Category: 620-20-2

Zhang, Yurong published the artcileAn alternatively metal-free synthesis of 1,3,5-triazines or 1,2,4-thiadiazoles from benzyl chlorides and benzylamines mediated by elemental sulfur, COA of Formula: C7H6Cl2, the publication is Tetrahedron Letters (2019), 60(49), 151289, database is CAplus.

An elemental sulfur mediated reaction of benzyl chlorides with benzylamines was developed, which allows the practical synthesis of valuable 1,3,5-triazines. This protocol that was metal free, ligand free, and uses inexpensive elemental sulfur as oxidant or raw material displays mild reaction conditions, a broad substrate scope and moderate to good yields. Moreover, the modified sulfur-mediated reaction system was used to synthesize 1,2,4-thiadiazoles, by simply switching the stoichiometry of sulfur powder from 0.75 equiv to 5 equivalent

Tetrahedron Letters published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C15H12O6, COA of Formula: C7H6Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ren, Erfang published the artcileAnalysis of flavor difference of macadamia nuts dried with different methods based on electronic sensory technology combined with GC-MS, Recommanded Product: 3-Chlorobenzylchloride, the publication is Xiandai Shipin Keji (2021), 37(11), 304-316, 84, database is CAplus.

In order to evaluate scientifically the differences in the flavor of macadamia nuts dried with different methods, electronic tongue and electronic nose sensory technologies combined with gas chromatog.-mass spectrometry (GC-MS) were used to analyze their flavor quality. The results showed that there were significant differences between fresh macadamia nuts and different dried macadamia nuts in umami, salty, sour and bitter tastes, and the cumulative contribution rate of the first two principal components of linear discriminant anal. (LDA) was 96.60%, which could distinguish completely macadamia nuts dried in different ways. The responses of the electronic nose to macadamia nuts processed differently differed significantly. The cumulative contribution rate of the first two principal components in principal component anal. (PCA) reached 98.79%, which could well distinguish the volatile flavor compounds of the macadamia nuts dried by different treatments. The sensors W1S, W3S and W3C played major roles in the principal component anal. As a supplement to the electronic nose, GC-MS identified a total of 227 volatile components, with alkanes and aldehydes being dominant in types and contents. The relative contents of alkanes in the four different treatments of macadamia nuts were 26.29%, 40.76%, 23.64% and 39.46%, resp., and the relative contents of aldehydes were 29.01%, 18.96%, 26.03% and 23.87%, resp. Therefore, the combination of electronic tongue, electronic nose and GC-MS can better distinguish macadamia nuts dried with different methods, thereby providing a theor. reference for postharvest primary processing of macadamia nuts in growing regions.

Xiandai Shipin Keji published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Menghan published the artcileMolecular hybridization used to design and synthesize neo-tanshinlactone derivatives as PD-1/PD-L1 inhibitors, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2022), 116579, database is CAplus and MEDLINE.

Four series of mol. hybrids (37 final products) of neo-tanshinlactone, a natural product extracted from Salvia miltiorrhiza Bunge, and known PD-1/PD-L1 interaction inhibitors were prepared as possible chemotherapeutic agents against triple neg. breast cancer. Screening using a homogenous time-resolved fluorescence method resulted in three lead compounds (MZ52 IC50 74 ± 4 nM; MZ58 IC50 134 ± 17 nM; MZ61 IC50 225 ± 19 nM). With less T cell cytotoxicity and effects in activating CD8+ T cells in a T cell proliferation assay and a functionality experiment, MZ58 was selected as the best candidate for animal experiments MZ58 exhibited antitumor effects in a s.c. transplantation tumor model as well as effects in reducing T cell exhaustion. In conclusion, after in vivo and in vitro experiments, we successfully acquired an effective candidate (MZ58) showing antitumor effects with low cytotoxicity toward T cells as well as the ability to activate CD8+ T cells and reduce T cell exhaustion.

Bioorganic & Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C14H12N2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hu, Weitao published the artcileSynthesis of Multisubstituted Allylic Alcohols via a Nickel-Catalyzed Cross-Electrophile Ring-Opening Reaction, SDS of cas: 620-20-2, the publication is Organic Letters (2022), 24(31), 5751-5755, database is CAplus and MEDLINE.

Herein, a nickel-catalyzed cross-electrophile ring-opening reaction of vinyl epoxides I (R¹ = Ph, 1-naphthyl, benzodioxol-5-yl, etc.; R² = H, Me, phenyl; R³ = H, Ph, furan-2-yl, thiophen-2-yl) was reported, wherein aryl iodides, alkyl iodides, and benzyl chlorides R⁴X (R⁴ = Pr, cyclohexyl, phenyl; X = I, Cl) can all serve as the electrophilic coupling partners, providing a new approach to preparing multisubstituted allylic alcs. R¹C(CH(OH)R³)=C(R²)CH₂R⁴. This new method features broad substrate scope multisubstituted allylic alcs., good step-economy, and high L/B- and E/Z selectivity as well as mild reaction conditions.

Organic Letters published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, SDS of cas: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Yonghong published the artcileSodium Selenosulfate from Sodium Sulfite and Selenium Powder: An Odorless Selenylating Reagent for Alkyl Halides to Produce Dialkyl Diselenide Catalysts, Safety of 3-Chlorobenzylchloride, the publication is Synlett (2019), 30(14), 1698-1702, database is CAplus.

Na₂SeSO₃, which can be generated in situ by the reaction of Na₂SO₃ with Se power, was found to be an odorless reagent for the selenenylation of alkyl halides RX (R = Bu, cyclohexyl, 3-fluorobenzyl, etc.; X = Cl, Br) to produce dialkyl diselenides RSeSeR. By using aqueous EtOH as the solvent and avoiding the generation of a malodorous selenol intermediate, the selenylation reaction with Na₂SeSO₃ is much more environmentally friendly than conventional methods. Owing to the cheap and abundant starting materials and selenium reagents, the novel synthetic method reduces the production costs of dialkyl diselenides as organoselenium catalysts, thereby advancing practical applications of organoselenium-catalysis technologies.

Synlett published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Safety of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Yunlong published the artcileStereoselective Synthesis of Trisubstituted Alkenes by Nickel-Catalyzed Benzylation and Alkene Isomerization, Name: 3-Chlorobenzylchloride, the publication is Angewandte Chemie, International Edition (2022), 61(26), e202202674, database is CAplus and MEDLINE.

Herein, diastereo- and regioselective synthesis of trisubstituted alkenes via nickel-catalyzed benzylation and isomerization of terminal olefins with benzyl chlorides in presence of trimethylsilyl triflate and trimethylamine additives was described. Control experiments provided evidence for a mechanism involving branched-selective Heck-type benzylation that overrides substrate control, followed by trans-selective 1,3-hydrogen shift. The method represented a significant addition to the toolbox of reactions for the concise synthesis of unsaturated biol. active compounds

Angewandte Chemie, International Edition published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C13H10N2S, Name: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pan, Nianjuan published the artcileNovel pyrimidine derivatives bearing a 1,3,4-thiadiazole skeleton: design, synthesis, and antifungal activity, Related Products of chlorides-buliding-blocks, the publication is Frontiers in Chemistry (Lausanne, Switzerland) (2022), 922813, database is CAplus and MEDLINE.

In this study, twenty novel pyrimidine derivatives bearing a 1,3,4-thiadiazole skeleton were designed and synthesized. Then their antifungal activity against Botrytis cinereal (B. cinereal), Botryosphaeria dothidea (B. dothidea), and Phomopsis sp. were determined using the poison plate technique. Biol. test results showed that I revealed lower EC₅₀ values (25.9 and 50.8μg/mL) on Phompsis sp. than those of pyrimethanil (32.1 and 62.8μg/mL).

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shi, Lei published the artcileSynthesis and anticancer activity of novel coumarin derivatives, Computed Properties of 620-20-2, the publication is Youji Huaxue (2020), 40(6), 1598-1607, database is CAplus.

Nineteen novel 3,4,5-trimethoxyphenyl coumarin derivatives have been synthesized and evaluated for antitumor activity against three human cancer cell lines (EC-109, PC-3 and MGC-803). These chem. structures were well characterized by NMR and HRMS spectroscopic methods. N-Benzyl-2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)-N-(3,4,5-trimethoxyphenyl) acetamide (4a) and N-((5-chlorobenzo[b]thiophen-3-yl)methyl)-2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)-N-(3,4,5-trimethoxyphenyl)acetamide (4n) had better inhibitory activity against three kinds of tumor cells than 5-fluorouracil. Compound 4n showed the most potent antitumor activity against PC-3 cells with an IC₅₀ value of 4.18μmol/L.

Youji Huaxue published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C8H8BFO2, Computed Properties of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xiao, Yulong published the artcileDesign, Synthesis, and Antifungal Activity of Sulfoximine Derivatives Containing Nitroguanidine Moieties, Name: 3-Chlorobenzylchloride, the publication is Chemistry & Biodiversity (2022), 19(3), e202100839, database is CAplus and MEDLINE.

To discover novel pesticide candidates, a series of sulfoximine derivatives were designed and synthesized via the oxidation coupling reaction of sulfides and N-alkyl nitroguanidines. The compounds were evaluated for their antifungal activity against six phytopathogenic fungi. Most of them exhibited a broad spectrum of fungicidal activity in vitro. Compound 8IV-b displayed good fungicidal activity against Sclerotinia sclerotiorum, Rhizoctonia solani, Botrytis cinerea, Fusarium graminearum, and Phytophthora capsici, with EC50 value of 12.82, 12.50, 17.25, 31.08, and 30.11 mg/L, resp. In addition, compounds 8III-c and 8IV-e had EC50 values of 22.23 and 20.67 mg/L against P. capsic, which were significantly better than that of the com. procymidone (118.15 mg/L). Strikingly, 8IV-d exhibited satisfactory fungicidal activity against B. cinerea, which was comparable to control procymidone in terms of their EC50 values (7.42 vs. 10.83 mg/L), and the bioassays in vivo further confirmed that 8IV-d possessed potent protective effect against B. cinerea at 200 mg/L (72.2 %). These present findings will facilitate the design and development of novel potent fungicides.

Chemistry & Biodiversity published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C65H82N2O18S2, Name: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Karpina, Veronika R. published the artcileA novel series of [1,2,4]triazolo[4,3-a]pyridine sulfonamides as potential antimalarial agents: in silico studies, synthesis and in vitro evaluation, Recommanded Product: 3-Chlorobenzylchloride, the publication is Molecules (2020), 25(19), 4485, database is CAplus and MEDLINE.

For the development of new and potent antimalarial drugs, the virtual library with three points of randomization of novel [1,2,4]triazolo[4,3-a]pyridines bearing a sulfonamide fragment, e.g., I has been described. The library of 1561 compounds has been investigated by both virtual screening and mol. docking methods using falcipain-2 as a target enzyme. 25 Chosen hits were synthesized and evaluated for their antimalarial activity in vitro against Plasmodium falciparum. 3-Ethyl-N-(3-fluorobenzyl)-N-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine-6-sulfonamide and 2-(3-chlorobenzyl)-8-(piperidin-1-ylsulfonyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one showed in vitro good antimalarial activity with inhibitory concentration IC₅₀ = 2.24 and 4.98μM, resp. This new series of compounds may serve as a starting point for future antimalarial drug discovery programs.

Molecules published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics