Category: 611-19-8

Sonawane, Rahul B.; Sonawane, Swapnali R.; Rasal, Nishant K.; Jagtap, Sangeeta V. published the artcile< Room-Temperature, Base-Mediated Selective Synthesis of 2-(Arylamino)ethanols and 2-Aryloxyethanols>, Reference of 611-19-8, the main research area is aniline chloroethanol potassium dichromate alkylation; phenyllamino ethanol bishydroxyethyl aniline preparation; phenol chloroethanol potassium dichromate alkylation; phenoxyethanol preparation.

A simple and efficient protocol for base-mediated selective synthesis of 2-(arylamino)ethanols from primary aromatic amines and 2-aryloxyethanols from phenols, promoted by K2CO3 was achieved under mild conditions. Even in presence of excess alkyl halide, selective mono-N-alkylation was achieved. Tolerance of a variety of functional groups was demonstrated by 15 examples of selective N-alkylation of aromatic amines and 19 examples of O-alkylation of phenols. The efficacy of the protocol was demonstrated by the formal synthesis of Ticlopidine, Vildagliptin, Quetiapine and Gemfibrozil .

SynOpen published new progress about Alkylation. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Reference of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Su, Shijun; Chen, Mei; Li, Qin; Wang, Yihui; Chen, Shuai; Sun, Nan; Xie, Chengwei; Huai, Ziyou; Huang, Yinjiu; Xue, Wei published the artcile< Novel penta-1,4-diene-3-one derivatives containing quinazoline and oxime ether fragments: Design, synthesis and bioactivity>, Reference of 611-19-8, the main research area is quinazolinyl pentadieneone oxime ether preparation diastereoselective antitumor SAR drug; Anticancer; Oxime ether; Penta-1, 4-diene-3-one; Quinazoline; SMMC-7721 cells.

A series of novel penta-1,4-diene-3-one derivatives I [R = H, [(2,4-dichlorophenyl)methyl]oxidanyl, [(2-chlorophenyl)methyl]oxidanyl, [(4-chlorophenyl)methyl]oxidanyl, [(2-fluorophenyl)methyl]oxidanyl; R1 = thiophen-2-yl, pyridin-2-yl; R2 = H, [(2-fluorophenyl)methyl]oxidanyl, [(2,4-dichlorophenyl)methyl]oxidanyl, [(3-methylphenyl)methyl]oxidanyl, etc.; R3 = H, 6-Cl, 8-Me] containing quinazoline and oxime ether moieties were designed and synthesized. Their anticancer activities were evaluated by MTT assay, and the results showed that most compounds exhibited extremely inhibitory effects against hepatoma SMMC-7721 cells. In particular, compounds I [R = R3 = H; R1 = pyridin-2-yl; R2 = [(3-methylphenyl)methyl]oxidanyl] (II) and I [R = H; R1 = pyridin-2-yl; R2 = [(4-chlorophenyl)methyl]oxidanyl; R3 = 6-Cl] (III) displayed the more potent inhibitory activity with IC50 values of 0.64 and 0.63μM, which were better than that of gemcitabine (1.40μM). Further mechanism studies indicated that compounds II, III, I [R = [(2,4-dichlorophenyl)methyl]oxidanyl; R1 = pyridin-2-yl; R2 = R3 = H] and I [R = [(2,4-dichlorophenyl)methyl]oxidanyl; R1 = pyridin-2-yl; R2 = H; R3 = 6-Cl] could control the migration of SMMC-7721 cells effectively, and inhibit the proliferation of cancer cells by inhibiting the DNA replication. Western-blot results showed that compounds II and III induced irreversible apoptosis of SMMC-7721 cells by regulating the expression level of apoptose-related proteins. Those studies demonstrated that the penta-1,4-diene-3-one derivatives I containing quinazoline and oxime ether fragments merited further research as potential anticancer agents.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Reference of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zeng, Fang; Zhang, Mingjuan; Li, Yiqun published the artcile< Cu2+ ion crosslinked carboxymethylcellulose/diatomite composite beads as an efficient catalyst for CuAAC reactions>, Recommanded Product: 1-Chloro-2-(chloromethyl)benzene, the main research area is diatomite supported copper ion crosslinked CM cellulose preparation surface structure; alkyne benzyl halide sodium azide copper catalyst regioselective cycloaddition; benzyl triazole preparation green chem.

Cu2+-crosslinked CM-cellulose/diatomite composite beads (CuII@CMC/DE) were prepared in simple and efficient way using ionic crosslinking techniques. In CuII@CMC/DE beads, diatomite serves as a reinforcing filler, and divalent copper cation acts as crosslinking agent. The chem. structure and morphol. of as-fabricated CuII@CMC/DE beads were well characterized using various techniques such as ICP, FT-IR, XRD, SEM, EDS, elemental mapping, TEM, XPS, and TGA. The CuII@CMC/DE beads exerted superior catalytic performance in CuAAC reactions of benzyl halides, sodium azide, and alkynes to yield regioselective 1,4-disubstituted-1,2,3-triazoles in excellent yields under green conditions. In these resultant catalytic composite beads, Cu2+ was used not only as a crosslinking agent but also as a metal catalyst for CuAAC reaction. The composite beads can be easily separated by filter and reused at least four times without any significant decrease on its activity and selectivity.

Polymers for Advanced Technologies published new progress about 1,3-Dipolar cycloaddition catalysts. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Recommanded Product: 1-Chloro-2-(chloromethyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Parada, Luz Karime Luna; Kouznetsov, Vladimir V. published the artcile< 5-chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline>, Safety of 1-Chloro-2-(chloromethyl)benzene, the main research area is triazolyl quinoline hybrid preparation; alkyne azide dipolar cycloaddition copper catalyst.

The title quinoline derivative, 5-chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline, was synthesized in a common three-step procedure from 5-chloro-8-hydroxyquinoline using O-propargylation reaction/copper-catalyzed 1,3-dipolar cycloaddition sequence. The hybrid obtained could be an interesting model for antifungal bio-essays or a suitable precursor in the synthesis of more complex triazolyl-quinoline hybrids, potential pharmacol. agents.

Molbank published new progress about 1,3-Dipolar cycloaddition reaction. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Safety of 1-Chloro-2-(chloromethyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bhandu, Priyanka; Verma, Himanshu; Singh, Manmeet; Kumar, Manoj; Narendra, Gera; Choudhary, Shalki; Singh, Pankaj Kumar; Silakari, Om published the artcile< Rational designing of quinazolin-4(3H)-one based ALR2 inhibitors: Synthesis and biological evaluation>, COA of Formula: C7H6Cl2, the main research area is quinazolinone benzyl chloride nucleophilic substitution reaction; benzyl quinazolinone preparation ALR2 inhibition SAR mol docking.

Herein, using scaffold hoping, quinazolin-4(3H)-one was obtained as one of the top bioisostere with good BIF, shape and field scores. The designed inhouse library of quinazolin-4(3H)-one was studied for their SAR profile based on the developed qual. model via Activity atlas option. Important field points i.e., pos. and neg. electrostatics along with shape properties were analyzed that are crucial for ALR2 inhibitory activity. Some structure-based approaches including mol. docking and dynamics also suggested that the designed quinazolin-4(3H)-one based derivatives can be putative ALR2 inhibitors. These mols. were synthesized and evaluated for in-vitro ALR2 inhibitory activity. It was observed that compound three of the compounds were most potent inhibitors with IC50 values of 2.56 ± 0.03, 1.72 ± 0.02 and 1.47 ± 0.03μM, resp. Addnl., the predicted ADMET properties were also found to be favorable in comparison to Zenarestat.

Journal of Molecular Structure published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, COA of Formula: C7H6Cl2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jing, Ke; Wei, Ming-Kai; Yan, Si-Shun; Liao, Li-Li; Niu, Ya-Nan; Luo, Shu-Ping; Yu, Bo; Yu, Da-Gang published the artcile< Visible-light photoredox-catalyzed carboxylation of benzyl halides with CO2: Mild and transition-metal-free>, Application In Synthesis of 611-19-8, the main research area is aryl acetic acid preparation visible light; benzyl chloride bromide carbon dioxide carboxylation photoredox catalyst.

The visible-light photoredox-catalyzed carboxylation of benzyl chlorides and bromides with CO2 has been reported. With inexpensive organic dyes as photocatalysts and amines as electron donors, this carboxylation proceeds well in the absence of sensitive organometallic reagents, transition metal catalysts, or metallic reductants. A wide range of com. available and inexpensive benzyl halides undergo such carboxylation to give valuable aryl acetic acids, including several pharmaceutical mols. and drug precursors, in moderate to high yields. Moreover, this reaction features mild reaction conditions (one atm. pressure of CO2 and room temperature), broad substrate scope, good functional group tolerance, easy scalability, and low catalyst loading, thus providing an efficient approach for the assembly of aryl acetic acids.

Chinese Journal of Catalysis published new progress about Benzyl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Application In Synthesis of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Keivanloo, Ali; Lashkari, Saeed; Sepehri, Saghi; Bakherad, Mohammad; Abbaspour, Sima published the artcile< Ligand-assisted click reaction for the synthesis of new hybrid compounds based on 1,2,3-triazoles and 5,5-diphenylimidazolidine-2,4-dione and evaluation of their antibacterial activities>, Formula: C7H6Cl2, the main research area is triazole diphenylimidazolidinedione preparation regioselective click reaction antibacterial activity.

The new hybrid compounds based on 1,2,3-triazoles and 5,5-diphenylimidazolidine-2,4-dione I (R = 3-nitrophenyl, 2-chloro-4-nitrophenyl, 4-chloro-2-nitrophenyl, 4-chloro-3-nitrophenyl), II (R1 = 4-nitrophenyl, 4-chloro-3-nitrophenyl, 2-chloro-4-nitrophenyl) and III (X = H, 2-Cl, 4-Me) were successfully synthesized by copper-catalyzed click reaction in the presence of water-soluble ligand, sodium 4-amino-5-hydroxy-7-sulfonaphthalene-2-sulfonate and copper salt. The click reaction of 5,5-diphenyl-3-(prop-2-yn-1-yl)imidazolidine-2,4-dione and 5,5-diphenyl-1,3-di(prop-2-yn-1-yl)imidazolidine-2,4-dione with aryl azides RN3 or sodium azide and benzyl chloride XC6H4CH2Cl in water produced new 1,2,3-triazoles linked-5,5-diphenylimidazolidine-2,4-dione. The 4-amino-5-hydroxy-7-sulfonaphthalene-2-sulfonate was used as ligand, which enhanced the reactions and reduced the quantity of the toxic copper salt. The in vitro antibacterial activities of the all synthesized compounds I, II and III were screened against the Gram-pos. and Gram-neg. bacteria, by the use of well diffusion method. The results showed that all compounds I, II and III were active against both M. luteus and P. aeruginosa bacteria.

Monatshefte fuer Chemie published new progress about Antibacterial agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Formula: C7H6Cl2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Xu-Jun; Zhang, Wei; Zhao, Chi-Na; Wu, Qing-Lai; Li, Jun-Kai; Xu, Zhi-Hong published the artcile< Synthesis and fungicidal activity of phenazine-1-carboxylic triazole derivatives>, Synthetic Route of 611-19-8, the main research area is phenazine carboxylic triazole preparation SAR fungicidal; Derivatives; fungicidal activity; phenazine-1-carboxylic acid; synthesis; triazole.

A total of 15 novel-substituted 3-(benzylsulfanyl)-1H-1,2,4-triazol-5-ylamines I [R = 3-MeC6H4, 2-FC6H4, 2,4-Cl2C6H3, etc.] and 10 novel-substituted 3-benzylmercapto-1,2,4-triazole derivatives II were synthesized based on the natural product phenazine-1-carboxylic acid (PCA). Their structures were confirmed by 1H-NMR, 13C-NMR, HRMS and X-ray. Most substituted 3-benzylmercapto-1,2,4-triazole derivatives II displayed very strong fungicidal activity against one or multiple plant pathogens in vitro and in vivo. Compounds II [R = 4-MeC6H4, 4-iPrC6H4, 4-tBuC6H4, etc.] showed a broad spectrum of fungicidal activity. Further field experiments indicated that compounds II [R = 4-MeC6H4, 2-FC6H4, 4-iPrC6H4, etc.] displayed better efficacy against rice blast (Pyricularia oryzae) than PCA. These data demonstrated that compounds II [R = 4-MeC6H4, 2-FC6H4, 4-iPrC6H4, etc.] were promising fungicidal candidates, deserving further studies.

Journal of Asian Natural Products Research published new progress about Agrochemical fungicides. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Synthetic Route of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sahin-Bolukbasi, Serap; Sahin, Neslihan; Tahir, Muhammad Nawaz; Arici, Cengiz; Cevik, Esranur; Gurbuz, Nevin; Ozdemir, Ismail; Cummings, Brian S. published the artcile< Novel N-heterocyclic carbene silver(I) complexes: Synthesis, structural characterization, and anticancer activity>, SDS of cas: 611-19-8, the main research area is preparation crystal structure silver heterocyclic carbene complex; anticancer activity silver heterocyclic carbene complex.

The authors synthesized four novel unsym. substituted NHC ligands (1a-d) and their Ag(I) complexes (2a-d). All new compounds were characterized using elemental anal., FTIR, 1H NMR, and 13C NMR spectroscopy and X-ray crystallog. The mol. structure of complex 2d was elucidated through single crystal X-ray diffraction analyses. Single crystal structural studies for complex 2d show that the benzene rings (C9-C14) and the central benzimidazole ring system make dihedral angles of 85.65(11)°. The Ag-Cl and Ag-C single bond lengths are 2.3553(7) and 2.096(2) Å, resp. The C-Ag-Cl bond angle is 168.27(7)°. Both salts and complexes were tested for their anti-cancer potential against three human cancer cell lines (DU-145, MCF-7, and MDA-MB-231) and non-cancer cells adipose from mouse (L-929) for 24 h, 48 h and 72 h using the MTT assays. However, the Ag(I)-NHC complexes (2a-d) showed a dose and time-dependent cytotoxic activity against all cell lines. MDA-MB-231 human breast carcinoma cells were the most sensitive to the Ag(I)-NHC complex displaying IC50 <1 μM all time points. Further, the IC50s for Ag(I)-NHC were higher in non-cancer cells, suggesting that complexes possessed noteworthy selectivity for human cancer cells. Inorganica Chimica Acta published new progress about Antitumor agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, SDS of cas: 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ghiasbeigi, Elahe; Soleiman-Beigi, Mohammad published the artcile< Ammonium salts as economical and eco-friendly N-sources applied to green, simple and scale-up synthesis of trialkyl amines in water>, Computed Properties of 611-19-8, the main research area is trialkyl amine preparation green chem; alkyl halide alkylation.

A selective synthesis of tertiary amines R3N (R = benzyl, (2-methylphenyl)methyl, prop-2-en-1-yl, etc.) using alkyl halide RX and ammonium salts as the amine sources in water have been introduced. This green process has outstanding superiorities, such as being eco-friendly, possessing ammonium salts, and using water as a green solvent in the absence of organic ligands or catalysts. It is worth mentioning that the presence of t-Bu alc. and potassium hydroxide leads to synthesize tertiary amines, while under other conditions the formation of byproducts was witnessed. Other factors affecting the synthesis of various tertiary amines are temperature ranges. Note that various tertiary amines and the process of scale-up were synthesized in moderate to high yields.

Iranian Chemical Communication published new progress about Alkylation. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Computed Properties of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics