Category: 61343-99-5

Yeager, Gary W. published the artcileA convenient method for the preparation of 4-aryloxyphenols, Synthetic Route of 61343-99-5, the main research area is arylphenol; phenol aryl.

The treatment of p-RC6H4OH (R = H, Cl, Br, CMe3, OMe, OPh, CO2Et) with p-FC6H4COR1 (I; R1 = H, Me) in the presence of K2CO3 gave di-Ph ethers II. The Baeyer-Villiger oxidation of II followed by acid hydrolysis gave 4-aryloxyphenols III. Bisphenols IV (X = p-C6H4, 4,4′-C6H4OC6H4, 4,4′-biphenylene) were prepared similarly from HOXOH and I.

Synthesis published new progress about arylphenol; phenol aryl. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Synthetic Route of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Peng, Dongpo published the artcileA 2,2′-bipyridine-palladacycle catalyzed the coupling of arylboronic acids with nitroarenes, Quality Control of 61343-99-5, the main research area is diaryl ether preparation arylboronic acid nitroarene cross coupling; cross coupling arylboronic acid nitroarene bipyridine palladacycle catalyst.

A novel palladium-catalyzed protocol for the synthesis of diaryl ethers derivatives has been developed. In the presence of 2,2′-bipyridine-cyclopalladated ferrocenylimine complex, diaryl ethers were selectively generated by adjusting reaction parameters through the coupling of arylboronic acids and nitroarenes with yields ranging from poor to good. The efficiency of this reaction was demonstrated by its compatibility with a range of groups. Moreover, the rigorous exclusion of air or moisture was not required in these transformations.

Tetrahedron published new progress about Air. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Quality Control of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Vendrell, Marc published the artcileSolid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor, Name: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is solid phase synthesis BODIPY dye development Ig fluorescent sensor.

The diversification of the BODIPY scaffold has been hindered by its controversial adaptability to solid-phase chem. Herein the authors report the first solid-phase synthesis of a BODIPY library in high purities. The authors screened the library against a set of proteins, identified an Ig fluorescent sensor (Ig Orange) and confirmed its binding by SPR experiments

Chemical Communications (Cambridge, United Kingdom) published new progress about Affinity. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Name: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Arienti, Kristen L. published the artcileCheckpoint Kinase Inhibitors: SAR and Radioprotective Properties of a Series of 2-Arylbenzimidazoles, Name: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is checkpoint kinase inhibitor radioprotective arylbenzimidazole structure activity relationship.

The discovery of a series of novel, potent, and highly selective inhibitors of the DNA damage control kinase chk2 is disclosed. Here we report the first SAR study around inhibitors of this kinase. High-throughput screening of purified human chk2 led to the identification of a novel series of 2-arylbenzimidazole inhibitors of the kinase. Optimization was facilitated using homol. models of chk2 and docking of inhibitors, leading to the highly potent 2-arylbenzimidazole 2h (IC50 15 nM). Compound 2h is an ATP-competitive inhibitor of chk2 that dose dependently protects human CD4+ and CD8+ T-cells from apoptosis due to ionizing radiation. This work suggests that a selective small mol. inhibitor of chk2 could be a useful adjuvant to radiotherapy, increasing the therapeutic window of such treatment.

Journal of Medicinal Chemistry published new progress about Apoptosis. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Name: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Keith, John M. published the artcileAryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate, HPLC of Formula: 61343-99-5, the main research area is aryl piperazinyl urea preparation FAAH inhibitor SAR analgesic; FAAH; FAAH-2; anandamide; enzyme; ethanolamides; urea.

A series of aryl piperazinyl ureas that act as covalent inhibitors of fatty acid amide hydrolase (FAAH) is described. A potent and selective (does not inhibit FAAH-2) member of this class, JNJ-40355003 (I), was found to elevate the plasma levels of three fatty acid amides: anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide, in the rat, dog, and cynomolgous monkey. The elevation of the levels of these lipids in the plasma of monkeys suggests that FAAH-2 may not play a significant role in regulating plasma levels of fatty acid ethanolamides in primates.

ACS Medicinal Chemistry Letters published new progress about Analgesics. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, HPLC of Formula: 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Elkamhawy, Ahmed published the artcileDesign, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-β modulators, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is benzylidene thiazolidinedione diastereoselective preparation antiinflammatory cytotoxicity allosteric IKKbeta modulator; thiazolidinedione benzaldehyde Knoevenagel condensation; Allosteric modulation; IKK-β modulators; NF-κB signaling pathway; Thiazolidinediones.

A series of thiazolidinedione-scaffold based chem. entities I [n = 3, 4, 5; R1 = 2-methoxyethyl, 3-methoxypropyl, cyclopropylmethyl, cyclopropanecarbonyl, methylsulfonyl; R2 = 4-(4-fluorophenoxy)phenyl, 4-(4-chlorophenoxy)phenyl, 4-(4-bromophenoxy)phenyl, 4-(4-nitrophenoxy)phenyl, 3-chloro-4-morpholino-phenyl] was synthesized and evaluated as potential allosteric covalent IKK-β modulators. Relative to the starting hit compound, derivatives I [n = 4, R1 = cyclopropylmethyl, R2 = 4-(4-nitrophenoxy)phenyl (II), 4-(4-fluorophenoxy)phenyl; n = 3, R1 = cyclopropylmethyl, R2 = 4-(4-nitrophenoxy)phenyl] elicited enhanced activity by 57-69 folds showing low micromolar IC50 values within the range of 1.4-1.7 mM. In addition, derivatives I [n = 5, R1 = cyclopropylmethyl, R2 = 4-(4-fluorophenoxy)phenyl (III), 3-chloro-4-morpholino-Ph; n = 3, R1 = cyclopropylmethyl, R2 = 3-chloro-4-morpholino-Ph (IV)] showed submicromolar IC50 values within the range of 0.4-0.9 mM, which was 243, 139 and 105 folds enhanced values. Kinetic study of compounds III and IV confirmed this class of modulators as irreversible inhibitors. Cellular assays presented compounds II and III as anti-inflammatory agents which suppressed both LPS-induced PGE2 and TNF-α production without non-specific cytotoxicity. Assay of hERG inhibition demonstrated a safe profile of compound II suggesting it as a lead for further development of IKK-β modulators.

European Journal of Medicinal Chemistry published new progress about Allosterism. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Ji-Chun published the artcileDesign, synthesis and insecticidal evaluation of aryloxy dihaloropropene derivatives, Name: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is insecticide aryloxy dihaloropropene derivative; Aryloxy dihalopropene derivatives; Insecticidal activities; Intermediate Derivatization Methods (IDM); Structure–activity relationship.

Plutella xylostella (P. xylostella) is a highly migratory, cosmopolitan species and one of the most important pest of cruciferous crops worldwide. Pyridalyl as a novel class of insecticides has good efficacy against P. xylostella. On the basis of the com. insecticide pyridalyl, a series of new aryloxy dihaloropropene derivatives were designed and synthesized by using Intermediate Derivatization Methods. Their chem. structures were confirmed by 1H NMR, high-resolution mass spectrum (HRMS), and single-crystal X-ray diffraction anal. The insecticidal activities of the new compounds against P. xylostella were evaluated. The results of bioassays indicated that most of the compounds showed moderate to high activities at the tested concentration, especially compounds (I) and (II) displayed more than 75% insecticidal activity against P. xylostella at 6.25 mg/L, while pyridalyl showed 50% insecticidal activity at the same concentration The field trials result of the insecticidal activities showed that compound I as a 10% emulsifiable concentrate (EC) was effective in the control of P. xylostella at 75-150 g a.i./ha, and the mortality of P. xylostella for treatment with compound 10e at 75 g a.i./ha was equivalent to pyridalyl at 105 g a.i./ha.

Bioorganic & Medicinal Chemistry published new progress about Insecticides. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Name: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kursun Aktar, Bedriye Seda published the artcileDesigning heterocyclic chalcones, benzoyl/sulfonyl hydrazones: An insight into their biological activities and molecular docking study, Application of 4-(4-Chlorophenoxy)benzaldehyde, the main research area is BChE chalcone antiproliferative antioxidant anticholinesterase mol docking.

The aim of this study is to investigate the antioxidant, anticholinesterase and the antiproliferative activities of some chalcones, benzoyl and sulfonyl hydrazones. The antioxidant activity was studied by way of four complimentary assays and the anticholinesterase activity was studied using the Ellman method. The antiproliferative activity of the compounds was determined using a BrdU cell proliferation ELISA assay. Compound 32 (IC50: 15.58 ± 0.01μg/mL) against the brain (C6) and 29 (IC50: 5.02 ± 0.05μg/mL) against cervical (HeLa) cancer cell lines exhibited higher antiproliferative activity than the other compounds Two sulfonyl hydrazone derivatives 45 and 47 exhibited very good antioxidant activity. The results of anticholinesterase activity indicated that nine compounds 3, 8, 10, 14, 24, 25, 27, 38, and 45 significantly inhibited acetylcholinesterase enzymes and thirty-three compounds 1-4, 7-14, 22-28, 32-41, 44-47 inhibited butyrylcholinesterase enzymes (BChE) more than galantamine. In addition, virtual screening methods based on ligand 45 having the best activity against BChE was used to define new human BChE inhibitors. The interactions of ligand 8 against acetylcholinesterase (AChE) were also examined Important key residues were determined and visualized on completion of the methodol. All calculations indicated the suitability of use of the mol. docking approach for understanding interaction mechanisms and crucial fragments of novel hit compounds such as the potential lead AChE and BChE inhibitor candidates.

Journal of Molecular Structure published new progress about Antioxidants. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Application of 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

McClure, Kelly J. published the artcileNovel non-benzimidazole chk2 kinase inhibitors, Formula: C13H9ClO2, the main research area is chk2 kinase inhibitor SAR benzimidazole analog preparation.

In a recent paper we described the discovery of a class of benzimidazole chk2 kinase inhibitors, exemplified by compound I, which had radio-protective effects in human T-cells subjected to ionizing radiation. Here, a series of non-benzimidazole analogs intended to define the scope of the SAR about this new series of inhibitors and allow for refinement of the binding model of these compounds to the chk2 kinase is described.

Bioorganic & Medicinal Chemistry Letters published new progress about Hydrogen bond. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Formula: C13H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Carrasco, Marta P. published the artcileProbing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites, Computed Properties of 61343-99-5, the main research area is azaaurone msbar antimalarial Plasmodium; antiprotozoal agents; azaaurones; erythrocytic stage; liver stage; malaria.

The potential of azaaurones as dual-stage antimalarial agents was investigated by assessing the effect of a small library of azaaurones on the inhibition of liver and intraerythrocytic lifecycle stages of the malaria parasite. The whole series was screened against the blood stage of a chloroquine-resistant Plasmodium falciparum strain and the liver stage of P. berghei, yielding compounds with dual-stage activity and sub-micromolar potency against erythrocytic parasites. Studies with genetically modified parasites, using a phenotypic assay based on the P. falciparum Dd2-ScDHODH line, which expresses yeast dihydroorotate dehydrogenase (DHODH), showed that one of the azaaurone derivatives has the potential to inhibit the parasite mitochondrial electron-transport chain. The global urgency in finding new therapies for malaria, especially against the underexplored liver stage, associated with chem. tractability of azaaurones, warrants further development of this chemotype. Overall, these results emphasize the azaaurone chemotype as a promising scaffold for dual-stage antimalarials.

ChemMedChem published new progress about Antimalarials. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Computed Properties of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics