Hsu, Ya- Ling; Hung, Jen-Yu; Tsai, Eing-Mei; Wu, Cheng-Ying; Ho, Ya-Wen; Jian, Shu-Fang; Yen, Meng-Chi; Chang, Wei-An; Hou, Ming-Feng; Kuo, Po-Lin published the artcile< Benzyl butyl phthalate increases the chemoresistance to doxorubicin/cyclophosphamide by increasing breast cancer-associated dendritic cell-derived CXCL1/GROα and S100A8/A9>, Formula: C7H17Cl2N2O3P, the main research area is benzyl butyl phthalate doxorubicin cyclophosphamide chemoresistance breast cancer; CXCL1 GFO S100A8A9 dendritic cell breast cancer chemoresistance.
Phthalates are used as plasticizers in the manufacture of flexible vinyl, which is used in food contact applications. Phthalates have been demonstrated to have an adverse impact on human health, particularly in terms of cancer development. In the present study, we showed for the first time that benzyl Bu phthalate (BBP) potentiates the effect of tumor-associated dendritic cells (TADCs) on the chemoresistance of breast cancer. Specific knockdown anal. revealed that S100A9 is the major factor responsible for the chemoresistance of doxorubicin/cyclophosphamide induced by BBP-stimulated TADCs in breast cancer. BBP exposure also increased tumor infiltrating myeloid-derived suppressor cell (MDSC) secretion of S100A8/A9, thereby exacerbating the resistance of breast cancer to doxorubicin with cyclophosphamide. In addition, BBP also stimulated the production of CXCL1/GROα by TADCs, which increased the angiogenesis of breast cancer in a mouse model. Inhibition of CXCL1/GROα by a neutralizing antibody, decreased the BBP-induced angiogenesis induced by BBP after chemotherapy in the mouse model. These results, for the first time, provide evidence that BBP influences the efficacy of chemotherapy by remodeling the tumor microenvironment of breast cancer.
Oncology Reports published new progress about Angiogenesis. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Formula: C7H17Cl2N2O3P.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics