Category: 622-86-6

Related Products of 622-86-6, A common heterocyclic compound, 622-86-6, name is (2-Chloroethoxy)benzene, molecular formula is C8H9ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-Bromophenyl acetic acid (5.0 g, 23.3 mmol,)was suspended in trifluoroacetic anhydride (13.5 mL, 93.5 mmol).Chloroethyoxylbenzene (3.3 mL, 23.3 mmol) was added to the stirred suspensiondropwise. The resulting mixture was allowed to stir overnight at roomtemperature. The reaction was quenched with 40% aqueous sodium hydroxidesolution and then extracted with ethyl acetate (2 x 20 mL). The combined organic layers were dried overanhydrous magnesium sulfate and concentrated on a rotary evaporator. The resulting residue was purified bychromatography on silica gel (ethyl acetate/hexane) to afford 5.98 g (73%) ofthe desired product as a light orange solid. 1H NMR (400 MHz, CDCl3)delta 8.05 (d, J = 8.9 Hz, 2H), 7.60 (d, J = 8.5 Hz, 1H), 7.24 (m, 2H), 7.18 (m,1H), 6.96 (d, J = 9.0 Hz, 2H), 4.40 (s, 2H), 4.37 (t, J = 5.5 Hz, 2H), 3.88 (t,J = 5.7 Hz, 2H); MS (ESI) (m/z) 354.0/356.0 (M+H)+.

The synthetic route of 622-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Childers, Wayne; Fan, Rong; Martinez, Rogelio; Colussi, Dennis J.; Melenski, Edward; Liu, Yuxiao; Gordon, John; Abou-Gharbia, Magid; Jacobson, Marlene A.; Bioorganic and Medicinal Chemistry Letters; vol. 30; 2; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 622-86-6, name is (2-Chloroethoxy)benzene, A new synthetic method of this compound is introduced below., SDS of cas: 622-86-6

Example 29 N-2-(4-(2-phenoxyethoxy)-phenyl)-propyl-2-propanesulfonamide. To a stirred mixture of N-tertbutoxyacetyl-2-(4-hydroxyphenyl)propyl-2-propanesulfonamide (0.250 g,.70 mmol) in dry dimethylformamide (4 mL) was added sodium hydride (0.062 g, 0.87 mmol) under nitrogen. The resulting mixture was stirred 30 minutes at ambient temperature or until hydrogen gas evolution had ceased. Next, beta-chlorophenetole (0.120 g, 0.77 mmol) and sodium iodide (0.042 g, 0.25 mmol) are added and the resulting mixture was heated to 65C for 12 h. The resulting mixture was cooled and partitioned between ethyl acetate and water. The organic layer was washed with water (2 X 20 mL) and brine (1 X 20 mL), dried over magnesium sulfate, and filtered. Evaporation of the filtrate in vacuo followed by chromatography on silica gel eluding with ethyl acetate-hexane gave 0.250 g (75%) of the protected sulfonamide. To a stirred mixture of dichloromethane: trifluoroacetic acid (2 mL, 1:1) was added the protected sulfonamde (0.220 g, 0.42 mmol) under nitrogen. The resulting mixture was stirred at ambient temperature for 4 h. The mixture was partitioned between dichloromethane and 10% aqueous potassium carbonate. The organic layer was washed with brine (1 X 20 mL), dried over magnesium sulfate, and filtered. Evaporation of the filtrate in vacuo gives 0.166 g (96%) of the pure title compound. Mass Spectrum: MS +1= 378.5

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ELI LILLY AND COMPANY; EP994110; (2000); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 622-86-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 622-86-6 as follows.

5.23mL of 1-(2-chloroethoxy)benzene (38.45mmol), previously distilled on CaH2, were dissolved in 50mL of dry THF to give a colorless solution. 25mL of a solution 2M of sodium cyclopentadienide in THF were added drop-wise at -78C. The solution was warmed up to room temperature and left stirred overnight to give a white precipitate and a dark pink solution. Afterwards the mixture was quenched with methanol and cold water. The organic product was extracted by 3x 50mL ether fraction. The solution was dried over magnesium sulphate and had its solvent removed at reduced pressure to yield a brown oil (yield 89%). 1H NMR (300MHz, CDCl3) delta 2.88 [t, 2H, C5H5-(CH2CH2OC6H5),], 4.14 [t, 2H, C5H5-(CH2CH2OC6H5)], 3.01-3.20 [m, 1H, C5H5-(CH2CH2OC6H5)], 6.17-6.52 [m, 4H, C5H5-(CH2CH2OC6H5)], 6.92-7.32 [m, 5H, C5H5-(CH2CH2OC6H5)]. 13C NMR (75MHz, C6D6) delta 30.1 [C5H5-(CH2CH2OPh)], 67.8 [C5H5-(CH2CH2OPh)], 44.1 [C5H5-(CH2CH2OPh)], 114.8, 120.9, 128.1, 129.7, 134.4, 134.9, 159.1 [C5H5-(CH2CH2OPh)]. Mass (GC-MS): 186.1 [M]+.

According to the analysis of related databases, 622-86-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Saturnino, Carmela; Sirignano, Esther; Botta, Antonio; Sinicropi, Maria Stefania; Caruso, Anna; Pisano, Assunta; Lappano, Rosamaria; Maggiolini, Marcello; Longo, Pasquale; Bioorganic and Medicinal Chemistry Letters; vol. 24; 1; (2014); p. 136 – 140;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 622-86-6, These common heterocyclic compound, 622-86-6, name is (2-Chloroethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-(4-Nitrophenyl) butanoic acid (1.66 g, 7.9mmol) was dissolved in trifluoroacetic anhydride (1.1 mL, 7.9 mmol), then(2-chloroethoxy)benzene (1.0 ml, 7.2 mmol) was added dropwise. The resultingmixture was allowed to stir at room temperature overnight. The reaction mixture was poured into saturatedaqueous sodium bicarbonate solution (50 mL) and extracted with ethyl acetate (2x 50 mL). The combined organic phases were driedover anhydrous magnesium sulfate and concentrated on a rotaryevaporator. The resulting residue waspurified by chromatography on silica gel (ethyl acetate/hexane) to afford 1.49g (59%) of the desired compound as a white solid. 1HNMR (400 MHz, CDCl3) delta8.21 (d, J = 8.8 Hz, 2H), 7.96 (d, J = 8.9 Hz, 2H), 7.51 (d, J = 8.8 Hz, 2H),6.93 (d, J = 9.0 Hz, 2H), 4.56 (t, J = 7.3 Hz, 1H), 4.28 (t, J = 5.8 Hz 2H), 3.83 (t, J = 5.8 Hz, 2H),2.26 (m, 1H), 1.78 (m, 1H), 0.94 (t, J = 7.4 Hz, 3H); MS (ESI) (m/z) 348.1/350.1(M+H)+.

Statistics shows that (2-Chloroethoxy)benzene is playing an increasingly important role. we look forward to future research findings about 622-86-6.

Reference:
Article; Childers, Wayne; Fan, Rong; Martinez, Rogelio; Colussi, Dennis J.; Melenski, Edward; Liu, Yuxiao; Gordon, John; Abou-Gharbia, Magid; Jacobson, Marlene A.; Bioorganic and Medicinal Chemistry Letters; vol. 30; 2; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 622-86-6, name is (2-Chloroethoxy)benzene, A new synthetic method of this compound is introduced below., COA of Formula: C8H9ClO

b. Preparation of 2-(4-Chlorophenyl)-4-phenoxybutanenitrile To a flask was added 7.2 g. (0.150 mole) of a 50% oil dispersion of sodium hydride. After washing the sodium hydride several times with hexane to remove the mineral oil, 18.9 g. (0.125 mole) of 4-chlorobenzyl cyanide in 50 ml of dry DMF was added dropwise at 0 C. Upon completion of the addition, the reaction was stirred for one hour while warming to room temperature, then 20.0 g. (0.128 mole) of 1-chloro-2-phenoxyethane was added dropwise at 15 C. over a 30 minute period. The stirred reaction was allowed to warm to room temperature and was complete in two hours. The reaction mixture was diluted with 300 ml. of water and extracted three times with 100 ml. portions of methylene chloride. The combined extracts were washed with dilute hydrochloric acid and water followed by drying using sodium sulfate. Upon removal of the solvent, 33 g. of the crude 2-(4-chlorophenyl)-4-phenoxybutanenitrile was obtained (96% yield).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Rohm and Haas Company; US5527816; (1996); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 622-86-6, name is (2-Chloroethoxy)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H9ClO

Example 1233-{[(frans-4-Methylcyclohexyl)carbonyl][2-(phenyloxy)ethyl]amino}-1-(4-pyrazolo[1,5- a]pyrimidin-2-ylphenyl)-1H-pyrazole-4-carboxylic acidTo Intermediate 119 (200 mg) was added anhydrous DMF (8 mL), and the resulting suspension was stirred at room temperature, under nitrogen for 5 minutes. Sodium hydride (60% dispersion in mineral oil) (34 mg) was then added, and the reaction mixture stirred at room temperature, under nitrogen for 25 minutes. Beta-chlorophenetole (331 mg) was added, and the reaction was stirred at 5O0C, under nitrogen for 20 h. Water (2 mL) was added to quench the reaction, and the mixture was stirred for 15 minutes before the solvent was removed by evaporation. The residue was then suspended in THF (2 mL) and ethanol (2 mL), and 2M lithium hydroxide solution (2 mL) was then added. The reaction mixture was stirred at room temperature for 24 h, and then neutralised using 2M HCI, and partitioned between water and DCM. The layers were stirred for 30 minutes, and then separated using a hydrophobic frit. The organic phase was then concentrated by evaporation, and purified using ISCO Companion C18 chromatography eluting with a gradient of acetonitrile (containing 0.05% formic acid) in water ( containing 0.1% formic acid) to give the title compound. MS calcd for (C32H32N6O4+H)+: 565 MS found (electrospray): (M+H)+= 565

The synthetic route of 622-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/39146; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 622-86-6, name is (2-Chloroethoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H9ClO

3- Bromophenylacetic acid (4.0 g, 18.6 mmol) was dissolved in trifluoroacetic anhydride (3.6 mL, 25.9 mmol), then (2-chloroethoxy)benzene (2.56 mL, 18.6 mmol) was added dropwise. The resulting mixture was allowed to stir at room temperature overnight. The reaction mixture was quenched with saturated aqueous sodium bicarbonate solution and then extracted twice with ethyl acetate. The organic layers were combined, dried over anhydrous magnesium sulfate and then concentrated on a rotary evaporator. The resulting residue was purified by chromatography on silica gel to afford the desired product (5.46 g, 83% yield) as a yellow solid. NMR (400 MHz, MeOD) delta 8.07 (d, J =8.9 Hz, 2H), 7.47-7.40 (m, 2H), 7.25-7.24 (m, 2H), 7.07(d, J = 8.9 Hz, 2H), 4.37-4.33 (m, 4H), 3.92-3.89 (m, 2H); MS (ESI) (m/z) 355 (M+H)+. (0862)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 622-86-6.

Reference:
Patent; TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; CHILDERS, Wayne, E.; ABOU-GHARBIA, Magid; JACOBSON, Marlene, A.; FAN, Rong; MARTINEZ, Rogelio, L.; MELENSKI, Edward, George; (126 pag.)WO2017/205451; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 622-86-6, name is (2-Chloroethoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 622-86-6

EXAMPLE 5 Preparation of 4-(2-phenoxyethylthio)-1-B-D-ribofuranosylprazolo(3,4-d)pyrimidine Crude 2-phenoxyethyl chloride (2.7 g) was added to a stirred solution of 4-mercapto-1-B-D-ribofuranosylpyrazolo(3,4-d)pyrimidine (2.0 g) and potassium carbonate (1.07 g) in N,N-dimethylformamide. The solution was heated (40 C. on an oil bath) for 24 hours. After cooling the reaction mixture was poured into water (0.20 l) and the resultant precipitate was collected. The 4-(2-phenoxyethylthio)-1-B-D-ribofuranosylpyrazolo(3,4-d)pyrimidine so obtained was recystallised from methanol, m.p. 125-126 C.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 622-86-6.

Reference:
Patent; Burroughs Wellcome Co.; US4299823; (1981); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 622-86-6, name is (2-Chloroethoxy)benzene, A new synthetic method of this compound is introduced below., Recommanded Product: (2-Chloroethoxy)benzene

2-(4-Chlorophenyl)butanoic acid (397.3 mg, 2.0mmol) was suspended with stirring in trifluoroacetic anhydride (277.4 uL, 2.0mmol). Then (2-chloroethoxy)benzene (252.4 uL, 1.8 mmol) was added dropwise andthe resulting mixture was stirred at room temperature overnight. The reactionwas quenched with saturated sodium bicarbonate solution (5 mL) and extractedwith ethyl acetate (2 x 15 mL). Thecombined organic layers were dried over anhydrous magnesium sulfate andconcentrated on a rotary evaporator. Theresulting residue was purified by reverse-phased chromatography (C-10 column,gradient of acetonitrile in water with 0.1% trifluoroacetic acid) to afford297.1 mg (49%) of the desired product as a yellow solid. 1H NMR (400 MHz, MeOD) delta 7.99 (d,J = 8.9 Hz, 2H), 7.28 (m, 4H), 6.96 (d, J = 8.9 Hz, 2H), 4.58 (t, J = 7.2Hz,1H), 4.27 (t, J = 5.5 Hz, 2H), 3.84 (t, J = 5.5 Hz, 2H), 2.11 (m, 1H), 1.78(m, 1H), 0.88 (t, J = 7.3 Hz 3H); MS (ESI) (m/z) 318.1/320.1 (M+H)+.

The synthetic route of 622-86-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Childers, Wayne; Fan, Rong; Martinez, Rogelio; Colussi, Dennis J.; Melenski, Edward; Liu, Yuxiao; Gordon, John; Abou-Gharbia, Magid; Jacobson, Marlene A.; Bioorganic and Medicinal Chemistry Letters; vol. 30; 2; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 622-86-6, name is (2-Chloroethoxy)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 622-86-6, Recommanded Product: 622-86-6

General procedure: A solution of 3-imidazolyl-4-chromanone-(E)-oxime (4, 0.75 mmol) in dry DMF (1.5 mL) was mixed with a suspension of NaH (18 mg, 0.75 mmol) in dry DMF (1.5 mL). The reaction mixture was stirred at room temperature for 0.5 h. Then, a solution of phenoxyethyl chloride derivative 6 (0.825 mmol) in dry DMF (1 mL) was added gradually and stirring was continued at room temperature for 2 days. After completion of the reaction, the reaction mixture was poured into water (20 mL) and left in refrigerator overnight. The separated viscous oil was dissolved in propan-2-ol (2 mL) and treated with 65% HNO3 (0.07 mL) and the mixture was left in a fridge to form nitrate salts. The precipitated crystals were separated and wash with cold propan-2-ol to give pure compound 7.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (2-Chloroethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Babazadeh-Qazijahani, Mojtaba; Badali, Hamid; Irannejad, Hamid; Afsarian, Mohammad Hosein; Emami, Saeed; European Journal of Medicinal Chemistry; vol. 76; (2014); p. 264 – 273;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics