Reference of 6120-31-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6120-31-6, name is 5,6-Dichlorobenzo[d][1,3]dioxole belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
ft-BuLi (2.5 M, 500 uL) was added drop wise to a mixture of 5,6-dichloro- 1,3- benzodioxole (200 mg, 1.1 mmol) in THF (5 mL) at -78 C. After 30 min, B(OMe)3 (163 mg, 1.6 mmol) was added at -78 C. The reaction was allowed to warm to 20 C for over 2 hr and IN HCl was added. After extraction with EtOAc the combined organic layers were washed with brine, dried over Na2S04, filtered and concentrated under reduced pressure to give (5,6-dichloro- l,3-benzodioxol-4-yl)boronic acid (200 mg, 684 umol, 80% purity) as a light yellow solid. (1078) LCMS (ESI): m/z: [M -H] calculated for C7H4BCI2C : 232.9; found 233.0.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,6-Dichlorobenzo[d][1,3]dioxole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; REVOLUTION MEDICINES, INC.; LI, Jie Jack; KOLTUN, Elena S.; GILL, Adrian Liam; BUCKL, Andreas; WON, Walter; AAY, Naing; MELLEM, Kevin; TZITZILONIS, Christos; JOGALEKAR, Ashutosh; CREGG, James Joseph; (177 pag.)WO2019/75265; (2019); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics