Schroeter, G.’s team published research in Justus Liebigs Annalen der Chemie in 426 | CAS: 61551-49-3

Justus Liebigs Annalen der Chemie published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, HPLC of Formula: 61551-49-3.

Schroeter, G. published the artcileHydrogenated naphthalenes and their transformations. III. Tetrahydronaphthalenesulfonic acids, tetrahydronaphthols and their derivatives, HPLC of Formula: 61551-49-3, the publication is Justus Liebigs Annalen der Chemie (1922), 83-160, database is CAplus.

2-Tetralinsulfonic acid (tetrahydronaphthalene-2-sulfonic acid),formed by the action of concentrated H2SO4 upon C10H12, seps. with 2 H2O from H2SO4, m. 75°. Sodium salt, glistening leaflets with 1 H2O; barium salt, leaflets; lead salt,with 1 H2O, small leaflets. Ammonium salt, glistening leaflets Chloride, plates, b18 197-200°, m. 58°. With NH3 it yields the amide, m. 135-7°, and with PhNH2, the anilide, m. 155-6°. The mixture of acids obtained when the sulfonation is carried out with ClSO3H may be separated by crystallization of the acids from CHCl3, the 1-acid separating first, or by precipitating the Pb salt of the 1-acid with Pb(OAc)2 or by crystallizing the 2-amide from NaOH. 1-Tetralinsulfonic acid: lead salt, glistening leaflets with 3H2O; sodium salt, leaflets with 2 H2O, and barium salt, 3 H2O. Amide, leaflets, m. 139-40°;chloride, m. 70-2°; anilide, m. 148-9°. Upon reduction of the chloride mixture with Zn dust, the tetralylthiols result. 2-Tetralylthiolacetic acid, by the reaction of ClCH2CO2Na upon C10H11SNa, needles, m. 78-80°. Ammonium salt, glistening leaflets. Concentrated H2SO4gives a greenish yellow color; on boiling the dilute solution and making alk. with NaOH, sodium bis-ar-tetrahydrothionaphthenedisulfonate is precipitated as fine steel-blue needles with Cu luster. The 1-thiolacetic acid crystallizes in glistening plates, m. 133-5°. Whenα-C10H7OH is reduced with H at 200°in the presence of Ni, the product consists of about 10% ofα-ketotetrahydronaphthalene, 25-30 %C10H11OH and a large quantity of C10H12. At low temperatures the ketone is the main product. In the reduction of the ketone with Na and EtOH, it yields ac-C10H11OH. ac-β-C10H11OH is the principal product of the catalytic reduction of β-C10H7OH. The SO3H acids are therefore valuable starting points in the production of C10H11OH, which are formed by fusion with alkalies. These are called tetralols. 2-Tetralolmethyl ether, by the action of Me2SO4 in NaOH, b11 129-31°; acetate, rather viscous oil,b14 158°; benzoate, prisms, b10220-2°, m. 96°. 2-Tetralol-3-sulfonic acid, by warming in concentrated H2SO4 until soluble in H2O,needles, with 2 H2O, m. 92°. The sodium and barium salts are difficultly soluble With diazo solutions it couples to form strongly colored azo dyes. Methoxy derivative, from C10H11OMe and concentrated H2SO4, m. 107°. 1-Bromo-2-tetralol, by the direct action of Br in CCl4, b13160°, m. 74°; also prepared by desulfonation of 1-bromo-2-tetralol-3-sulfonic acid (sodium salt, with 3H2O) with HCl. This has a greater toxic effect upon bacteria than lysol or PhOH. 1,3-Dibromo-2-tetralol,b12 198-201°, m. 37°. Acetate, m. 87°, is the best means of purification. 1-Bromo-3-nitro-2-tetralol, by the action of HNO3 on the SO3H derivative, long yellow needles, m. 129°. Sodium salt, glistening red leaflets,which color wool a light orange shade. Methyl ether, yellow needles, m. 64°. 1-Chloro-3-nitro-2-tetralol, yellow needles,m. 96°. 1-Bromo-3-amino-2-tetralol, by reduction of the NO2 derivative with SnCl2 in Et2O saturated with HCl, fine needles, m. 127° (hydrochloride, sulfate and nitrate sparingly soluble in cold H2O); methyl ether,isolated as the sulfate, long needles with 4 H2O. 3-Amino-2-tetralol (A) is also formed in the above reduction and forms leaflets, m. 202°. Its hydrochloride and nitrate are easily soluble in H2O, while the sulfate is difficultly soluble Carbonyl-3,2-aminotetralol,C10H10.NH.CO.O by heating the azide in C7H8, m. 196°, also forms A when heated with concentrated HCl in a sealed tube. With piperonal A gives piperonylidene-3,2-aminotetratol, yellow, m. 160°; with alk. Me2SO4 it yields piperonylidene-3,2-aminotetralol methyl ether, m. 120°. With dilute HCl this yields the methyl ether of A, large leaflets, m.86°. 1-Amino-2-tetralol (B), obtained by coupling 2-C10H11OH with sulfanilic acid diazide and reducing with SnCl2 or from 1-benzeneazo-2-tetralol(red, m. 84°; monobromo derivative m. 204°) with Na2S2O4, leaflets, m. 148°. An isomer, m. 173°, is sometimes obtained which gives a carbonyl-aminotetralol, red needles, m. 188°. Carbonyl-1-amino-2-tetralol, m. 189-90°. Methyl ether of B, m.64°, is obtained by reducing 1,2-O2NC10H6OMe with SnCl2, isolating the product and reducing this with Na and AmOH, and yields B upon heating with HCl in a sealed tube. 1,3-Nitrotetralinsulfonic acid, obtained by the action of concentrated H2SO4 on 1-C10H11NO2, forms an amide m.189°, and upon reduction with SnCl2 and excess of HCl, or Fe and HCl, gives 1-aminotetralin-3-sulfonic acid (C),leaflets. When a mixture of the 1- and 2-NO2 derivatives is sulfonated, 2-nitrotetralin-4-sulfonic acid is also formed, the amide of which m. 211-2°, and which yields 2-aminotetralin-4-sulfonic acid on reduction, the hydrochloride of which is soluble in 120 parts H2O. The action of alkalies on C gives, as the main product, AcNHC10H11. 4-Acetamino-2-tetralol is obtained by heating the diazo solution from 4,2-AcNHC10H10NH2, m. 222°,and, on saponification, gives 4-amino-2-tetralol, leaflets, m. 177°. 1,3-Dinitro-2-tetralol, pale yellow needles, m. 141°. Sodium salt, orange-yellow; potassium salt, orange-yellow; ammonium salt,citron-yellow; barium and lead salts. The 1st 2 salts change color on heating and explode at 180-90°, while the last 3 do not change color and burn quietly on heating. Methyl ether (D), from MeNaSO4 and(O2N)2C10H9ONa in C7H8, needles, m. 86.5°. Reduced with SnCl2 in Et2O, 1-nitro-3-amino-2-tetralol results, Cu-colored needles, m. 127°. Hydrochloride, pale yellow leaflets. Methyl ether, by the reduction of D, yellow leaflets, m. 117°. Hydrochloride, sparingly soluble in HCl, but decomposed by H2O. Reduced with SnCl2 in EtOH,1,3-diamino-2-tetralol is formed, leaflets, m. 214-6°. Methyl ether, prisms, m. 89°. Heated under pressure with CO2 in the presence of alkalies,2-C10H11OH gives 2,3-tetralsalicylic acid, m.182°; sodium and calcium salts. Methyl ester, b15179°, m. 42°. Ethyl ester, b13 179°. 2-Tetralol-3-carbonic hydrazide, m. 146°. Acetonehydrazone, m.235°. Azide, long needles, m. 99-100°. Anilide, m.182-4°. 2,3-Acetyltetralol-carboxylic acid, m. 142-3°. 1-Nitro-2-tetralol-3-carboxylic acid, yellow needles, m.200-2°, which may be reduced to the 1-amino derivative, prisms,m. 208-10°; the hydrochloride is sparingly soluble in HCl and the diacetate m. 180-1°. 4-Amino-1-tetralol, needles m. 146-7°, may be obtained by reducing p-ONC10H10OH with SnCl2, or 1-tetralol-4-azobenzene-4′-sulfonic acid, red dye, by means of alk. Na2S2O4. Ethyl ether (Ber. 31, 898), by reduction of EtOC10H10N2 Ph with H, m. 60°,and gives p-ethoxytetralylurea, m. 240-1°. 2-Amino-1-tetralol, m. 110-1°, gives with urea an oxazolone, m. 205°. 3-Acetamino-1-tetralol, from the diazo compound, needles, m.211°. 3-Amino-1-tetralol, leaflets, m. 197°;hydrochloride, needles. With K2CO3 and CO2 this gives 1,2-tetralsalicylic acid, m. 165-6°,the sodium salt of which crystallizes as leaflets with 3H2O. Acetate, m. 170°. Methyl ester,b16 190°, m. 56°. Hydrazide, long needles, m.205°. Acetonehydrazone, m. 136°. Azide, m. 84°.

Justus Liebigs Annalen der Chemie published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, HPLC of Formula: 61551-49-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hanessian, Stephen’s team published research in Bioorganic & Medicinal Chemistry Letters in 18 | CAS: 61551-49-3

Bioorganic & Medicinal Chemistry Letters published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Recommanded Product: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride.

Hanessian, Stephen published the artcileDesign, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs, Recommanded Product: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(6), 1972-1976, database is CAplus and MEDLINE.

Guided by available X-ray crystal structure data on the serine protease thrombin, a series of pyridin-2-one derivatives, e.g., I·HCl, were designed and synthesized having diverse functionality at the P1 and P3 sites. Potent in vitro activity against thrombin, with excellent selectivity over trypsin was found for selected analogs.

Bioorganic & Medicinal Chemistry Letters published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Recommanded Product: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kamdem, Nestor’s team published research in Magnetic Resonance in 2 | CAS: 61551-49-3

Magnetic Resonance published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Computed Properties of 61551-49-3.

Kamdem, Nestor published the artcileSmall-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling, Computed Properties of 61551-49-3, the publication is Magnetic Resonance (2021), 2(1), 355-374, database is CAplus.

Dishevelled (Dvl) proteins are important regulators of the Wnt signalling pathway, interacting through their PDZ domains with the Wnt receptor Frizzled. Blocking the Dvl PDZ-Frizzled interaction represents a potential approach for cancer treatment, which stimulated the identification of small-mol. inhibitors, among them the anti-inflammatory drug Sulindac and Ky-02327. Aiming to develop tighter binding compounds without side effects, we investigated structure-activity relationships of sulfonamides. X-ray crystallog. showed high complementarity of anthranilic acid derivatives in the GLGF loop cavity and space for ligand growth toward the PDZ surface. Our best binding compound inhibits Wnt signalling in a dose-dependent manner as demonstrated by TOP-GFP assays (IC50 ∼ 50 μM) and Western blotting of β-catenin levels. Realtime PCR showed reduction in the expression of Wnt-specific genes. Our compound interacted with Dvl-1 PDZ (KD = 2.4 μM) stronger than Ky-02327 and may be developed into a lead compound interfering with the Wnt pathway.

Magnetic Resonance published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Computed Properties of 61551-49-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Davies, W.’s team published research in Journal of the Chemical Society in | CAS: 61551-49-3

Journal of the Chemical Society published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Related Products of chlorides-buliding-blocks.

Davies, W. published the artcilePolymerization of thiophene derivatives. V. The self-condensation of 4,5- and 6,7-benzothianaphthene 1,1-dioxides. A new route to 1-(1-naphthyl)- and 4-(2-naphthyl)phenanthrene, Related Products of chlorides-buliding-blocks, the publication is Journal of the Chemical Society (1956), 2609-14, database is CAplus.

cf. C.A. 50, 1752d. 2-(1-Naphthyl)ethanol, b0.2 130-2°, with PBr3 gave 2-(1-naphthylethyl) bromide (I). I (98 g.) was refluxed and stirred 15 hrs. with 170 g. of Na2SO3.7H2O to give 81 g. of Na 2-(1-naphthyl)ethanesulfonate (II). II stirred 30 min. with 66 g. PCl5 at room temperature, the mixture warmed 30 min. on a steam bath and extracted with Et2O, and the extract cooled precipitated gave 48 g. 2-(1-naphthyl)ethanesulfonyl chloride (III), m. 48-8.5°; anilide, m. 133.5-34°; amide, m. 172.5-73°. III (40 g.) in 75 ml. PhNO2 was added to 24 g. powd. AlCl3 in 200 ml. PhNO2, the mixture kept 1 hr. at room temperature and 2 hrs. at 70°, the complex decomposed with dilute HCl, the solvent steam distilled, and the residue extracted with C6H6 gave 14.8 g. 2,3-dihydro-4,5-benzothianaphthene 1,1-dioxide (IV), m. 178-8.5°. IV (6.0 g.) refluxed 8 hrs. with 4.8 g. N-bromosuccinimide and 0.1 g. Bz2O2 in 150 ml. CCl4, the solvent removed, and the residue dissolved in hot C6H6, filtered, and chromatographed on Al2O3 gave 2.7 g. 4,5-benzothianaphthene 1,1-dioxide (V), m. 136-7° or 141-2° with evolution of SO2. V was reduced with LiAlH4 to give 2,3-dihydrothianaphthene (VI), m. 86.5-87°. VI refluxed with chloranil in xylene 6 hrs. and the mixture cooled, filtered, diluted with C6H6, and chromatographed gave 4,5-benzothianaphthene. V (2.5 g.) in 50 ml. xylene was refluxed until evolution of SO2 ceased. Evaporation gave 1.6 g. 10,11-dihydro-9-thia-5,6-benzonaphtho(1′,2′,3,4)fluorene 9,9-dioxide (VII), m. 226°. VII refluxed 10 min. in 50% aqueous KOH in (HOCH2CH2)2O and the mixture diluted with H2O and extracted with Et2O gave 1-(1-naphthyl)phenanthrene, m. and mixed m.p. 115-16°. By the same sequence of reactions, the following compounds were prepared from 2-(2-naphthyl)ethanol, m. 66°: Na 2-(2-naphthyl)ethanesulfonate; 2,2′-naphthylethanesulfonyl chloride, m. 66-6.5° (amide, m. 200-200.5°); 2,3-dihydro-6,7-benzothianaphthene 1,1-dioxide, m. 187.5-88°; 6,7-benzothianaphthene 1,1-dioxide, m. 181-2°or 194-5° (decomposition); 10,11-dihydro-9-thia-7,8-benzonaphtho(2′,1′-3,4)fluorene 9,9-dioxide, m. 166-7°; and 4-(2-naphthyl)phenanthrene, m. 105-6°. 6-Tetralinsulfonyl chloride, m. 57-8°, was reduced with Zn and H2SO4 to 6-mercaptotetralin (VIII), b35 161-2°. VIII added to still-reacting Na in EtOH, followed by chloroacetal and NaBr, the mixture refluxed 6 hrs., the solution extracted with 2% aqueous NaOH, then Et2O, the Et2O extract distilled gave (6-tetralylthio)acetaldehyde di-Et acetal (IX), b0.5 160-1°. Slow addition of IX to mixed P2O5 and H3PO4 gave a yellow oil which was distilled to give a mixture of tetrahydrobenzothianaphthenes, b0.3 119-21°. Tetralin (50 g.) stirred 1 hr. into ClSO3H at -5° warmed to room temperature, the mixture precipitated with ice and extraction with CCl4, and the extract evaporated gave a mixture of 68 g. of 5- and 6-tetralinsulfonyl chlorides; this product (20 g.) added to 14.5 g. ClCH2CO2H on 12 g. NaOH in 250 ml. H2O and the mixture heated 1 hr. on a water bath, cooled, and acidified precipitated 25 g. of an acid mixture (X). X (20 g.) in 80 ml. 5% KOH was added to 40 ml. 40% KOH. The acidified precipitate gave 9.2 g. (6-tetralylthio)acetic acid, m. 78.5-79. Acidification of the filtrate gave 9.0 g. of (5-tetralylthio)acetic acid, m. 133-4°.

Journal of the Chemical Society published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lee, Hui-Soon’s team published research in Archives of Pharmacal Research in 23 | CAS: 61551-49-3

Archives of Pharmacal Research published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Product Details of C10H11ClO2S.

Lee, Hui-Soon published the artcileEffect of substituents on benzenesulfonyl motif of 4-phenyl-1-arylsulfonylimidazolidinones for their cytotoxicity, Product Details of C10H11ClO2S, the publication is Archives of Pharmacal Research (2000), 23(6), 579-584, database is CAplus and MEDLINE.

To explore the effect of substituents on Ph motif on sulfonyl function of novel anticancer 4-phenyl-1-benzenesulfonylimidazolidinones, electron donating or withdrawing substituents were introduced at 3 or 4-position and the analogs were tested against human lung (A549) and colon (HCT-15) cancer cell lines. Quant. structure activity relation of the 4-substituted series shows that only STERIMOL L values are well correlated. The increment of substituent’s volume enhances the activity against both cell lines. The small substituent at 3-position addnl. increases the activity. However naphthyl group in place of Ph reduces the activity. Therefore the Ph motif with sterically large substituent at 4-position and small substituent at 3-position may be important for their activity. Integration of these substituents’ effects into the structural design led to discover the more potent analog, 4-phenyl-1-(N-acetylindoline-5-sulfonyl)imidazolidinone.

Archives of Pharmacal Research published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Product Details of C10H11ClO2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, De-Yong’s team published research in Journal of Organic Chemistry in 86 | CAS: 61551-49-3

Journal of Organic Chemistry published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C21H37BO, Application of 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride.

Yang, De-Yong published the artcilePhotoredox Catalyzed Radical Cascade Aroylation (Sulfonylation)/Cyclization Enables Access to Fused Indolo-pyridones, Application of 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, the publication is Journal of Organic Chemistry (2021), 86(24), 18042-18055, database is CAplus and MEDLINE.

A visible-light-initiated radical cascade reaction toward the synthesis of structurally diverse fused indolo-pyridones is described. The reaction involves the addition of aroyl or sulfonyl radicals to N-alkyl-acryloyl-1H-indole-3-carboxamides, cyclization, and oxidative aromatization. This telescoped method circumvents lengthy prefunctionalization steps of radical precursors, which is further underpinned by the superior compatibility with a series of C-centered radicals, allowing the rapid and facile construction of numerous valuable architectures.

Journal of Organic Chemistry published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C21H37BO, Application of 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lee, Koo’s team published research in Bioorganic & Medicinal Chemistry Letters in 9 | CAS: 61551-49-3

Bioorganic & Medicinal Chemistry Letters published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Application In Synthesis of 61551-49-3.

Lee, Koo published the artcileFluorobenzamidrazone thrombin inhibitors: influence of fluorine on enhancing oral absorption, Application In Synthesis of 61551-49-3, the publication is Bioorganic & Medicinal Chemistry Letters (1999), 9(17), 2483-2486, database is CAplus and MEDLINE.

LB30057 (I, R = H) is a selective and efficacious oral thrombin inhibitor. Fluorine-substitution on the phenylene ring of the benzamidrazone portion in both compound I (R = H) and its derivatives gave, in many cases, enhanced oral absorption in rats while maintaining the intrinsic potency and selectivity. Compound I (R = F) demonstrated a 3-fold increase in absorption.

Bioorganic & Medicinal Chemistry Letters published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Application In Synthesis of 61551-49-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yoshii, Yoshihiro’s team published research in Nippon Kagaku Kaishi in | CAS: 61551-49-3

Nippon Kagaku Kaishi published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C25H23NO4, Computed Properties of 61551-49-3.

Yoshii, Yoshihiro published the artcileFriedel-Crafts phenylsulfonylation of o-xylene, indan, and tetralin in nitrobenzene, Computed Properties of 61551-49-3, the publication is Nippon Kagaku Kaishi (1986), 1117-21, database is CAplus.

Friedel-Crafts reactions of o-xylene, indan, and tetralin with PhSO2Cl in the presence of AlCl3 in PhNO2 were studied in relation to temperature effects on isomer distribution under kinetic conditions. In indan, the isomer ratio (3 to 4) increased with temperature, while the ratio (3 to 4) decreased in o-xylene and in tetralin. Differences of activation energies and activation entropies in the 3- and 4-position for o-xylene, indan, and tetralin were -0.39 kcal/mol, -2.0 e.u./mol; 0.16, -0.2; and -0.31, -1.5. Isokinetic temperature were -81 and -62° for o-xylene and tetralin, resp. These results suggest that the 3-position of o-xylene or tetralin is more reactive than the 4-position, whereas the 4-position is more reactive in indan. The reaction proceeded with a concerted mechanism in which strong acid-catalytic effect by AlCl3 and base-catalyzed deprotonation by solvent and/or AlCl4 on the 3-position were observed in o-xylene and tetralin.

Nippon Kagaku Kaishi published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C25H23NO4, Computed Properties of 61551-49-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lee, Koo’s team published research in Bioorganic & Medicinal Chemistry in 6 | CAS: 61551-49-3

Bioorganic & Medicinal Chemistry published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Name: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride.

Lee, Koo published the artcileStructural modification of an orally active thrombin inhibitor, LB30057: replacement of the D-pocket-binding naphthyl moiety, Name: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, the publication is Bioorganic & Medicinal Chemistry (1998), 6(6), 869-876, database is CAplus and MEDLINE.

Amidrazonophenylalanine derivative LB30057 (I) was identified as a potent (Ki=0.38 nM), selective, and orally active thrombin inhibitor. As a continuation of studies into benzamidrazone-based thrombin inhibitors, we have structurally modified I by replacing the naphthyl group with a variety of hydrophobic moieties. This study led to discovery of several compounds with significantly enhanced potency in thrombin inhibition without sacrificing selectivity against trypsin and oral absorption. The highest activity was obtained with benzocycloheptyl derivative II (Ki = 0.045 nM).

Bioorganic & Medicinal Chemistry published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Name: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cervena, Irena’s team published research in Collection of Czechoslovak Chemical Communications in 46 | CAS: 61551-49-3

Collection of Czechoslovak Chemical Communications published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Formula: C10H11ClO2S.

Cervena, Irena published the artcileNeurotropic and psychotropic agents. CXLIX. Synthesis of arylthioacetamidoximes as potential antidepressants, Formula: C10H11ClO2S, the publication is Collection of Czechoslovak Chemical Communications (1981), 46(5), 1188-98, database is CAplus.

Reactions of PhSH and 16 of its derivatives with ClCH2CN gave arylthioacetonitriles which were treated with NH2OH to gave the title compounds I [R1R2 = H, 4-Me, 4-Et, 4-Cl, 2-, 3- and 4-OMe, 4-OEt, 4-SMe, 4-SEt, 2-OMe-4-Cl, 3-OMe-4-Cl, 3,4-(OMe)2, 2,3-benzo, 3,4-benzo, 2,3-(CH2)4, 3,4-(CH2)4]. Some of the compounds exhibited antireserpine activity in the tests of ptosis and reserpine hypothermia in mice (LD and ED given).

Collection of Czechoslovak Chemical Communications published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Formula: C10H11ClO2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics