Category: 611-19-8

Maleki, Ali; Panahzadeh, Morteza; Eivazzadeh-keihan, Reza published the artcile< Agar: a natural and environmentally-friendly support composed of copper oxide nanoparticles for the green synthesis of 1,2,3-triazoles>, Reference of 611-19-8, the main research area is magnetic agar support copper oxide preparation thermal stability; alkyne benzyl halide sodium azide copper catalyst dipolar cycloaddition; benzyl triazole regioselective preparation green chem.

A novel, green and cost-effective heterogeneous nanocatalyst was synthesized by supporting copper (I) oxide nanoparticles on magnetic agar (Cu2O/Agar@Fe3O4). Then, it was characterized with multiple techniques, such as SEM and transmission electron microscopy images, energy-dispersive X-ray anal., Fourier-transform IR (FT-IR) spectroscopy, thermogravimetric (TG) anal., X-ray diffraction pattern, vibrating sample magnetometer curve, and inductively coupled plasma anal. The catalytic activity of the newly designed catalyst was investigated in a one-pot three-component reaction of alkyl halides, sodium azide and alkynes to obtain 1,4-disubstituted 1,2,3-triazoles in high yields in water-ethanol media. The present catalyst was simply separated from the reaction media by an external magnet and reused at least five subsequent runs without significant activity loss.

Green Chemistry Letters and Reviews published new progress about 1,3-Dipolar cycloaddition catalysts (regioselective). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Reference of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhao, Xuelian; Zhan, Xuehui; Zhang, Huilin; Wan, Yichao; Yang, Huizhong; Wang, Yutian; Chen, Yanda; Xie, Wenlin published the artcile< Synthesis and biological evaluation of isatin derivatives containing 1,3,4-thiadiazole as potent a-glucosidase inhibitors>, Safety of 1-Chloro-2-(chloromethyl)benzene, the main research area is thiadiazolylhydrazono benzyloxindole preparation diastereoselective glucosidase inhibition kinetics SAR docking; 1,3,4-Thiadiazole; Isatin; Triethyl orthoformate; α-Glucosidase.

A series of isatin derivatives containing 1,3,4-thiadiazole derivatives I [R = 2-F, 3-CN, 4-Cl, etc.] were designed and synthesized. All newly synthesized compounds I were evaluated for their α-glucosidase inhibitory activity with resveratrol as pos. control in-vitro. Except for compounds I [R = 2-CN, 3-CN], all of the compounds I showed a potent inhibitory activity against α-glucosidase with IC50 values in the range of 3.12 ± 1.25 to 45.95 ± 1.26μM and the purity of these compounds were greater than 95%. The IC50 values were being compared to the standard resveratrol (IC50 = 22.00 ± 1.15μM) and it was found that compounds I [R = H, 2-F, 2-Cl, 3-Cl, 4-Cl, 2-Br] were found to be more active than resveratrol. Specifically,I [R = 4-Cl] exhibited the most potent α-glucosidase inhibitory activity with IC50 value of 3.12 ± 1.25μM. The kinetic anal. revealed that compound I [R = 4-Cl] was noncompetitive inhibitor. Structure activity relationship was established for all compounds I. Furthermore, the binding interactions of compound I [R = 4-Cl] with the active site of α-glucosidase were confirmed through mol. docking. This study was identified a new class of potent α-glucosidase inhibitors for further investigation.

Bioorganic & Medicinal Chemistry Letters published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Safety of 1-Chloro-2-(chloromethyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Lijuan; Wang, Xiaobin; Tang, Xu; Xia, Rongjiao; Guo, Tao; Zhang, Cheng; Li, Xiangyang; Xue, Wei published the artcile< Design, synthesis, antiviral bioactivities and interaction mechanisms of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold>, Application of C7H6Cl2, the main research area is tobacco mosaic virus pentadieneone oxime ether quinazolinone antiviral; Antiviral activity; Interaction mechanisms; Molecular docking study; Oxime ether; Penta-1,4-diene-3-one; Quinazolin-4(3H)-one; Tobacco mosaic virus.

penta-1,4-diene-3-one oxime ether and quinazolin-4(3H)-one derivatives possess favorable agricultural activities. Aiming to discover novel mols. with highly-efficient agricultural activities, a series of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold were synthesized and evaluated for their antiviral activities. Antiviral bioassays indicated that some title compounds exhibited significant antiviral activity against tobacco mosaic virus (TMV). In particular, compounds 8c, 8j and 8k possessed appreciable curative activities against TMV in vivo, with half-maximal effective concentration (EC50) values of 138.5, 132.9 and 125.6 μg/mL, resp., which are better than that of ningnanmycin (207.3 μg/mL). Furthermore, the microscale thermophoresis experiments (MST) on the interaction of compound 8k with TMV coat protein (TMV CP) showed 8k bound to TMV CP with a dissociation constant of 0.97 mmol/L. Docking studies provided further insights into the interaction of 8k with the Arg90 of TMV CP. Sixteen penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold were designed, synthesized, and their antiviral activities against TMV were evaluated. Antiviral bioassays indicated that some target compounds exhibited remarkable antiviral activities against TMV. Furthermore, through the MST and docking studies, we can speculate that 8k inhibited the virulence of TMV by binding Arg90 in TMV CP. These results indicated that this kind of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold could be further studied as potential alternative templates in the search for novel antiviral agents.

BMC Chemistry published new progress about Antiviral agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Application of C7H6Cl2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xia, Rongjiao; Guo, Tao; Chen, Mei; Su, Shijun; He, Jun; Tang, Xu; Jiang, Shichun; Xue, Wei published the artcile< Synthesis, antiviral and antibacterial activities and action mechanism of penta-1,4-dien-3-one oxime ether derivatives containing a quinoxaline moiety>, Category: chlorides-buliding-blocks, the main research area is antiviral antibacterial pentadienone oxime ether.

A series of penta-1,4-dien-3-one oxime ether derivatives containing a quinoxaline moiety were synthesized and their antibacterial and antiviral activities were evaluated. Bioassay activity indicated that some of the compounds displayed significant antibacterial and antiviral activities. In particular, some title compounds were found to show remarkable antiviral activities against Tobacco mosaic virus (TMV). Compound 6i showed remarkable curative, protective and inactivation activity against TMV, with a 50% effective concentration (EC50) of 287.1, 157.6 and 133.0μg mL-1, resp. These results were better than or comparable to those of ningnanmycin (356.3, 233.7 and 121.6μg mL-1, resp.). Microscale thermophoresis (MST) also showed that the binding of compound 6i to TMV coat protein (TMV-CP) gave a Kd value of 0.115 ± 0.092μmol L-1, which was better than that of ningnanmycin (0.523 ± 0.254μmol L-1). Meanwhile, the EC50 values of compound 6k against Xanthomonas axonopodis pv. Citri (Xac) and Xanthomonas oryzae pv. oryzae (Xoo) were 16.8 and 33.4μg mL-1 resp., and that of compound 6i against Ralstonia solanacearum (Rs) was 33.9μg mL-1. These results were better than those of bismerthiazol (44.3, 42.5 and 62.4μg mL-1, resp.). The mechanism of antibacterial action of compound 6k against Xac was analyzed through SEM (SEM). This study indicated that the title compounds are valuable in the search for novel agrochems.

New Journal of Chemistry published new progress about Antibacterial agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tao, Zhihua; Li, Yuanxun; Peng, Yi Xiao; Su, Hua; Han, Likun; Liu, Guanting published the artcile< Electrochemical studies of prothioconazole as a novel corrosion inhibitor for copper in acidic solutions>, Application In Synthesis of 611-19-8, the main research area is prothioconazole copper corrosion current density electrochem impedance.

Prothioconazole is a fungicide that has a wide number of applications in agriculture, and it can ensure the safety of crops, users, and the environment. Prothioconazole, as a suppressor of copper dissolution in 0.5 M H2SO4 solution, has been evaluated using electrochem. experiments, weight loss tests, quantum chem. calculations, and SEM (SEM). The electrochem. test results showed that prothioconazole was an excellent inhibitor, and the anticorrosion ability increased with the inhibitor concentration The interaction of prothioconazole with copper is a spontaneous adsorption process accompanied by typical chemisorption. The number of water mols. (X) displaced by one prothioconazole mol. was obtained using diverse substitutional adsorption models based on electrochem. impedance spectroscopy (EIS) data. In addition, the Fukui functions indicate that the triazole and benzene rings and the -C=S atoms were the main active sites for the adsorption process.

RSC Advances published new progress about Adsorption. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Application In Synthesis of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tao, Zhihua; Li, Yuanxun; Peng, Yi Xiao; Su, Hua; Han, Likun; Liu, Guanting published the artcile< Electrochemical studies of prothioconazole as a novel corrosion inhibitor for copper in acidic solutions>, Application In Synthesis of 611-19-8, the main research area is prothioconazole copper corrosion current density electrochem impedance.

Prothioconazole is a fungicide that has a wide number of applications in agriculture, and it can ensure the safety of crops, users, and the environment. Prothioconazole, as a suppressor of copper dissolution in 0.5 M H2SO4 solution, has been evaluated using electrochem. experiments, weight loss tests, quantum chem. calculations, and SEM (SEM). The electrochem. test results showed that prothioconazole was an excellent inhibitor, and the anticorrosion ability increased with the inhibitor concentration The interaction of prothioconazole with copper is a spontaneous adsorption process accompanied by typical chemisorption. The number of water mols. (X) displaced by one prothioconazole mol. was obtained using diverse substitutional adsorption models based on electrochem. impedance spectroscopy (EIS) data. In addition, the Fukui functions indicate that the triazole and benzene rings and the -C=S atoms were the main active sites for the adsorption process.

RSC Advances published new progress about Adsorption. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Application In Synthesis of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bazzi, Sakna; Schulz, Emmanuelle; Mellah, Mohamed published the artcile< Electrogenerated Sm(II)-Catalyzed CO2 Activation for Carboxylation of Benzyl Halides>, Computed Properties of 611-19-8, the main research area is phenylacetic acid preparation; benzyl halide carbon dioxide reductive electrochem carboxylation samarium catalyst.

Sm(II)-catalyzed carboxylation of benzyl halides is reported through the electrochem. reduction of CO2. The transformation proceeds under mild reaction conditions to afford the corresponding phenylacetic acids in good to excellent yields. This user-friendly and operationally simple protocol represents an alternative to traditional strategies, which usually proceeds through the C(sp3)-halide activation pathway.

Organic Letters published new progress about Aromatic carboxylic acids Role: SPN (Synthetic Preparation), PREP (Preparation). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Computed Properties of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Dachuan; Cheng, Xiu; Wang, Ying published the artcile< Design, synthesis and biological evaluation of benzo[d]thiazole with dimethylpyrazole derivatives>, Application of C7H6Cl2, the main research area is dimethylpyrazolyl benzothiazole preparation antitumor anticonvulsant SAR neurotoxicity; Benzothiazole; Dimethylpyrazol; MTT assay, GABAergic; Maximal Electroshock.

A series of new benzothiazole derivatives containing dimethylpyrazole I [R = H, n-pentyl, benzyl, etc.] were synthesized and evaluated for their anticonvulsant activity, neurotoxicity and cytotoxicity by using the maximal electroshock (MES), rotarod neurotoxicity (TOX) and MTT colorimetric assay. Among the compounds studied, four compounds I [R = Bu, n-pentyl, 2-fluorobenzyl, 2,6-dichlorobenzyl] showed better anticonvulsant than the others at 300 mg/kg and they also showed anticonvulsant activity at the dose of 100 mg/kg. All the synthetic compounds I showed lower neurotoxicity and little cytotoxicity, so that the compounds, which with better activities, also had higher protective index. In particular, the compound I [R = 2-fluorobenzyl] showed better activity with an ED50 value of 160.4 mg/kg and higher protective index (PI) values of 2.74 in the MES test than the standard drugs sodium valproate, which used as pos. controls in this study. After that the compound I [R = 2-fluorobenzyl] demonstrated antagonistic activity against seizures induced by pentylenetetrazol, which proved compound I [R = 2-fluorobenzyl] may be exert activity through effecting GABAergic neurotransmission.

Asian Pacific Journal of Cancer Prevention published new progress about Anticonvulsants. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Application of C7H6Cl2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kaur, Sukhvir; Kaur, Manjinder; Kaur, Jasmeen; Bansal, Yogita; Bansal, Gulshan published the artcile< Synthesis, antimicrobial evaluation and chemical stability studies of novel trisubstitued benzimidazoles>, Safety of 1-Chloro-2-(chloromethyl)benzene, the main research area is benzoyl nitrobenzimidazole preparation antibacterial antifungal docking SAR enzyme inhibitor; benzyl nitrobenzimidazole preparation antibacterial antifungal docking SAR enzyme inhibitor.

The current study was aimed at designing, synthesizing and exploring novel benzimidazoles derived compounds I [R = H, 2-Cl, 4-Cl, 4-O2N; R1 = 3-pyridinyl, 2-furyl; X = CH2, C=O] as potential antimicrobial agents. The designed compounds were synthesized from o-phenylenediamine, nicotinic acid, furfuraldehyde and varied benzoyl/benzyl chlorides through a 4-steps synthetic scheme. In-vitro antimicrobial evaluation was carried out by measuring zone of inhibition at different concentrations (1.56-100 μg/mL) of target compounds and streptomycin. Docking anal. was carried out using GlcN-6-P synthase as target enzyme as it was essential for microbial cell wall synthesis and docking studies showed good binding affinity of target compounds toward GlcN-6-P. Hydrolytic stability of the most active compound I [R = 4-Cl; R1 = 3-pyridinyl; X = C=O] in GIT was evaluated in non-enzymic simulated gastric and intestinal fluids through HPLC method. Compounds I [R = H, 2-Cl; R1 = 3-pyridinyl; X = CH2, C=O] exhibited good antibacterial activity, whereas I [R = H, 2-Cl, 4-O2N; R1 = 2-furyl; X = C=O] had potent antifungal properties. Compound I [R = 4-Cl; R1 = 3-pyridinyl; X = C=O] was maximally lethal from the series and equipotent to streptomycin against S. aureus, E. coli and P. aeruginosa with MIC 4.16 ± 1.04, 5.20 ± 1.04 and 10.41 ± 2.08 μg/mL, resp., compound I[R = 2-Cl; R1 = 2-furyl; X= C=O] (MIC 20.83 ± 4.16 μg/mL) was equipotent to fluconazole against C. albicans. Compound I [R = 4-Cl; R1 = 3-pyridinyl; X = C=O] was found stable in non-enzymic simulated gastric and intestinal fluids up to 4h.

Chemica Sinica published new progress about Amides, tertiary Role: PAC (Pharmacological Activity), PRP (Properties), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Safety of 1-Chloro-2-(chloromethyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rilvin-Derrick, Eloise; Oram, Niall; Richardson, Jeffery published the artcile< An Efficient Palladium-Catalyzed Aminocarbonylation of Benzyl Chlorides>, Related Products of 611-19-8, the main research area is chloromethyl arene amine carbon monoxide palladium catalyst aminocarbonylation; arylacetamide preparation.

An improved procedure for the aminocarbonylation of benzyl chloride derivatives using carbon monoxide and either primary or secondary amines were developed. Studying the competing background alkylation reaction allowed the solvent and base to be selected for a simple catalyst screen, which in turn, enabled the discovery of a method for the preparation of 2-arylacetamides under mild conditions, with minimal side-products using an inexpensive phosphine ligand. This non-traditional optimization strategy allowed us to overcome the background alkylation, which was cited as justification for the development of more complex and less atom-economical approaches.

Synlett published new progress about Acetamides Role: SPN (Synthetic Preparation), PREP (Preparation). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Related Products of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics