Category: 61881-19-4

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 61881-19-4

Compound 4 (0.91 g, 4.09 mmol) was dissolved in 5ml acetone, and then2,2,2-trifluoro-N-phenylethanimidoyl chloride (0.87 g, 4.19 mmol) and potassiumcarbonate (0.58 g, 4.19 mmol) were successively added. After stirring at roomtemperature for about 18 h, the mixture was evaporated under reduced pressure.The residue was purified by column chromatography on silica gel (200-300 mesh) toafford pure 8, yield 87%. TLC (ethyl acetate/petroleum ether 4:1, V:V); 1H NMR (400MHz, CDCl3) delta: 1.31 (m, 3H, CH3), 1.35 (m, 3H, CH3), 3.15 (m, 1H, CH), 3.22 (m, 1H,CH), 3.50 (s, 3H, CH3), 3.59 (s, 3H, CH3), 3.61 (m, 2H, CH2), 3.69 (m, 1H, CH), 3.75(m, 1H, CH), 5.25 (s, 1H, CH); 6.88(m, 1H, CH), 7.14 (s, 1H, CH), 7.33 (m, 1H, CH),7.44 (s, 1H, CH); 7.59 (s, 1H, CH) ; 13C NMR (100 MHz, CDCl3) delta: 15.6, 17.8, 59.2,61.1, 67.8, 70.7, 79.7, 82.0, 96.2, 117.3, 119.5, 120.4, 125.4, 129.2, 129.4,133.9, 143.6; MS (ESI) cal for C18H24F3NO5 [M+Na]+ 414.14988, found [M+Na]+414.15034.

According to the analysis of related databases, 61881-19-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhang, Kai; Liu, Shenglan; Liu, Anjun; Chai, Hongxin; Li, Jiarong; Lamusi; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 2603 – 2609;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 61881-19-4, These common heterocyclic compound, 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a typical experimental procedure, a dry, two-necked, 50 mL round-bottomed flask equipped with a nitrogen inlet was charged with 5 mL of dry MeCN, 0.117 g (1.0 mmol) of indole and 0.24 g (1.0 mmol) of NaH. The solution was stirred under a nitrogen atmosphere at room temperature for 30 min, then a solution of 2a (1.0 mmol in 2 mL of dry MeCN) was added dropwise via a syringe. The mixture was stirred at room temperature for 20 h under an N2 atmosphere and then filtered. After removing the solvent under reduced pressure, the crude product was purified by preparative thin-layer chromatography on silica gel [eluent: n-hexane/EtOAC, 4:1] to give the product 4a. The products obtained from indole-3-carbaldehyde were purified by recrystallization from EtOH (twice).

Statistics shows that 2,2,2-Trifluoro-N-phenylacetimidoyl chloride is playing an increasingly important role. we look forward to future research findings about 61881-19-4.

Reference:
Article; Darehkordi, Ali; Rahmani, Fariba; Hashemi, Vahide; Tetrahedron Letters; vol. 54; 35; (2013); p. 4689 – 4692;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 61881-19-4, The chemical industry reduces the impact on the environment during synthesis 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, I believe this compound will play a more active role in future production and life.

General procedure: Add sodium acetate, trifluoroethylimidyl chloride (II), hydrazone (III), and 1 mL of organic solvent to the 35 mL Schlenk tube according to the raw material ratio in Table 1.Mix and stir well. After the reaction is completed according to the reaction conditions in Table 2, 2-4 hours,Add elemental iodine, continue the reaction for 1-2 hours, filter, and stir the sample in silica gel.After purification by column chromatography, the corresponding 5-trifluoromethyl-substituted 1,2,4-triazole compound (I) is obtained. The reaction process is shown by the following formula:

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang Sci-Tech University; Chen Zhengkai; Hu Sipei; Yang Zuguang; (10 pag.)CN110467579; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C8H5ClF3N

To a stirred solution of 25 (0.05 g, 0.05 mmol) in acetone(0.5 ml) was added K2CO3 (8 mg, 0.06 mmol) and N-phenyl trifluoroacetimidoylchloride (0.01 ml, 0.07 mmol) were added. The reactionmixture was stirred for 3 days under a dry atmosphere at rt.The reaction mixture was dried over MgSO4 and concentrated invacuo. Column chromatography yielded compound 26 (0.056 g,0.05 mmol) in >98% yield. TLC: Rf 0.76 (20% EtOAc/pentane); IR(neat, cm1): 3311, 2954, 2924, 2854, 2112, 1714, 1207, 1151,1112, 731, 696; 1H NMR (400 MHz, CDCl3): d = 7.65-6.78 (m,35H), 5.17-5.16 (m, 1H), 5.06-5.03 (m, 1H), 4.94-4.89 (m, 1H),4.80-4.75 (m, 3H), 4.59-4.55 (m, 3H), 4.46-4.37 (m, 1H), 4.15-3.91 (m, 6H), 3.78-3.58 (m, 5H), 1.07 (s, 9H); 13C NMR (101 MHz,CDCl3): d = 138.3, 138.2, 137.6, 137.5, 135.6, 133.3, 133.1, 129.9,128.8, 128.7, 128.6, 128.5, 128.4, 128.3, 128.2, 128.1, 128.0,127.9, 127.8, 127.6, 124.5, 119.4, 94.5, 77.53, 75.6, 75.1, 74.974.5, 73.6, 73.6, 72.7, 72.0, 70.4, 67.8, 62.7, 61.7, 59.7, 27.0; HRMS:[C64H66F3N7O9Si+Na] requires 1184.45356, found 1184.45410

According to the analysis of related databases, 61881-19-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; van der Es, Daan; Groenia, Nadia A.; Laverde, Diana; Overkleeft, Herman S.; Huebner, Johannes; van der Marel, Gijsbert A.; Codee, Jeroen D.C.; Bioorganic and Medicinal Chemistry; vol. 24; 17; (2016); p. 3893 – 3907;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 61881-19-4 as follows. Application In Synthesis of 2,2,2-Trifluoro-N-phenylacetimidoyl chloride

4.3 3,4-Di-O-benzoyl-2-O-triisopropylsilyl-alpha-L-fucopyranosyl N-phenyltrifluoroacetimidate (6) To a solution of 3,4-di-O-benzoyl-2-O-triisopropylsilyl-L-fucopyranose (5) (0.25?g, 0.5?mmol) in CH2Cl2 (3.5?mL) CF3C(NPh)Cl [ 94 ] (0.37?mL, 2.2?mmol) and Cs2CO3 (290?mg, 0.9?mmol) were added at 0?C. The reaction mixture was stirred at 20?C for 20?h. Then the mixture was diluted with CHCl3 (50?mL), organic layer was separated and washed with H2O (50?mL), concentrated under reduced pressure and the residue dried in vacuo and purified by silica gel column chromatography (petroleum ether-EtOAc, 10:1???3:1) to give imidate 6 as a white foam (310?mg, 93%). [alpha]D23 -167.0 (c 1.0, CHCl3). Rf?=?0.71 (petroleum ether-EtOAc, 4:1). 1H NMR (300?MHz, CDCl3, delta, ppm, J, Hz): 0.73-1.10 (m, 21H, (CH3)2CH), 1.31 (d, 3H, J6,5 6.5, H-6), 4.50 (q, 1H, J5,6 6.5, H-5), 4.77 (dd, 1H, J2,1 3.5, J2,3 10.2, H-2), 5.70-5.85 (m, 2H, H-3, H-4), 6.58 (br.s, 1H, H-1), 6.80-6.95 (m, 2H, PhN (H-2, H-6)), 7.08-7.20 (m, 1H, PhN (H-4)), 7.24-7.40 (m, 4H, Ph), 7.46-7.57 (m, 3H, Ph), 7.59-7.70 (m, 1H, PhCO (H-4)), 7.78-7.87 (m, 2H, PhCO (H-2, H-6)), 8.04-8.15 (m, 2H, PhCO (H-2, H-6)). 13C NMR (75?MHz, CDCl3, delta, ppm, J, Hz): 12.4 ((CH3)2CH), 16.1 (C-6), 17.75, 17.78 ((CH3)2CH), 67.2 (C-2), 67.6 (C-5), 71.6, 71.7 (C-3 C-4), 95.4 (C-1), 116.2 (q, J 286.8, CF3), 119.4 (PhN (C-2, C-6)), 124.2 (PhN (C-4)), 128.1 (Ph (C-3, C-5)), 128.5 (Ph (C-3, C-5)), 128.7 (Ph (C-3, C-5)), 129.45 (PhCO (C-1)), 129.54 (PhCO (C-2, C-6)), 129.73 (PhCO (C-1)), 129.76 (PhCO (C-2, C-6)), 133.0, 133.4 (PhCO (C-4)), 143.6 (q, J 35.4, CF3C=N), 143.7 (PhN (C-1)), 165.67, 165.73 (CO). HRESIMS: found m/z 722.2729 [M+Na]+. Calcd for C37H44F3NNaO7Si: 722.2731. Found m/z 738.2468 [M+K]+. Calcd for C37H44F3KNO7Si: 738.2471.

According to the analysis of related databases, 61881-19-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Abronina, Polina I.; Zinin, Alexander I.; Romashin, Denis A.; Tereshina, Valeria V.; Chizhov, Alexander O.; Kononov, Leonid O.; Carbohydrate Research; vol. 464; (2018); p. 28 – 43;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 61881-19-4,Some common heterocyclic compound, 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, molecular formula is C8H5ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Perbenzoylated glucopyranoside (2.00 g, 2.85 mmol) was dissolved in CH2Cl2 (10 mL) followedby addition of 30% HBr/AcOH (1.33 mL). The reaction mixture was stirred for 3 h and thenpoured into ice water (100 mL). The aqueous phase was extracted with CH2Cl2 (2×50 mL). Thecombined organic phases were dried over MgSO4, filtered and concentrated. Without furtherpurification the off-white solid was dissolved in acetone (10 mL) and H2O (0.5 mL). Ag2CO3 (0.404 g, 1.46 mmol) wasadded and the reaction mixture was stirred for 2 h at 22 C. The suspension was filtered through a plug of celite andconcentrated to give the product in quantitative yield. Rf 0.36 (2:1 heptane/EtOAc).The residue was dissolved in CH2Cl2 (20 mL). The solution was cooled to 0 C followed by addition of PTFAICl (1.18 g,5.70 mmol) and Cs2CO3 (1.86 g, 5.70 mmol). The reaction was stirred at 0 C for 5 h. The reaction was filtered,concentrated and the crude was purified by flash chromatography (9:1 Tol/EtOAc) to give the product 9 as a whitepowder. Yield: 1.73 g (79% over two steps)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, its application will become more common.

Reference:
Article; Andersen, Mathias C.F.; Boos, Irene; Marcus, Susan E.; Kra?un, Stjepan K.; Rydahl, Maja Gro; Willats, William G.T.; Knox, J. Paul; Clausen, Mads H.; Carbohydrate Research; vol. 436; (2016); p. 36 – 40;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 61881-19-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 61881-19-4 name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3.1.16 Methyl 4-O-acetyl-2,3-di-O-benzyl-alpha-d-galactopyranosyluronate-(1?2)-3,4-di-O-benzyl-alpha-l-rhamnopyranosyl 1-N-phenyltrifluoroacetimidate (26) To a solution of 25 (261 mg, 0.33 mmol) in dry THF/MeOH (5.0 mL/5.0 mL), PdCl2 (28 mg, 0.16 mmol) was added. After being stirred at room temperature for 5 h, the solution was filtered through Celite and concentrated under vacuum. The resulting syrup was purified by chromatography on silica gel (petroleum ether/ethyl acetate, 2.5:1) to provide the hemiacetal as a colorless syrup (236 mg, 95%). To a solution of the hemiacetal (216 mg, 0.28 mmol) in acetone (2.5 mL), K2CO3 (116 mg, 0.84 mmol), and N-phenyl trifluoroacetimidoyl chloride (118 mg, 0.56 mmol) were added. After stirring at ambient temperature for 4 h, the mixture was filtered and concentrated in vacuo. The resulting residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate, 6:1) to afford 26 (242 mg, 92%), which was used directly without characterization.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, and friends who are interested can also refer to it.

Reference:
Article; Ma, Yuyong; Cao, Xin; Yu, Biao; Carbohydrate Research; vol. 377; (2013); p. 63 – 74;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, molecular formula is C8H5ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 61881-19-4

3.1.7 Methyl 4-O-acetyl-2,3-di-O-benzyl-alpha-d-galactopyranosiduronate 1-N-phenyltrifluoroacetimidate (7) Compound 17 (2.40 g, 5.4 mmol) was dissolved in AcOH (90 mL) and Ac2O (90 mL). The reaction mixture was cooled in an ice bath for 10 min, H2SO4 (0.9 mL) was then slowly added. The reaction was monitored by TLC (petroleum ether/ethyl acetate, 2:1) and showed completion after approximately 3 h. The reaction mixture was allowed to warm to rt during the progress of the reaction. NaOAc (9.2 g) was added and the mixture was stirred until all NaOAc had dissolved. The mixture was then evaporated to dryness, taken up in EtOAc, washed with H2O (extracted with EtOAc), dried over Na2SO4, filtered, evaporated to dryness, and finally co-evaporated three times with EtOH. The resulting syrup was purified by chromatography on silica gel (petroleum ether/ethyl acetate, 3:1) to provide a white solid (2.37 g, 93%, alpha and beta isomers were not separable). Ammonia gas was bubbled through a solution of the above product (2.16 g, 4.6 mmol) in a mixture of THF/CH3OH (v/v, 7: 3, 45 mL) cooled in an ice bath for 20 min. The solvent was then concentrated under reduced pressure to give a residue, which was purified by column chromatography on silica gel (petroleum ether/ethyl acetate, 2:1) to afford 18 (1.48 g, 75%) as a white solid. A suspension of hemiacetal 18 (472 mg, 1.1 mmol), K2CO3 (455 mg, 3.3 mmol), and N-phenyl trifluoroacetimidoyl chloride (457 mg, 2.2 mmol) in acetone (6.6 mL) was stirred at ambient temperature for 2 h. TLC showed the completion of the reaction. The mixture was filtered and concentrated in vacuo. The resulting residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate, 7:1) to afford 7 (570 mg, 87%), which was used directly without characterization.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 61881-19-4, its application will become more common.

Reference:
Article; Ma, Yuyong; Cao, Xin; Yu, Biao; Carbohydrate Research; vol. 377; (2013); p. 63 – 74;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61881-19-4, SDS of cas: 61881-19-4

Disaccharide 92 (1.0 g, 1.03 mmol) was dissolved in a mixture of CH3CN/ /H20 (30 mL/7.5 mL). Ceric ammonium nitrate (1.69 g, 3.09 mmol) was added to the solution at 0 C and then the mixture was stirred at room temperature under N2 for 2 h. The mixture was concentrated to dryness and the residue was diluted with DCM (100 mL) and the organic phase was washed with H20 and then dried over Na2S04, filtered and the solvents were removed in vacuum. Silica gel column chromatography (3:2 hexanes-EtOAc) afforded the corresponding hemiacetal 93 (730 mg, 82%>). Compound 93, N-phenyltrifluoroacetimidoyl chloride (0.68 mL, 4.2 mmol) and DCM (50 mL) was cooled down to 0 C. DBU (127 mu, 0.95 mmol) was added and the mixture was stirred at room temperature for 1 h. The mixture was concentrated. Silica gel column chromatography (2: 1 hexanes-EtOAc) afforded the disaccharide donor 3 as a white solid (650 mg, 75%>).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, and friends who are interested can also refer to it.

Reference:
Patent; UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.; BOONS, Geert-Jan; WANG, Zhen; WO2012/135049; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 61881-19-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 61881-19-4 as follows.

A solution of isomaltose (100 mg, 0.292 mmol) in dry pyridine(2.0 mL) was treated with acetic anhydride (0.8 mL) and 4-(N,Ndimethylamino)pyridine (5 mg) at 0 C and after 20 h at ambienttemperature, excessive reagent was destroyed by adding dry MeOH(2.0 mL) at 0 C. After 10 min the solvent was coevaporated withtoluene (3×) and the residual oil was purified by chromatography(n-hexane/EtOAc 1:1 ? 1:2) affording an alpha/beta-mixture (1:1) ofperacetylated isomaltose (198 mg, quantitative yield). The residue(101 mg, 0.149 mmol)was dissolved in dry DMF (2.0 mL) and treatedwith hydrazine acetate (27 mg, 0.298 mmol) at 40 C for 2 h underAr. The mixture was diluted with EtOAc, washed with cold brineand the organic layer was dried (MgSO4) and filtered. Concentrationof the filtrate provided a crude product, which was purifiedby chromatography (n-hexane/EtOAc 1:2) to obtain an alpha/beta-mixture (1:0.3) of the hemiacetal (85 mg, 90%): 1H NMR (CDCl3): delta5.53 (dd, 1H, J3alpha,2alpha 10.1, J3alpha,4alpha 9.4 Hz, H-3alpha), 5.46 (app t, 1H, J3?beta,2?beta ~ J3?beta,4?beta9.8 Hz, H-3?beta), 5.45 (app t, 1H, J3?alpha,2?alpha ~ J3?alpha,4?alpha 9.8 Hz, H-3?alpha), 5.40(app t, 1H, J1alpha,2alpha ~ J1alpha,OH 3.5 Hz, H-1alpha), 5.23 (app t, 1H, J3beta,2beta ~ J3beta,4betaHz, H-3beta), 5.14 (d, 1H, J1?beta,2?beta 3.8 Hz, H-1?beta), 5.13 (d, 1H, J1?alpha,2?alpha3.8 Hz, H-1?alpha), 5.02-4.97 (m, 3H, H-4?alpha, H-4beta, H-4alpha), 4.94 (dd, 1H,J4alpha,5alpha 10.3 Hz, H-4alpha), 4.85-4.78 (m, 4H, H-2alpha, H-2?alpha, H-2beta, H-2?beta),4.73 (app t, 1H, J 8.0 Hz, H-1beta), 4.24 (ddd, 1H, J5alpha,6aalpha 6.5, J5alpha,6balpha2.5 Hz, H-5alpha), 4.21-4.05 (m, 7H, H-5?alpha, H-5?beta, H-6?aalpha, H-6?abeta,H-6?balpha, H-6?bbeta, OHbeta), 4.02-3.99 (m, 1H, OHalpha), 3.74-3.57 (m,5H, H-5beta, H-6aalpha, H-6abeta, H-6balpha, H-6bbeta), 2.10 to 2.00 (10 s, 14×COCH3); ESI-TOF HRMS: m/z = 659.1794; calcd for C26H36O18Na+:659.1798.The residue (70 mg, 0.110 mmol) was dissolved in dry CH2Cl2(1.8 mL) and dry acetone (1.0 mL). Potassium carbonate (30 mg,0.220 mmol) and 2,2,2-trifluoro-N-phenylacetimidoyl chloride (35 muL,0.220 mmol) were added successively under Ar. The suspension wasstirred for 12 h at rt, then filtered through a pad of Celite, rinsedwith CH2Cl2 and the filtrate was concentrated. Swift chromatographicpurification (n-hexane/EtOAc 1:1) provided 17 (80mg, 90%)which was directly used for the subsequent glycosylation reaction.1H NMR spectra of 17 (CDCl3) displayed broad signalscorresponding to a 2.5:1 mixture; 13C NMR (125 MHz, CDCl3, selecteddata): delta 169.8-168.9 (C = O, Ac), 142.8, 128.9, 128.8 124.7 and119.4 (arom. C), 96.0 (C-1, C-1?), 66.4 and 66.2 (C-6), 61.7 (C-6?), 20.6-20.4 (CH3CO).

According to the analysis of related databases, 61881-19-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Pokorny, Barbara; Kosma, Paul; Carbohydrate Research; vol. 422; (2016); p. 5 – 12;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics