Category: 620-20-2

Gan, Haifeng published the artcileFacile Preparation of Benzoxazoles from S₈-Promoted Cyclization of 2-Nitrophenols with Arylmethyl Chloride, COA of Formula: C7H6Cl2, the publication is ChemistrySelect (2019), 4(9), 2858-2860, database is CAplus.

A simple, metal-free methodol. has been obtained for the preparation of 2-arylbenzoxazoles I (R = H, 6-Me, 5-NHC(O)CH₃, etc.; R¹ = Ph, naphthalen-2-yl, pyridin-4-yl, etc.) from 2-nitrophenols 2-NO₂-R² -C₆H₃OH (R = H, 5-Me, 4-F, etc.) and arylmethyl chlorides R¹CH₂Cl via an elemental sulfur-promoted cyclization reaction. The reactions proceeded in moderate to good yields, and gram-scale is applicable.

ChemistrySelect published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, COA of Formula: C7H6Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

de Vasconcelos, Alana published the artcile2,4-Thiazolidinedione as Precursor to the Synthesis of Compounds with Anti-glioma Activities in C6 and GL261 Cells, Application of 3-Chlorobenzylchloride, the publication is Medicinal Chemistry (Sharjah, United Arab Emirates) (2021), 17(6), 601-610, database is CAplus and MEDLINE.

Thiazolidinediones (TZDs) represent an important class of heterocyclic compounds that have versatile biol. activities, including anticancer activity. Glioma is one of the most common primary brain tumors, and it is responsible for most of the deaths caused by primary brain tumors. In the present work, 2,4-thiazolidinediones were synthesized via a multicomponent microwave one-pot procedure. The cytotoxicity of compounds was analyzed in vitro using rat (C6) and mouse (GL261) glioblastoma cell lines and primary cultures of astrocytes. This study aims to synthesize and characterize 2,4-thiazolidinediones and evaluate their antitumor activity. TZDs were synthesized from three components: 2,4-thiazolidinedione, arene-aldehydes, and aryl chlorides. The reactions were carried out inside a microwave and monitored using thinlayer chromatog. (TLC). Compounds were identified and characterized using gas chromatog. coupled to mass spectrometry (CG-MS) and hydrogen (¹H-NMR) and carbon NMR spectroscopy (¹³C-NMR). The antitumor activity was analyzed using the 3-(4,5- dimethyl)-2,5-diphenyltetrazolium bromide (MTT) reduction test, in which cell viability was verified in the primary cultures of astrocytes and in rat and mouse glioblastoma cells exposed to the synthesized compounds The cytotoxicity of all derivatives was analyzed at the 100 μM concentration, both in astrocytes and in the mouse and rat glioblastoma cell lines. The compounds that showed the best results, 4CI and 4DI, were also tested at concentrations 25, 50, 100, 175, and 250 μM to obtain the IC₅₀. Seventeen TZD derivatives were easily obtained through one-pot reactions in 40 min with yields ranging from 12% to 49%. All compounds were cytotoxic to both glioblastoma cell lines without being toxic to the astrocyte primary cell line at 100 μM, thus demonstrating a selective activity. Compounds 4CI and 4DI showed the best results in the C6 cells: IC₅₀ of 28.51 μM and 54.26 μM, resp. The compounds were not cytotoxic in astrocyte culture, demonstrating selectivity for malignant cells. Changes in both rings are important for anti-glioma activity in the cell lines tested. TZD 4CI had the best anti-glioma activity.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Application of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Xian published the artcileReductive hydrobenzylation of terminal alkynes via photoredox and nickel dual catalysis, Application In Synthesis of 620-20-2, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(74), 9414-9417, database is CAplus and MEDLINE.

A photoredox/nickel dual catalyzed reductive hydrobenzylation of alkynes and benzyl chlorides by employing alkyl amines as a stoichiometric reductant is described. This synergistic protocol proceeds via Markovnikov-selective migratory insertion of an alkyne into nickel hydride, followed by cross-coupling with benzyl chloride, providing facile access to important 1,1-disubstituted olefins. This reaction enables the generation of nickel hydride by utilizing readily available alkyl amines as the hydrogen source. The mild conditions are compatible with a wide range of aryl and alkyl alkynes as well as chlorides.

Chemical Communications (Cambridge, United Kingdom) published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C18H20N2O12, Application In Synthesis of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Guan published the artcileDiscovery of a Novel Dual-Target Inhibitor of ERK1 and ERK5 That Induces Regulated Cell Death to Overcome Compensatory Mechanism in Specific Tumor Types, Application of 3-Chlorobenzylchloride, the publication is Journal of Medicinal Chemistry (2020), 63(8), 3976-3995, database is CAplus and MEDLINE.

ERK1 and ERK5 are proposed to have pivotal roles in several types of cancer. Under some circumstance, ERK5 may provide a common bypass route, which rescues proliferation upon abrogation of ERK1 signaling. Thus, we accurately classified the tumor types from The Cancer Genome Atlas (TCGA) based on the expression levels of ERK1 and ERK5. We proposed a novel therapeutic strategy to overcome the above-mentioned compensatory mechanism in specific tumor types by co-targeting both ERK1 and ERK5. On the basis of the idea of overcoming ERK5 compensation mechanism, 22ac (ADTL-EI1712) as the first selective dual-target inhibitor of ERK1 and ERK5 was discovered to have potent antitumor effects in vitro and in vivo. Interestingly, this compound was found to induce regulated cell death accompanied by autophagy in MKN-74 cells. Taken together, our results warrant the potential of this dual-target inhibitor as a new candidate drug that conquers compensatory mechanism in certain tumor types.

Journal of Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C11H11NO2, Application of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Guangqian published the artcileStudy of the in vivo antiviral activity against TMV treated with novel 1-(t-butyl)-5-amino-4-pyrazole derivatives containing a 1,3,4-oxadiazole sulfide moiety, SDS of cas: 620-20-2, the publication is Pesticide Biochemistry and Physiology (2021), 104740, database is CAplus and MEDLINE.

A series of new 1-tert-butyl-5-amino-4-pyrazole bioxadiazole sulfide derivatives containing a 1,3,4-oxadiazole moiety were designed and synthesized. The bioactivity results showed that some title compounds exhibited excellent protective activity against TMV and certain insecticidal activity. Among the tested compounds, the EC₅₀ values of 5d, 5j, 5k and 5l were 165.8, 163.2, 159.7 and 193.1 mg/L, resp., which are better than the EC₅₀ value of ningnanmycin (271.3 mg/L). The chlorophyll contents and the defense enzyme activities of the tobacco leaves after treatment with 5j were significantly increased, which indicated that this series of title compounds may induce the systemic acquired resistance of host to defend against diseases. Further in vivo protective activity research on 5j using TMV with a GFP gene tag found that it can effectively inhibit the spread of TMV in inoculated tobacco. A morphol. study with TEM revealed that title compound 5h can cause a distinct break of the rod-shaped TMV. Moreover, the insecticidal activity revealed that the fatality rates of 5a, 5b and 5m against aphidoidea were 85%, 83% and 87%, resp., which indicated that the title compounds can effectively block the common carrier of plant viruses, thereby effectively reducing the TMV infection risk of tobacco. This series of synergistic effects provide key information for the research and development of antiviral agents.

Pesticide Biochemistry and Physiology published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C15H10O2, SDS of cas: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

An, Shaoyu published the artcileMetal-Free Synthesis of Selenodihydronaphthalenes by Selenoxide-Mediated Electrophilic Cyclization of Alkynes, SDS of cas: 620-20-2, the publication is European Journal of Organic Chemistry (2021), 2021(21), 3059-3070, database is CAplus.

A transition-metal-free, selenium mediated electrophilic cyclization reaction was realized through a one-pot procedure between simple alkynes and triflic anhydride-activated selenoxides to give selenium containing dihydronaphthalene products. This method gave good to very high yields for all products, including selenium-substituted phenanthrene, dihydroquinoline, 2H-chromene, and coumarin, which can be further transformed to other functionalized compounds

European Journal of Organic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, SDS of cas: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Qian published the artcileMetal-free oxidative coupling of alkyl chlorides with thiols: An efficient access to sulfoxides, Computed Properties of 620-20-2, the publication is Tetrahedron Letters (2020), 61(7), 151492, database is CAplus.

An efficient and step-economical access to sulfoxides from thiols and alkyl halides in the presence of I₂O₅ and DBU via direct oxidative coupling was described. It is the first case that combined Williamson sulfide synthesis and subsequent sulfide oxidation into one step manipulation for sulfoxides preparation This protocol features wide substrate scope, mild and metal-free conditons, the use of naturally abundant starting materials and avoidance of over-oxidation

Tetrahedron Letters published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Computed Properties of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Jianyang published the artcileFacile one-pot synthesis of diarylacetylenes from arylaldehydes via an addition-double elimination process, Safety of 3-Chlorobenzylchloride, the publication is Organic & Biomolecular Chemistry (2021), 19(21), 4701-4705, database is CAplus and MEDLINE.

A practical one-pot protocol has been developed to synthesize diarylacetylenes ArCCAr¹ (Ar = Ph, naphthalen-1-yl, furan-2-yl, etc.; Ar¹ = Ph, 4-chlorophenyl, naphthalen-2-yl, etc.) from arylaldehydes ArCHO by treatment with 1-(arylmethyl)benzotriazoles I and LiN(SiMe₃)₂. The reaction proceeded through imine formation, Mannich-type addition and double elimination to deliver products in up to 99% yields with broad substrate scope. In addition, gram-scale synthesis of diarylacetylene (Ar = 4-bromophenyl, Ar¹ = Ph) has been demonstrated.

Organic & Biomolecular Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Safety of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, He published the artcileAn improved method for the synthesis of phenylacetic acid derivatives via carbonylation, HPLC of Formula: 620-20-2, the publication is Journal of Chemical Research (2019), 43(11-12), 548-552, database is CAplus.

A series of phenylacetic acid derivatives RCH₂CO₂H [R = 2-ClC₆H₄, 4-MeC₆H₄, 2,4-Cl₂C₆H₃, etc.] was synthesized via bistriphenylphosphine palladium dichloride catalyzed carbonylation reaction of benzyl chloride derivatives in presence of tetraethylammonium chloride and sodium hydroxide as reagents and xylene as solvent at 80°C under a CO atm. 2,4-Dichlorophenylacetic acid was obtained in a maximum yield of 95% from 2,4-dichlorobenzyl chloride using the same reaction system.

Journal of Chemical Research published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, HPLC of Formula: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Jie published the artcileDesign, synthesis, and screening of novel ursolic acid derivatives as potential anti-cancer agents that target the HIF-1α pathway, Computed Properties of 620-20-2, the publication is Bioorganic & Medicinal Chemistry Letters (2019), 29(6), 853-858, database is CAplus and MEDLINE.

The transcription factor hypoxia-inducible factor-1α (HIF-1α) plays an important role in tumor angiogenesis, growth, and metastasis and is recognized as an important potential therapeutic target for cancer. Here, we designed and synthesized three novel series of ursolic acid derivatives containing an aminoguanidine moiety and evaluated them as HIF-1α inhibitors and anticancer agents using human cancer cell lines. Most of the compounds exhibited significant inhibition of HIF-1α transcriptional activity, as measured using a Hep3B cell-based luciferase reporter assay. Among these compounds, I was the most potent inhibitor of HIF-1α expression under hypoxic conditions (IC₅₀ 4.0 μM) and did not display significant cytotoxicity against any cell lines tested. The mechanism of action of I was investigated, we found that I downregulated HIF-1α protein expression, possibly by suppressing its synthesis, reduced production of vascular endothelial growth factor, and inhibited the proliferation of cancer cells.

Bioorganic & Medicinal Chemistry Letters published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C12H10FeO4, Computed Properties of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics