good levels of site-selectivity were achieved in the O-arylation at a proximal Tyr residue in a number of cases, including a peptide-small mol. hybrid.Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Recommanded Product: 5781-53-3) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Recommanded Product: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Sakamoto, Ryota; Odagi, Minami; Izumiseki, Atsuto; Konuki, Kaname; Nagasawa, Kazuo published an article in Journal of Organic Chemistry. The title of the article was 《Stereodivergent Synthesis of 1,3-Dienes via Protodeboronation of Homoallenylboronic Esters》.Recommanded Product: 5781-53-3 The author mentioned the following in the article:

A versatile synthesis of homoallenylboronic esters via lithiation-borylation and subsequent 1,2-rearrangement was reported. The resulting homoallenylboronic esters were successfully converted into Z- and E-1,3-dienes by protodeboronation using Bu4NF and B(C6F5)3/PhOH, resp. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Recommanded Product: 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Recommanded Product: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Luo, Zhonghua; Sun, Guodong; Wu, Shuming; Chen, Yong; Lin, Yicao; Zhang, Lei; Wang, Zhongqing published an article in 2021. The article was titled 《η6-Arene CH-O Interaction Directed Dynamic Kinetic Resolution-Asymmetric Transfer Hydrogenation (DKR-ATH) of α-Keto/enol-Lactams》, and you may find the article in Advanced Synthesis & Catalysis.Recommanded Product: Methyl 2-chloro-2-oxoacetate The information in the text is summarized as follows:

Dynamic kinetic resolution – asym. transfer hydrogenation (DKR-ATH) methodol. for α-keto/enol-lactams, e.g., I (R1 = Me, i-Pr, n-Bu, PhCH2, 4-MeOC6H4; R2 = Me, MeO2C, PhCH2, 2-thienylmethyl, etc.), that provided a series of the corresponding chiral hydroxy lactams, e.g., II, has been developed. A possible catalytic mechanism evolving a transition state stabilized by η6-arene CH-O interaction was also proposed. This efficient approach can be applied to a wide range of substrates including non-aryl ones which would be difficult to prepare by other asym. reduction methods. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Recommanded Product: Methyl 2-chloro-2-oxoacetate)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Recommanded Product: Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Stoichiometric Photochemical Carbene Transfer by Bamford-Stevens Reaction》 was written by Jana, Sripati; Li, Fang; Empel, Claire; Verspeek, Dennis; Aseeva, Polina; Koenigs, Rene M.. Formula: C3H3ClO3 And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:

A protocol that takes advantage of the in-situ generation of donor-acceptor diazoalkanes from functionalized tosyl hydrazones by Bamford-Stevens reaction is described. This approach was used in C-H and N-H functionalization and cyclopropanation of nitrogen heterocycles, and the wide scope is illustrated by 51 examples. For example, irradiation of N-tosyl hydrazones RC(CO2Me):NNHTs (R = Ph, 4-MeC6H4, 3-Me-4-MeOC6H4. 4-ClC6H4, etc.) with various R1-substituted N-R2-indoles (R1 = H, 5-Br, 5-MeO2C, 6-F, 4-Br, etc.; R2 = Me, H2C:CHCH2, PhCH2, 4-MeOC6H4, 2-thienyl, etc.) under basic conditions provided the corresponding indoleacetates I in moderate to high yields. Following this strategy, the concentration of the diazoalkane reaction partner was minimized to reduce unwanted side reactions and to now conduct photochem. carbene transfer reactions under stoichiometric reaction conditions. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Formula: C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Formula: C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《General Access to Concave-Substituted cis-Dioxabicyclo[3.3.0]octanones: Enantioselective Total Syntheses of Macfarlandin C and Dendrillolide A》 was written by Allred, Tyler K.; Dieskau, Andre P.; Zhao, Peng; Lackner, Gregory L.; Overman, Larry E.. Electric Literature of C3H3ClO3 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

The evolution of a strategy to access the family of rearranged spongian diterpenoids harboring a concave-substituted cis-2,8-dioxabicyclo[3.3.0]octan-3-one fragment is described. The approach involves late-stage fragment coupling of a tertiary-carbon radical and an electron-deficient double bond to form vicinal quaternary and tertiary stereocenters with high fidelity. A stereoselective Mukaiyama hydration is the key step in the subsequent elaboration of the cis-2,8-dioxabicyclo[3.3.0]octan-3-one moiety. This strategy was utilized in enantioselective total syntheses of (-)-macfarlandin C and (+)-dendrillolide A. An efficient construction of enantiopure tetramethyloctahydronaphthalenes was developed during the construction of (-)-macfarlandin C. In addition to this study using Methyl 2-chloro-2-oxoacetate, there are many other studies that have used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Electric Literature of C3H3ClO3) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Electric Literature of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhao, Shizhen; Li, Xinping; Wang, Le; Peng, Wenjing; Ye, Wenling; Li, Weiguo; Wang, Yan-Dong; Chen, Wei-Dong published their research in Bioorganic & Medicinal Chemistry in 2021. The article was titled 《Design, synthesis and evaluation of 1-benzyl-1H-imidazole-5-carboxamide derivatives as potent TGR5 agonists》.Quality Control of Methyl 2-chloro-2-oxoacetate The article contains the following contents:

A series of novel 1-benzyl-1H-imidazole-5-carboxamides I [R1 = 4-methylanilino, 4-fluoro-N-methyl-anilino, 4-phenylpiperazin-1-yl, etc.] and II [R2 = H, 2-Cl, 2,4-di-F, etc.] were designed, synthesized and evaluated in-vitro and in-vivo. The most potent compounds II [R2 = 2,4-di-Cl, 2,5-di-Cl] exhibited excellent agonistic activities against hTGR5, which was superior to those of the reference drugs INT-777 and LCA. In addition, compounds II [R2 = 2,4-di-Cl, 2,5-di-Cl] exhibited good selectivity against FXR and presented significant glucose-lowering effects in-vivo. Compound II [R2 = 2,4-di-Cl] stimulated GLP-1 secretion by activating of TGR5.Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Quality Control of Methyl 2-chloro-2-oxoacetate) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Quality Control of Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《An incisive optical recognition of monohydrogen phosphate by a fluorescein-based chemodosimeter》 was written by Asthana, Sharad Kumar; Pandey, Abha; Kumar, Ajit; Upadhyay, K. K.. COA of Formula: C3H3ClO3 And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

Numerous methods for the determination of phosphates (H2PO4-, HPO42-, PO43-, PPi) are described in the literature. However, the design of optical probes which are able to recognize specifically monohydrogen phosphate (MHP) ions, i.e. HPO42-, has been rarely considered. We herein devised an incisive chemodosimeter (FLH) for detecting HPO42- over other phosphates successfully. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3COA of Formula: C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.COA of Formula: C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics