Category: 5860-95-7

Zhang, Guang-Wu published the artcileCatalytic Enantioselective Alkynylation of Trifluoromethyl Ketones: Pronounced Metal Fluoride Effects and Implications of Zinc-to-Titanium Transmetalation, Category: chlorides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2011), 50(15), 3538-3542, S3538/1-S3538/84, database is CAplus and MEDLINE.

Trifluoromethyl ketones were alkynylated stereoselectively in presence of cinchona alkaloid ligands, titanium tetraisopropoxide, dimethylzinc, and barium fluoride. The barium fluoride proved to be essential for asym. induction. The mechanism of zinc-to-titanium transmetalation is discussed.

Angewandte Chemie, International Edition published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C5H8N2O, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ashraf, Muhammad Awais published the artcileSustainable radical approaches for cross electrophile coupling to synthesize trifluoromethyl- and allyl-substituted tert-alcohols, COA of Formula: C8H4ClF3O, the publication is iScience (2021), 24(12), 103388, database is CAplus and MEDLINE.

Trifluoromethylated mols. have gained privileged recognition among the medicinal and pharmaceutical chemists. Sustainable photoredox- and electrochem. processes were employed to facilitate the relatively less explored radical cross-electrophile coupling to access trifluoromethyl- and allyl-substituted tert-alcs. I (Ar = Ph, 2-ClC₆H₄, 2-naphthyl, etc.). Reactions proceed through trifluoromethyl ketyl radical and allyl radical intermediates, which underwent challenging radical-radical cross-coupling. The developed transformations are mild and chemo-selective to give cross-coupled products and deliver a wide range of valuable trifluoromethyl- and allyl-containing tertiary alcs. Both processes can also be applied for the synthesis of amine variant containing trifluoromethyl and allyl moiety, which is considered as amide bioisostere.

iScience published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, COA of Formula: C8H4ClF3O.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tanaka, Yusuke published the artcileA new entry for the oxidation of fluoroalkyl-substituted methanol derivatives: Scope and limitation of the organoiodine(V) reagent-catalyzed oxidation, Related Products of chlorides-buliding-blocks, the publication is Journal of Fluorine Chemistry (2012), 99-104, database is CAplus.

Oxidation of various fluoroalkyl-substituted methanol derivatives under the influence of a catalytic amount of sodium 2-iodobenzenesulfonate and oxone in CH₃CN or CH₃NO₂ was investigated in detail. The efficiency of the newly developed oxidation was also evaluated by comparison to other oxidations, such as Dess-Martin, PDC, and Swern oxidation

Journal of Fluorine Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H6ClN, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Jun published the artcileIndium-promoted preparation of α-methylene-γ-trifluoromethyl-γ-lactams via one-pot reaction, Category: chlorides-buliding-blocks, the publication is Youji Huaxue (2017), 37(11), 2985-2992, database is CAplus.

An one-pot reaction of trifluoroacetaldehyde Me hemiacetal or trifluoroketones, acylhydrazines and Et 2-(bromomethyl)acrylate promoted by indium powder was investigated, and a series of α-methylene-γ-trifluoromethyl-γ-lactams were obtained with high yields. The features of this process included readily available starting materials as trifluoromethyl source, mild conditions and easy operation. The reaction provided a new method for the synthesis of trifluoromethylated α-methylene-γ-lactams.

Youji Huaxue published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Romero, F. Anthony published the artcilePotent and Selective α-Ketoheterocycle-Based Inhibitors of the Anandamide and Oleamide Catabolizing Enzyme, Fatty Acid Amide Hydrolase, Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2007), 50(5), 1058-1068, database is CAplus and MEDLINE.

A study of the structure-activity relationships (SAR) of 2f (I, OL-135), a potent inhibitor of fatty acid amide hydrolase (FAAH), is detailed, targeting the 5-position of the oxazole. Examination of a series of substituted benzene derivatives (12-14) revealed that the optimal position for substitution was the meta-position with selected members approaching or exceeding the potency of 2f. Concurrent with these studies, the effect of substitution on the pyridine ring of 2f was also examined A series of small, nonaromatic C5-substituents was also explored and revealed that the K_i follows a well-defined correlation with the Hammett σ_p constant (ρ = 3.01, R² = 0.91) in which electron-withdrawing substituents enhance potency, leading to inhibitors with K_is as low as 400 pM (20n). Proteomic-wide screening of the inhibitors revealed that most are exquisitely selective for FAAH over all other mammalian proteases, reversing the 100-fold preference of 20a (C5 substituent = H) for the enzyme TGH.

Journal of Medicinal Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Crotti, Simone published the artcileEnantioselective Synthesis of Trifluoromethyl α,β-Unsaturated δ-Lactones via Vinylogous Aldol-Lactonization Cascade, Name: 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, the publication is Journal of Organic Chemistry (2018), 83(20), 12440-12448, database is CAplus and MEDLINE.

The novel vinylogous aldol-lactonization cascade of alkylidene oxindole with trifluoromethyl ketones is presented. The reaction, catalyzed by a bifunctional tertiary amine, provides an efficient application of the vinylogous reactivity of alkylidene oxindoles for the preparation of enantioenriched trifluoromethylated α,β-unsaturated δ-lactones.

Journal of Organic Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Name: 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Han, Zhaomeng published the artcileFluoroform: an Efficient Precursor for the Trifluoromethylation of Aromatic Esters by Sodium Diisopropylamide with Trialkylamines, HPLC of Formula: 5860-95-7, the publication is European Journal of Organic Chemistry (2019), 2019(29), 4658-4661, database is CAplus.

The trifluoromethanide anion is the postulated key intermediate in nucleophilic trifluoromethylation reactions. It is believed to be incompatible with Na⁺ cation due to the strong Na-F bond. However, herein we demonstrate that it could be prepared for the first time. Trialkylamines can be used as cation chelating agents to stabilize the isolated ^–CF₃ ion to realize trifluoromethylation reaction. With this strategy, trifluoromethyl aromatic ketones could be effectively synthesized from fluoroform and aromatic esters with diisopropyl aminosodium (NaDA) and trialkylamines.

European Journal of Organic Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, HPLC of Formula: 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics