Category: 60811-18-9

Application of 60811-18-9,Some common heterocyclic compound, 60811-18-9, name is 4-Bromo-1-chloro-2-fluorobenzene, molecular formula is C6H3BrClF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-{4-rhoiperidi?vloxv)phengammal]elhvi]oxv)~2-thlophe?ecarboxamideStep A – 1~Bromo-4-chioro-5-fluoro-2-rjitrobenzeneTo a solution of 4-bromo1-chioro-2-fluorobenzene (8.4 g, 40 mmoi) and ammonium nitrate in DCM (335 mL) at 00C was added TFA anhydride (41.3 mL) via addomegan funnel over 15 min. The reaction mixture was stirred at 0 0C for 15 min and then at rt for 2 h. The reaction was quenched with 560 ml saturated NaHCO3 solution and the layers separated. The aqueous layer was extracted with DCM and then EtOAc. The combined organic layer was dried over Na2SO4, filtered and silica gel was added, The volatites were evaporated under reduced pressure, and the residue was purified by flash column chromatography (0 to 15% EtOAc; hexane) to give 3.7 g (38%) of the title compound. 1H NMR (400 iVIHz, DMSO-cfe): delta 8.48 (d, J= 6.9 Hz1 IH), 8.18 (d, J= S-S Hz5 IH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-1-chloro-2-fluorobenzene, its application will become more common.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/143456; (2007); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 60811-18-9, name is 4-Bromo-1-chloro-2-fluorobenzene, molecular formula is C6H3BrClF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H3BrClF

EXAMPLE 1 A mixture of 0.1 mole of 4′-n-propyl-4-biphenylboronic acid (obtained by the reaction of the Grignard reagent of 4′-n-propyl-4-bromobiphenyl and trimethyl borate), 0.1 mole of 4-chloro-3-fluorobromobenzene, tetrakis (triphenylphosphine) palladium (1 mole %), 2 m sodium carbonate solution (150 ml), toluene (250 ml) and IMS (60 ml) is stirred and refluxed for 16 hrs under a nitrogen atomosphere. After usual work-up 4-chloro-3-fluoro-4′-(p-n-propylphenyl) -biphenyl is obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 60811-18-9, its application will become more common.

Reference:
Patent; Merck Patent Gesellschaft mit beschrankter Haftung; US5482653; (1996); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 60811-18-9, name is 4-Bromo-1-chloro-2-fluorobenzene, A new synthetic method of this compound is introduced below., 60811-18-9

(5) Metal magnesium in an amount of 1.2 g was suspended in 20 ml of THF under nitrogen gas stream, and a solution prepared by dissolving 9.6 g of 3-fluoro-4-chloro-bromobenzene in 50 ml of THF was added dropwise thereto and stirred at room temperature for 1 hour to prepare a solution of Grignard reagent. In 30 ml of THF was dissolved 9.7 g of the 4-(trans-4-(2-(trans-4-n-propylcyclohexyl)ethyl)cyclohexyl)iodobenzene mentioned above, 1 g of palladium chloride was added thereto, and they were stirred under a reflux. The Grignard reagent prepared by the procedures mentioned above was added dropwise thereto and they were reacted while stirring for 2 hours. Reaction solution thus obtained was added to 100 ml of dilute hydrochloric acid and the product was extracted with 100 ml of heptane. Organic layer was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under a reduced pressure to obtain a yellow-brown oily product. This product was purified by a column chromatography over an alumina by using heptane as an eluent. Further, the product was recrystallized from heptane to obtain 2.3 g of the subject compound. CN 138.1, NI 227.7 According to the procedures mentioned above, following Compounds No. 2 to No. 63 were synthesised:

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Chisso Corporation; US5858275; (1999); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60811-18-9 name is 4-Bromo-1-chloro-2-fluorobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 60811-18-9

[Example 112] Preparation of 4-(trans-4-(2-(trans-4-n-propyl-4-silacyclohexyl)ethyl)cyclohexyl)-3′-fluoro-4′-cyanobiphenyl 20.9 g (0.1 mol) of 1-bromo-4-chloro-3-fluorobenzene was dripped into a mixture of 2.5 g (0.11 mol) of magnesium and 300 ml of THF to obtain a Grignard’s reagent. This solution was then dripped into a 500 ml THF solution of 0.5 g of tetrakis triphenylphosphine palladium and 43.6 g (0.1 mol) of 4-(trans-4-(2-(trans-4-n-propyl-4-silacyclohexyl)ethyl)cyclohexyl)phenyl bromide. After a conventional after treatment, purification was conducted by means of chromatography to obtain 36.4 g (yield 75.1%) of 4-(trans-4-(2-(trans-4-n-propyl-4-silacyclohexyl)ethyl)cyclohexyl)-3′-fluoro-4′-cyanobiphenyl was obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-chloro-2-fluorobenzene, and friends who are interested can also refer to it.

Reference:
Patent; Shin-Etsu Chemical Co., Ltd.; US5582764; (1996); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics