Category: 622-95-7

Khoramjouy, Mona; Rezaee, Elham; Khoshnevis, Afshan; Nazari, Maryam; Nematpour, Manijeh; Shahhosseini, Soraya; Tabatabai, Sayyed Abbas; Faizi, Mehrdad published their research in Bioorganic Chemistry in 2021. The article was titled 《Synthesis of 4,6-diphenylpyrimidin-2-ol derivatives as new benzodiazepine receptor ligands》.Electric Literature of C7H6BrCl The article contains the following contents:

In the quest for new benzodiazepine agonists with more selectivity and low adverse effects, novel derivatives of 4,6-diphenylpyrimidin-2-ol I (X = H, 2-F, 4-Cl, etc.; Y = 4-Me, 4-OMe, 4-NO2, etc.) were designed, synthesized, and evaluated. In this series, compound I (X = H; Y = 4-F) was the most potent analog in radioligand binding assay with an IC50 value of 19 nM compared to zolpidem (IC50 = 48 nM), a nonbenzodiazepine central BZD receptor (CBR) agonist. Some compounds with a variety of affinities in radioligand receptor binding assay were selected for in vivo evaluations. Compound I (X = H; Y = 4-Cl) (IC50 = 25 nM), which possessed chlorine instead of fluorine in position 4 of the Ph ring, exhibited an excellent ED50 value in most in vivo tests. Proper sedative-hypnotic effects, potent anticonvulsant activity, appropriate antianxiety effect, and no memory impairment served compound I (X = H; Y = 4-Cl), a desirable candidate as a benzodiazepine agonist. The pharmacol. effects of compound I (X = H; Y = 4-Cl) were antagonized by flumazenil, a selective BZD receptor antagonist, confirming the BZD receptors’ involvement in the biol. effects of the novel ligand. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Electric Literature of C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Electric Literature of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Bioorganic Chemistry included an article by Gholampour, Maryam; Ranjbar, Sara; Edraki, Najmeh; Mohabbati, Maryam; Firuzi, Omidreza; Khoshneviszadeh, Mehdi. Formula: C7H6BrCl. The article was titled 《Click chemistry-assisted synthesis of novel aminonaphthoquinone-1,2,3-triazole hybrids and investigation of their cytotoxicity and cancer cell cycle alterations》. The information in the text is summarized as follows:

A series of 12 novel 1,4-naphthoquinone-1,2,3-triazole hybrids were designed and synthesized through copper-catalyzed click reaction of 2-(prop-2-ynylamino)naphthalene-1,4-dione (3) and different azidomethyl-benzene derivatives The synthesized compounds were assessed for their anticancer activity against three cancer cell lines (MCF-7, HT-29 and MOLT-4) by MTT assay. The results showed that the majority of the synthesized compounds displayed cytotoxic activity. Derivatives 6f and 6h, bearing 4-trifluoromethyl-benzyl and 4-tert-butyl-benzyl groups, resp., as well as intermediate 3 demonstrated good cytotoxic potential against all tested cancer cell lines, among which compound 6f showed the highest activity. Flow cytometric anal. revealed that compounds 3, 6f and 6h arrested cell cycle at G0/G1 phase in MCF-7 cells. Therefore, synthesized aminonaphthoquinone-1,2,3-triazole derivatives can be introduced as promising mols. for further development as potential anticancer agents. The results came from multiple reactions, including the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Photoredox-Catalyzed Functionalization of Alkenes with Thiourea Dioxide: Construction of Alkyl Sulfones or Sulfonamides》 was published in Chinese Journal of Chemistry in 2020. These research results belong to Li, Yuewen; Liu, Jin-Biao; He, Fu-Sheng; Wu, Jie. Formula: C7H6BrCl The article mentions the following:

Sulfonylation of alkenes through photoredox-catalyzed functionalization of alkenes with thiourea dioxide under visible-light irradiation is achieved. The reaction of alkenes, thiourea dioxide and electrophiles provides a green and efficient access to alkyl sulfones and sulfonamides. A broad reaction scope is presented with good functional group compatibility and excellent regioselectivity. A plausible mechanism involving a radical addition process with sulfur dioxide radical anion (SO2-) derived from the oxidation of sulfur dioxide anion (SO22-) is proposed, which is supported by fluorescence quenching experiments The results came from multiple reactions, including the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Efficient Assembly of Molecular Complexity Enabled by Palladium-Catalyzed Heck Coupling/C(sp2)-H Activation/ C(sp3)-H Activation Cascade》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to He, Chen; Han, Wen-Yong; Cui, Bao-Dong; Wan, Nan-Wei; Chen, Yong-Zheng. COA of Formula: C7H6BrCl The article mentions the following:

A palladium-catalyzed [2+2+1] annulation among 3-iodochromones, benzyl bromides, and norbornene has been developed. This annulation consists of a domino sequence involving Heck coupling/C(sp2)-H activation/C(sp3)-H activation, affording a variety of complex chromone derivatives I (R = H, 6-Me, 7-F, etc.; R1 = C6H5, 3-MeC6H4, 4-FC6H4, etc.) bearing five contiguous tertiary carbon centers in up to 94% yield and 99:1 dr. Interestingly, the diastereoselectivity could be switched by fine-tuning the solvent, in which endo isomer and exo isomer were obtained using mesitylene/CH3CN and mesitylene, resp.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7COA of Formula: C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.COA of Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rezaei, Elham Babazadeh; Abedinifar, Fahimeh; Azizian, Homa; Montazer, Mohammad Nazari; Asadi, Mehdi; Hosseini, Samanesadat; Sepehri, Saghi; Mohammadi-Khanaposhtani, Maryam; Biglar, Mahmood; Larijani, Bagher; Amanlou, Massoud; Mahdavi, Mohammad published their research in Chemical Papers in 2021. The article was titled 《Design, synthesis and evaluation of metronidazole-1,2,3-triazole derivatives as potent urease inhibitors》.Formula: C7H6BrCl The article contains the following contents:

A new series of benzyl-(imidazolylmethyl)triazole derivatives I [R = H, 2-Me, 4-Br, etc.] was synthesized and evaluated as Helicobacter pylori urease inhibitors. All the synthesized compounds were more potent than standard inhibitor thiourea against urease. Among the synthesized compounds, compound I [R = 4-F] (IC50 = 1.975 ± 0.25μM) with inhibitory activity around 11-fols more than thiourea (IC50 = 22.00 ± 0.14μM) was the most potent compound Kinetic study of this compound revealed that compound I [R = 4-F] inhibited urease in an uncompetitive mode. Based on mol. modeling study, compound I [R = 4-F] pointed toward the bi-nickel center and stabilized by H-bond and T-shape π-π hydrophobic interactions with the critical residues His492 and Asp633. Moreover, it anchored to the helix-turn-helix motif in the active site cavity through interaction with His593 and Arg609. Consequently, it proposed that compound I [R = 4-F] through stabilization of active site flap inhibited urease activity. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Naichen; Ye, Yuanzhi; Bai, Lu; Liu, Jingjing; Wang, Han; Luan, Xinjun published an article in 2022. The article was titled 《Transition metal-free dearomatization of halonaphthols with C(sp3)-electrophiles》, and you may find the article in Chinese Chemical Letters.COA of Formula: C7H6BrCl The information in the text is summarized as follows:

The first intermol. electrophilic dearomatization of halonaphthols I (R1 = H, 7-MeO, 6-Me3Si, 3-Cl, etc.) with benzyl/allyl bromides R2Br (R2 = PhCH2, PhCHMe, 4-MeO2CC6H4CH2, H2C:CHCH2, PhCH:CH, etc.) is described. Halonaphthols are used as carbon nucleophiles in dearomatization to form three-dimensional cyclic enones II with excellent chemoselectivity, in which etherification of phenolic hydroxyl group could be restrained by using cesium carbonate as the base. A wide range of cyclic enones was directly prepared from various substituted benzyl/allyl bromides and halonaphthols. Mechanistic investigations suggest a direct SN2 reaction pathway.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7COA of Formula: C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.COA of Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Organic Chemistry Frontiers included an article by Zhang, Huiru; Sun, Nan; Hu, Baoxiang; Shen, Zhenlu; Hu, Xinquan; Jin, Liqun. Formula: C7H6BrCl. The article was titled 《Copper-catalyzed direct couplings of terminal alkynes with primary and secondary benzyl bromides》. The information in the text is summarized as follows:

A facile Cu-catalyzed benzylation of terminal alkynes RCCH (R = Ph, thiophen-3-yl, cyclopropyl, n-C6H13, etc.) from easily available benzyl bromides R1CH(R2)Br (R1 = Ph, thiophen-2-yl, naphthalen-2-yl, etc.; R2 = H, Me, Et) and 1-(phenylethynyl)-indane, 1-(phenylethynyl)-1,2,3,4-tetrahydronaphthalene, 4-(phenylethynyl)chroman have been developed. Both primary and secondary benzylic bromides have been successfully coupled with various aryl alkynes, alkyl alkynes and enynes, selectively affording benzyl alkynes RCCCH(R2)R1 in moderate to excellent yields. Examples of scale-up reactions as well as the application for preparing substituted allenes as 1,3-diphenylpropa-1,2-diene, 1,3-diphenyl-buta-1,2-diene and 9-benzyl-10-methylphenanthrene have further demonstrated the practicality and efficiency of the developed strategy. The results came from multiple reactions, including the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Neerathilingam, Nalladhambi; Anandhan, Ramasamy published an article in RSC Advances. The title of the article was 《Metal-free photoredox-catalyzed direct α-oxygenation of N,N-dibenzylanilines to imides under visible light》.HPLC of Formula: 622-95-7 The author mentioned the following in the article:

An efficient synthesis of imides using metal-free photoredox-catalyzed direct α-oxygenation of N,N’-disubstituted anilines in the presence of 9-mesityl-10-methylacridinium [Acr+-Mes]BF4 as a photoredox catalyst and mol. oxygen as a green oxidant under visible light was developed. This photochem. approach offered operational simplicity, high atom economy with a low E-factor and functional group tolerance under mild reaction conditions. Control and quenching experiments confirmed the occurrence of a radical pathway and superoxide radical anion α-oxygenation reactions and also provided strong evidence for the reductive quenching of [Acr+-Mes]BF4 based on a Stern-Volmer plot, which led to the proposed mechanism of this reaction. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7HPLC of Formula: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.HPLC of Formula: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kumar, Dhirendra; Maury, Suresh Kumar; Kumari, Savita; Kamal, Arsala; Singh, Himanshu Kumar; Singh, Sundaram; Srivastava, Vandana published an article in 2022. The article was titled 《TBAI-catalyzed C-N bond formation through oxidative coupling of benzyl bromides with amines: a new avenue to the synthesis of amides》, and you may find the article in Synthetic Communications.Name: 1-(Bromomethyl)-4-chlorobenzene The information in the text is summarized as follows:

A new green approach for the synthesis of amide R1PhC(O)NR2R3 [R1 = H, NO2, Cl, etc.; R2 = H, n-Bu., Bn, etc.; R3 = H, Me, Et; R2,R3 = (CH2)4, (CH2)5, (CH2)2O] was developed through TBAI-catalyzed oxidative coupling of benzyl bromides with amines in the presence of tert-Bu hydroperoxide as an oxidant. Various electron-donating and withdrawing groups containing benzyl bromides and various amines were subjected to the reaction and transformed to the corresponding amide in good to excellent yields. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Name: 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Name: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Organic & Biomolecular Chemistry included an article by Yu, Yanbo; Liang, Qianwa; Liu, Hui; Luo, Zonghua; Hu, Hongzheng; Perlmutter, Joel S.; Tu, Zhude. Related Products of 622-95-7. The article was titled 《Development of a carbon-11 PET radiotracer for imaging TRPC5 in the brain》. The information in the text is summarized as follows:

The transient receptor potential channel subfamily member 5 (TRPC5) is a calcium permeable cation channel widely expressed in the brain. Accumulating evidence indicates that it plays a crucial role in psychiatric disorders including depression and anxiety. Positron emission tomog. (PET) combined with a TRPC5 specific radioligand may provide a unique tool to investigate the functions of TRPC5 in animal disease models to guide drug development targeting TRPC5. To develop a TRPC5 PET radiotracer, the potent TRPC5 inhibitor HC608 was chosen for C-11 radiosynthesis through the N-demethyl amide precursor 7 reacting with [11C]methyl iodide. Under optimized conditions, [11C]HC608 was achieved with good radiochem. yield (25 ± 5%), high chem. and radiochem. purity (>99%), and high specific activity (204-377 GBq μmol-1, decay corrected to the end of bombardment, EOB). The in vitro autoradiog. study revealed that [11C]HC608 specifically binds to TRPC5. Moreover, initial in vivo evaluation of [11C]HC608 performed in rodents and the microPET study in the brain of non-human primates further demonstrated that [11C]HC608 was able to penetrate the blood brain barrier and sufficiently accumulate in the brain. These results suggest that [11C]HC608 has the potential to be a PET tracer for imaging TRPC5 in vivo. The experimental part of the paper was very detailed, including the reaction process of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Related Products of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Related Products of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics