Category: 620-20-2

Safety of 3-ChlorobenzylchlorideOn June 7, 2021, An, Shaoyu; Zhang, Zhong; Li, Pingfan published an article in European Journal of Organic Chemistry. The article was 《Metal-Free Synthesis of Selenodihydronaphthalenes by Selenoxide-Mediated Electrophilic Cyclization of Alkynes》. The article mentions the following:

A transition-metal-free, selenium mediated electrophilic cyclization reaction was realized through a one-pot procedure between simple alkynes and triflic anhydride-activated selenoxides to give selenium containing dihydronaphthalene products. This method gave good to very high yields for all products, including selenium-substituted phenanthrene, dihydroquinoline, 2H-chromene, and coumarin, which can be further transformed to other functionalized compounds The results came from multiple reactions, including the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Safety of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Safety of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nafie, Mohamed S.; Elghazawy, Nehal H.; Owf, Salma M.; Arafa, Kholoud; Abdel-Rahman, Mohamed A.; Arafa, Reem K. published an article on January 5 ,2022. The article was titled 《Control of ER-positive breast cancer by ERα expression inhibition, apoptosis induction, cell cycle arrest using semisynthetic isoeugenol derivatives》, and you may find the article in Chemico-Biological Interactions.Category: chlorides-buliding-blocks The information in the text is summarized as follows:

New semi-synthetic effective and safe anticancer agents isoeugenol derivatives were synthesized, characterized, and screened for their cytotoxic activity against MCF-7. Moreover, their selective cytotoxicity was assessed against MCF-10A. Three derivatives, 2, 8 and 10 were significantly more active than the reference drug 5-FU with IC50 values of 6.59, 8.07 and 9.63 and 30.93 μM, resp. Also interestingly, these derivatives demonstrated some degree of selectivity to cancer cells over normal cells. Furthermore, derivative 2 was subjected to other in vitro experiments against MCF-7 where it inhibited colony formation by 87.5% and lowered ERα concentration to 395.7 pg/mL compared to 1129 pg/mL in untreated control cells. In continuation of the investigation, the apoptotic activity of compound 2, was assessed where it significantly enhanced total apoptotic cell death by 9.16-fold (18.70% compared to 1.64% for the untreated MCF-7 control cells) and arrested the cell cycle at the G2/M phase. Furthermore, the mol. mechanism of apoptotic activity was investigated at both the gene (RT-PCR) and protein (western plotting) levels where upregulation of pro-apoptotic and down regulation of anti-apoptotic genes was detected. Addnl., compound 2 treatment enhanced the antioxidant (GSH, CAT, SOD) activities. Finally, in vivo experiments verified the effective anticancer activity of compound 2 through inhibition of tumor proliferation by 47.6% compared to 22.9% for 5-FU and amelioration of the hematol., biochem., and histopathol. examinations near normal. In effect, compound 2 can be viewed as a promising semi-synthetic derivative of isoeugenol with some degree of selectivity for management of breast cancer through apoptotic induction and ERα downregulation. The results came from multiple reactions, including the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Category: chlorides-buliding-blocks)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Safety of 3-ChlorobenzylchlorideOn March 11, 2021, Langston, Steven P.; Grossman, Stephen; England, Dylan; Afroze, Roushan; Bence, Neil; Bowman, Douglas; Bump, Nancy; Chau, Ryan; Chuang, Bei-Ching; Claiborne, Christopher; Cohen, Larry; Connolly, Kelly; Duffey, Matthew; Durvasula, Nitya; Freeze, Scott; Gallery, Melissa; Galvin, Katherine; Gaulin, Jeffrey; Gershman, Rachel; Greenspan, Paul; Grieves, Jessica; Guo, Jianping; Gulavita, Nanda; Hailu, Shumet; He, Xingyue; Hoar, Kara; Hu, Yongbo; Hu, Zhigen; Ito, Mitsuhiro; Kim, Mi-Sook; Lane, Scott Weston; Lok, David; Lublinsky, Anya; Mallender, William; McIntyre, Charles; Minissale, James; Mizutani, Hirotake; Mizutani, Miho; Molchinova, Nina; Ono, Koji; Patil, Ashok; Qian, Mark; Riceberg, Jessica; Shindi, Vaishali; Sintchak, Michael D.; Song, Keli; Soucy, Teresa; Wang, Yana; Xu, He; Yang, Xiaofeng; Zawadzka, Agatha; Zhang, Ji; Pulukuri, Sai M. published an article in Journal of Medicinal Chemistry. The article was 《Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer》. The article mentions the following:

SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of SUMOylating proteins involves an enzymic cascade, the first step of which entails the activation of a SUMO protein through an ATP-dependent process catalyzed by SUMO-activating enzyme (SAE). Here, we describe the identification of TAK-981, a mechanism-based inhibitor of SAE which forms a SUMO-TAK-981 adduct as the inhibitory species within the enzyme catalytic site. Optimization of selectivity against related enzymes as well as enhancement of mean residence time of the adduct were critical to the identification of compounds with potent cellular pathway inhibition and ultimately a prolonged pharmacodynamic effect and efficacy in preclin. tumor models, culminating in the identification of the clin. mol. TAK-981. In the part of experimental materials, we found many familiar compounds, such as 3-Chlorobenzylchloride(cas: 620-20-2Safety of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Safety of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocksOn May 6, 2022 ,《Nickel/Photo-Cocatalyzed Acyl C-H Benzylation of Aldehydes with Benzyl Chlorides》 appeared in European Journal of Organic Chemistry. The author of the article were Li, Xiantang; Mao, Yujia; Fan, Pei; Wang, Chuan. The article conveys some information:

Authors have developed a nickel/TBADT cocatalyzed acyl C-H benzylation of both aliphatic and aromatic aldehydes with primary and secondary benzyl chlorides under mild reaction conditions. The protocol provides a convenient and efficient method to synthesize a variety of ketones. In the experimental materials used by the author, we found 3-Chlorobenzylchloride(cas: 620-20-2Category: chlorides-buliding-blocks)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 620-20-2On September 30, 2021 ,《Copper immobilized on biomimetic assembled calcium carbonate/carboxymethylcellulose hybrid: a highly active recoverable catalyst for CuAAC reactions》 was published in Research on Chemical Intermediates. The article was written by Zhang, Mingjuan; Xu, Jinxi; Zhang, Tianzhu; Li, Yiqun. The article contains the following contents:

A novel copper immobilized on biomimetic assembled CM-cellulose/calcium carbonate hybrid (CuII@CMC/CaCO3) as an efficient heterogeneous catalyst for the synthesis of 1,2,3-triazoles has been described herein. The fabrication of CuII@CMC/CaCO3 is accomplished through a bioinspired mineralization process using sodium CM-cellulose (CMC-Na) as the template and ion exchange agent, while the metathesis, nucleation, assemble, hybridization, and immobilization of Cu(II) occurred by successful treatment with CaCl2, Na2CO3, and CuSO4 in water at room temperature The resultant CuII@CMC/CaCO3 hybrid was well characterized by various analyses such as FT-IR, XRD, SEM, EDX, EDX-mapping, TEM, and TGA techniques. In the presence of low copper loading of CuII@CMC/CaCO3 hybrid, benzylic halides, azide, and alkynes proceeded smoothly to afford 1,4-disubstituted 1,2,3-triazoles in high yields. The catalyst can be conveniently recovered from the reaction mixture by filter and reused for at least 5 consecutive runs with a slight drop in its catalytic activity. The remarkable activity and stability of the catalyst may be attributed to the coordination of both carboxyl and hydroxyl groups of the hybrid of CMC/CaCO3. In addition to this study using 3-Chlorobenzylchloride, there are many other studies that have used 3-Chlorobenzylchloride(cas: 620-20-2SDS of cas: 620-20-2) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.SDS of cas: 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《A new insight into the push-pull effect of substituents via the stilbene-like model compounds》 was written by Cao, Chaotun; Zeng, Zhao; Cao, Chenzhong. Computed Properties of C7H6Cl2 And the article was included in Journal of Physical Organic Chemistry on April 30 ,2022. The article conveys some information:

In this paper, authors report on 1-pyridyl-2-arylethenes, 1-furyl-2-arylethylenes, 1,2-diphenylpropylenes and substituted cinnamyl anilines as stilbene-like model compounds to investigate the factors dominating the push-pull effect of substituents via using the NMR chem. shift of bridging bond carbon atoms. It is demonstrated that the maximum push-pull effect is not always between the strong electron-donating D and strong electron-accepting A groups in D-π-A compounds The action mode of push-pull effect of substituents in D-π-A compounds is dominated by their mol. parent structure. The contribution of field/inductive effect and conjugative effect of a group to the push-pull effect is unequal. When the D-π-A parent mol. is in a plane, the influence of field/inductive effect of a group on the push-pull effect is greater than or close to that of its conjugative effect does. Although the parent mol. is sterically twisted, the push-pull effect is mainly dependent on the conjugative effect of a group. The results of this paper can provide us a new insight into the push-pull effect of substituents. The results came from multiple reactions, including the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Computed Properties of C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Computed Properties of C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocksOn September 30, 2021 ,《Determination and application of the excited-state substituent constants of pyridyl and substituted phenyl groups》 was published in Journal of Physical Organic Chemistry. The article was written by Cao, Chao-Tun; Yan, Lu; Cao, Chenzhong. The article contains the following contents:

Thirty six 1-pyridyl-2-arylethenes XCH=CHArY (abbreviated XAEY) were synthesized, in which, X is 2-pyridyl, 3-pyridyl and 4-pyridyl, and Y is OMe, Me, H, Br, Cl, F, CF3, and CN. Their UV absorption spectra were measured in anhydrous ethanol, and their wavelengths of absorption maximum, λmax, were recorded. Also, 234 λmax values of 1-substituted phenyl-2-arylethylene compounds (XAEY, where X is substituted phenyl) were collected. The excited-state substituent constants of three pyridyl groups and 23 substituted Ph groups (a total of 26) were obtained by means of the curve-fitting method. Taking the λmax values of 358 samples of bi-arylethene derivatives as a data set and 126 samples of bi-aryl Schiff bases (including nine compounds synthesized by this work (data not shown)) as another data set, quant. correlation analyses were performed by employing the obtained excited-state substituent constants as a parameter, and good results were obtained for the two data sets. The reliability of the obtained excited-state substituent constant values was verified. The results of this paper provided excited-state substituent constants for the studied compounds and application of optical properties of conjugated organic compounds containing aryl groups. In addition to this study using 3-Chlorobenzylchloride, there are many other studies that have used 3-Chlorobenzylchloride(cas: 620-20-2Category: chlorides-buliding-blocks) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Influence of substituent and push-pull effect on the chemical shifts of the carbon in bridging bond of 1-furyl/thienyl-2-arylethylene》 was written by Cao, Chao-tun; Yan, Lu; Cao, Chenzhong; Qu, Junyan. SDS of cas: 620-20-2 And the article was included in Journal of Physical Organic Chemistry on April 30 ,2021. The article conveys some information:

Sixty-six samples of 1-furyl/thienyl-2-arylethylene model compounds XCH=CHArY (abbreviated XEBY) were synthesized. The NMR spectra (NMR) of model compounds were determined The chem. shift δC(X) and δC(Y) of the carbon atoms in bridging bond CH=CH which connected to the X group and the ArY group, resp., were confirmed with the two-dimensional NMR method. The effect of substituent on the δC(X) and δC(Y) was studied, meanwhile, the push-pull effect of substituent on ΔδC = δC(Y) – δC(X) and δC(Y/X) = δC(Y)/δC(X) were discussed. The results show the following: (a) Both the δC(X) and δC(Y) are affected by excited-state substituent constant σCCexX of group X, Hammett constant σ(Y), and excited-state substituent constantσCCexY of group Y. The effect of σ(Y) on the δC(X) is pos., whereas that on the δC(Y) is neg. That is to say, the σ(Y) of group Y has an alternative influence on the δC(X) and δC(Y). (b) Compared with furyl, there is a p-d effect formed by the 3d orbit of S atom and the p electron of the π system in thienyl, which increase the chem. shift of the carbon atoms in bridging bond. (c) The push-pull effect between substituent X and Y is not only affected by the σ parameter but also related to the σCCex parameter, which results from the combined effect of the two parameters σ and σCCex. The observation of this paper provides a new perspective in understanding the push-pull effect of substituent. In the experiment, the researchers used 3-Chlorobenzylchloride(cas: 620-20-2SDS of cas: 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.SDS of cas: 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocksOn November 1, 2021 ,《Design, synthesis and antitumor activity evaluation of trifluoromethyl-substituted pyrimidine derivatives》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Liu, Limin; Wang, Zhengjie; Gao, Chao; Dai, Honglin; Si, Xiaojie; Zhang, Yang; Meng, Yaqi; Zheng, Jiaxin; Ke, Yu; Liu, Hongmin; Zhang, Qiurong. The article conveys some information:

In order to find efficient new antitumor drugs, a series of novel trifluoromethyl-substituted pyrimidine derivatives were designed and synthesized and the bioactivity against four human tumor cells (PC-3, MGC-803, MCF-7 and H1975) was evaluated by MTT assay. Compound I displayed potent anti-proliferative activity on H1975 (IC50 = 2.27 μM), which was better than the pos. control 5-FU (IC50 = 9.37 μM). Further biol. evaluation studies showed that compound I apoptosis of H1975 cells and arrested the cell cycle at G2/M phase. Furthermore, compound I induced H1975 cells apoptosis through increasing the expression of pro-apoptotic proteins Bax and p53 and down-regulating the anti-apoptotic protein Bcl-2. In addition, compound I was able to be tightly embedded in the active pocket of EGFR. These results demonstrated that compound I has a potential as a lead compound for further investigation.3-Chlorobenzylchloride(cas: 620-20-2Category: chlorides-buliding-blocks) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: 620-20-2On May 6, 2020 ,《Reagent Control Enables Selective and Regiodivergent Opening of Unsymmetrical Phenonium Ions》 appeared in Journal of the American Chemical Society. The author of the article were Xu, Shiyan; Holst, Hannah M.; McGuire, Shelby B.; Race, Nicholas J.. The article conveys some information:

The first examples of selective and regiodivergent chlorination of unsym. benzyl-substituted epoxides, I [R = 4-methoxyphenyl, Ph, 2H-1,3-benzodioxol-5-yl, 1-[(4-methylbenzene)sulfonyl]-2,3-dihydro-1H-indol-5-yl, etc.; R1 = Pr, 4-methoxyphenyl, 4-cyanobutyl, 4-(benzyloxy)butyl, etc.] have been reported. These reactions are enabled by the dual role of SnCl4 and TiCl4 as Lewis acids and chloride nucleophiles. Reagent control dictates addition of chloride at either the substituted internal position (SnCl4) or unsubstituted terminal position (TiCl4) of the phenonium ion. These reactions are highly selective, stereospecific, and operationally simple, and proceed in good to excellent yields. Diverse product utility is demonstrated. In the experiment, the researchers used many compounds, for example, 3-Chlorobenzylchloride(cas: 620-20-2HPLC of Formula: 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.HPLC of Formula: 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics