Category: 61881-19-4

Reference of 61881-19-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 61881-19-4 as follows.

To a solution of 10 (1 .5 g, 1 .4 mmol) in DCM (10 ml) and 2,2,2-trifluoro-/V-phenylacetimidoyl chloride (3 equiv), Cs2C03 (1 equiv) was added at 0C, and the reaction stirred at rt for 3 h. The solid was filtered off and the solvent evaporated. The crude was purified by flash chromatography (8:2 tol:acetone) to afford 11 as a brown foam in 82% yield (1 .15 g). HR ESI- MS m/z C55H55F3N202i [M+Na]+ 1 159.3147; found 1 159.3065. (Ando et al. Carbohydrate Research 338 (2003) 503-514)

According to the analysis of related databases, 61881-19-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GSK VACCINES S.R.L.; ADAMO, Roberto; BERTI, Francesco; CARBONI, Filippo; MARGARIT Y ROS, Immaculada; (66 pag.)WO2017/175082; (2017); A1;,
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Some common heterocyclic compound, 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, molecular formula is C8H5ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 61881-19-4

General procedure: A mixture of acetimidoyl chloride (1 mmol), sodium azide (1 mmol), and acetonitrile (3 mL) was irradiated in a microwave oven at 300 W for 8-10 min, after completion of the reaction, as indicated by TLC, the reaction mixture was filtered. After removing the solvent under reduced pressure, if necessary, the crude products were purified by washing with n-hexane to give the target product 3a-3j (90-95%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 61881-19-4, its application will become more common.

Reference:
Article; Rahmani, Fariba; Darehkordi, Ali; Notash, Behrouz; Journal of Fluorine Chemistry; vol. 166; (2014); p. 84 – 87;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 61881-19-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

3,4,6-Tri-O-benzyl-2-deoxy-2-trichloroacetamido-alpha/beta-D-galactopyranosyl N-phenyltrifluoroacetimidate (181). The hemiacetal (1.85 g, 3.11 mmol), obtained from the thioglycoside 24, was dissolved in acetone (31 mL). N-(phenyl)trifluoroacetimidoyl chloride (1.29 g, 6.22 mmol) and Cs2CO3 (1.12 g, 3.42 mmol, 1.1 equiv.) were added to the solution. The mixture was stirred for 4 h at rt. The reaction mixture was filtered and concentrated. The residue was purified by flash chromatography (Chex/EtOAc 85:15 to 7:3 + 1% Et3N) to give N-phenyltrifluoroacetimidate 181 (2.10 g, 88%) as a light yellow oil. 1H NMR (CDCl3), delta 7.61-7.09 (m, 18H, HAr), 6.77 (d, 2H, J = 7.6 Hz, HAr), 6.48 (do, 1H, JNH,2 = 7.7 Hz, NH), 6.47 (bso, 1H, H-1), 4.97 (d, 1H, J = 11.4 Hz, HBn), 4.76 (dpo, 1H, J = 11.9 Hz, HBn), 4.73 (m, 1H, H-2), 4.64 (d, 1H, HBn), 4.57-4.48 (m, 3H, HBn), 4.20 (bs, 1H, H-4), 4.07 (pt, 1H, H-5), 3.88 (dd, 1H, J2,3 = 11.0 Hz, J3,4 = 1.4 Hz, H-3), 3.72 (pt, 1H, J5,6a = 7.8 Hz, H-6a), 3.62 (dd, 1H, J5,6b = 5.7 Hz, J6a,6b = 9.1 Hz, H-6b). 13C NMR (CDCl3), delta 161.8 (NHCO), 143.1, 138.0, 137.7, 137.0 (4C, CIVAr), 129.4-119.3 (20C, CAr), 94.3 (C-1, 1JCH = 162.9 Hz), 92.3 (CCl3), 75.5 (C-3), 74.8, 73.7 (2C, CBn), 72.5 (C-5), 71.6 (C-4), 71.3 (CBn), 68.1 (C-6), 50.6 (C-2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; INSTITUT PASTEUR; Centre National de la Recherche Scientifique; Institut National De La Sante Et De La Recherche Medicale; UNIVERSITE PARIS DESCARTES; Mulard, Laurence; Chassagne, Pierre; Sansonetti, Philippe; EP2724730; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61881-19-4, Recommanded Product: 2,2,2-Trifluoro-N-phenylacetimidoyl chloride

In a flask with a dry inert atmosphere are introduced 260 ml of anhydrous THF, it is cooled to -78C and 225 ml are added of LDA 2M solution in THF/n-heptane at a rate allowing to maintain the temperature under -65C. After this diethylmethylphosphonate (34.25 g, 0.225 mol) is quickly added dropwise dissolved in 30 ml of THF and it is shaken for 30 minutes at -78C. N-phenyltrifluoroacetymidoyl chloride is then added dropwise (46.7 g, 0.225 mol) dissolved in 40 ml of THF and it is left with shaking in the same conditions for 1 hour. A solution is added of 2,4-difluorobenzaldehyde (33.6 g, 0.236 mol) in 40 ml of THF, the cold bath is removed and the temperature is allowed to rise to ambient temperature. It is left shaking overnight in these conditions. The following morning 450 ml of HCl 2N are added and the shaking continued for 24 hours. The THF is removed in the rotovapor and the resulting aqueous solution is extracted with AcOEt ( 2×200 ml), washed with a solution of 5% NaHCO3 and with a saturated NaCl solution, it is dried with sodium sulphate, filtered and the solvent evaporated with the rotovapor. In this way are obtained 54.6 g of a reddish liquid crude that solidifies. The crude is distilled at a pressure of 35 mbar and a fraction is collected of (E)-1,1,1-trifluoro-4-(2,4-difluorophenyl)-3-buten-2-one at 107-14C (43 g, 81%). Melting point : 50-1C IR (KBr, cm-1) : 1717, 1602, 1583, 1277, 1146, 1059, 7061H-RMN (CDCl3) : 6,9 (m, 2H), 7.05 (d, J=16 Hz, 1H), 7,6 (m, 1H), 8.0 (d, J=16Hz, 1H)13C-RMN (CDCl3): 105.1 (t,J=26Hz), 112,6(dd, J=4, 22Hz) , 116.4 (q, J=291Hz), 118.2, 118.5, 131.5 (dd, J=4, 11Hz), 141.5, 162.5 (dd, J=13, 193Hz), 165,7 (dd, J=13, 190Hz), 180 (q, J=36Hz)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; EP1384477; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61881-19-4, Product Details of 61881-19-4

To a solution of 28 (0.91 g, 1.7 mmol) in acetone (17 mL) wereadded CF3C(=NPh)Cl (0.53 mL, 3.3 mmol) and K2CO3 (1.1 g,8.3 mmol) at 0 C. After stirring for 2.5 h at the same temperature, thecompletion of the reaction was confirmed by TLC (5:1 n-hexane/EtOAc). The reaction mixture was filtered through Celite pad and thepad was washed with CHCl3. The filtrate and washings were concentrated.The resulting residue was purified by silica gel columnchromatography (25:1 n-hexane/EtOAc) to give 29 (1.2 g, quant.) ascolorless syrup. 1H NMR (500 MHz, CDCl3) delta 7.44-6.70 (m, 17H, Ar),5.08-4.83 (br m, 4H, H-1, H-2, H-3, H-4), 4.15-3.65 (br m, 3H, H-5, H-6a, H-6b), 1.08 (s, 9H, tBu), 1.01 (s, 9H, tBu); 13C NMR (125 MHz,CDCl3) delta 143.5, 143.3, 138.9, 138.6, 135.4, 135.3, 135.3, 135.2, 133.1,133.1, 128.7, 128.4, 128.4, 128.3, 128.2, 128.2, 128.1, 128.1, 128.0,127.9, 127.7, 127.7, 127.7, 126.9, 126.5, 126.2, 126.1, 126.1, 126.0,126.0, 125.6, 124.4, 119.4, 119.2, 84.0, 81.2, 80.0, 77.9, 77.7, 77.5,75.8, 75.5, 75.5, 73.9, 71.0, 68.8, 66.5, 66.2, 27.4, 27.0, 26.9, 22.7,20.0. HRMS (ESI) m/z: found [M+Na]+ 744.2935, C40H46F3NO6Sicalcd for [M+Na]+ 744.2939.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Takato, Koichi; Kurita, Motoki; Yagami, Nahoko; Tanaka, Hide-Nori; Ando, Hiromune; Imamura, Akihiro; Ishida, Hideharu; Carbohydrate Research; vol. 483; (2019);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 61881-19-4,Some common heterocyclic compound, 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, molecular formula is C8H5ClF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To the stirred suspension of p-methoxybenzyl alcohol (2.00 g, 14.5 mmol)and N-phenyl-2,2,2-trifluoroacetimidate chloride (3.40 g, 16.3 mmol) inDCM (70 mL), NaH (60% in mineral oil, 0.635 g, 15.8 mmol) was added portionwise at 0C.The mixture was stirred for 2h at rt. After an addition of ice, the organic phase was washedwith water (3 x 40 mL), dried (MgSO4), filtered, and evaporated. The resulting residue wascrystallized from Et2O/PE, to give 1 as white needles (4.00 g, 89%). mp 90-91C, 1H NMR(360 MHz in CDCl3, ppm): delta 7.37 (2H, br d, J = 8.5 Hz, Ph), 7.29 (2H, br t, J = 2.0 Hz, J =6.5 Hz, J = 7.5 Hz, Ph), 7.08 (1H, br t, J = 1.0 Hz, J = 7.0 Hz, J = 7.5 Hz, Ph), 6.92 (2H, br d,J = 8.5 Hz, Ph-OCH3, PMB), 6.82 (2H, br d, J = 8.5 Hz, Ph-OCH3, PMB), 5.25 (2H, s, CH2,PMB), 3.83 (3H, s, OCH3, PMB), 13C NMR (90 MHz in CDCl3, ppm): delta 160.08 (Cquat-OCH3,PMB), 145.28 (q, JC-C-F = 35,0 Hz), 144.58 (Cquat arom), 130.42, 128.89, 127.23, 124.04,119.73 (CH arom), 116.38 (q, JC-F = 285,5 Hz), 114.13 (Cm PMB), 69.69 (CH2,PMB), 53.32 (OCH3, PMB), HRMS (ESI) m/z [M+Na] 332.0869; found 332.0859, AnalCalcd C16H14F3NO2 : Calcd. C 62.13, H 4.56, N 4.53; found C 62.30, H 4.59, N 4.44.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, its application will become more common.

Reference:
Article; Barroca-Aubry, Nadine; Benchekroun, Mohamed; Gomes, Filipe; Bonnaffe, David; Tetrahedron Letters; vol. 54; 37; (2013); p. 5118 – 5121;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 61881-19-4, The chemical industry reduces the impact on the environment during synthesis 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, I believe this compound will play a more active role in future production and life.

General procedure: To an ice cooled suspension of NaH (3.3mmol) in dry THF (20mL) under nitrogen atmosphere was slowly added a solution of the ketone 8a-e(1mmol) in THF (5mL). The resulting suspension was stirred for 30min at 0C and then a solution of the corresponding trifluoroacetimidoyl chloride 9a-e (1mmol) in dry THF (3mL) was slowly added dropwise at 0C and then further stirred at room temperature for 3h. The resulting orange-brown solution was evaporated under reduced pressure, water was added carefully (20mL) and extracted with CHCl3 (2×20mL). The organic extract was separated, dried over anhydrous magnesium sulfate and evaporated obtaining a brown oil, which was further purified either by recrystallization or column chromatography (silicagel, Hex 7: EtOAc 3).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Romero, Angel H.; Salazar, Jose; Lopez, Simon E.; Journal of Fluorine Chemistry; vol. 169; (2015); p. 32 – 37;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 61881-19-4, A common heterocyclic compound, 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, molecular formula is C8H5ClF3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound II – 1 (200 mg, 0 . 187 mmol), N – benzene three fluorine second grades acyl chloride (116 mg, 0 . 56 mmol, 3 eq) dissolved in 5 ml acetone, batches adding potassium carbonate (77 mg, 0 . 56 mmol, 3 eq), stirring at room temperature 1 hour (TLC detection consumption end), filtering, the filtrate turns on lathe does, column to obtain white solid (229 mg, yield 99%)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Lin Feng; Lu Rui; Xu Qiulong; Chen Jianli; Han Jine; (33 pag.)CN104231009; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, A new synthetic method of this compound is introduced below., Quality Control of 2,2,2-Trifluoro-N-phenylacetimidoyl chloride

1.46 g (1.45 mmol) VIII and 0.93 g (4.5 mmol)2,2,2-Trifluoro-N-phenyliminoacetyl chloride is dissolved in 30 mL of acetone,0.62 g (4.5 mmol) of potassium carbonate was added in portions and allowed to react at room temperature overnight.TLC (PE: EA = 2:1) was monitored and the reaction was completed.The reaction was quenched with 0.2 mL of methanol, filtered, and the filtrate was dried.Column chromatography (PE: EA = 4:1) gave 1.7 g of VI white solid, yield 99%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Zhang Hongliang; Wang Zhefeng; Yi Bing; Wang Shengli; Liang Qian; Li Changsheng; (18 pag.)CN108299523; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 61881-19-4

To 10 (3.0 g, 1.5 mmol) and N-phenyl trifluoroacetimidoyl chloride (0.95 g, 4.59 mmol, 3.0 eq) in acetone (57.5 ml) was added K2CO3 (0.6 g, 4.59 mmol, 3.0 eq), and the mixture was stirred at room temperature for 1 h. The mixture was filtered, concentrated, and purified by silica gel column chromatography (hexane : ethyl acetate = 2:1) to obtain the 11 (3.2 g, 97%) as a white solid. m.p. 149 – 151 oC. [a]25D = – 218.6 (c = 1.00 in CHCl3). 1H NMR (400 MHz, CDCl3) delta 8.57 – 6.52 (m, 65H), 6.25 (d, J = 10.5 Hz, 1H), 6.12 – 6.03 (m, 2H), 5.97 (d, J = 2.9 Hz, 1H), 5.89 – 5.68 (m, 4H), 5.59 (dd, J = 10.5, 3.2 Hz, 1H), 5.17 (d, J = 9.1 Hz, 1H), 4.61 (dd, J = 12.4, 6.2 Hz, 2H), 4.48 (d, J = 12.9 Hz, 1H), 4.35 (d, J = 12.3 Hz, 1H), 4.31 – 4.01 (m, 8H), 3.93 (d, J = 9.6 Hz, 1H), 3.88 – 3.65 (m, 5H), 1.64 (s, 3H).13C NMR (100 MHz, CDCl3) delta 171.1-164.7 (C, C=O), 143.1 (C, N-C), 141.0 133.9-128.0 (C, Ar), 124.9 (C, C-F), 119.2, 116.2q, CF3, 106.3, 100.7, 100.6, 98.8, 70.5, 70.2, 69.9, 69.8, 69.5, 69.1, 68.5, 67.4, 67.2, 66.9, 63.8, 63.3, 62.6, 61.5, 60.4, 60.1, 59.2, 58.8, 20.0.ESI-MS (m/z): [M+Na]+ : calcd for C118H96F3NO34Na+ 2150.5658, found 2150.5673.

According to the analysis of related databases, 61881-19-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhang, Hongliang; Wang, Hengtao; Xu, Qiulong; Lu, Rui; Cao, Yunhua; Wang, Zhefeng; Tang, Pingping; Lin, Feng; Li, Yingxia; Carbohydrate Research; vol. 448; (2017); p. 6 – 9;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics