Category: 620-20-2

《Synthesis and fungicidal activity of phenazine-1-carboxylic triazole derivatives》 was published in Journal of Asian Natural Products Research in 2021. These research results belong to Li, Xu-Jun; Zhang, Wei; Zhao, Chi-Na; Wu, Qing-Lai; Li, Jun-Kai; Xu, Zhi-Hong. Category: chlorides-buliding-blocks The article mentions the following:

A total of 15 novel-substituted 3-(benzylsulfanyl)-1H-1,2,4-triazol-5-ylamines I [R = 3-MeC6H4, 2-FC6H4, 2,4-Cl2C6H3, etc.] and 10 novel-substituted 3-benzylmercapto-1,2,4-triazole derivatives II were synthesized based on the natural product phenazine-1-carboxylic acid (PCA). Their structures were confirmed by 1H-NMR, 13C-NMR, HRMS and X-ray. Most substituted 3-benzylmercapto-1,2,4-triazole derivatives II displayed very strong fungicidal activity against one or multiple plant pathogens in vitro and in vivo. Compounds II [R = 4-MeC6H4, 4-iPrC6H4, 4-tBuC6H4, etc.] showed a broad spectrum of fungicidal activity. Further field experiments indicated that compounds II [R = 4-MeC6H4, 2-FC6H4, 4-iPrC6H4, etc.] displayed better efficacy against rice blast (Pyricularia oryzae) than PCA. These data demonstrated that compounds II [R = 4-MeC6H4, 2-FC6H4, 4-iPrC6H4, etc.] were promising fungicidal candidates, deserving further studies. The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Category: chlorides-buliding-blocks)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Guangqian; Zheng, Huanlin; Shao, Wubin; Liu, Liwei; Wu, Zhibing published an article on January 31 ,2021. The article was titled 《Study of the in vivo antiviral activity against TMV treated with novel 1-(t-butyl)-5-amino-4-pyrazole derivatives containing a 1,3,4-oxadiazole sulfide moiety》, and you may find the article in Pesticide Biochemistry and Physiology.COA of Formula: C7H6Cl2 The information in the text is summarized as follows:

A series of new 1-tert-butyl-5-amino-4-pyrazole bioxadiazole sulfide derivatives containing a 1,3,4-oxadiazole moiety were designed and synthesized. The bioactivity results showed that some title compounds exhibited excellent protective activity against TMV and certain insecticidal activity. Among the tested compounds, the EC50 values of 5d, 5j, 5k and 5l were 165.8, 163.2, 159.7 and 193.1 mg/L, resp., which are better than the EC50 value of ningnanmycin (271.3 mg/L). The chlorophyll contents and the defense enzyme activities of the tobacco leaves after treatment with 5j were significantly increased, which indicated that this series of title compounds may induce the systemic acquired resistance of host to defend against diseases. Further in vivo protective activity research on 5j using TMV with a GFP gene tag found that it can effectively inhibit the spread of TMV in inoculated tobacco. A morphol. study with TEM revealed that title compound 5h can cause a distinct break of the rod-shaped TMV. Moreover, the insecticidal activity revealed that the fatality rates of 5a, 5b and 5m against aphidoidea were 85%, 83% and 87%, resp., which indicated that the title compounds can effectively block the common carrier of plant viruses, thereby effectively reducing the TMV infection risk of tobacco. This series of synergistic effects provide key information for the research and development of antiviral agents. After reading the article, we found that the author used 3-Chlorobenzylchloride(cas: 620-20-2COA of Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.COA of Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhao, Yunlong; Liu, Chen-Fei; Lin, Leroy Qi Hao; Chan, Albert S. C.; Koh, Ming Joo published an article in Angewandte Chemie, International Edition. The title of the article was 《Stereoselective Synthesis of Trisubstituted Alkenes by Nickel-Catalyzed Benzylation and Alkene Isomerization》.COA of Formula: C7H6Cl2 The author mentioned the following in the article:

Herein, diastereo- and regioselective synthesis of trisubstituted alkenes via nickel-catalyzed benzylation and isomerization of terminal olefins with benzyl chlorides in presence of trimethylsilyl triflate and trimethylamine additives was described. Control experiments provided evidence for a mechanism involving branched-selective Heck-type benzylation that overrides substrate control, followed by trans-selective 1,3-hydrogen shift. The method represented a significant addition to the toolbox of reactions for the concise synthesis of unsaturated biol. active compounds In the experimental materials used by the author, we found 3-Chlorobenzylchloride(cas: 620-20-2COA of Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.COA of Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhao, Xuelian; Zhan, Xuehui; Zhang, Huilin; Wan, Yichao; Yang, Huizhong; Wang, Yutian; Chen, Yanda; Xie, Wenlin published their research in Bioorganic & Medicinal Chemistry Letters on December 15 ,2021. The article was titled 《Synthesis and biological evaluation of isatin derivatives containing 1,3,4-thiadiazole as potent a-glucosidase inhibitors》.Reference of 3-Chlorobenzylchloride The article contains the following contents:

A series of isatin derivatives containing 1,3,4-thiadiazole derivatives I [R = 2-F, 3-CN, 4-Cl, etc.] were designed and synthesized. All newly synthesized compounds I were evaluated for their α-glucosidase inhibitory activity with resveratrol as pos. control in-vitro. Except for compounds I [R = 2-CN, 3-CN], all of the compounds I showed a potent inhibitory activity against α-glucosidase with IC50 values in the range of 3.12 ± 1.25 to 45.95 ± 1.26μM and the purity of these compounds were greater than 95%. The IC50 values were being compared to the standard resveratrol (IC50 = 22.00 ± 1.15μM) and it was found that compounds I [R = H, 2-F, 2-Cl, 3-Cl, 4-Cl, 2-Br] were found to be more active than resveratrol. Specifically,I [R = 4-Cl] exhibited the most potent α-glucosidase inhibitory activity with IC50 value of 3.12 ± 1.25μM. The kinetic anal. revealed that compound I [R = 4-Cl] was noncompetitive inhibitor. Structure activity relationship was established for all compounds I. Furthermore, the binding interactions of compound I [R = 4-Cl] with the active site of α-glucosidase were confirmed through mol. docking. This study was identified a new class of potent α-glucosidase inhibitors for further investigation. In the experimental materials used by the author, we found 3-Chlorobenzylchloride(cas: 620-20-2Reference of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Reference of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 620-20-2On March 17, 2021, Zhang, Xiao; Wang, Yiping; Xu, Zhiping; Shao, Xusheng; Liu, Zewen; Xu, Xiaoyong; Maienfisch, Peter; Li, Zhong published an article in Journal of Agricultural and Food Chemistry. The article was 《Design, Synthesis, and Synergistic Activity of Eight-Membered Oxabridge Neonicotinoid Analogues》. The article mentions the following:

Insecticide synergists are sought-after due to their potential in improving the pesticide control efficacy with a reduced dose of an active ingredient. We previously reported that a cis-configuration neonicotinoid (IPPA08) exhibited specific synergistic activity toward neonicotinoid insecticides. In this study, we synthesized a series of structural analogs of IPPA08 by converting the pyridyl moiety of IPPA08 into Ph groups, via facile double-Mannich condensation reactions between nitromethylene compounds and glutaraldehyde. All of the oxabridged neonicotinoid compounds were found to increase the toxicity of imidacloprid against Aphis craccivora. Notably, compound (I) at 0.75 mg/L lowered the LC50 value of imidacloprid against A. craccivora by 6.54-fold, while a 3.50-fold reduction of the LC50 value was observed for IPPA08. The results of bee toxicity test showed that compound I display selectivity in its effects on imidacloprid toxicity against the honey bee (Apis mellifera L.). In summary, replacing the pyridyl ring with a Ph ring was a viable approach to obtain a novel synergist with oxabridged moiety for neonicotinoid insecticides. The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Application of 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Application of 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,ARKIVOC (Gainesville, FL, United States) included an article by De Luca, Laura; Mirabile, Salvatore; Ricci, Federico; Adornato, Ilenia; Cacciola, Anna; Germano, Maria Paola; Gitto, Rosaria. Reference of 3-Chlorobenzylchloride. The article was titled 《Synthesis and biochemical evaluation of 5-(pyridin-4-yl)-3-(alkylsulfanyl)-4H-1,2,4-triazol-4-amine-based inhibitors of tyrosinase from Agaricus bisporus》. The information in the text is summarized as follows:

A series of small mols. able to inhibit diphenolase activity of tyrosinase from Agaricus bisporus. The designed compounds I [n = 1,2; R = H, 4-Me, 2,4-F etc.] were readily synthesized by S-alkylation and the synthesized compounds I were tested through biochem. screening, thus provided structure-affinity relationships for this class of comp. I . In addition, docking simulations suggested the binding mode within the catalytic site of the targeted enzyme.3-Chlorobenzylchloride(cas: 620-20-2Reference of 3-Chlorobenzylchloride) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Reference of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C7H6Cl2On October 30, 2019 ,《First Discovery of Novel Pyrido[1,2-a]pyrimidinone Mesoionic Compounds as Antibacterial Agents》 was published in Journal of Agricultural and Food Chemistry. The article was written by Liu, Dengyue; Zhang, Jian; Zhao, Lei; He, Wengjing; Liu, Zhengjun; Gan, Xiuhai; Song, Baoan. The article contains the following contents:

Plant bacterial diseases cause tremendous decreases in crop yield and quality, and there is a lack of highly effective and low-risk antibacterial agents. A series of novel pyrido[1,2-a]pyrimidinone mesoionic compounds containing vanillin moieties were synthesized, and the application of these mesoionic compounds as plant antibacterial agents was reported here for the first time. The bioassay results revealed that the mesoionic compounds had good antibacterial activity. Of these compounds, compound (I) showed excellent in vitro activity against Xanthomonas oryzae pv. oryzae, with an EC50 value of 1.1μg/mL, which was substantially better than that of bismerthiazol (92.7μg/mL) and thiodiazole copper (105.4μg/mL). Moreover, greenhouse condition trials indicated that the protective and curative activities of compound I against rice bacterial leaf blight were 75.12% and 72.04%, resp., which were better than those of bismerthiazol (62.24% and 50.83%, resp.) and thiodiazole copper (53.35% and 65.04%, resp.). These results provide a basis for the application of mesoionic vanillin moieties as new antibacterial agents. In the experiment, the researchers used 3-Chlorobenzylchloride(cas: 620-20-2Computed Properties of C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Computed Properties of C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Rational Optimization and Action Mechanism of Novel Imidazole (or Imidazolium)-Labeled 1,3,4-Oxadiazole Thioethers as Promising Antibacterial Agents against Plant Bacterial Diseases》 was written by Wang, Pei-Yi; Wang, Ming-Wei; Zeng, Dan; Xiang, Meng; Rao, Jia-Rui; Liu, Qing-Qing; Liu, Li-Wei; Wu, Zhi-Bing; Li, Zhong; Song, Bao-An; Yang, Song. Formula: C7H6Cl2 And the article was included in Journal of Agricultural and Food Chemistry on April 3 ,2019. The article conveys some information:

The emergence and widespread occurrence of plant bacterial diseases that cause global production constraints have become major challenges to agriculture worldwide. To promote the discovery and development of new bactericides, imidazole-labeled 1,3,4-oxadiazole thioethers were first fabricated by integrating the crucially bioactive scaffolds of the imidazole motif and 1,3,4-oxadiazole skeleton in a single mol. architecture. Subsequently, a superior antibacterial compound A6 was gradually discovered possessing excellent competence against plant pathogens Xanthomonas oryzae pv oryzae and Xanthomonas axonopodis pv citri with EC50 values of 0.734 and 1.79 μg/mL, resp. These values were better than those of com. agents bismerthiazol (92.6 μg/mL) and thiodiazole copper (77.0 μg/mL). Further modifying the imidazole moiety into the imidazolium scaffold led to the discovery of an array of potent antibacterial compounds providing the corresponding min. EC50 values of 0.295 and 0.607 μg/mL against the two strains. Moreover, a plausible action mechanism for attacking pathogens was proposed based on the concentration dependence of SEM, transmission electron microscopy, and fluorescence microscopy images. Given the simple mol. structures, easy synthetic procedure, and highly efficient bioactivity, imidazole (or imidazolium)-labeled 1,3,4-oxadiazole thioethers can be further explored and developed as promising indicators for the development of com. drugs.3-Chlorobenzylchloride(cas: 620-20-2Formula: C7H6Cl2) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Improved Multigram Route to a Tricyclic Key Intermediate for Dibenzosuberone-Based p38 Inhibitors via an Optimized Early-Stage Heck Coupling》 was written by Forster, Michael; Wentsch-Teltschik, Heike K.; Laufer, Stefan A.. Electric Literature of C7H6Cl2 And the article was included in Organic Process Research & Development on August 20 ,2021. The article conveys some information:

The p38α MAP kinase has been a heavily investigated target in the last two decades. The structural class of dibenzosuberone-based p38 inhibitors, exemplified by the promising candidate skepinone-L, was already successfully validated in several in vivo models of inflammatory as well as oncol. indications. The increasing demand of key intermediates and final compounds caused by the ongoing development of this inhibitor class urged the conception of an optimized route for the preparation of the core dibenzosuberone scaffold in multigram quantities. Rerouting of the initial discovery route resulted in an almost 4-fold increase of overall yield to 46%, the elimination of chromatog. purification, and the substitution of two critical reaction steps, which hindered a feasible scale-up. The key modification was the introduction and optimization of an early-stage Heck coupling based on Buchwald precatalysts allowing consistently high yields (ca. 90%) at multigram scales with a favorably low Pd loading of 0.1 mol %. This newly developed synthetic access to the dibenzosuberone intermediate 2-chloro-7-hydroxy-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one is capable of ensuring the supply of skepinone-L and other candidates during further development. In the experimental materials used by the author, we found 3-Chlorobenzylchloride(cas: 620-20-2Electric Literature of C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Electric Literature of C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design, synthesis and biological evaluation of benzo[d]thiazole with dimethylpyrazole derivatives》 was published in Asian Pacific Journal of Cancer Prevention in 2019. These research results belong to Liu, Dachuan; Cheng, Xiu; Wang, Ying. Synthetic Route of C7H6Cl2 The article mentions the following:

A series of new benzothiazole derivatives containing dimethylpyrazole I [R = H, n-pentyl, benzyl, etc.] were synthesized and evaluated for their anticonvulsant activity, neurotoxicity and cytotoxicity by using the maximal electroshock (MES), rotarod neurotoxicity (TOX) and MTT colorimetric assay. Among the compounds studied, four compounds I [R = Bu, n-pentyl, 2-fluorobenzyl, 2,6-dichlorobenzyl] showed better anticonvulsant than the others at 300 mg/kg and they also showed anticonvulsant activity at the dose of 100 mg/kg. All the synthetic compounds I showed lower neurotoxicity and little cytotoxicity, so that the compounds, which with better activities, also had higher protective index. In particular, the compound I [R = 2-fluorobenzyl] showed better activity with an ED50 value of 160.4 mg/kg and higher protective index (PI) values of 2.74 in the MES test than the standard drugs sodium valproate, which used as pos. controls in this study. After that the compound I [R = 2-fluorobenzyl] demonstrated antagonistic activity against seizures induced by pentylenetetrazol, which proved compound I [R = 2-fluorobenzyl] may be exert activity through effecting GABAergic neurotransmission. After reading the article, we found that the author used 3-Chlorobenzylchloride(cas: 620-20-2Synthetic Route of C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Synthetic Route of C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics