Category: 622-95-7

In 2022,Zhou, Yu; Yang, Cheng-Li; Ye, Lei; Dong, Zhi-Bing published an article in Synthesis. The title of the article was 《Copper-Catalyzed C-S Formation for the Synthesis of Benzyl Phenyl Sulfides from Dithiocarbamates》.Category: chlorides-buliding-blocks The author mentioned the following in the article:

An odorless and efficient protocol for the synthesis of benzyl Ph sulfides RSCH2R1 [R = Ph, 2-MeC6H4, 4-ClC6H4, etc.; R1 = Ph, 4-MeOC6H4, 2-BrC6H4, etc.] was reported. Starting from environmentally friendly Ph dithiocarbamates and com. available benzyl halides as starting materials, the target compounds (benzyl Ph sulfides) could be obtained smoothly and easily by using copper salt as catalyst and Cs2CO3as base. This method featured ligand/additive-free, the use of readily available starting materials, inexpensive catalysts, and good substrate suitability, illustrating its potentially synthetic value for the convenient preparation of some biol. active mols. The results came from multiple reactions, including the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Category: chlorides-buliding-blocks)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Category: chlorides-buliding-blocks It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,RSC Advances included an article by Li, Chen; Chen, Xian; Bao, Rui-Peng; Li, Dong-Li; Zhang, Kun; Wang, Dong-Hui. Category: chlorides-buliding-blocks. The article was titled 《Ir(III)-catalyzed thioether directed arene C-H alkenylation》. The information in the text is summarized as follows:

In this study, an Ir(III)-catalyzed thioether directed alkenylation of arene C-H bonds under mild reaction conditions has been described. The selectivity for mono- or di-alkenylation is controlled by the concentration of alkene and oxidant loading. Various functional groups are tolerated, and moderate to good yields of alkenylated products are achieved. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Category: chlorides-buliding-blocks)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Category: chlorides-buliding-blocks It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

He, Tao; Klare, Hendrik F. T.; Oestreich, Martin published their research in ACS Catalysis in 2021. The article was titled 《Silylium-Ion Regeneration by Protodesilylation Enables Friedel-Crafts Alkylation with Less Isomerization and No Defunctionalization》.Recommanded Product: 622-95-7 The article contains the following contents:

An improved protocol for the Friedel-Crafts alkylation of benzene as well as its methylated and halogenated derivatives with alkyl and benzyl bromides is reported. The reaction is promoted by a counteranion-stabilized silylium ion in the presence of stoichiometric amounts of a simple phenyl-substituted tetraorganosilane. This additive functions as a proton scavenger, regenerating the catalytically active silylium ion through protonation (protodesilylation) by the Wheland intermediate. It is a productive “”proton-into-silylium ion”” generator. The higher proton affinity of silylated compared with alkylated arenes results in fast proton transfer from the Bronsted acidic Wheland intermediate to the ipso position of that phenylsilane, thereby preventing otherwise competing defunctionalization and isomerization at the stage of the Wheland intermediate. The additive was also found to be crucial for turnover in the alkylation with primary alkyl bromides and for the suppression of transbenzylation in the benzylation with more reactive benzyl bromides. The experimental part of the paper was very detailed, including the reaction process of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Recommanded Product: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Novel preparation of N-arylmethyl-N-arylmethyleneamine N-oxides from benzylic bromides with zinc and isobutyl nitrite》 were Yanai, Kei; Togo, Hideo. And the article was published in Tetrahedron in 2019. Category: chlorides-buliding-blocks The author mentioned the following in the article:

Treatment of benzylic bromides with Zn and LiCl, followed by the reaction with i-Bu nitrite gave N-arylmethyl-N-arylmethyleneamine N-oxides in moderate yields [e.g., 4-methylbenzyl bromide → I (47%)]. The present reaction is a novel and simple method for the preparation of nitrones from benzylic bromides, although the yields are moderate. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Category: chlorides-buliding-blocks)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Category: chlorides-buliding-blocks It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Yaru; Ren, Pengju; Zhang, Dongsheng; Qiao, Wei; Wang, Dan; Yang, Xiaoqin; Wen, Xiaodong; Rummeli, Mark H.; Niemantsverdriet, Hans; Lewis, James P.; Besenbacher, Flemming; Xiang, Hongwei; Li, Yongwang; Su, Ren published their research in ACS Catalysis in 2021. The article was titled 《Rationally Designed Metal Cocatalyst for Selective Photosynthesis of Bibenzyls via Dehalogenative C-C Homocoupling》.Category: chlorides-buliding-blocks The article contains the following contents:

Cu is a promising candidate to promote the coupling of aromatic halides RCH2X (Ph, 3,4-dimethylphenyl, 4-chloro-3-methoxyphenyl, etc.; X = Br, Cl) due to the optimized adsorption energy of the reaction intermediates (benzyl radical and Br atom) over a series of transition metals. The Cu-modified TiO2 shows a remarkable apparent quantum efficiency (15%) and a great tolerance of harsh reaction conditions for the homocoupling of benzyl bromides into bibenzyls R(CH2)2R under UV irradiation The low-cost photocatalyst also shows high performance upon scaling-up and selective coupling of a series of benzyl bromide derivatives, demonstrating the heterogeneous photocatalytic C-C coupling as an attractive process for applications. Addnl., the design strategy can be applied to modify other photocatalysts (i.e., g-C3N4) to realize the C-C coupling of benzyl bromide under visible light. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Category: chlorides-buliding-blocks)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Category: chlorides-buliding-blocks It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zang, Yingda; Liu, Ke; Wang, Weiping; Li, Chuangjun; Ma, Jie; Yang, Jingzhi; Chen, Xinyi; Wang, Xiaoliang; Zhang, Dongming published their research in Molecules in 2021. The article was titled 《Claulansine F-donepezil hybrids as anti-Alzheimer’s disease agents with cholinergic, free-radical scavenging, and neuroprotective activities》.Name: 1-(Bromomethyl)-4-chlorobenzene The article contains the following contents:

The multifactorial nature of Alzheimer’s disease (AD) calls for the development of multitarget agents addressing key pathogenic processes. Twenty-six Claulansine F-donepezil hybrids I (X = nothing, CH2, CH2CH2; R1 = OMe, t-Bu; R2 = PhCH2, 2-FC6H4CH2, 4-ClC6H4CH2, etc.) were designed and synthesized as multitarget drugs. Among these compounds, six compounds exhibited excellent acetylcholinesterase (AChE) inhibitory activity (half maximal inhibitory concentration (IC50) 1.63-4.62μM). Moreover, the compound I [X = CH2; R1 = t-Bu; R2 = 2-ClC6H4CH2; (II)] exhibited better neuroprotective effects against OGD/R (oxygen-glucose deprivation/reoxygenation) than lead compound Claulansine F. Furthermore, the compound II could cross the blood-brain barrier in vitro. More importantly, compared to edaravone, the compound II had stronger free-radical scavenging activity. Mol. docking studies revealed that II could interact with the catalytic active site of AChE. All of these outstanding in vitro results indicate the compound II as a leading structure worthy of further investigation.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Name: 1-(Bromomethyl)-4-chlorobenzene) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Name: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,RSC Advances included an article by Xiao, Jing; Ma, Yonghao; Wu, Xiaofang; Gao, Jing; Tang, Zilong; Han, Li-Biao. SDS of cas: 622-95-7. The article was titled 《Phosphonic acid mediated practical dehalogenation and benzylation with benzyl halides》. The information in the text is summarized as follows:

For the first time, by using H3PO3/I2 system, various benzyl chlorides and bromides RCH2X (R = C6H5, 4-O2NC6H4, 1-naphthyl, etc.; X = Cl, Br) were dehalogenated successfully. In the presence of H3PO3, benzyl halides underwent electrophilic substitution reactions with electron-rich arenes, leading to a broad range of diarylmethanes RCH2R1 (R1 = C6H5, 2,4,6-(CH3)3C6H2, 4-CH3OC6H4, etc.) in good yields. These transformations feature green, cheap reducing reagents and metal-free conditions. In the experiment, the researchers used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7SDS of cas: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.SDS of cas: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《One-pot synthesis of N-alkyl indole from indoline-2-carboxylic acids and alkyl halides by 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) mediated oxidative decarboxylative aromatization》 was published in Youji Huaxue in 2020. These research results belong to Zhu, Runyu; Zhai, Min; Liu, Shuang; Liu, Xingtong; Wang, Zhen; Ju, Ruijun; Yu, Xinhong. Name: 1-(Bromomethyl)-4-chlorobenzene The article mentions the following:

Synthesis of N-alkyl indoles via 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) mediated intramol. oxidative decarboxylative aromatization of N-alkylindoline-2-carboxylic acids was reported. The good compatibility of this process leaded to the development of a mild and metal-free one-pot synthesis of N-alkyl indoles from alkyl halides and indoline carboxylic acid. The one-pot three-component synthesis of 1,4-bis((1H-indol-1-yl)methyl)benzene was also disclosed in satisfied yields. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Name: 1-(Bromomethyl)-4-chlorobenzene) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Name: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Copper-Catalyzed Selective 1,2-Difunctionalization of N-Heteroaromatics through Cascade C-N/C=C/C=O Bond Formation》 was written by He, Qianlin; Xie, Feng; Xia, Chuanjiang; Liang, Wanyi; Guo, Ziyin; Zhu, Zhongzhi; Li, Yibiao; Chen, Xiuwen. COA of Formula: C7H6BrCl And the article was included in Organic Letters in 2020. The article conveys some information:

This study presents an efficient strategy for constructing 1,2-difunctionalized quinoline derivatives via the multicomponent cascade coupling of N-heteroaromatics with alkyl halides and different terminal alkynes. This reaction was achieved through sequential functionalization at the one- and two-positions of quinolines, which displayed a broad substrate scope, environmental friendliness, excellent functional group tolerance, high atom efficiency, and chemoselectivity. The multicomponent coupling involved the abnormal construction of new C-N, C=C, and C=O bonds in one pot. The applicability of this method was further demonstrated by the late-stage functionalization of complex drug mols. under the established conditions.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7COA of Formula: C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.COA of Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Pd-Catalyzed Regioselective Olefination of N-Tosylhydrazones with Benzyl Bromides》 was written by Sun, Zhenze; He, Jing; Li, Weiwei; Li, Xuezhen; Feng, Yijiao; Liu, Yan; Liu, Ping; Han, Sheng. Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene And the article was included in ChemistrySelect in 2020. The article conveys some information:

A palladium-catalyzed regioselective olefination of cycloalkylphenylmethylene N-tosylhydrazones and benzyl bromide was developed. A series of E-type tri-substituted olefin compounds were obtained in 43-95% through the highly selective β-H elimination. The results showed that the β-H at the benzyl position took precedence over the β-H at the cycloalkyl position for the alkylpalladium intermediate, avoiding the formation of tetra-substituted olefins. High regioselectivity, wide substrate scope, and good functional group tolerance were the advantages of this reaction. The experimental part of the paper was very detailed, including the reaction process of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics