Category: 59237-53-5

Rare Medium-Sized Rings Prepared via Hydrolytic Imidazoline Ring Expansion (HIRE) was written by Osipyan, Angelina;Sapegin, Alexander;Novikov, Alexander S.;Krasavin, Mikhail. And the article was included in Journal of Organic Chemistry in 2018.Quality Control of Methyl 6-chloro-5-nitronicotinate This article mentions the following:

The hydrolytic imidazoline ring expansion (HIRE) methodol. was extended to readily available tetracyclic [1,4]thiazepines as well as sulfoxide and sulfone analogs thereof. The reactions resulted in the facile formation of a rare medium-sized [1,4,7]thiazecine ring system that has an emerging utility in bioactive compound design. Comparing the HIRE rates for representative compounds in the three groups of substrates allowed drawing some generalizations about the substituent effects on the course of the reaction. In the experiment, the researchers used many compounds, for example, Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5Quality Control of Methyl 6-chloro-5-nitronicotinate).

Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Quality Control of Methyl 6-chloro-5-nitronicotinate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, Synthesis, and Biological Evaluation of Amidobenzimidazole Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists was written by Xi, Qiumu;Wang, Mingjin;Jia, Wenqiang;Yang, Mingjian;Hu, Jinping;Jin, Jing;Chen, Xiaoguang;Yin, Dali;Wang, Xiaojian. And the article was included in Journal of Medicinal Chemistry in 2020.Product Details of 59237-53-5 This article mentions the following:

Stimulator of interferon genes (STING) is an endoplasmic reticulum-localized adaptor protein (STING receptor) that has been shown to be activated by binding to natural cyclic dinucleotide (CDN) ligands and plays a vital role in innate immune sensing of exogenous or endogenous DNA, which then induces type I interferons and other cytokines. In this paper, we described a series of amidobenzimidazole STING agonists with high potency for the STING receptor and presented the relevant structure-activity relationships (SARs). The relative potencies of compounds I, II, and III were measured by a STING competition binding assay. A more thorough study of the effect on the STING signaling pathway demonstrated that three compounds, I, II, and III, significantly increased the protein levels and mRNA levels of IFN-尾, CXCL10, and IL-6, and II as a representative compound effectively triggered the phosphorylation of STING, TBK1, and IRF3 in both human peripheral blood mononuclear cells (hPBMCs) and WT THP-1 cells. In addition, compound II demonstrated impressive antitumor efficacy in mice with established syngeneic colon tumors by i.v. administration. Furthermore, the pharmacokinetic profile of compound II was fully evaluated. In the experiment, the researchers used many compounds, for example, Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5Product Details of 59237-53-5).

Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Product Details of 59237-53-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and facile dearomatization of highly electrophilic nitroisoxazolo[4,3-b]pyridines was written by Bastrakov, Maxim A.;Fedorenko, Alexey K.;Starosotnikov, Alexey M.;Fedyanin, Ivan V.;Kokorekin, Vladimir A.. And the article was included in Molecules in 2020.HPLC of Formula: 59237-53-5 This article mentions the following:

A number of novel 6-R-isoxazolo[4,3-b]pyridines were synthesized and their reactions with neutral C-nucleophiles (1,3-dicarbonyl compounds, 蟺-excessive (het)arenes, dienes) were studied. The reaction rate was found to be dependent on the nature of the substituent 6-R. The most reactive 6-nitroisoxazolo[4,3-b]pyridines were able to add C-nucleophiles in the absence of a base under mild conditions. In addition, these compounds readily undergo [4+2]-cycloaddition reactions on aromatic bonds C=C(NO₂) of the pyridine ring, thus indicating the superelectrophilic nature of 6-NO₂-isoxazolo[4,3-b]pyridines. In the experiment, the researchers used many compounds, for example, Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5HPLC of Formula: 59237-53-5).

Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.HPLC of Formula: 59237-53-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models was written by Winter-Holt, Jon J.;Bardelle, Catherine;Chiarparin, Elisabetta;Dale, Ian L.;Davey, Paul R. J.;Davies, Nichola L.;Denz, Christopher;Fillery, Shaun M.;Guerot, Carine M.;Han, Fujin;Hughes, Samantha J.;Kulkarni, Meghana;Liu, Zhaoqun;Milbradt, Alexander;Moss, Thomas A.;Niu, Huijun;Patel, Joe;Rabow, Alfred A.;Schimpl, Marianne;Shi, Junjie;Sun, Dongqing;Yang, Dejian;Guichard, Sylvie. And the article was included in Journal of Medicinal Chemistry in 2022.Synthetic Route of C7H5ClN2O4 This article mentions the following:

ATAD2 is an epigenetic bromodomain-containing target which is overexpressed in many cancers and has been suggested as a potential oncol. target. While several small mol. inhibitors have been described in the literature, their cellular activity has proved to be underwhelming. In this work, we describe the identification of a novel series of ATAD2 inhibitors by high throughput screening, confirmation of the bromodomain region as the site of action, and the optimization campaign undertaken to improve the potency, selectivity, and permeability of the initial hit. The result is compound 5 (AZ13824374)(I), a highly potent and selective ATAD2 inhibitor which shows cellular target engagement and antiproliferative activity in a range of breast cancer models. In the experiment, the researchers used many compounds, for example, Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5Synthetic Route of C7H5ClN2O4).

Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Synthetic Route of C7H5ClN2O4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reactions of 3-R-5-nitropyridines with nucleophiles: Nucleophilic substitution vs conjugate addition was written by Bastrakov, Maxim A.;Nikol’skiy, Vladislav V.;Starosotnikov, Alexey M.;Fedyanin, Ivan V.;Shevelev, Svyatoslav A.;Knyazev, Daniil A.. And the article was included in Tetrahedron in 2019.Related Products of 59237-53-5 This article mentions the following:

A number of 3-R-5-nitropyridines I (R¹ = H, NO₂, Cl, Br, C(O)OMe) were synthesized and their reactions with various types of nucleophiles such as OMe, N₃, furan-2-ylmethylsulfanyl, cyclohexylsulfanyl, etc. were investigated. The reaction outcome depends on the nature of a nucleophile, where, in case of anionic O-, N- and S-nucleophiles, the previously unreported substitution of non-activated nitro group occurred while carbon nucleophiles underwent dearomatization of the pyridine ring with the formation of products of 1,2-I (R¹ = 4-hydroxy-3,5-dimethylphenyl, 2-cyclopropyl-2-oxoethyl, 3,3-dimethyl-2-oxobutyl, 1H-indol-3-yl, etc.) and 1,4-addition II (R² = Me, cyclopropyl, t-Bu, Ph, etc.). In the experiment, the researchers used many compounds, for example, Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5Related Products of 59237-53-5).

Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 59237-53-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics