Category: 59178-12-0

Asinger, Fritz’s team published research in Monatshefte fuer Chemie in 1933 | CAS: 59178-12-0

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C7H3Cl2NO3

The author of 《Nitration of 3,5-dichlorobenzaldehyde and 3,5-dichlorobenzoic acid》 were Asinger, Fritz. And the article was published in Monatshefte fuer Chemie in 1933. Computed Properties of C7H3Cl2NO3 The author mentioned the following in the article:

3,5-Cl2C6H3CHO (10 g.) and 100 cc. HNO3 (d. 1.48) at room temperature for 3-4 hrs. give 99% (crude yield) of 2-nitro-3,5-dichlorobenzaldehyde (I), m. 91.5°; oxidation gives 3,5,2-Cl2(O2N)C6H2CO2H, m. 194° I yields an aldoxime, m. 97°, and a phenylhydrazone, blood-red, m. 175°. I and PCl5 in C6H6 give 2-nitro-3,5-dichlorobenzal chloride, m. 45°; this also results by nitration of 3,5-Cl2C6H3CHCl2. I, heated with Ac2O and AcONa 7 hrs. at 180°, gives 65% of 2-nitro-3,5-dichlorocinnamic acid, pale yellow, m. 227°. I and NAOH in Me2CO give 97% of 5,7,5′,7′-tetrachloroindigo. Reduction of I with FeSO4 and NH4OH gives 84% of the 2-NH2 derivative, pale yellow, m. 123°; aldoxime, m. 175°; phenylhydrazone, yellow-green, m. 118°. 3,5-Cl2C6H3CO2H and HNO3 (d. 1.48) at 70° give 83% of the 2-NO2 derivative (II), m. 194°; the Ca salt seps. with 4.5 mols. H2O; the Ba salt has 2.5 mols. H2O; the Ag salt is anhydrous; acid chloride, m. 94.5°; amide, m. 180°; Me ester, m. 73°; Et ester, m. 69°. Reduction of II gives the 2-NH2 derivative, m. 230-1° (98% yield). In the experiment, the researchers used 3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0Computed Properties of C7H3Cl2NO3)

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C7H3Cl2NO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kiruthika, Selvarangam E.’s team published research in Organic Letters in 2014 | CAS: 59178-12-0

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Quality Control of 3,5-Dichloro-2-nitrobenzaldehyde Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Kiruthika, Selvarangam E.; Perumal, Paramasivan Thirumalai published an article on January 17 ,2014. The article was titled 《CuI-Catalyzed Coupling of gem-Dibromovinylanilides and Sulfonamides: An Efficient Method for the Synthesis of 2-Amidoindoles and Indolo[1,2-a]quinazolines》, and you may find the article in Organic Letters.Quality Control of 3,5-Dichloro-2-nitrobenzaldehyde The information in the text is summarized as follows:

N-[(Dibromovinyl)aryl]acetamides I (R = H, Cl; R1 = H, Cl, Br) underwent chemoselective cyclocondensation with sulfonamides such as N-(ar)alkyl-p-toluenesulfonamides TsNHCH2R2 [R2 = Ph, 4-MeC6H4, 4-MeOC6H4, 3,4-(MeO)2C6H3, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 1-naphthyl, 2-fluorenyl, 2-thienyl, 3,4-(MeO)2C6H3CH2, n-Pr] in the presence of CuI and 1,10-phenanthroline with Cs2CO3 in THF to give (sulfonylamino)indoles such as II [R = H, Cl; R1 = H, Cl, Br; R2 = Ph, 4-MeC6H4, 4-MeOC6H4, 3,4-(MeO)2C6H3, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 1-naphthyl, 2-fluorenyl, 2-thienyl, 3,4-(MeO)2C6H3CH2, n-Pr] in 75-89% yields. Reaction of I (R = R1 = H) with ortho-bromoarylmethyltosylamides TsNHCH2R2 [R2 = 2-BrC6H4, 2-Br-4,5-(MeO)2C6H2, 2-Br-3-pyridinyl, 1-Br-3,4-dihydro-2-naphthyl, 2-Br-3,4,5-(MeO)3C6H] under analogous conditions yielded dihydroindoloquinazolines such as III; treatment of III with Cs2CO3 at 110° yielded the indoloquinazoline IV. Ynamide intermediates in the preparation of sulfonamidoindoles were isolated in some cases. The structure of a trimethoxydihydroquinazolinoindole was determined by X-ray crystallog. After reading the article, we found that the author used 3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0Quality Control of 3,5-Dichloro-2-nitrobenzaldehyde)

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Quality Control of 3,5-Dichloro-2-nitrobenzaldehyde Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Markovac, A.’s team published research in Journal of Medicinal Chemistry in 1976 | CAS: 59178-12-0

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Synthetic Route of C7H3Cl2NO3

The author of 《Antimalarials. 9. Methylthio- and methylsulfonyl-substituted 9-phenanthrenemethanols》 were Markovac, A.; LaMontagne, M. P.. And the article was published in Journal of Medicinal Chemistry in 1976. Synthetic Route of C7H3Cl2NO3 The author mentioned the following in the article:

Nine di- and trisubstituted 9-phenanthrenemethanols bearing methylthio and methylsulfonyl substituents in the 2 and/or 6 positions of the phenanthrene nucleus were prepared and screened for antimalarial activity against Plasmodium berghei in mice. Six of the nine compounds were curative at or below 160 mg/kg. The most active structures contained a methylthio substituent in combination with two chlorine atoms. The most effective compound was 2,4-dichloro-α-dibutylaminomethyl-6-methylthio-9-phenanthrenemethanol-HCl (I) [59215-48-4]. The results came from multiple reactions, including the reaction of 3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0Synthetic Route of C7H3Cl2NO3)

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Synthetic Route of C7H3Cl2NO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Muthu Ramalingam, Bose’s team published research in Journal of Medicinal Chemistry in 2018 | CAS: 59178-12-0

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Safety of 3,5-Dichloro-2-nitrobenzaldehyde The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Muthu Ramalingam, Bose; Dhatchana Moorthy, Nachiappan; Chowdhury, Somenath Roy; Mageshwaran, Thiyagarajan; Vellaichamy, Elangovan; Saha, Sourav; Ganesan, Karthikeyan; Rajesh, B. Navin; Iqbal, Saleem; Majumder, Hemanta K.; Gunasekaran, Krishnasamy; Siva, Ramamoorthy; Mohanakrishnan, Arasambattu K. published an article on February 8 ,2018. The article was titled 《Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues》, and you may find the article in Journal of Medicinal Chemistry.Safety of 3,5-Dichloro-2-nitrobenzaldehyde The information in the text is summarized as follows:

A series of calothrixin B analogs bearing substituents at the ‘E’ ring and their corresponding deoxygenated quinocarbazoles lacking quinone unit were synthesized. The cytotoxicities of calothrixins and quinocarbazole analogs were investigated against nine cancer cell lines. Two quinocarbazoles inhibited the catalytic activity of human topoisomerase II. The plasmid DNA cleavage abilities of calothrixins identified compound I causing DNA cleavage comparable to that of calothrixin A. Calothrixin A, 3-fluorocalothrixin I and 4-fluoroquinocarbazole II induced extensive DNA damage followed by apoptotic cell death. Spectral and plasmid unwinding studies demonstrated an intercalative mode of binding for quinocarbazoles. We identified two promising drug candidates, the 3-fluorocalothrixin B I with low toxicity in animal model and its deoxygenated derivative 4-fluoroquinocarbazole II as having potent cytotoxicity against NCI-H460 cell line with a GI50 of 1 nM. In the experiment, the researchers used 3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0Safety of 3,5-Dichloro-2-nitrobenzaldehyde)

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Safety of 3,5-Dichloro-2-nitrobenzaldehyde The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Raju, Potharaju’s team published research in European Journal of Organic Chemistry in 2015 | CAS: 59178-12-0

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Computed Properties of C7H3Cl2NO3 Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

《Unusual Reactivity of Aryl Aldehydes with Triethyl Phosphite and Zinc Bromide: A Facile Preparation of Epoxides, Benzisoxazoles, and α-Hydroxy Phosphonate Esters》 was published in European Journal of Organic Chemistry in 2015. These research results belong to Raju, Potharaju; Gobi Rajeshwaran, Ganesan; Nandakumar, Meganathan; Mohanakrishnan, Arasambattu K.. Computed Properties of C7H3Cl2NO3 The article mentions the following:

A facile preparation of trans-epoxides was achieved by a (EtO)3P-ZnBr2-mediated deoxygenation reaction of the corresponding 2-nitrobenzaldehydes. The sterically hindered analogs of 2-nitrobenzaldehyde underwent a reaction with tri-Et phosphite in the presence of ZnBr2 as the catalyst to form benzisoxazoles as the sole product. Under identical conditions, the reactions of electron-rich as well as moderately electron-deficient aryl aldehydes furnished the corresponding α-hydroxy phosphonate esters. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0Computed Properties of C7H3Cl2NO3)

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Computed Properties of C7H3Cl2NO3 Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Muthu Ramalingam, Bose’s team published research in Journal of Medicinal Chemistry in 2018 | CAS: 59178-12-0

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Safety of 3,5-Dichloro-2-nitrobenzaldehyde The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Muthu Ramalingam, Bose; Dhatchana Moorthy, Nachiappan; Chowdhury, Somenath Roy; Mageshwaran, Thiyagarajan; Vellaichamy, Elangovan; Saha, Sourav; Ganesan, Karthikeyan; Rajesh, B. Navin; Iqbal, Saleem; Majumder, Hemanta K.; Gunasekaran, Krishnasamy; Siva, Ramamoorthy; Mohanakrishnan, Arasambattu K. published an article on February 8 ,2018. The article was titled 《Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues》, and you may find the article in Journal of Medicinal Chemistry.Safety of 3,5-Dichloro-2-nitrobenzaldehyde The information in the text is summarized as follows:

A series of calothrixin B analogs bearing substituents at the ‘E’ ring and their corresponding deoxygenated quinocarbazoles lacking quinone unit were synthesized. The cytotoxicities of calothrixins and quinocarbazole analogs were investigated against nine cancer cell lines. Two quinocarbazoles inhibited the catalytic activity of human topoisomerase II. The plasmid DNA cleavage abilities of calothrixins identified compound I causing DNA cleavage comparable to that of calothrixin A. Calothrixin A, 3-fluorocalothrixin I and 4-fluoroquinocarbazole II induced extensive DNA damage followed by apoptotic cell death. Spectral and plasmid unwinding studies demonstrated an intercalative mode of binding for quinocarbazoles. We identified two promising drug candidates, the 3-fluorocalothrixin B I with low toxicity in animal model and its deoxygenated derivative 4-fluoroquinocarbazole II as having potent cytotoxicity against NCI-H460 cell line with a GI50 of 1 nM. In the experiment, the researchers used 3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0Safety of 3,5-Dichloro-2-nitrobenzaldehyde)

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Safety of 3,5-Dichloro-2-nitrobenzaldehyde The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Raju, Potharaju’s team published research in European Journal of Organic Chemistry in 2015 | CAS: 59178-12-0

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Computed Properties of C7H3Cl2NO3 Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

《Unusual Reactivity of Aryl Aldehydes with Triethyl Phosphite and Zinc Bromide: A Facile Preparation of Epoxides, Benzisoxazoles, and α-Hydroxy Phosphonate Esters》 was published in European Journal of Organic Chemistry in 2015. These research results belong to Raju, Potharaju; Gobi Rajeshwaran, Ganesan; Nandakumar, Meganathan; Mohanakrishnan, Arasambattu K.. Computed Properties of C7H3Cl2NO3 The article mentions the following:

A facile preparation of trans-epoxides was achieved by a (EtO)3P-ZnBr2-mediated deoxygenation reaction of the corresponding 2-nitrobenzaldehydes. The sterically hindered analogs of 2-nitrobenzaldehyde underwent a reaction with tri-Et phosphite in the presence of ZnBr2 as the catalyst to form benzisoxazoles as the sole product. Under identical conditions, the reactions of electron-rich as well as moderately electron-deficient aryl aldehydes furnished the corresponding α-hydroxy phosphonate esters. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0Computed Properties of C7H3Cl2NO3)

3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Computed Properties of C7H3Cl2NO3 Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics