Category: 61343-99-5

Speri, Enrico published the artcileCinnamonitrile Adjuvants Restore Susceptibility to β-Lactams against Methicillin-Resistant Staphylococcus aureus, Synthetic Route of 61343-99-5, the main research area is preparation cinnamonitrile adjuvant beta lactam MRSA infection.

β-Lactams are used routinely to treat Staphylococcus aureus infections. However, the emergence of methicillin-resistant S. aureus (MRSA) renders them clin. precarious. We describe a class of cinnamonitrile adjuvants that restore the activity of oxacillin (a penicillin member of the β-lactams) against MRSA. The lead adjuvants were tested against six important strains of MRSA, one vancomycin-intermediate S. aureus (VISA) strain, and one linezolid-resistant S. aureus strain. Five compounds out of 84 total compounds showed broad potentiation. At 8 μM (E)-3-(5-(3,4-dichlorobenzyl)-2-(trifluoromethoxy)phenyl)-2-(methylsulfonyl)acrylonitrile (26) potentiated oxacillin with a >4000-fold reduction of its MIC (from 256 to 0.06 mg·L-1). This class of adjuvants holds promise for reversal of the resistance phenotype of MRSA.

ACS Medicinal Chemistry Letters published new progress about Antibacterial agent resistance. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Synthetic Route of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Campanico, Andre published the artcileAzaaurones as potent antimycobacterial agents active against MDR- and XDR-TB, Product Details of C13H9ClO2, the main research area is azaaurone antimycobacterial MDR XDR Mycobacterium tuberculosis; Mycobacterium tuberculosis; azaaurones; drug discovery; multidrug-resistant tuberculosis.

Herein we report the screening of a small library of aurones and their isosteric counterparts, azaaurones and N-acetylazaaurones, against Mycobacterium tuberculosis. Aurones were found to be inactive at 20 μM, whereas azaaurones and N-acetylazaaurones emerged as the most potent compounds, with nine derivatives displaying MIC99 values ranging from 0.4 to 2.0 μM. In addition, several N-acetylazaaurones were found to be active against multidrug-resistant (MDR) and extensively drug-resistant (XDR) clin. M. tuberculosis isolates. The antimycobacterial mechanism of action of these compounds remains to be determined; however, a preliminary mechanistic study confirmed that they do not inhibit the mycobacterial cytochrome bc1 complex. Addnl., microsomal metabolic stability and metabolite identification studies revealed that N-acetylazaaurones are deacetylated to their azaaurone counterparts. Overall, these results demonstrate that azaaurones and their N-acetyl counterparts represent a new entry in the toolbox of chemotypes capable of inhibiting M. tuberculosis growth.

ChemMedChem published new progress about Antibacterial agent resistance (overcoming). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Product Details of C13H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Hailei published the artcileFirst palladium-catalyzed denitrated coupling reaction of nitroarenes with phenols, Product Details of C13H9ClO2, the main research area is aryl ether chemoselective preparation; dimeric tolyliminoethylideneferrocene palladacycle catalyst substitution nitroarene phenol.

In the presence of 0.75 mol% of a dimeric (tolyliminoethylidene)ferrocene palladacycle catalyst, nitroarenes RNO2 (R = 4-OHCC6H4, 2-OHCC6H4, 4-NCC6H4, 2-NCC6H4, 4-O2NC6H4, 4-EtO2CC6H4) underwent substitution reactions with phenols R1OH with Cs2CO3 in DMF under air at 100° to give diaryl ethers ROR1 in 58-98% yields. Copyright © 2013 John Wiley & Sons, Ltd.

Applied Organometallic Chemistry published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Product Details of C13H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Du, Yingying published the artcileHighly efficient heterogeneous copper-catalysed O-arylation of phenols by nitroarenes leading to diaryl ethers, SDS of cas: 61343-99-5, the main research area is diaryl ether green preparation; phenol nitroarene arylation copper catalyst.

The heterogeneous O-arylation of phenols by nitroarenes was achieved in DMF at 100° by using an MCM-41-immobilized bidentate nitrogen copper(II) complex [MCM-41-2N-Cu(OAc)2] as catalyst, yielding a variety of unsym. diaryl ethers I (R1 = 4-OH, 2-OH, 4-NC, etc.; R2 = H, 4-Me, 4-MeO, etc.) in good to excellent yields. This heterogeneous copper catalyst can be easily prepared by a simple procedure from com. readily available and inexpensive reagents, recovered by filtration of the reaction solution and recycled at least seven times without significant loss of activity.

Journal of Chemical Research published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, SDS of cas: 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zheng, Xing-Wang published the artcileThe Coupling of Arylboronic Acids with Nitroarenes Catalyzed by Rhodium, Computed Properties of 61343-99-5, the main research area is diarylether preparation; arylboronic acid nitroarene coupling rhodium catalyst.

The coupling of arylboronic acids with electron-deficient nitroarenes was realized for the first time by using a rhodium(I) catalyst under an air atm., achieving unsym. diaryl ethers, e.g., I with yields ranging from poor to good. From a deuterium labeling experiment, the oxygen atom is derived from ambient water. The efficiency of this reaction was demonstrated by its compatibility with fluoro, bromo, chloro, and trifluoromethyl groups.

Organic Letters published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Computed Properties of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Jilei published the artcileLigand-free copper-catalyzed coupling of nitroarenes with arylboronic acids, Name: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is ligand free copper catalyzed coupling nitro arene arylboronic acid.

The first example of copper-catalyzed coupling of nitro arenes with arylboronic acids was developed, providing diaryl ethers in moderate to excellent yields. The efficiency of this reaction was demonstrated by compatibility with a wide range of groups. Moreover, the rigorous exclusion of air/moisture is not required in these transformations. Thus, the method represents a simple and facile procedure to access diaryl ethers. Preliminary mechanistic experiments using deuterium labeling showed that the oxygen atom was derived from water.

Green Chemistry published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Name: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mohammadinezhad, Arezou published the artcileCoII Immobilized on Aminated Magnetic-Based Metal-Organic Framework: An Efficient Heterogeneous Nanostructured Catalyst for the C-O Cross-Coupling Reaction in Solvent-Free Conditions, Synthetic Route of 61343-99-5, the main research area is arylether preparation green chem; arylalc aryl halide cross coupling cobalt nanocatalyst solvent free.

In this paper, synthesis of Fe3O4@AMCA-MIL53(Al)-NH2-CoII NPs based on the metal-organic framework structures as a magnetically separable and environmentally friendly heterogeneous nanocatalyst is reported. The prepared nanostructured catalyst efficiently promotes the C-O cross-coupling reaction I (R1 = H, 4-CH3, 4-NO2, etc.; R2 = C6H5, 4-CH3C6H5, 4-ClC6H5, etc.) in solvent-free conditions without the need for using toxic solvents and/or expensive palladium catalyst.

Catalysis Letters published new progress about Allyl ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Synthetic Route of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Elkamhawy, Ahmed published the artcileOptimization study towards more potent thiazolidine-2,4-dione IKK-β modulator: Synthesis, biological evaluation and in silico docking simulation, Application of 4-(4-Chlorophenoxy)benzaldehyde, the main research area is arylidene methylpiperazinylbutoxyphenyl thiazolidinedione diastereoselective preparation IKK inhibition SAR docking; IKK-β modulator; Molecular docking; NF-κB signaling pathway; Thiazolidine-2,4-dione.

A novel class of thiazolidine-2,4-diones I [R1 = 3-imidazol-1-ylphenyl, 5-phenylthiophen-2-yl, 4-chlorophenoxyphenyl, etc.] as structurally novel modulators for IKK-β was identified. A hit optimization study via analog synthesis strategy aiming to acquire more potent derivatives, probe the structure activity relationship (SAR) and get reasonable explanations for the elicited IKK-β inhibitory activities though an in-silico docking simulation study was reported. Accordingly, a new series of eighteen thiazolidine-2,4-dione derivatives was rationally synthesized, identified with different spectroscopic techniques and biol. evaluated as noteworthy IKK-β potential modulators. Successfully, new IKK-β potent modulators were obtained, including the most potent analog up-to-date I [R1 = 4-chlorophenoxyphenyl] with IC50 value of 260 nM. A detailed structure activity relationship (SAR) was discussed and a mechanistic study for I [R1 = 4-chlorophenoxyphenyl] was carried out indicating its irreversible inhibition mode with IKK-β (Kinact value = 0.01 (min-1)). Furthermore, the conducted in-silico simulation study provided new insights for the binding modes of this novel class of modulators with IKK-β.

Bioorganic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Application of 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Jiuxi published the artcileLigand-free copper-catalyzed O-arylation of nitroarenes with phenols, SDS of cas: 61343-99-5, the main research area is aryl ether preparation; nitroarene phenol arylation copper catalyst.

The first example of ligand-free copper-catalyzed O-arylation of nitroarenes with phenols was developed, achieving unsym. diaryl ethers in moderate to excellent yields. This arylation proceeded smoothly without promotion of the ligands, and displayed great functional group compatibility. Thus, the method represents a new, facile, and cost-effective approach to access unsym. diaryl ethers.

Tetrahedron published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, SDS of cas: 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Leo, Pedro published the artcileA recyclable Cu-MOF-74 catalyst for the ligand-free O-arylation reaction of 4-nitrobenzaldehyde and phenol, Computed Properties of 61343-99-5, the main research area is reusable copper MOF catalyst arylation reaction green chem; nitrobenzenealdehyde phenol formyldiphenyl ether; 4-formyldiphenyl ether; 4-nitrobenzaldehyde; MOF; O-arylation reaction; catalyst; ligand-free; phenol; recyclable Cu-MOF-74.

The activity and recyclability of Cu-MOF-74 as a catalyst was studied for the ligand-free C-O cross-coupling reaction of 4-nitrobenzaldehyde (NB) with phenol (Ph) to form 4-formyldiphenyl ether (FDE). Cu-MOF-74 is characterized by having unsaturated copper sites in a highly porous metal-organic framework. The influence of solvent, reaction temperature, NB/Ph ratio, catalyst concentration, and basic agent (type and concentration) were evaluated. High conversions were achieved at 120°C, 5 mol % of catalyst, NB/Ph ratio of 1:2, DMF as solvent, and 1 equiv of K2CO3 base. The activity of Cu-MOF-74 material was higher than other ligand-free copper catalytic systems tested in this study. This catalyst was easily separated and reused in five successive runs, achieving a remarkable performance without significant porous framework degradation The leaching of copper species in the reaction medium was negligible. The O-arylation between NB and Ph took place only in the presence of Cu-MOF-74 material, being negligible without the solid catalyst. The catalytic advantages of using nanostructured Cu-MOF-74 catalyst were also proven.

Nanomaterials published new progress about Aromatic ethers Role: IMF (Industrial Manufacture), PREP (Preparation). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Computed Properties of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics