Category: 59772-49-5

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59772-49-5 as follows. HPLC of Formula: C6H5BrClN

Benzofuran-3-ylboronic acid2-bromo-6-chloroaniline (189 g, 1100 mmol) was dissolved in toluene (Toluene), EtOH, H2O (400 mg, 400 mL). Pd (PPh3) 4 (58 g, 50 mmol) and NaHCO3 (252 g, 3000 mmol) were added thereto and refluxed for 4 hours. After completion of reaction, MC is extracted by cooling to room temperature. After drying over anhydrous MgSO4, the solvent is removed by rotary evaporator. Column chromatography (MC: Hx = 1: 3) was used to obtain the desired compound 461-5. (190 g, 91percent, brown oil)

According to the analysis of related databases, 59772-49-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; L Ti Material Co., Ltd.; Oh Han-guk; Lee Yun-ji; Ji Hye-su; Jeong Won-jang; Choi Jin-seok; Choi Dae-hyeok; (212 pag.)KR2019/33885; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 59772-49-5, name is 2-Bromo-6-chloroaniline, A new synthetic method of this compound is introduced below., Safety of 2-Bromo-6-chloroaniline

Benzo [b] thiophen-3-ylboronic acid (162 g, 1000 mmol),2-bromo-6-chloroaniline (189 g, 1100 mmol) was dissolved in toluene (toluene) (Pd (PPh3) 4 (58 g, 50 mmol) was dissolved in 400 mL of EtOH,NaHCO3 (252 g, 3000 mmol) was added thereto and refluxed for 4 hours.After completion of reaction, MC is extracted by cooling to room temperature.After drying over anhydrous MgSO4, the solvent is removed by rotary evaporator. Column chromatography (MC: Hx = 1: 3) was used to obtain the desired compound 1-5. (190 g, 91percent, brown oil)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; L Ti Material Co., Ltd.; Oh Han-guk; Lee Yun-ji; Ji Hye-su; Jeong Won-jang; Choi Jin-seok; Choi Dae-hyeok; (212 pag.)KR2019/33885; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics