Category: 622-95-7

《Catalytic Detoxification of Organophosphorus Nerve Agents by Butyrylcholinesterase-Polymer-Oxime Bioscavengers》 was published in Biomacromolecules in 2020. These research results belong to Zhang, Libin; Murata, Hironobu; Amitai, Gabriel; Smith, Paige N.; Matyjaszewski, Krzysztof; Russell, Alan J.. Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene The article mentions the following:

Organophosphorus nerve agents (OPNAs), used in chem. warfare, irreversibly inhibit essential cholinesterases (ChEs) in the cholinergic neurotransmission system. Several potent nucleophilic oximes have been approved for the treatment of acute poisoning by OPNAs, but they are rapidly cleared from blood circulation. Butyrylcholinesterase (BChE) stoichiometrically binds nerve agents, but because the mol. weight of a nerve agent is about 500-fold less than the enzyme, the bioscavenger has had limited utility. We synthesized BChE-polymer-oxime conjugates using atom transfer radical polymerization (ATRP) and azide-alkyne “”click”” chem. The activity of the BChE-polymer-oxime conjugates was dependent on the degree of oxime loading within the copolymer side chains. The covalent modification of oxime-containing copolymers prolonged the activity of BChE in the presence of the VX- and cyclosarin-fluorogenic analogs EMP-MeCyC and CMP-MeCyC, resp. After complete inactivation by VX and cyclosarin fluorogenic analogs, the conjugates demonstrated efficient self-reactivation of up to 80% within 3-6 h. Repeated inhibition and high-level self-reactivation assays revealed that the BChE-polymer-oxime conjugates were excellent reactivators of OPNA-inhibited BChE. Recurring self-reactivation of BChE-polymer-oxime conjugates following repeated BChE inhibition by fluorogenic OPNAs (Flu-OPNAs) opens the door to developing the next generation of nerve agent “”catalytic”” bioscavengers. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Microwave-Assisted Tandem Kornblum Oxidation and Biginelli Reaction for the Synthesis of Dihydropyrimidones》 was published in ChemistrySelect in 2020. These research results belong to Malik, Asif A.; Dangroo, Nisar A.; Ara, Tabassum. Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene The article mentions the following:

A simple and straightforward approach for the synthesis of dihydropyrimidones I (X = O, S; Ar = Ph, 4-FC6H4, pyridin-2-yl, 1H-pyrrol-2-yl, etc.) via sequential Kornblum oxidation/Biginelli reaction has been developed. The protocol involves an in situ oxidation of benzyl bromides ArCH2Br which serve as a carbonyl equivalent followed by cyclocondensation with (thio)urea and Et acetoacetate to furnish dihydropyrimidones I under catalyst- and base-free conditions in a one-pot tandem manner under microwave irradiation Further, the product purification using aqueous recrystallization avoids large quantities of volatile and a toxic organic solvent usually required for work-up and significantly less time required for this process makes the method environmentally friendly. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Pd-Catalyzed Cross-Coupling of Sb-Aryl Stibines with Halogenomethyl Arenes to Give Unsymmetric Diarylmethanes》 was written by Zhang, Dejiang; Xu, Zhi; Tang, Ting; Le, Liyuan; Wang, Cairong; Kambe, Nobuaki; Qiu, Renhua. Recommanded Product: 622-95-7This research focused onunsym diarylmethane preparation; halogenomethyl arene aryl stibine cross coupling palladium catalyst. The article conveys some information:

Herein, a general method for the synthesis of unsym. diarylmethanes RCH2R1 (R = 4-cyanophenyl, 3-fluorophenyl, 2-chloro-4-fluorophenyl, etc.; R1 = Ph, 4-methoxyphenyl, 3-furanyl, etc.) from (hetero)aryl Me halides RCH2X (X = Br, Cl) and Sb-aryl stibines I was described. This protocol shows a broad substrate scope and a good functional group tolerance. Drug mols., including beclobrate and bifemelane, and drug derivatives, including celecoxib, ibuprofen, and probenecid, were efficiently synthesized on a gram scale. The experimental part of the paper was very detailed, including the reaction process of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Recommanded Product: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,ChemistrySelect included an article by Di Mola, Antonia; Macchia, Antonio; Tedesco, Consiglia; Pierri, Giovanni; Palombi, Laura; Filosa, Rosanna; Massa, Antonio. COA of Formula: C7H6BrCl. The article was titled 《Synthetic Strategies and Cascade Reactions of 2-Cyanobenzophenones for the Access to Diverse 3,3-Disubstituted Isoindolinones and 3-Aryl-3-Hydroxyisoindolinones》. The information in the text is summarized as follows:

New methodologies for the synthesis of the challenging ketones 2-cyanobenzophenones, based on Suzuki-Miyaura type cross-coupling reactions and very mild oxidation of 2-benzylbenzonitriles. The investigation of the reactivity of the obtained ketones highlighted a very good electrophilicity in the presence of mild carbon- and hetero-nucleophiles, allowing the synthesis of 3,3-disubstituted isoindolin-1-ones. All the developed methodologies were highly efficient and tolerated combinations of functional groups present on both the aromatic rings. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7COA of Formula: C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.COA of Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: 1-(Bromomethyl)-4-chlorobenzeneIn 2021 ,《Tandem Conjugate Addition/Aromatization/Acyl Transfer Reaction between 3-Aryl-2-nitropropanoates and Quinone Monoimines》 appeared in ChemistrySelect. The author of the article were Cheng, Shao-Bing; Liu, Hui; Jing, Yi; Cao, Lian-Yi; Zhang, Xiao-Mei. The article conveys some information:

A tandem conjugate addition/aromatization/acyl transfer reaction between 3-aryl-2-nitropropanoates and quinone monoimines was described. In the presence of NMM, the reaction proceeded smoothly gave various 1,2-diarylnitroethanes in low to good yields. The structure of one product was determined by an X-ray crystal structural anal. Accordingly, a plausible reaction mechanism was proposed. The experimental part of the paper was very detailed, including the reaction process of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Name: 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Name: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,ChemistrySelect included an article by Gojiya, Dinesh G.; Vekariya, Mitesh B.; Kapupara, Vimal H.; Bhatt, Tejal D.; Kalavadiya, Prakash L.; Joshi, Hitendra S.. Quality Control of 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《Rapid, Simple and Efficient Microwave-Assisted Alkylation of 6-Acetyl-2H-Benzo[e][1, 3]Oxazine-2,4(3H)-Dione》. The information in the text is summarized as follows:

A simple, efficient and eco-friendly method has been developed for the synthesis of biol. active alkyl derivatives of 6-acetyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione I (R = 3-n- Bu, MeC6H4, 4-O2NC6H4, etc.) by using microwave irradiations. The N-alkylation of 6-acetyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione with substituted alkyl derivatives under microwave radiations in presence of tetra-Bu ammonium bromide as a phase transfer catalyst to give the desired products. Comparison between conventional and microwave-assisted synthesis revealed that it reduced the reaction time, improve the yield and purity of 6-acetyl-3-(substituted alkyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-diones analog mols. All the final compounds were characterized by FT-IR, 1HNMR, 13CNMR, HRMS and Mass spectroscopic anal., also succeeded to develop and analyze the single crystal XRD of compound I (R = C6H5). The antimicrobial evaluation studies show moderate activities against used microbes. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Quality Control of 1-(Bromomethyl)-4-chlorobenzene) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Quality Control of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,ChemistrySelect included an article by Chavan, Pramod V.; Charate, Shrinivas P.; Desai, Uday V.; Rode, Chandrashekhar V.; Wadgaonkar, Prakash P.. Formula: C7H6BrCl. The article was titled 《Bentonite-Clay-Supported Cuprous Iodide Nanoparticles (BENT-CuI NPs): A New Heterogeneous Catalyst in Diversity-Oriented Synthesis of 1,2,3-Triazoles in Aqueous Medium》. The information in the text is summarized as follows:

Bentonite clay supported cuprous iodide nanoparticles (BENT-CuI NPs) were prepared and demonstrated for the first time as an efficient heterogeneous catalyst in diversity oriented, green synthesis of 1,2,3-triazoles by one-pot, three component reaction between alkyl halides, arylboronic acids or epoxides with alkynes and sodium azide in aqueous medium. The catalyst was characterized by Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES), Energy Dispersive X-ray Spectroscopy (EDS), SEM, X-Ray Powder Diffraction (XRD), Transmission Electron Microscopy (TEM) as well as Brunauer-Emmett-Teller (BET) techniques and was found to be reusable for five consecutive runs without significant loss of activity. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis, inhibition properties against xanthine oxidase and molecular docking studies of dimethyl N-benzyl-1H-1,2,3-triazole-4,5-dicarboxylate and (N-benzyl-1H-1,2,3-triazole-4,5-diyl)dimethanol derivatives》 was written by Yagiz, Guler; Noma, Samir Abbas Ali; Altundas, Aliye; Al-khafaji, Khattab; Taskin-Tok, Tugba; Ates, Burhan. Recommanded Product: 1-(Bromomethyl)-4-chlorobenzeneThis research focused ontriazole preparation green chem mol docking xanthine oxidase inhibitor; Double docking; Enzyme inhibition; Green synthesis; Triazole derivatives; Xanthine oxidase. The article conveys some information:

This study was focused on synthesis of various di-Me N-benzyl-1H-1,2,3-triazole-4,5-dicarboxylate and (N-benzyl-1H-1,2,3-triazole-4,5-diyl)dimethanol derivatives I (R = methoxycarbonyl, hydroxymethyl; X = 2-OH, 3-Br, 4-OMe, 2-OH-5-Cl, etc.) under the conditions of green chem. without the use of solvent and catalysts. Their inhibition properties were also investigated on xanthine oxidase (XO) activity. All dimethanol and dicarboxylate derivatives I exhibited significant inhibition activities with IC50 values ranging from 0.71 to 2.25μM. Especially, I [R = hydroxymethyl, X = 3-Br; and R = methoxycarbonyl, X = 4-Cl] compounds were found to be the most promising derivatives on the XO enzyme inhibition with IC50 values 0.71 and 0.73μM, resp. Moreover, the double docking procedure was used to evaluate compound modes of inhibition and their interactions with the protein (XO) at at. level. Surprisingly, the docking results showed a good correlation with IC50 [correlation coefficient (R2 = 0.7455)]. Also, the docking results exhibited that the I [R = hydroxymethyl, X = 3-Br; R = methoxycarbonyl, X = 4-OH; and R = methoxycarbonyl, X = 4-Cl] have lowest docking scores -4.790, -4.755, and -4.730, resp. These data were in agreement with the IC50 values. These results give promising beginning stages to assist in the improvement of novel and powerful inhibitor against XO. In the experimental materials used by the author, we found 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 622-95-7In 2021 ,《Photocatalytic N-benzylation of NH-sulfoximines》 was published in Synthetic Communications. The article was written by Feng, Tao; Luo, Xiaoli; Dong, Jingru; Mo, Junming. The article contains the following contents:

N-Benzylation of NH-sulfoximines via visible light photocatalysis is realized. Under mild reaction conditions, photocatalyst promotes the direct cross-coupling of NH-sulfoximines with benzyl bromides to form N-benzyl sulfoximines. Superbases which are usually used in reported coupling of NH-sulfoximines with alkyl halides were not needed. This method is also suitable for the synthesis of N-allyl sulfoximines.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7SDS of cas: 622-95-7) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.SDS of cas: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Jie; Song, Xue; Chen, Zhi-Chao; Du, Wei; Chen, Ying-Chun published an article in 2022. The article was titled 《Phosphine-catalysed intermolecular cyclopropanation reaction between benzyl bromides and activated alkenes》, and you may find the article in New Journal of Chemistry.COA of Formula: C7H6BrCl The information in the text is summarized as follows:

While phosphine-mediated reactions were extensively explored over the past few decades, the catalytic cyclopropanation reaction via a phosphonium ylide pathway has been significantly underdeveloped, and an intermol. version still remains to be disclosed. Presented herein was a catalytic cyclopropanation reaction between readily available benzyl bromides and activated alkenes, such as α-cyano chalcones, through in situ formation of phosphonium ylide intermediates. A spectrum of densely functionalized cyclopropane derivatives was efficiently constructed with excellent diastereoselectivity, which can be further converted to five-membered heterocycles after simple transformations. Moreover, moderate enantioselectivity can be obtained by using a com. available DuPhos catalyst. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7COA of Formula: C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.COA of Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics