Category: 611-19-8

Wang, Wei; Qi, Xinxin; Wu, Xiao-Feng published the artcile< Palladium-Catalyzed Thiocarbonylation of Benzyl Chlorides with Sulfonyl Chlorides for the Synthesis of Arylacetyl Thioesters>, Safety of 1-Chloro-2-(chloromethyl)benzene, the main research area is arylacetyl thioester preparation; chloromethyl benzene sulfonyl chloride thiocarbonylation palladium catalyst.

A convenient procedure for the synthesis of thioesters RCH2C(O)SR1 (R = Ph, 3,4-dimethylphenyl, naphthalen-1-yl, thiophen-3-yl, etc.; R1 = Ph, 2,4,6-trimethylphenyl, naphthalen-1-yl, etc.) has been developed via a palladium-catalyzed thiocarbonylation of benzyl chlorides RCH2Cl with sulfonyl chlorides R1S(O)2Cl. Various arylacetyl thioesters were produced in good yields by using sulfonyl chlorides as an odorless sulfur source. Furthermore, W(CO)6 exhibited dual roles as both a solid CO surrogate and reductant here.

Advanced Synthesis & Catalysis published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Safety of 1-Chloro-2-(chloromethyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhou, Yu; Yang, Cheng-Li; Ye, Lei; Dong, Zhi-Bing published the artcile< Copper-Catalyzed C-S Formation for the Synthesis of Benzyl Phenyl Sulfides from Dithiocarbamates>, Recommanded Product: 1-Chloro-2-(chloromethyl)benzene, the main research area is benzyl phenyl sulfide green preparation; phenyl dithiocarbamate benzyl halide coupling copper catalyst.

An odorless and efficient protocol for the synthesis of benzyl Ph sulfides RSCH2R1 [R = Ph, 2-MeC6H4, 4-ClC6H4, etc.; R1 = Ph, 4-MeOC6H4, 2-BrC6H4, etc.] was reported. Starting from environmentally friendly Ph dithiocarbamates and com. available benzyl halides as starting materials, the target compounds (benzyl Ph sulfides) could be obtained smoothly and easily by using copper salt as catalyst and Cs2CO3as base. This method featured ligand/additive-free, the use of readily available starting materials, inexpensive catalysts, and good substrate suitability, illustrating its potentially synthetic value for the convenient preparation of some biol. active mols.

Synthesis published new progress about Benzyl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Recommanded Product: 1-Chloro-2-(chloromethyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhou, Yan; Zhou, Zebiao; Liu, Siqi; Cai, Mingzhong published the artcile< Recyclable palladium-catalyzed cyclocarbonylation between benzyl chlorides and salicylic aldehydes towards coumarins>, Electric Literature of 611-19-8, the main research area is silica immobilized bidentate phosphine palladium complex preparation; salicylic aldehyde aralkyl chloride palladium catalyst cyclocarbonylation; coumarin preparation.

A novel and practical route to coumarin derivatives was developed via the heterogeneous Pd-catalyzed carbonylative reaction and subsequent intramol. condensation process starting from com. easily available benzyl chlorides and salicylic aldehydes. Reactions were performed in the existence of 2 mol% of an SBA-15-immobilized bidentate phosphine palladium complex [SBA-15-P,P-PdCl2] in dioxane at 110°C with Et3N as base under 10 bar of CO to afford a wide range of coumarin derivatives mostly with good to high yields. Importantly, this new heterogenized palladium complex was easy to recover via filtration of the reaction mixture, and was recyclable up to 8 times without apparent drop in its catalytic performance.

Molecular Catalysis published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Electric Literature of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lu, Tong; Dong, Ling; Pan, Hongmei; Wu, Xuedan; Chen, Xia; Gu, Chengwen; Tao, Naili; Wang, Ao; Zhang, Kehua; Jin, Jie published the artcile< Design and synthesis of C-ring quinoxaline-substituted sinomenine 1,2,3-triazole derivatives via click reactions>, Computed Properties of 611-19-8, the main research area is quinoxalinyl triazolyl sinomenine preparation.

The synthesis of C-ring quinoxaline-substituted sinomenine 1,2,3-triazole derivatives at the 4-OH via click reactions was accomplished, and a total of 16 novel sinomenine double N-heterocyclic derivatives are obtained in 74%-95% yields. The C-ring is first transformed into a 1,2-diketone structure under the action of hydrochloric acid, and then reacted with o-phenylenediamine to obtain a C-ring quinoxaline-substituted structure. The 4-OH of sinomenine reacted with chloropropyne to give an alkynyl sinomenine, and then reacts with sodium azide and various benzyl chlorides to give the target compounds All the synthesized derivatives were characterized by Fourier-transform IR spectrometry, high resolution mass spectrometry, 1H NMR, and 13C NMR spectroscopy.

Journal of Chemical Research published new progress about Aralkyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Computed Properties of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ji, Shunli; Gao, Hongbin; Xia, Xingya; Zheng, Feng published the artcile< A new HPLC-UV derivatization approach for the determination of potential genotoxic benzyl halides in drug substances>, Related Products of 611-19-8, the main research area is benzyl halide antipyrine oroxylin A genotoxicity HPLCUV derivatization method.

Benzyl halides, widely used as alkylation reagents in drug synthesis, are potential genotoxic impurities (PGTIs) required to be controlled at trace levels. However, the existing anal. methods for benzyl halides often suffer from matrix interferences or low derivatization efficiency of benzyl chlorides. In this paper, a simple derivatization HPLC-UV method was developed for the anal. of these residual trace benzyl halides in drug substances. 1-(4-Nitrophenyl) piperazine (4-NPP) was selected as a new derivatization reagent because it shifted well the benzyl halides derivatives away to the near visible range (392 nm), which could minimize the matrix interferences from the drug substances and related impurities. Meanwhile, potassium iodide (KI) was used to convert the mixed benzyl halides into benzyl iodides before derivatization. The derivatization parameters were also optimized using the design of experiments (DoE) for achieving the best reaction efficiency. The results showed that the new approach had high specificity and sensitivity, and the LOQs were 7-9 μg g-1 relative to 5 mg mL-1 antipyrine and 17.5-22.5 μg g-1 relative to 2 mg mL-1 oroxylin A. The method is a valuable alternative for the determination of residual benzyl halides in the drug substances.

RSC Advances published new progress about Benzyl halides Role: ANT (Analyte), ANST (Analytical Study). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Related Products of 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics