Category: 5860-95-7

He, Hualing published the artcileCatalytic Asymmetric Reduction of α-Trifluoromethylated Imines with Catecholborane by BINOL-Derived Boro-phosphates, HPLC of Formula: 5860-95-7, the publication is Journal of Organic Chemistry (2021), 86(5), 4336-4345, database is CAplus and MEDLINE.

A catalytic enantioselective reduction of α-trifluoromethylated imines by a BINOL-derived boro-phosphate employing catecholborane as hydride source has been developed. This method provides an efficient route to prepare synthetically useful chiral α-trifluoromethylated amines in high yields and with excellent enantioselectivities (up to 98% yield and 96% ee) under mild conditions.

Journal of Organic Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, HPLC of Formula: 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Lili published the artcileChiral thiourea catalyzed asymmetric Henry reaction: construction of stereogenic center bearing a CF₃ group from 2,2,2-trifluoroacetophenone substrates, SDS of cas: 5860-95-7, the publication is Youji Huaxue (2017), 37(4), 936-942, database is CAplus.

An asym. Henry reaction with 2,2,2-trifluoroacetophenone as trifluoromethyl building block was described. This reaction was catalyzed by bifunctional thiourea derived from quinine to give the product bearing a CF₃ stereogenic center in good yield with good enantioselectivity.

Youji Huaxue published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C24H12, SDS of cas: 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Zhifang published the artcileMerging Imidazolidines with a Trifluoromethylated Tetrasubstituted Carbon through Tungsten Catalyzed 1,3-Dipolar Cycloaddition, HPLC of Formula: 5860-95-7, the publication is Journal of Organic Chemistry (2021), 86(11), 7714-7724, database is CAplus and MEDLINE.

An unprecedented 1,3-dipole cycloaddition between acyclic CF₃-ketimines and N-benzyl azomethine ylide has been allowed by tungsten catalysis, furnishing a range of novel imidazolidines bearing a trifluoromethylated tetrasubstituted carbon center. This reaction appears as one of rare examples that challenging acyclic CF₃-ketimines have been engaged in 1,3-cycloaddition reactions. The capability for gram-scale synthesis and variant derivatizations of cycloaddition adducts illustrates the synthetic potential of this approach. This protocol provides a facile access to a rapidly enlarging pool of motifs with a trifluoromethylated fully substituted carbon.

Journal of Organic Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, HPLC of Formula: 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Shuming published the artcileArylketone π-Conjugation Controls Enantioselectivity in Asymmetric Alkynylations Catalyzed by Centrochiral Ruthenium Complexes, Product Details of C8H4ClF3O, the publication is Journal of the American Chemical Society (2018), 140(15), 5146-5152, database is CAplus and MEDLINE.

The origin of enantioselectivity in the asym. alkynylation of trihalomethyl ketones catalyzed by octahedral stereogenic-at-ruthenium complexes has been investigated through d. functional theory calculations Computational results support a mechanism involving formation of a ruthenium acetylide, followed by pre-coordination of the trihalomethyl ketone through the carbonyl oxygen and intramol. attack of the acetylide via a compact four-membered transition state. Differences in computed free energies of activation for the formation of the major and minor propargyl alc. enantiomers are in good agreement with the exptl. observed levels of asym. induction. Anal. of fragment distortion energies shows that disfavored transition states are destabilized due to the more severe distortion and loss of π-conjugation in the coordinated arylketone fragments. Examination of the different substitution patterns in the ketone substrate and the catalyst reveals the key steric factors that control the enantioselectivity. Finally, calculations indicate promising directions for the simplification of the catalyst scaffold while preserving the high levels of enantioselectivity of these alkynylation reactions.

Journal of the American Chemical Society published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Product Details of C8H4ClF3O.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Jun-Hao published the artcileEnantioselective vinylogous aldol/lactonization cascade reaction between β,γ-unsaturated amides and trifluoromethyl ketones: facile access to chiral trifluoromethyl dihydropyranones, Safety of 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, the publication is Organic & Biomolecular Chemistry (2020), 18(39), 7848-7851, database is CAplus and MEDLINE.

An efficient asym. vinylogous aldol/lactonization cascade reaction between β,γ-unsaturated amides I (R¹ = C₆H₅, 2-thienyl, 1-naphthyl, etc.) and trifluoromethyl ketones has R²C(O)CF₃ (R² = C₆H₅, 2-ClC₆H₄, CH=CHC₆H₅, etc.) been developed. Using a chiral cyclohexanediamine-based tertiary amine-thiourea catalyst II [Ar = 3,5-(CF₃)₂C₆H₃], optically active trifluoromethyl dihydropyranones (S)-III have been constructed in moderate-to-excellent yields (up to 99%) with excellent stereoselectivities (96-> 99.5% ee).

Organic & Biomolecular Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Safety of 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qi, Jing published the artcileNew Radical Borylation Pathways for Organoboron Synthesis Enabled by Photoredox Catalysis, Category: chlorides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2020), 59(31), 12876-12884, database is CAplus and MEDLINE.

Radical borylation using N-heterocyclic carbene (NHC)-BH₃ complexes as boryl radical precursors has emerged as an important synthetic tool for organoboron assembly. However, the majority of reported methods are limited to reaction modes involving carbo- and/or hydroboration of specific alkenes and alkynes. Moreover, the generation of NHC-boryl radicals relies principally on hydrogen atom abstraction with the aid of radical initiators. A distinct radical generation method is reported, as well as the reaction pathways of NHC-boryl radicals enabled by photoredox catalysis. NHC-boryl radicals are generated via a single-electron oxidation and subsequently undergo cross-coupling with the in-situ-generated radical anions to yield gem-difluoroallylboronates. A photoredox-catalyzed radical arylboration reaction of alkenes was achieved using cyanoarenes as arylating components from which elaborated organoborons were accessed. Mechanistic studies verified the oxidative formation of NHC-boryl radicals through a single-electron-transfer pathway.

Angewandte Chemie, International Edition published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Du, Mengyuan published the artcileN-Protecting group tuning of the enantioselectivity in Strecker reactions of trifluoromethyl ketimines to synthesize quaternary α-trifluoromethyl amino nitriles by ion pair catalysis, SDS of cas: 5860-95-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(10), 1581-1584, database is CAplus and MEDLINE.

An enantioselective Strecker reaction to construct trifluoromethylated quaternary stereocenters with N-PMP and unexplored N-Boc trifluoromethyl ketimines RC(CF₃)=NR¹ [R = Ph, 3,5-difluorophenyl, thiophen-2-yl, etc.; R¹ = 4-methoxyphenyl, C(O)OC(CH₃)₃] catalyzed using an organophosphine dual-reagent catalyst has been developed. The enantioselectivities of the corresponding products (R/S)-RC(CF₃)(CN)NH(R¹) with the same catalyst could be switched by using different N-protecting groups (N-PMP or N-Boc). The trifluoromethyl amino nitriles (R/S)-RC(CF₃)(CN)NH(R¹) were obtained in high yield and high enantioselectivity in a short time and could be easily converted to a variety of useful trifluoromethyl-containing compounds

Chemical Communications (Cambridge, United Kingdom) published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, SDS of cas: 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sasaki, Shigeru published the artcileBisoxazoline-catalyzed asymmetric nucleophilic addition of diethyl zinc to fluorinated alkyl ketones: enantiofacial control by changing the bisoxazoline substituent, Application of 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, the publication is Bulletin of the Chemical Society of Japan (2015), 88(1), 200-208/1-200-208/9, 9 pp., database is CAplus.

Bisoxazoline (BOX)-catalyzed asym. nucleophilic addition of di-Et zinc to fluorinated alkyl ketones successfully afforded enantioenriched fluorinated alkyl tertiary alcs. The effect of the size of the substituent on the oxazoline ring on the stereoselectivity of the reaction was investigated. Furthermore, the enantioselectivity could be reversed by altering the BOX bridge structure while retaining the C-4 substituent on the oxazoline ring.

Bulletin of the Chemical Society of Japan published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Application of 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Xiao-Juan published the artcileConvenient and efficient decarboxylative aldol reaction of malonic acid half esters with trifluoromethyl ketones, Formula: C8H4ClF3O, the publication is Tetrahedron Letters (2012), 53(16), 2117-2120, database is CAplus.

A convenient and efficient decarboxylative ketone aldol condensation of malonic acid half esters was reported. In the presence of catalytic amount of triethylamine, a series of aromatic and alkyl trifluoromethyl ketones were transformed into the desired adducts in 61-99% yields. In a preliminary experiment, a moderate stereoselectivity was obtained. Direct reduction of the aldol product with LiAlH₄ afforded trifluoromethylated 1,3-diol.

Tetrahedron Letters published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Formula: C8H4ClF3O.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yearick, Kimberly published the artcileCatalytic enantioselective addition of diethylzinc to trifluoromethyl ketones. [Erratum to document cited in CA149:307341], Quality Control of 5860-95-7, the publication is Organic Letters (2008), 10(19), 4391, database is CAplus.

On page 3915, we overlooked previous work by Sasaki et. al. which discusses the enantioselective synthesis of tertiary alcs. via addition of diethylzinc to trifluoromethyl ketones in the presence of nitrogen-containing polydentate ligands. The following reference citation should be included: “Higashiyama, K.; Sasaki, S.; Kubo, H.; Yamauchi, T.; Ishii, A.; Kanai, M. Japanese Patent 200609692, Apr. 13, 2006.”.

Organic Letters published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C5H9IO2, Quality Control of 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics