Category: 60091-87-4

Shimpi, Nitin A. published the artcileNovel synthetic methodology for the synthesis of dibenzo azepines, Recommanded Product: 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, the publication is Journal of Chemical and Pharmaceutical Research (2016), 8(4), 318-326, database is CAplus.

New synthetic methodol. for the synthesis of dibenzo[b,e][1,4]diazepines, a key intermediates in the manufacturing of Clozapine which is indicated for use in therapy as dopamine receptor antagonist, Antipsychotic drug. Synthesis of 2-(4-chloro-2-nitrophenylamino) benzoic acid Me ester by simple rearrangement of 2-[[2-(4-chloro-2-nitrophenoxy)acetyl]amino]benzoic acid Me ester. The present work describes a novel, cost-effective and easily scalable process of dibenzo[b,e][1,4]diazepines.

Journal of Chemical and Pharmaceutical Research published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C12H15ClO3, Recommanded Product: 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

De Paulis, Tomas published the artcileSynthesis of [³H]clozapine, Application In Synthesis of 60091-87-4, the publication is Journal of Labelled Compounds and Radiopharmaceuticals (1988), 25(9), 1027-33, database is CAplus.

[³H]clozapine was prepared with a specific activity of 9.9 Ci/mmol by reaction of 8-chloro-11-(methylthio)-5H-dibenzo[b,e][1,4]diazepine with an excess of [³H]N-methylpiperazine. The latter was prepared from N-methylpyrazinium bromide in ethanolic HCl by reduction at room temperature with tritium over 5% Rh on Al₂O₃.

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, Application In Synthesis of 60091-87-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Capuano, Ben published the artcileSynthesis and preliminary pharmacological evaluation of 4′-arylmethyl analogues of clozapine. I. The effect of aromatic substituents, Formula: C13H9ClN2O4, the publication is Australian Journal of Chemistry (2002), 55(9), 565-576, database is CAplus.

As part of a research program to develop compounds with mixed dopamine D₄ and serotonin 5-HT_2A antagonist activity with potential for the treatment of schizophrenia, the preparation of 8-chloro-11-[4-(phenylmethyl)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine derivatives I (R = H, Br, Cl, F, Me, OMe, CF₃, OCF₃, etc.) based on a structural modification of the atypical antipsychotic clozapine was reported. Corresponding 8-chloro-11-[4-[(1H-indol-3-yl)methyl]-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine derivatives, bioisosteric 8-chloro-11-[4-[(pyridinyl)methyl]-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine derivatives, 4-[[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-piperazinyl]methyl]-1,2-benzenediol and 3-[[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-piperazinyl]methyl]-1H-indol-5-ol were also prepared The chem. synthesis, structural characterization and pharmacol. evaluation of a series 4′-arylmethyl analogs of clozapine are described. Preliminary receptor binding data are presented, examining primarily the electronic and positional effects of substituents on the introduced arylmethyl group, and secondarily the nature of the aryl ring.

Australian Journal of Chemistry published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, Formula: C13H9ClN2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jahan, Humera published the artcileAnthranilic Acid Derivatives: Novel Inhibitors of Protein Glycation and the Associated Oxidative Stress in the Hepatocytes, Computed Properties of 60091-87-4, the publication is Medicinal Chemistry (Sharjah, United Arab Emirates) (2018), 14(5), 516-523, database is CAplus and MEDLINE.

Anthranilic acid derivatives are important pharmacophores in drug discovery. Several of them are currently being used, such as mefenamic acid and meclofenamates, possess analgesic, anti-inflammatory and antipyretic activities. Some anthranilic acid-based scaffolds have also been reported for the management of metabolic disorders. The aim of the current study was to investigate the antiglycation potential of 2-anilino benzoic acid derivatives against (N-phenylanthranilic acid) fructose- human serum albumin (HSA) glycation. The study also analyzed the effects of newly identified antiglycation inhibitors on AGEs-mediated intracellular reactive oxygen species production, and associated impaired proliferation of the hepatocytes. The present study focuses on the antiglycation activity of 2- anilinobenzoic acid derivatives 1-18 in in-vitro human serum albumin (HSA)- fructose model. These derivatives were also identified as non-toxic to 3T3 mouse fibroblast cell-line using metabolic assay. The effect of the most promising derivative 1, 2- (2, 4- dinitroanilino)benzoic acid, was studied in a dose dependent manner, co-incubated with fructose-derived AGEs (0- 200 μg/mL), on rat hepatocytes proliferation and associated intracellular generation of ROS via MTT assay and DCFH-DA technique, resp. We found that derivative 1 ameliorates the elevated intracellular oxidative stress and associated diminished proliferation of the hepatocytes in response to AGEs. In conclusion, we identify novel 2- anilino benzoic acid derivatives as antiglycation agents through in-vitro and cellular-based models.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, Computed Properties of 60091-87-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Leyva-Perez, Antonio published the artcileBifunctional solid catalysts for chemoselective hydrogenation-cyclisation-amination cascade reactions of relevance for the synthesis of pharmaceuticals, COA of Formula: C13H9ClN2O4, the publication is Tetrahedron (2010), 66(41), 8203-8209, database is CAplus.

The benzodiazepines olanzapine (I) and clozapine (II) are nowadays manufactured by a three-step process with a final yield below 50%. An approach to environmentally-friendly intensive processes consists in the development of multifunctional solid catalyst able to catalyze multistep reactions. Here, a bifunctional metal-acid solid catalyst has been prepared and is able to carry out hydrogenation-cyclization-amination reactions in a cascade process. The catalytic system is illustrated for the synthesis of these important antipsychotics, being an alternative for the current industrial process that requires three steps batch reactions, using mineral acids and bases, and stoichiometric amounts of SnCl₂.

Tetrahedron published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, COA of Formula: C13H9ClN2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics