Category: 620-20-2

Huang, Zhaoxiang published the artcileSynergistic effects of cinnamaldehyde and cinnamic acid in cinnamon essential oil against S. pullorum, Category: chlorides-buliding-blocks, the publication is Industrial Crops and Products (2021), 113296, database is CAplus.

Cinnamon is an important spice crop that is widely cultivated in tropical regions. In this study, the antibacterial activities of four accessions of cinnamon essential oil (CEO) belonging to three different species (CEO1 and CEO4, Cinnamomum cassia Presl. (Lauraceae) bark; CEO2, Cinnamomum zeylanicum Blume (Lauraceae) bark; CEO3, Cinnamomum burmannii Blume (Lauraceae) bark) toward Salmonella enterica subsp. enterica serovar pullorum (S. pullorum) were evaluated by microdilution assay and kinetic anal. The min. inhibitory concentration (MIC) of the CEOs were all 0.31 mg/mL, and kinetic anal. suggested that the lag phase and maximum specific growth rate of bacteria were concentration dependent. Furthermore, to explore the synergistic antibacterial effects between main components and minor components, the volatile constituents of CEOs were determined by gas chromatog.-mass spectrometry (GC-MS). Cinnamaldehyde (CM) (57.73 %-91.79 %) was the principal constituent in CEO1-CEO4 (p < 0.05), with CEO3 having the highest CM contents. A synergistic effect against S. pullorum was observed when CA was combined with CM. To explore the potential synergistic mechanism, the membrane glycerophospholipid (GPL) composition of S. pullorum was characterized by ultra-performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS). CM, CA, and their combination regulated the levels of most phosphatidylethanolamines (PEs), phosphatidylglycerols (PGs), phosphatidic acids (PAs), and some cardiolipins (CLs).

Industrial Crops and Products published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jana, Gopal Chandra published the artcileDeciphering the positional impact of chlorine in a new series of berberine analogues towards the superb-selective “turn-on” hydrophobic signaling of bovine serum albumin at physiological pH, Formula: C7H6Cl2, the publication is New Journal of Chemistry (2020), 44(5), 1761-1771, database is CAplus.

The optical signals of serum albumin (SA) provide precious information for realizing its native functions, in addition to developing related biomedical applications. Herein, we report a new class of easy synthesizable and water-soluble compounds (BZ₁-BZ₅) based on different chlorine positions on 9-O-benzyl-substituted berberine scaffolds for the selective detection of bovine serum albumin (BSA) in CP buffer solution (10 mM, pH 7.2) based on two competing factors: hydrophobic interactions and steric repulsion. The frail emission intensities of these probes were enhanced upon the addition of BSA; exceptionally, a remarkable increase in emission intensity (140-fold) and remarkable lifetime and quantum yield increases make BZ₄ an excellent fluorescence turn-on hydrophobic BSA sensor. Selectivity and co-existence studies involving other proteins, free tryptophan, etc. revealed that the microenvironment around the tryptophan moiety in BSA incites drastic spectral changes upon the introduction of BSA. Moreover, the most efficient lumino-probe, BZ₄, can detect bovine serum albumin at a nanomolar level (LOD = 3.3 nM) with a broadened range of linearity and slight altering of the secondary structure of the protein. Our exptl. results and docking simulation studies show that the probe BZ₄ binds preferentially at “binding site II” of BSA. In addition, the binding and conformational alterations of BSA provoked by these analogs have been intensely investigated, and we fruitfully relate the binding results to the sensing outcome. The obtained results reveal how the different positioning of chlorine in benzyl-substituted berberine affects the hydrophobic sensing of BSA, making these probes a new category of BSA selective material with potential applications in proteome research.

New Journal of Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Formula: C7H6Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Junjie published the artcileSemicarbazone derivatives bearing phenyl moiety: synthesis, anticancer activity, cell cycle, apoptosis-inducing and metabolic stability study, Safety of 3-Chlorobenzylchloride, the publication is Chemical & Pharmaceutical Bulletin (2019), 67(4), 351-360, database is CAplus and MEDLINE.

A series of semicarbazone derivatives bearing Ph moiety I [R = Me, Et; R¹ = H, benzyloxidanyl, 2-(2H-1,3-benzodioxol-5-ylmethyl)-(1,3-thiazol-4-yl)-methyloxy, [(4-chlorophenyl)methyl]oxidanyl, etc.; R² = t-Bu, H, prop-2-en-1-yl; R³ = H, t-Bu] was synthesized and evaluated for the vitro anticancer activities in four human cancer cell lines (human colon cancer (HT29), human neuroblastoma (SK-N-SH), human breast cancer (MDA-MB-231), and human gastric cancer (MKN45)). Biol. evaluation led to the identification of I [(I) R = Me, R¹ H, R² = R³ = t-Bu; (II) R = Et, R¹ H, R² = R³ = t-Bu], which showed excellent anticancer activities against tested cancer cell lines with IC₅₀ values ranging from 0.32 to 1.57 μM, resp., while exhibiting weak cytotoxicity on the normal cells (human umbilical vein endothelial cell (HUVEC)). Flow cytometric assay for cell cycle and apoptosis revealed that (I) and (II) caused an arrest in the Sub-G1 cell cycle and inhibited proliferation of cancer cells by inducing apoptosis in a dose-dependent manner. Further enzymic assay suggested that (I) and (II) could significantly activated procaspase-3 to caspase-3. Metabolic stability study indicated that (I) and (II) showed moderate stability in vitro in human and rat liver microsomes. In view of promising pharmacol. activities of (I) and (II), which had emerged as the valuable lead for further development in the treatment for cancer.

Chemical & Pharmaceutical Bulletin published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Safety of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pedreira, Julia G. B. published the artcileBioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors, Application In Synthesis of 620-20-2, the publication is Journal of Medicinal Chemistry (2020), 63(13), 7347-7354, database is CAplus and MEDLINE.

The recent disclosure of type I 1/2 inhibitors for p38α MAPK demonstrated how the stabilization of the R-spine can be used as a strategy to greatly increase the target residence time (TRT) of inhibitors. Herein, for the first time, we describe N-acylhydrazone and selenophene residues as spine motifs, yielding metabolically stable inhibitors with high potency on enzymic, NanoBRET, and whole blood assays, improved metabolic stability, and prolonged TRT.

Journal of Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Application In Synthesis of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gokanapalli, Anusha published the artcileBenzimidazole bearing Pd-PEPPSI complexes catalyzed direct C2-arylation/heteroarylation of N-substituted benzimidazoles, SDS of cas: 620-20-2, the publication is Applied Organometallic Chemistry (2020), 34(10), e5869, database is CAplus.

A convenient and highly efficient palladium-catalyzed direct C2-arylation/heteroarylation of N-substituted benzimidazole derivatives such as N-benzyl/3-chlorobenzyl/2,4,6-trimethylbenzyl/2,4,6-triisopropylbenzyl/aryl benzimidazoles I (R = H; R¹ = Bn, 4-chlorophenyl, (2,4,6-trimethylphenyl)methyl, etc.) with various aryl/heteroaryl bromides R²Br (R² = Ph, thiophen-3-yl, phenanthren-9-yl, etc.) in the presence of Pd-PEPPSI (palladium-pyridine enhanced pre-catalyst preparation stabilization and initiation) complexes is reported. A series of different sym. and unsym. N,N’-diaralkyl benzimidazole-bearing Pd-PEPPSI complexes II (R = 5-Me, 5,6-dimethyl; R³ = Me, 4-fluorophenyl, (2,4,6-trimethylphenyl)methyl, etc.) was prepared Among all of the prepared complexes, II = (R = 5,6-di-Me, R¹ = R³ = [2,4,6-tris(propan-2-yl)phenyl]methyl) effectively tuned the reaction at a relatively higher rate under mild reaction conditions in an ethanol-water system. In addition, the catalytic process avoids the use of external ligand and additives. Further the reactivity was compared with com. available copper-N-heterocyclic carbene catalyst, but the reaction was less successful. With the optimized reaction conditions, a wide range of 2-aryl/heteroaryl-N-substituted benzimidazoles were synthesized in good to excellent yields via Csp²-H/Csp²-X biaryl cross-coupling.

Applied Organometallic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, SDS of cas: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

De Luca, Laura published the artcileSynthesis and biochemical evaluation of 5-(pyridin-4-yl)-3-(alkylsulfanyl)-4H-1,2,4-triazol-4-amine-based inhibitors of tyrosinase from Agaricus bisporus, Name: 3-Chlorobenzylchloride, the publication is ARKIVOC (Gainesville, FL, United States) (2022), 156-166, database is CAplus.

A series of small mols. able to inhibit diphenolase activity of tyrosinase from Agaricus bisporus. The designed compounds I [n = 1,2; R = H, 4-Me, 2,4-F etc.] were readily synthesized by S-alkylation and the synthesized compounds I were tested through biochem. screening, thus provided structure-affinity relationships for this class of comp. I . In addition, docking simulations suggested the binding mode within the catalytic site of the targeted enzyme.

ARKIVOC (Gainesville, FL, United States) published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Name: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Xiantang published the artcileNickel/Photo-Cocatalyzed Acyl C-H Benzylation of Aldehydes with Benzyl Chlorides, Synthetic Route of 620-20-2, the publication is European Journal of Organic Chemistry (2022), 2022(17), e202200214, database is CAplus.

Authors have developed a nickel/TBADT cocatalyzed acyl C-H benzylation of both aliphatic and aromatic aldehydes with primary and secondary benzyl chlorides under mild reaction conditions. The protocol provides a convenient and efficient method to synthesize a variety of ketones.

European Journal of Organic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Synthetic Route of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Badolato, Mariateresa published the artcileTriazolopyrimidinium salts: discovery of a new class of agents for cancer therapy, Recommanded Product: 3-Chlorobenzylchloride, the publication is Future Medicinal Chemistry (2020), 12(5), 387-402, database is CAplus and MEDLINE.

Aim: The [1,2,4]triazolo[1,5-a]pyrimidine core is highly privileged in medicinal chem. due to its versatile pharmacol. activity profile. Recently, the search for novel anticancer agents has focused on [1,2,4]triazolo[1,5-a]pyrimidine derivatives Results: Our hit functionalization has led to the discovery of new [1,2,4]triazolo[1,5-a]pyrimidinium salts with potential anticancer activity. Among a small library of mols., compound 9 significantly inhibits cancer cell growth in a panel of in vitro models. Mol. docking studies and preliminary binding assay have displayed that 9 could directly bind the Src homol. 2 (SH2) domain of STAT3 protein. Conclusion: Compound 9 is a novel promising lead compound that motivates addnl. evaluation of [1,2,4]triazolo[1,5-a]pyrimidinium salts as novel potential chemotherapeutics.

Future Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Jie published the artcileSynthesis and biological evaluation of ursolic acid derivatives containing an aminoguanidine moiety, Application of 3-Chlorobenzylchloride, the publication is Medicinal Chemistry Research (2019), 28(7), 959-973, database is CAplus.

Three series of ursolic acid derivatives containing an aminoguanidine moiety were designed, synthesized, and evaluated for anti-bacterial and anti-inflammatory activity. Some compounds displayed potent anti-bacterial activity against Gram-pos. bacterial strains (including multidrug-resistant clin. isolates) and Gram-neg. bacterial strains, with min. inhibitory concentration (MIC) values in the range of 2-64 μg/mL. Compounds 3a, 5a, and 7l showed significant inhibitory activity against the Gram-pos. bacterial strain Staphylococcus aureus RN 4220, the Gram-neg. bacterial strain Escherichia coli 1924, and four multidrug-resistant Gram-pos. bacterial strains, with MIC values of 2 and 4 μg/mL. In anti-inflammatory tests, most of the compounds exhibited potent activity, in particular compound 3a displayed the most potent activity with 81.61% inhibition after i.p. administration, which was more potent than ursolic acid and the reference drugs (ibuprofen and indomethacin). The cytotoxic activity of compound 3a was assessed in HeLa, Hep3B, and A549 cells.

Medicinal Chemistry Research published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C21H26BF4NO, Application of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Akgul, Ozlem published the artcileSultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain, COA of Formula: C7H6Cl2, the publication is European Journal of Medicinal Chemistry (2022), 113956, database is CAplus and MEDLINE.

We report a series of compounds 1-17 derived from the antiepileptic drug Sulthiame (SLT) from which both the benzenesulfonamide and the sultam moiety were retained. All compounds were tested in vitro for their inhibition activity against the human (h) Carbonic Anhydrase (CA; EC 4.2.1.1) I, II, VII, IX and XII isoforms. Among the series, derivatives 1 and 11 showed great enhancement of both inhibition potency and selectivity towards the hCA VII isoform, when compared to the reference SLT drug. The binding mode of 11 within the hCA VII active site was deciphered by means of X-ray crystallog. and revealed the sultam moiety being exposed to the rim of the active site. In vivo experiments on a model of neuropathic pain induced by oxaliplatin clearly showed 11 being an effective pain relieving agent and therefore worth of further exploitation towards the validation of the hCA VII as new target for the management of neuropathies.

European Journal of Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, COA of Formula: C7H6Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics