Category: 622-95-7

《Catalyst/Additive Free Oxidation of Benzyl Bromides to Benzaldehydes》 was published in ChemistrySelect in 2020. These research results belong to Aman, Hasil; Chen, Yuan-Ching; Tu, Jing-Wen; Chang, Chia-Chi; Chuang, Gary Jing. Formula: C7H6BrCl The article mentions the following:

An effective approach for the synthesis of aryl aldehydes from the corresponding benzyl bromides was accomplished. Without need of addnl. additives or stoichiometric oxidants, this environmental friendly and milder version of Kornblum oxidation simply utilized the irradiation of visible light in DMSO under O2, and was compatible with the substrate with different functional groups.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Hou, Yuxuan; Hu, Jinjin; Xu, Ruigang; Pan, Shulei; Zeng, Xiaofei; Zhong, Guofu. Quality Control of 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《Indium-Mediated Synthesis of Benzylic Hydroperoxides》. The information in the text is summarized as follows:

An indium(0)-metal-mediated efficient synthesis of benzylic hydroperoxides is described. The reaction proceeds efficiently with a broad range of benzyl bromides under aerobic conditions at room temperature to afford benzyl hydroperoxides in good to excellent yields. In addition, the tandem hydroperoxidn.-Michael addition of (E)-1-(bromomethyl)-2-(2-nitrovinyl)benzene was also demonstrated. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Quality Control of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Quality Control of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Niedbala, Patryk; Majdecki, Maciej; Grodek, Piotr; Jurczak, Janusz published an article in Molecules. The title of the article was 《H-Bond Mediated Phase-Transfer Catalysis: Enantioselective Generating of Quaternary Stereogenic Centers in β-Keto Esters》.Quality Control of 1-(Bromomethyl)-4-chlorobenzene The author mentioned the following in the article:

In this work, the development of a highly optimized method for generating the quaternary stereogenic centers in β-keto esters I (R = Me, i-Pr, t-Bu; R1 = H, 2-Me, 3-Me, 4-Me, 4-Cl; R2 = R3 = H; R2R3 = -CH=CH-CH=CH-) was presented. This enantioselective phase-transfer alkylation catalyzed by hybrid Cinchona catalysts II (R4 = naphthalen-2-yl, naphthalen-1-yl, quinolin-8-yl) allows for the efficient generation of the optically active products I with excellent enantioselectivity, using only 1 mol% of the catalyst. The vast majority of phase-transfer catalysts in asym. synthesis work is made by creating ionic pairs with the nucleophile-attacking anionic substrate. Therefore, it is a sensible approach to search for new methodologies capable of introducing functional groups into the precursor’s structure, maintaining high yields and enantiomeric purity. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Quality Control of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Quality Control of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Hou, Liting; Huang, Wenyi; Wu, Xianqing; Qu, Jingping; Chen, Yifeng published an article in Organic Letters. The title of the article was 《Nickel-Catalyzed Carbonylation of Cyclopropanol with Benzyl Bromide for Multisubstituted Cyclopentenone Synthesis》.Category: chlorides-buliding-blocks The author mentioned the following in the article:

Herein, the authors report a Ni-catalyzed carbonylation of cyclopropanol with benzyl bromide to afford multisubstituted cyclopentenone under 1 atm of CO. The reaction proceeds through a cascade carbonylation of benzyl bromides, followed by generation of nickel homoenolate from cyclopropanols via β-C elimination to afford 1,4-diketones, which undergoes intramol. aldol condensation to furnish highly substituted cyclopentenone derivatives I [Ar = Ph, R = Ph, 4-MeOC6H4, 3-ClC6H4, etc.; Ar = 2-naphthyl, 3-MeOC6H4, 4-ClC6H4, etc., R = Ph] in moderate to good yields. The reaction exhibited high functional group tolerance with broad substrate scope. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Category: chlorides-buliding-blocks)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Category: chlorides-buliding-blocks It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Abas, Hossay; Amer, Mostafa M.; Olaizola, Olatz; Clayden, Jonathan. Related Products of 622-95-7. The article was titled 《N-Chloroformylimidazolidinone Enolates as 1,3-Dipolar Reagents for the Stereoselective Synthesis of 3,4-Dihydroisoquinolones》. The information in the text is summarized as follows:

N-Chloroformyl imidazolidinone derivatives of enantiopure amino acids may be deprotonated to give remarkably well-behaved enolates with both nucleophilic and electrophilic character. The enolates undergo diastereoselective C-alkylation with benzylic halides. A Bischler-Napieralski-like cyclization reaction onto the chloroformyl group, induced by either nucleophilic (KI, 2,6-lutidine) or Lewis acid (AlCl3) catalysis, gives substituted 3,4-dihydroisoquinolone derivatives in enantioenriched form. The reaction sequence constitutes a formal [3 + 3] route to the six-membered lactam ring of the dihydroisoquinolones. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Related Products of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Related Products of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Borsoi, Ana Flavia; Paz, Josiane Delgado; Pissinate, Kenia; Rambo, Raoni Scheibler; Pestana, Victor Zajaczkowski; Bizarro, Cristiano Valim; Basso, Luiz Augusto; Machado, Pablo published their research in Molecules in 2021. The article was titled 《Ultrasound-assisted synthesis of 4-alkoxy-2-methylquinolines: an efficient method toward antitubercular drug candidates》.Formula: C7H6BrCl The article contains the following contents:

Herein, a new synthetic approach was established providing efficient and rapid access (15 min) to a series of 4-alkoxy-6-methoxy-2-methylquinolines I (R = 4-nitrophenyl, 3,4-difluorophenyl, naphthalen-2-yl, etc.) using ultrasound energy. The new synthetic protocol provides a simple procedure utilizing an open vessel system that affords the target products I at satisfactory yields (45-84%) and elevated purities (≳95%). The methodol. allows the evaluation of a larger number of mols. in assays against the bacillus, facilitating the determination of the structure-activity relationship with a reduced environmental cost. The results came from multiple reactions, including the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Koronka, Daniel; Miyatake, Kenji published an article in 2021. The article was titled 《Anion exchange membranes containing no β-hydrogen atoms on ammonium groups: synthesis, properties, and alkaline stability》, and you may find the article in RSC Advances.Electric Literature of C7H6BrCl The information in the text is summarized as follows:

Novel anion conductive polymer membranes have been designed and synthesized to investigate whether the absence of β-hydrogen atoms of ammonium groups affects the membranes’ properties and chem. stability. The hydrophilic monomer, 2,2-bis(4-chlorobenzyl)-2-phenyl-ethylamine (3), was obtained via a two-step reaction with an overall yield of 98% under mild reaction conditions. Ni(0)-promoted copolymerization of 3 with 2,2-bis(4-chlorophenyl)hexafluoropropane (1) afforded high mol. weight copolymers (Mn = 12.8-19.6 kDa, Mw = 82.1-224.6 kDa). After quaternization with iodomethane, QBAF-BS polymers formed bendable, robust membranes from solution casting. The ion exchange capacity (IEC) of the membranes ranged from 1.50 to 2.44 mequivalent g-1. The membranes exhibited high hydroxide ion conductivity in water (up to 191 mS cm-1 at 80°C for IEC = 2.25 mequivalent g-1), suggesting that the newly designed hydrophilic structure was effective in improving the ion conductivity Based on small-angle X-ray scattering (SAXS) analyses and transmission electron microscopy (TEM) images, all membranes featured nano-phase separated morphol. with a large dependence on the copolymer composition The strain properties were improved on increasing the content of the hydrophilic component up to IEC = 2.25 mequivalent g-1, above which the strain became smaller due to the larger water absorption. The membranes were not stable under harsh alk. conditions (in 8 M KOH at 80°C) gradually losing the hydroxide ion conductivity Compared to our previous AEMs which contained typical aliphatic ammonium groups, the lack of β-hydrogen atoms did not practically improve the alk. stability of AEMs possibly due to the main chain degradation but contributed to higher ion conductivity1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Electric Literature of C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Electric Literature of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzeneIn 2019 ,《Design, synthesis, biological evaluation, and molecular modeling studies of quinoline-ferulic acid hybrids as cholinesterase inhibitors》 appeared in Bioorganic Chemistry. The author of the article were Mo, Jun; Yang, Hongyu; Chen, Tingkai; Li, Qihang; Lin, Hongzhi; Feng, Feng; Liu, Wenyuan; Qu, Wei; Guo, Qinglong; Chi, Heng; Chen, Yao; Sun, Haopeng. The article conveys some information:

A series of quinoline-ferulic acid hybrids I (R = 1-chloro-4-(2-methoxyphenoxymethyl)benzene, 3-cyanophenyl, 4-(benzyloxy)-3-methoxyphenyl, etc.; R1 = H, Me; n = 1, 2, 3) has been designed, synthesized, and evaluated as cholinesterase inhibitors. Most of the compounds showed good inhibitory activities toward both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Among them, I (R = 1-bromo-4-(2-methoxyphenoxymethyl)benzene; R1 = Me; n = 1 (A)) was found to be the most potent inhibitor against AChE (IC50 = 0.62 ± 0.17 μM), and I (R = phenyl; R1 = Me; n = 3) was the most potent inhibitor against BChE (IC50 = 0.10 ± 0.01 μM). Representative compounds, such as (A) and I (R = 4-(trifluoromethyl)phenyl; R1 = Me; n = 1 (B)), act in a competitive manner when they inhibit AChE or BChE. Mol. docking and dynamic simulation revealed that the synthesized compounds bind to the target by simultaneously interacting with the catalytic active site (CAS) and the peripheral anionic site (PAS) of both AChE and BChE. The U-shaped confirmation was preferred when (B) bound to BChE, which was different from the linear conformation of (A) bound to AChE. Cell-based assays have confirmed the moderate neuroprotective effects of compounds (A) and (B) against H2O2-induced oxidative damage towards PC12 cells. Moreover, the hepatotoxicity of (B) was lower than that of tacrine, indicating its potential safety as an anti-Alzheimer’s agent. In summary, a new chemotype of multifunctional hybrid, which may be further modified to develop new anti-Alzheimer’s agents was reported. The experimental part of the paper was very detailed, including the reaction process of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,ChemistrySelect included an article by Dandia, Anshu; Saini, Pratibha; Bansal, Sarika; Parewa, Vijay. Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《One-Pot Copper(I)-Catalyzed Synthesis of 2-Aryl-quinazolin-4(3H)-ones via N-benzylation/Csp3-H Oxidation/CN Hydrolysis/Cyclization》. The information in the text is summarized as follows:

A Cu(I)-catalyzed straightforward synthesis of quinazolin-4(3H)-ones was attained by the reaction of 2-aminobenzonitrile with benzyl bromides. The reaction proceeded via one pot N-benzylation/CSp3- H oxidation/CN hydrolysis/cyclization sequence. Numerous controlled experiments were carried out to establish the appropriate mechanism and prerequisite of the reactions. The process was truly selective as only quinazolinones formed as desired product over dihydrogenated quinazolinones. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yan, Tingting; Babu, Kaki Raveendra; Wu, Yong; Li, Yang; Tang, Yuhai; Xu, Silong published their research in Organic Letters in 2021. The article was titled 《Phosphine-Catalyzed Cross-Coupling of Benzyl Halides and Fumarates》.HPLC of Formula: 622-95-7 The article contains the following contents:

A phosphine-catalyzed olefinic cross-coupling between benzyl halides and fumarates was described, which affords trisubstituted alkenes I [R = Me, Et, Bu; R1 = Ph, 4-MeC6H4, 3-MeOC6H4, etc.] in good yields and excellent E-selectivity under metal-free conditions. Mechanistic studies suggested a catalytic cycle involving phosphorus ylide formation, Michael addition, water-assisted hydrogen transfer and phosphine elimination. In the experimental materials used by the author, we found 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7HPLC of Formula: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.HPLC of Formula: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics