Category: 61343-99-5

Chaudhari, Hemchandra K. published the artcileDesign and Synthesis of Novel Oxadiazole and Diphenyl Ether Hydrazone Derivatives of Coumarin as Potential Antibacterial Agents, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is oxadiazole diphenyl ether hydrazone coumarin antibacterial agent.

Coumarins, possesing antimicrobial activity are often used by the researchers to develop novel synthetic and semisynthetic coumarin based therapeutic agents. Mol. hybridization concept was used to design coumarin hybrid mols. Synthesized mols. were evaluated for their in-vitro antibacterial activities. We designed Coumarin derivatives of di-Ph ether and oxadiazole. Most of the compounds showed antimicrobial activity against gram-pos. as well as gram-neg. bacteria. ADME properties of the mols. calculated by Qikprop program. It predicts both phys. appropriate descriptors and drug like properties. Oxadiazole and di-Ph ether hydrazone derivatives of coumarin were designed by mol. hybridization concept. Designed mols. were synthesized and confirmed by spectral data; further synthesized mols. were screened for antimicrobial activity by using the REMA plate method. We analyzed drug like properties with 44 phys. relevant descriptors of coumarin derivatives by Qikprop, out of 28 ligands 14 all coumarin-oxadiazole derivatives structures exhibited allowed values for the properties analyzed and exhibited drug-like characteristics derived from Lipinski’s rule of 5. Biol. screening of coumarin-oxadiazole derivative of nitrophenyl 8g was active against both gram pos. and neg. bacteria. It was seen that electron withdrawing substituent such as nitro group was important for activity. For coumarin -diphenyl hydrazone derivatives, halogens chloro substituent also exhibited significant activity as compare to fluoro substituted compounds The most active hydrazone derivatives were 6c and 6g with chloro and trifluoromethoxy substitution on benzene ring. In part B, fluoro substitution at aromatic ring had no effect on improvement of antibacterial activity. However it showed that electron withdrawing group were more active and exhibited significant improvement in the antibacterial activity. The efficient and instructive SAR study will provide deeper insight into further optimization of coumarin-oxadiazole and coumarin-diphenyl ether derivatives representing to promising leads for further exploration as antibacterial agents.

Current Bioactive Compounds published new progress about Antibacterial agents. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hossain, Mohammad Anwar published the artcileDesign, synthesis, and evaluation of compounds capable of reducing Pseudomonas aeruginosa virulence, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is Pseudomonas aeruginosa virulence synthesis compound; Anti-virulence; Ciprofloxacin; P. aeruginosa; Quorum sensing.

Anti-virulence approaches in the treatment of Pseudomonas aeruginosa (PA)-induced infections have shown clin. potential in multiple in vitro and in vivo studies. However, development of these compounds is limited by several factors, including the lack of mols. capable of penetrating the membrane of gram-neg. organisms. Here, we report the identification of novel structurally diverse compounds that inhibit PqsR and LasR-based signaling and diminish virulence factor production and biofilm growth in two clin. relevant strains of P. aeruginosa. It is the first report where potential anti-virulent agents were evaluated for inhibition of several virulence factors of PA. Finally, co-treatment with these inhibitors significantly reduced the production of virulence factors induced by the presence of sub-inhibitory levels of ciprofloxacin. Further, we have analyzed the drug-likeness profile of designed compounds using quant. estimates of drug-likeness (QED) and confirmed their potential as hit mols. for further development.

European Journal of Medicinal Chemistry published new progress about Antibacterial agents. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Elkamhawy, Ahmed published the artcileThiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents, Name: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is IKK beta modulators signaling pathway allosteric modulation antiinflammatory; Allosteric modulation; Anti-inflammatory; IKK-β modulators; NF-κB signaling pathway; Thiazolidine-2,4-diones.

Selective kinase inhibitors development is a cumbersome task because of ATP binding sites similarities across kinases. On contrast, irreversible allosteric covalent inhibition offers opportunity to develop novel selective kinase inhibitors. Previously, we reported thiazolidine-2,4-dione lead compounds eliciting in vitro irreversible allosteric inhibition of IKK-β. Herein, we address optimization into in vivo active anti-inflammatory agents. We successfully developed potent IKK-β inhibitors with the most potent compound eliciting IC50 = 0.20μM. Cellular assay of a set of active compounds using bacterial endotoxin lipopolysaccharide (LPS)-stimulated macrophages elucidated significant in vitro anti-inflammatory activity. In vitro evaluation of microsomal and plasma stabilities showed that the promising compound 7a is more stable than compound 7p. Finally, in vivo evaluation of 7a, which has been conducted in a model of LPS-induced septic shock in mice, showed its ability to protect mice against septic shock induced mortality. Accordingly, this study presents compound 7a as a novel potential irreversible allosteric covalent inhibitor of IKK-β with verified in vitro and in vivo anti-inflammatory activity.

European Journal of Medicinal Chemistry published new progress about Allosteric modulators. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Name: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gopal Hegde, Subramanya published the artcileRegioselective synthesis and biological evaluation of novel dispiropyrrolidine derivatives via one-pot four-component reaction, COA of Formula: C13H9ClO2, the main research area is sarcosine barbituric acid ninhydrin benzaldehyde magnesium silicate four component; dispiro indeno pyrrolidine pyrimidine pentaone regioselective preparation microwave irradiation; antitumor antibacterial activity SAR.

A new series of regioselective dispiropyrrolidine analogs I [Ar = Ph, 4-pyridinyl, 2-methyl-4-chlorophenyl, etc] via efficient one-pot four-component tandem reaction was discovered. The reaction was carried out in the presence of four common reactants and magnesium silicate nanoparticles (NPs) in ethanol under microwave irradiation The reaction proceeded rapidly and was completed within 60-90 min. This methodol. offered several significant advantages such as high yield, mild catalyst and easy to perform. The synthesized compound was further screened for antibacterial and antiproliferative activities. The results showed that compound I [Ar = 4-nitrophenyl, phenyl] were potent antibacterials against Gram-pos. and Gram-neg. bacteria. Further, compound I [Ar = phenyl] showed best antiproliferative activity against tested cell lines.

Synthetic Communications published new progress about Antibacterial agents. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, COA of Formula: C13H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thota, Sreekanth published the artcileSynthesis, characterization, DNA binding, DNA cleavage, protein binding and cytotoxic activities of Ru(II) complexes, HPLC of Formula: 61343-99-5, the main research area is preparation ruthenium phenylpyrrolyl dihydropyrazole carbothioamide bpy phen complex; DNA interaction ruthenium phenylpyrrolyl dihydropyrazole carbothioamide bpy phen complex; cytotoxic activity ruthenium phenylpyrrolyl dihydropyrazole carbothioamide bpy phen complex; anticancer activity ruthenium phenylpyrrolyl dihydropyrazole carbothioamide bpy phen complex; Antiproliferative; Bovine serum albumin; DNA-binding; Ru(II) compounds.

The authors report on the synthesis of novel Ru(II) compounds (Ru-1 to Ru-8: I, II) bearing R-pdc, 4-Cl-pbinh ligands (R = 4-CF3, 4-F, 4-OH pdc = 3-phenyl-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide, pbinh = phenoxybenzylidene isonicotinyl hydrazides) and their in vitro antitumor activity toward the cell lines murine leukemia L1210, human lymphocyte CEM, human epithelial cervical carcinoma HeLa, BEL-<7402≥ and Molt4/C8. Some of the complexes exhibited more potent antiproliferative activity against cell lines than the standard drug cisplatin. Ruthenium complex Ru-2 displayed potent cytotoxicity with than that of cisplatin. DNA-binding, DNA cleavage and protein binding properties of ruthenium complexes with these ligands are reported. Interactions of these ruthenium complexes with DNA revealed an intercalative mode of binding between them. Synchronous fluorescence spectra proved that the interaction of ruthenium complexes with bovine serum albumin (BSA) resulted in a conformational change of the latter. International Journal of Biological Macromolecules published new progress about Antiproliferative agents. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, HPLC of Formula: 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Emam, Soha H. published the artcileDesign and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-κB in LPS-induced RAW264.7 macrophage cells, Product Details of C13H9ClO2, the main research area is aryloxy methoxyaryl chalcone aryloxyaryloxopropenyl coumarin preparation antiinflammatory activity; structure methoxyarylaryloxychalcone aryloxyaryloxopropenylchalcone antiinflammatory activity; inhibition nitric oxide release macrophage methoxyarylaryloxychalcone aryloxyaryloxopropenylchalcone; mol docking methoxyarylaryloxychalcone IKKbeta; Anti-inflammatory; Chalcones; LPS-induced RAW264.7 macrophages; Molecular docking; Nitric oxide inhibition; Nuclear factor kappa B.

Exaggerated inflammatory responses may cause serious and debilitating diseases such as acute lung injury and rheumatoid arthritis. Two series of chalcone derivatives were prepared as anti-inflammatory agents. (Aryloxy)methoxychalcones and (aryloxyaryl)oxopropenylcoumarins were synthesized and compared for their inhibition of COX-2 enzyme and nitric oxide production suppression. Methoxylated phenyl-based chalcones showed better inhibition to COX-2 enzyme and nitric oxide suppression than the coumarin-based chalcones. Among the 18 synthesized chalcone derivatives, I exhibited the highest anti-inflammatory activity by inhibition of nitric oxide concentration in LPS-induced RAW264.7 macrophages (IC50 = 11.2μM). I showed suppression of iNOS and COX-2 enzymes and depressed the expression of NF-κB and phosphorylated IκB in LPS-stimulated macrophages. Finally, mol. docking studies suggested the inhibition of IKKβ as a mechanism of action and highlighted the importance of hydrophobic interactions with I.

Bioorganic Chemistry published new progress about Anti-inflammatory agents. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Product Details of C13H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Song, Hyeseung published the artcileDiscovery of potent and selective rhodanine type IKKβ inhibitors by hit-to-lead strategy, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is preparation rhodanine IKK NFkappaB inhibitor antiinflammatory cancer; rheumatoid arthritis rhodanine derivative.

Regulation of NF-κB activation through the inhibition of IKKβ has been identified as a promising target for the treatment of inflammatory and autoimmune disease such as rheumatoid arthritis. In order to develop novel IKKβ inhibitors, we performed high throughput screening toward around 8000 library compounds, and identified a hit compound containing rhodanine moiety. We modified the structure of hit compound to obtain potent and selective IKKβ inhibitors. Throughout hit-to-lead studies, we have discovered optimized compounds which possess blocking effect toward NF-κB activation and TNFα production in cell as well as inhibition activity against IKKβ. Among them, compound 3q showed the potent inhibitory activity against IKKβ, and excellent selectivity over other kinases such as p38α, p38β, JNK1, JNK2, and JNK3 as well as IKKα.

Bioorganic & Medicinal Chemistry Letters published new progress about Anti-inflammatory agents. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Telvekar, Vikas N. published the artcileNovel 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives as anti-tubercular agents, Related Products of chlorides-buliding-blocks, the main research area is aryloxy benzylidene hydrazinyl benzothiazole preparation antitubercular.

A series of structurally novel, substituted 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives incorporating 2-hydrazinyl benzothiazole and 4-(aryloxy)benzaldehyde were designed and synthesized using mol. hybridization approach. All the synthesized compounds exhibited promising activity (MIC 1.5-29.00 μg/mL) against Mycobacterium tuberculosis H37Rv strains of using REMA. Five of the evaluated compounds exhibit MIC <3.0 μg/mL. Compound (E)-6-chloro-2-(2-(4-(2,4-dichlorophenoxy)benzylidene)hydrazinyl) benzothiazole showed MIC of 1.5 μg/mL. Thus, this compound could act as a potential lead for further development of new anti-tubercular drugs. Bioorganic & Medicinal Chemistry Letters published new progress about Mycobacterium tuberculosis. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Related Products of chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kharas, Gregory B. published the artcileNovel copolymers of styrene. 8. Phenoxy ring-substituted butyl 2-cyano-3-phenyl-2-propenoates, SDS of cas: 61343-99-5, the main research area is phenoxy substituted butyl cyano phenyl propenoate styrene copolymer preparation.

Novel trisubstituted ethylenes, phenoxy ring-substituted Bu 2-cyano-3-phenyl-2-propenoates, RPhCH = C(CN)CO2C4H9 (where R is 2-(4-chlorophenoxy), 3-(4-chlorophenoxy), 4-(3-chlorophenoxy), 4-(4-chlorophenoxy), 4-(4-fluorophenoxy), 2-(3-methoxyphenoxy), 2-(4-methoxyphenoxy), 3-(4-methoxyphenoxy), 4-(4-methoxyphenoxy), 3-(4-methylphenoxy)) were prepared and copolymerized with styrene. The monomers were synthesized by the piperidine catalyzed Knoevenagel condensation of ring-substituted benzaldehydes and Bu cyanoacetate, and characterized by CHN anal., IR, 1H and 13C-NMR. All the ethylenes were copolymerized with styrene (M1) in solution with radical initiation (ABCN) at 70°C. The compositions of the copolymers were calculated from nitrogen anal. and the structures were analyzed by IR, 1H and 13C-NMR. Decomposition of the copolymers in nitrogen occurred in two steps, first in the 200-500°C range with residue (3.1-6.5% wt), which then decomposed in the 500-800°C range.

Journal of Macromolecular Science, Part A: Pure and Applied Chemistry published new progress about Glass transition temperature. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, SDS of cas: 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kharas, G. B. published the artcileNovel copolymers of styrene. 4. halophenoxy ring-substituted 2-cyano-3-phenyl-2-propenamides, Computed Properties of 61343-99-5, the main research area is halophenoxycyanophenylpropenamide styrene copolymer preparation thermal property.

Novel electrophilic trisubstituted ethylenes, halophenoxy ring substituted 2-cyano-3-phenyl-2-propenamides, RC6H4CH=C(CN)CONH2, where R is 4-(4-bromophenoxy), 2-(4-chlorophenoxy), 3-(4-chlorophenoxy), 4-(3-chlorophenoxy), 4-(4-chlorophenoxy), and 4-(4-fluorophenoxy) were prepared and copolymerized with styrene. The monomers were synthesized by potassium hydroxide catalyzed Knoevenagel condensation of ring-substituted benzaldehydes and cyanoacetamide, and characterized by CHN elemental anal., IR, 1H- and 13C-NMR. Novel copolymers of the ethylenes and styrene were prepared at equimolar monomer feed composition by solution in the presence of a radical initiator, AIBN at 70°C. The compositions of the copolymers were calculated from nitrogen anal., and the structures were analyzed by IR, 1H- and 13C-NMR, GPC, DSC, and TGA. Thus, the order of relative reactivity (1/r1) was 4-(4-ClC6H4O) (2.01) > 4-(4-FC6H4O) (0.89) > 4-(4-BrC6H4O) (0.73) > 3-(4-ClC6H4O) (0.65) > 2-(4-ClC6H4O) (0.24) > 4-(3-ClC6H4O) (0.22). High Tg of the copolymers in comparison with that of polystyrene indicated a substantial decrease in chain mobility of the copolymer due to the high dipolar character of the trisubstituted ethylene monomer unit. Decomposition of the copolymers in nitrogen occurred in two steps, first in the 200-500°C range with residue (10.4-15.0 wt%), which then decomposed in the 500-800°C range.

Journal of Macromolecular Science, Part A: Pure and Applied Chemistry published new progress about Glass transition temperature. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Computed Properties of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics