Category: 622-86-6

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 622-86-6 as follows. Application In Synthesis of (2-Chloroethoxy)benzene

To a stirred solution of l-(2-chloroethoxy)benzene (48 g, 1.0 eq) in 400 mL CH2CI2 at 0 C was added dropwise a solution of 4-methoxybenzoyl chloride (62 g, 1.2 eq) and AICI3 (49 g, 1.2 eq) in 400 mL CH2CI2 while maintaining the temperature at 0 C. After the addition, the reaction was stirred at rt for 1 h. Then added ice water to quench the reaction and extracted with CH2CI2. The extract was washed with brine, dried and evaporated in vacuo. Hexane (500 mL) was added to the residue, cooled to 0 C and stirred for 30 min, then filtered and washed with cold hexane and dried to give the product as a white solid (85 g, 96%). NMR (400 MHz, CDC13) 67.79 (dd, J = 6.8 Hz, 2.0 Hz, 4H), 6.97 (dd, J = 8.8 Hz, 2.0 Hz, 4H), 4.32 (t, J = 6.0 Hz, 2H), 3.89 (s, 3H), 3.86 (t, J = 6.0 Hz, 2H).

According to the analysis of related databases, 622-86-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin; WO2013/97773; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 622-86-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 622-86-6 name is (2-Chloroethoxy)benzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The synthesis of Intermediates 8, 9 and 10 was carried out according to Hardcastle et al. (1995) and is shown in Scheme II.The mixture containing the tamoxifen precursor Intermediate 10 obtained after column chromatography was dried under high vacuum and minimum volume of absolute ethanol was added to dissolve it. It was heated to boiling and then transferred to the freezer at 0 0C. After 2 hrs it was brought out of the freezer and kept at room temperature. The sudden temperature difference makes the E- isomer to precipitate as fluffy white crystals that should be kept under constant supervision so as to filter the crystals off at the right moment before the Z-isomer also starts that has to be followed by 1H NMR of the precipitated crystals. EPO Sometimes the crystals of E-isomer also start falling out when it is in the freezer, thus the solution should be continuously monitored so that after the initiation of the crystallization process it can be brought out of the freezer and kept at room temperature. The total time taken for crystallization varies depending on the room temperature. At 30 C it takes about 2-3 hrs and at low room temperature it may take 10-12 hours. Thus, it is preferable to heat the room at 30 0C for faster and efficient crystallization.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2-Chloroethoxy)benzene, and friends who are interested can also refer to it.

Reference:
Patent; YEDA RESEARCH AND DEVELOPMENT CO. LTD.; WO2006/80022; (2006); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 622-86-6, name is (2-Chloroethoxy)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 622-86-6, Formula: C8H9ClO

2-(3-bromophenyl)aceticacid (4.0 g, 18.6mmol) was dissolved in trifluoroacetic anhydride (3.6 mL), then (2-chloroethoxy)benzene(2.56 mL, 19.5 mmol) was added dropwise. The resulting mixture was allowed tostir at room temperature for overnight. The reaction mixture was quenched with saturatedaqueous sodium bicarbonate and then extracted twice with ethyl acetate. Theorganic phases were combined and dried over anhydrous magnesium sulfate andconcentrated on a rotary evaporator. Purification with normal phasechromatography (ethyl acetate/hexane) afforded 5.46 g (83%) of the desiredproduct as a yellow solid (83%). 1H NMR (400MHz, CDCl3) delta 8.07 (d, J =8.9 Hz, 2H), 7.47-7.40(m, 2H), 7.25-7.24 (m, 2H), 7.07(d, J = 8.9 Hz, 2H), 4.35 (m, 4H), 3.92-3.89(m, 2H); MS (ESI) (m/z) 353.0/355.0 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2-Chloroethoxy)benzene, and friends who are interested can also refer to it.

Reference:
Article; Childers, Wayne; Fan, Rong; Martinez, Rogelio; Colussi, Dennis J.; Melenski, Edward; Liu, Yuxiao; Gordon, John; Abou-Gharbia, Magid; Jacobson, Marlene A.; Bioorganic and Medicinal Chemistry Letters; vol. 30; 2; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 622-86-6, name is (2-Chloroethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H9ClO

2-(4-Fluorophenyl)butanoic acid (250.3 mg, 1.4mmol) was suspended with stirring in trifluoroacetic anhydride (194.2 uL, 2.0mmol). Then (2-chloroethoxy)benzene (173 uL, 1.3 mmol) was added the resultingmixture was stirred at room temperature overnight. The reaction was quenchedwith saturated sodium bicarbonate solution (5 mL) and extracted with ethylacetate (2 x 15 mL). The combinedorganic layers were dried over anhydrous magnesium sulfate and concentrated ona rotary evaporator. The resultingresidue was purified by reverse-phased chromatography (C-10 column, gradient ofacetonitrile in water with 0.1% trifluoroacetic acid) to afford 105.2 mg (26%)of the desired product as a yellow solid.1H NMR (400 MHz, CDCl3) delta 7.90 (d, J=8.8 Hz, 2H), 7.50 (d,J=8.7 Hz, 2H), 7.23 (m, 2H), 6.95 (d, J=8.7 Hz, 2H), 4.25 (m, 3H), 3.86 (t,J=7.2 Hz, 2H), 2.18 (m, 1H), 1.60 (m, 1H), 0.90 (t, J=7.3 Hz, 3H); MS (ESI)(m/z) 321.1/323.1 (M+H)+.

The synthetic route of (2-Chloroethoxy)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Childers, Wayne; Fan, Rong; Martinez, Rogelio; Colussi, Dennis J.; Melenski, Edward; Liu, Yuxiao; Gordon, John; Abou-Gharbia, Magid; Jacobson, Marlene A.; Bioorganic and Medicinal Chemistry Letters; vol. 30; 2; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 622-86-6, name is (2-Chloroethoxy)benzene, A new synthetic method of this compound is introduced below., name: (2-Chloroethoxy)benzene

Phenyl acetic acid (2.6 g, 19 mmol) wassuspended in trifluoroacetic anhydride (11 mL, 76 mmol). Chloroethyoxylbenzene(2.7 mL, 19 mmol) was added to the stirred suspension dropwise. The resultingmixture was allowed to stir overnight at room temperature. The reaction wasquenched with 40% aqueous sodium hydroxide solution and then extracted withethyl acetate (2 x 15 mL). The combinedorganic layers were dried over anhydrous magnesium sulfate and concentrated ona rotary evaporator. The resultingresidue was purified by chromatography on silica gel (ethyl acetate/hexane) toafford 3.56 g (68%) of the desired product as a yellow solid. 1H NMR (400 MHz, CDCl3)delta 7.93 (d, J = 6.8 Hz, 2H), 7.22 (m, 5H), 6.87 (d, J = 6.9 Hz, 2H), 4.21 (t, J=5.8 Hz, 2H), 4.17 (s, 2H), 3.76 (t, J = 5.8 Hz, 2H); MS (ESI) (m/z) 275.1/277.1(M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Childers, Wayne; Fan, Rong; Martinez, Rogelio; Colussi, Dennis J.; Melenski, Edward; Liu, Yuxiao; Gordon, John; Abou-Gharbia, Magid; Jacobson, Marlene A.; Bioorganic and Medicinal Chemistry Letters; vol. 30; 2; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 622-86-6, These common heterocyclic compound, 622-86-6, name is (2-Chloroethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 3 Preparation of N-n-propyl-N-2-phenoxyethyl amine Into a 1-liter glass reactor, which can withstand a pressure of 6 atmospheres, fitted with a stirrer, heat-ing mantle and a pressure gauge, were added 100 g 2-phenoxy ethyl chloride, 150 g propyl amine, 130 ml ethanol and 100 ml water. The reaction was heated to 100 C. for 5 hours, during which time the pressure increased to 2.2 atmospheres. Afterwards the mixture was cooled to 50 C. to lower the pressure, the propyl amine was distilled off, about 200 ml of 20% aqueous HCl was added and the white hydrochloride precipitated out. This afforded 133 g having a purity of 95% in a yield of 93%.

Statistics shows that (2-Chloroethoxy)benzene is playing an increasingly important role. we look forward to future research findings about 622-86-6.

Reference:
Patent; Makhteshim Chemical Works Ltd.; US5093526; (1992); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 622-86-6, name is (2-Chloroethoxy)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 622-86-6, Recommanded Product: 622-86-6

2-Bromophenyl acetic acid (5.0 g, 23.3 mmol,) was suspended in trifluoroacetic anhydride (13.5 mL, 93.5 mmol). Chloroethyoxylbenzene (3.3 mL, 23.3 mmol) was added to the stirred suspension dropwise. The resulting mixture was allowed to stir overnight at room temperature. The reaction was quenched with 40% aqueous sodium hydroxide solution and then extracted with ethyl acetate (2 x 20 mL). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated on a rotary evaporator. The resulting residue was purified by chromatography on silica gel (ethyl acetate/hexane) to afford 5.98 g (73%) of the desired product as a light orange solid. NMR (0836) (400 MHz, CDC13) delta 8.05 (d, J = 8.9 Hz, 2H), 7.60 (d, J = 8.5 Hz, 1H), 7.24 (m, 2H), 7.18 (m, 1H), 6.96 (d, J = 9.0 Hz, 2H), 4.40 (s, 2H), 4.37 (t, J = 5.5 Hz, 2H), 3.88 (t, J = 5.7 Hz, 2H); MS (ESI) (m/z) 354.0/356.0 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2-Chloroethoxy)benzene, and friends who are interested can also refer to it.

Reference:
Patent; TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; CHILDERS, Wayne, E.; ABOU-GHARBIA, Magid; JACOBSON, Marlene, A.; FAN, Rong; MARTINEZ, Rogelio, L.; MELENSKI, Edward, George; (126 pag.)WO2017/205451; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 622-86-6, name is (2-Chloroethoxy)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 622-86-6, name: (2-Chloroethoxy)benzene

A.27 Synthesis of [(PhOCH2CH2)2ImH]Cl (27) (2-chloroethoxy)benzene (5.02 g, 32.05 mmol) and l-(trimethylsilyl)imidazole (1.33 g, 9.48 mmol) and toluene (5 mL) were stirred at 1 10C for 7 days in complete darkness. The resultant biphasic mixture was cooled to room temperature and the top layer was discarded. The viscous bottom layer was dissolved in dichloromethane (1 mL) and pentane (50 mL) was added. The precipitated oil was washed with pentane (3×20 mL) and dried under high vacuum (3.27 g, quantitative). The product is an extremely viscous wax which solidifies completely over the course of several weeks. The following analytical data were obtained. *H NMR (CD2C12): delta 1 1.12 (s, 1H, NCHN), 7.57 (s, 2H, NCHCHN), 7.26 (t, 3JH-H= 7.7 Hz, 4H, m- CH), 6.97 (t, 4.8 Hz, 4H, 2xCH2), 4.39 (vt, 3JH-H= 4.8 Hz, 4H, 2xCH2). 13C NMR Patent; THE GOVERNING COUNCIL OF UNIVERSITY OF TORONTO; LANXESS Deutschland GmbH; MUELLER, Julia Maria; STEPHEN, Douglas; LUND, Clinton; SGRO, Michael; ONG, Christopher; CARIOU, Renan; WO2013/24119; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 622-86-6 as follows. Safety of (2-Chloroethoxy)benzene

a. Diethyl 2,2-di(2-phenoxyethyl)malonate To a stirred solution of sodium (2.3 g) in absolute EtOH (50 ml) was added diethyl malonate (15.2 ml) followed by 2-phenoxyethyl chloride (15. 7 g). The reaction mixture was then refluxed for 12 hr. The EtOH was evaporated under vacuum and the mixture diluted with water (40 ml). The aqueous phase was extracted with Et2 O. The combined Et2 O extracts were washed (brine), dried (MgSO4) filtered and evaporated. Bulb to bulb distillation afforded 12.2 g (27%) of the title diester as a clear liquid, bp 155-175 (106 Pascals, 0.8 Torr); TLC, Rf =0.34, CH2 Cl2.

According to the analysis of related databases, 622-86-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ICI Americas Inc.; US4910190; (1990); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 622-86-6, name is (2-Chloroethoxy)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of (2-Chloroethoxy)benzene

2-(4-Aminophenyl) butanoic acid (Compound 10, step 1) (397.3 mg, 2.0 mmol) was suspended with stirring intrifluoroacetic anhydride (277.4 uL, 2.0 mmol). Then (2-chloroethoxy)benzene(252.4 uL, 1.8 mmol) was added dropwise and the resulting mixture was stirredat room temperature overnight. The reaction was quenched with saturated sodiumbicarbonate solution (5 mL) and extracted with ethyl acetate (2 x 15 mL). The combined organic layers were dried overanhydrous magnesium sulfate and concentrated on a rotary evaporator. The resulting residue was purified byreverse-phased chromatography (C-10 column, gradient of acetonitrile in waterwith 0.1% formic acid) to afford 297.1 mg (49%) of the desired product as ayellow solid. 1H NMR (400MHz, MeOD) delta 7.99 (d, J = 8.9 Hz, 2H), 7.28 (m, 4H), 6.96 (d, J = 8.9 Hz, 2H),4.58 (t, J = 7.2 Hz,1H), 4.27 (t, J = 5.5 Hz, 2H), 3.84 (t, J = 5.5 Hz, 2H),2.11 (m, 1H), 1.78 (m, 1H), 0.88 (t, J = 7.3 Hz 3H); MS (ESI) (m/z) 318.1/320.1(M+H)+.

The synthetic route of 622-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Childers, Wayne; Fan, Rong; Martinez, Rogelio; Colussi, Dennis J.; Melenski, Edward; Liu, Yuxiao; Gordon, John; Abou-Gharbia, Magid; Jacobson, Marlene A.; Bioorganic and Medicinal Chemistry Letters; vol. 30; 2; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics