Category: 61343-99-5

Tok, Fatih published the artcileSynthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors, HPLC of Formula: 61343-99-5, the main research area is monoamine oxidase cholinesterase inhibitor pyrazolone Schiff base preparation neurodegeneration; Acetylcholinesterase; Butyrylcholinesterase; Docking; Monoamine oxidase A; Monoamine oxidase B; Schiff base.

In the current work, Schiff base derivatives of antipyrine were synthesized. The chem. characterization of the compounds was confirmed using IR, 1H NMR, 13C NMR and mass spectroscopies. The inhibitory potency of synthesized compounds was investigated towards acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and monoamine oxidases A and B (MAO-A and MAO-B) enzymes. Some of the compounds displayed significant inhibitory activity against AChE and MAO-B enzymes, resp. According to AChE enzyme inhibition assay, compounds 3e and 3g were found as the most potent derivatives with IC50 values of 0.285 μM and 0.057 μM, resp. Also, compounds 3a (IC50 = 0.114 μM), 3h (IC50 = 0.049 μM), and 3i (IC50 = 0.054 μM) were the most active derivatives against MAO-B enzyme activity. To understand inhibition type, enzyme kinetics studies were carried out. Furthermore, mol. docking studies were performed to define and evaluate the interaction mechanism between compounds 3g and 3h and related enzymes. ADME (Absorption, Distribution, Metabolism, and Excretion) and BBB (Blood, Brain, Barrier) permeability predictions were applied to estimate pharmacokinetic profiles of synthesized compounds

Bioorganic Chemistry published new progress about Cholinesterase inhibitors (acetylcholinesterase, butyrylcholinesterase). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, HPLC of Formula: 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Phan, Nam T. S. published the artcileLigand-Free Copper-Catalyzed Coupling of Phenols with Nitroarenes by using a Metal-Organic Framework as a Robust and Recoverable Catalyst, Quality Control of 61343-99-5, the main research area is phenol coupling nitroarene copper metal organic framework catalyst; ligand free copper metal organic framework catalyst coupling reaction.

A highly porous metal-organic framework Cu2(BDC)2(DABCO) (H2BDC = 1,4-benzenedicarboxylic acid, DABCO = 1,4-diazabicyclo[2.2.2]octane) was synthesized and used as an efficient recyclable heterogeneous catalyst for the coupling reaction of phenols with nitroarenes to form diaryl ethers without using a ligand. Phys. characterization of the MOF was obtained by using XRD, SEM, TEM, thermogravimetric anal. (TGA), FTIR spectroscopy, at. absorption spectrophotometry (AAS), H2 temperature-programmed reduction (H2-TPR), and N2 physisorption measurements. The Cu2(BDC)2(DABCO)-catalyzed coupling reaction offers several advantages compared to the conventional Ullmann reaction for the synthesis of unsym. diaryl ethers. To the best of our knowledge, the ligand-free Cu-catalyzed O-arylation reaction of phenols with nitroarenes that uses a heterogeneous catalyst has not been mentioned previously in the literature.

ChemCatChem published new progress about Aromatic nitro compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Quality Control of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Carrasco, Marta P. published the artcileProbing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity, Application In Synthesis of 61343-99-5, the main research area is aurone preparation antimalarial structure activity; coupling palladium catalyst aurone preparation antimalarial; Aurones; Cross-coupling reactions; Malaria; Plasmodium falciparum.

A library comprising 44 diversely substituted aurones derivatives, e.g., I [R3 = H, 2-Br, 4-NHCH2Ph, 3-(3′-quinolinyl), etc.], was synthesized by straightforward aldol condensation reactions of benzofuranones and the appropriately substituted benzaldehydes. Microwave enhanced synthesis using palladium catalyzed protocols was introduced as a powerful strategy for extending the chem. space around the aurone scaffold. Addnl., Mannich-base derivatives, containing a 7-aminomethyl-6-hydroxy substitution pattern at ring A, were also prepared Screening against the chloroquine resistant Plasmodium falciparum W2 strain identified novel aurones with IC50 values in the low micromolar range. The most potent compounds contained a basic moiety, with the ability to accumulate in acidic digestive vacuole of the malaria parasite. However, none of those aurones revealed significant activity against hemozoin formation and falcipain-2, two validated targets expressed during the blood stage of P. falciparum infection and functional in digestive vacuole of the parasite. Overall, this study highlights (i) the usefulness of aurones as platforms for synthetic procedures using palladium catalyzed protocols to rapidly deliver lead compounds for further optimization and (ii) the potential of novel aurone derivatives as promising antimalarial compounds

European Journal of Medicinal Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent) (benzaldehydes). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Application In Synthesis of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Begum, Tahshina published the artcilePalladium-on-Carbon-Catalyzed Coupling of Nitroarenes with Phenol: Biaryl Ether Synthesis and Evidence of an Oxidative-Addition-Promoted Mechanism, Application In Synthesis of 61343-99-5, the main research area is nitroarene phenol palladium coupling catalyst; ether biaryl preparation.

Nucleophilic substitution in nitroarenes to form biaryl ethers is of fundamental importance in organic synthesis. Under non-catalytic conditions, this can occur if highly activated nitroarenes are used or if the nucleophile is activated by a strong stoichiometric base. We established a new method involving the use of a ligand-free palladium-on-carbon (Pd/C) catalyst for the cross-coupling of activated nitroarenes with relatively non-nucleophilic phenol derivatives, including naphthol, in the absence of harsh bases. Control experiments, hot filtration, the three-phase test, and inductively coupled plasma at. emission spectroscopy anal. revealed that the catalysis proceeded through an usual oxidative addition step of the nitroarene to Pd/C, which resulted in the release of active palladium particles having extremely high catalytic activity. DFT calculations revealed the origin of the selectivity of the activated nitroarenes.

European Journal of Organic Chemistry published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation) (biaryl). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Application In Synthesis of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Alp, Mehmet published the artcileSynthesis and antiparasitic and antifungal evaluation of 2′-arylsubstituted-1H,1’H-[2,5′]bisbenzimidazolyl-5-carboxamidines, Name: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is phenylenediamine benzimidazolyl condensation aldehyde aryl; benzimidazole bis aryl amidino preparation antiparasitic antifungal activity.

A series of 2′-aryl-1H,1’H-[2,5′]-bisbenzimidazolyl-5-carboxamidines I (e.g., R1R2 = benzo, R3 = R4 = H) were prepared in a six-step process starting from 4-amino-3-nitrobenzonitrile. The antiparasitic activity against Trypanosoma brucei rhodesiense (T.b.r.), Plasmodium falciparum (P.f.), Leishmania donovani (L.d.) and Trypanosoma cruzi (T.c.) and antifungal activity against Candida albicans and Candida krusei were evaluated in vitro. Several compounds showed promising in vitro activity against T.b.r., P.f. and C. albicans and had superior activity against P.f. as compared to chloroquine.

European Journal of Medicinal Chemistry published new progress about Aromatic diamines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Name: 4-(4-Chlorophenoxy)benzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fadeeva, Anastasia A. published the artcileChlorination of Conjugated Nitroalkenes with PhICl2 and SO2 Cl2 for the Synthesis of α-Chloronitroalkenes, Computed Properties of 61343-99-5, the main research area is conjugated nitroalkene iodobenzene dichloride chemoselective chlorination; sulfuryl chloride conjugated nitroalkene chemoselective chlorination; chloro nitroalkene preparation.

Chlorination of conjugated nitroalkenes with iodobenzene dichloride or sulfuryl chloride to give target α-chloronitroalkenes in good yields was described. Details of the procedure depend on the donating ability of the nitroalkene substituents. The activity of the described chlorinating agents increases in order ‘PhICl2/Py’ < 'SO2Cl2' < 'SO2Cl2/HCl' with the former produced the best yields for highly donating substrates and the latter for non-activated groups. An autocatalytic role of hydrogen chloride and the chemoselectivity of chlorination were also demonstrated. Synthesis published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Computed Properties of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Keith, John M. published the artcileHeteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase, Computed Properties of 61343-99-5, the main research area is heteroaryl urea fused bicyclic diamine core preparation; fatty acid amide hydrolase inhibitory activity; Anandamide; Aryl urea; Covalent inhibitor; Endocannabinoid; Enzyme; FAAH; Inhibitors; Serine hydrolase.

A series of mechanism-based heteroaryl urea fatty acid amide hydrolase (FAAH) inhibitors with fused bicyclic diamine cores is described. In contrast to compounds built around a piperazine core, most of the fused bicyclic diamine bearing analogs prepared exhibited greater potency against rFAAH than the human enzyme. Several compounds I and II equipotent against both species were identified and profiled in vivo.

Bioorganic & Medicinal Chemistry Letters published new progress about Enzyme inhibitors (fatty acid amide hydrolase). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Computed Properties of 61343-99-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics