Category: 622-95-7

Zhang, Hong; Zhang, Rong-Hong; Liao, Xiang-Ming; Yang, Dan; Wang, Yu-Chan; Zhao, Yong-Long; Xu, Guo-Bo; Liu, Chun-Hua; Li, Yong-Jun; Liao, Shang-Gao; Zhou, Meng published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Discovery of β-Carboline Derivatives as a Highly Potent Cardioprotectant against Myocardial Ischemia-Reperfusion Injury》.Product Details of 622-95-7 The article contains the following contents:

Timely myocardial reperfusion salvages ischemic myocardium from infarction, whereas reperfusion itself induces cardiomyocyte death, which is called myocardial ischemia/reperfusion (MI/R) injury. Herein, β-carboline derivative I was designed and synthesized with obvious myocardial protective activity for the first time. Pretreatment of compound I effectively protected the cardiomyocyte H9c2 cells from H2O2-induced lactate dehydrogenase leakage and restored the endogenous antioxidants, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Besides, compound I effectively protected the mitochondria through decreasing the reactive oxygen species overproduction and enhancing the mitochondrial membrane potential. As a result, compound I significantly reduced the necrosis of cardiomyocytes in H2O2-induced oxidative stress, which was more potent than polydatin. In MI/R injury rats, compound I pretreatment obviously increased the levels of SOD and GSH-Px and inhibited the apoptosis of cardiomyocytes. Through this way, the size of myocardial infarction was significantly reduced after MI/R injury in vivo, better than that of polydatin, suggesting that compound I is a promising cardioprotectant for the prevention of MI/R injury. In the experimental materials used by the author, we found 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Product Details of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Product Details of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Taha, Muhammad; Ahmad Khan, Aftab; Rahim, Fazal; Imran, Syahrul; Salahuddin, Mohammed; Uddin, Nizam; Mohammed Khan, Khalid; Adnan Ali Shah, Syed; Zafar, Ameeduzzafar; Amiruddin Zakaria, Zainul published an article in Arabian Journal of Chemistry. The title of the article was 《Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of β-Glucuronidase and in silico study》.SDS of cas: 622-95-7 The author mentioned the following in the article:

New benzimidazole analogs I were synthesized and characterized through different spectroscopic techniques such as 1H NMR, 13C NMR and HREI-MS. All analogs were screened for β-glucuronidase inhibitory potential. All analogs showed varied degree of inhibitory potentials with IC50 values ranging between 1.10 ± 0.10 to 39.60 ± 0.70μM when compared with standard D-saccharic acid-1,4- lactone having IC50 value 48.30μM. Analogs I [R1 = 2,5-dichlorophenyl, R2 = 4-nitrobenzyl], I [R1 = 4-chlorophenyl, R2 = 2,4-dichlorobenzyl], I [R1 = 4-nitrophenyl, R2 = 4-nitrobenzyl], I [R1 = 4-chlorophenyl, R2 = 4-nitrobenzyl], I [R1 = p-tolyl, R2 = 4-nitrobenzyl] and I [R1 = 4-chlorophenyl, R2 = 4-chlorobenzyl] having IC50 values 1.10 ± 0.10, 1.70 ± 0.10, 2.30 ± 0.10, 5.30 ± 0.20, 6.20 ± 0.20 and 8.10 ± 0.20μM resp., showed excellent β-glucuronidase inhibitory potential many folds better than the standard All other analogs also showed good inhibitory potential better as compared to standard Structure activity relationships (SAR) had been established for all compounds The results from mol. docking studies supports the established SAR and developed a strong correlation with the results from in to vitro assay. The mol. docking results clearly highlighted how substituents like nitro and chloro affect the binding position of the active compounds in the active site. The docking results were also used to properly establish the effect of bulky substituents of least active compounds on reduced β-glucuronidase inhibitory activity. Compounds I [R1 = Ph, p-tolyl, 3-methoxyphenyl; R2 = 4-methoxybenzyl, 4-bromobenzyl, 4-methylbenzyl, etc] were found non-toxic. In the experimental materials used by the author, we found 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7SDS of cas: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.SDS of cas: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C7H6BrClIn 2020 ,《Selective C-P(O) Bond Cleavage of Organophosphine Oxides by Sodium》 was published in Journal of Organic Chemistry. The article was written by Zhang, Jian-Qiu; Ikawa, Eiichi; Fujino, Hiroyoshi; Naganawa, Yuki; Nakajima, Yumiko; Han, Li-Biao. The article contains the following contents:

Na exhibits better efficacy and selectivity than Li and K for converting Ph3P(O) to Ph2P(OM). The destiny of PhNa co-generated is disclosed. Alkyl halides R4X and aryl halides ArX all react with Ph2P(ONa) to produce the corresponding phosphine oxides in good to excellent yields. In the experiment, the researchers used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Computed Properties of C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Computed Properties of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Kumar N, Manoj; Nukala, Satheesh Kumar; Swamy T, Narasimha; M, Ravinder; Krishna, Thupurani Murali; Narsimha, Sirassu published an article in Journal of Molecular Structure. The title of the article was 《Benzothiazole-[1,2,3]triazolo[5,1-a]isoindoles: Synthesis, anticancer activity, bioavailability and in silico studies against Gama-Tubulin protein》.Synthetic Route of C7H6BrCl The author mentioned the following in the article:

The CuI catalyzed synthesis of some novel fused benzothiazole-1,2,3-triazole hybrids I (R = H, 5-Me, 4,6-dichloro, 4,5,6-trimethoxy, etc.) in one-pot was reported . The in vitro anticancer activity of these compounds revealed that the compounds I (R = 5-Cl (II), 5-F (III), 5-nitro (IV), 4,5,6-trimethoxy (V), 4,6-dimethoxy (VI)) showed superior activity against human cancer cell lines like MCF-7, A-549, DU-145 and HeLa than the standard Etoposide. Remarkably, the in vitro tubulin polymerization inhibitory assay of compounds (II), (III), (IV), (V) and (VI) revealed that the compounds (III) and (IV) showed superior activity than the standard CA-4, while the compounds (II), (V) and (VI) were shown comparable activity with the CA-4. Besides, the results of in vitro and in silico ADME studies of most potent compounds (III), (V), (VI), (III) and (IV) were supported the corresponding in vitro anticancer activity data. Finally, the mol. docking studies of compounds I on human γ-tubulin receptor suggested that the most potent compounds (III), (V), (VI), (II) and (IV) strongly bind to the protein and energy calculations were in good agreement with the corresponding IC50 values. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Synthetic Route of C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Synthetic Route of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Novel Furochromone Derivatives: Synthesis and Anticancer Activity Studies》 were Demir, Senem; Oezen, Cigdem; Ceylan-Uenluesoy, Meltem; Oeztuerk, Mehmet; Bozdag-Duendar, Oya. And the article was published in Journal of Heterocyclic Chemistry in 2019. Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene The author mentioned the following in the article:

In this study, khellin having furochromone structure, which was obtained from a well-known traditional medicinal plant, was selected. A series of furochromonyl compounds I (X = O, S; R = H, CH3, CH2C(O)OC2H5, 4-FC6H4CH2, 4-H3COC6H4C(O)CH2, etc.) was synthesized for their anticancer activities. Furochromonyl compounds I were synthesized by Knoevenagel reaction of substituted 2,4-thiazolidinediones/rhodanines II with khellin-2-carboxaldehyde, and their cytotoxicity was investigated in 22 cancer cell lines, which were originated from tissues such as liver, breast, colon, and cervix. As the first step, two hepatocellular carcinoma cell lines Huh7 and PLC/PRF/5 (Alexander cells) were treated with 10 μM of each compound for 72 h, and then sulforhodamine B assay was performed to analyze their anti-growth activities. Compound I (X = S; R = CH2C(O)OC2H5) was found as the most cytotoxic compound of primary screening. Afterwards, 12 hepatocellular carcinoma, seven breast cancer, two colon cancer, and cervical cancer cell lines were selected to test I (X = S; R = CH2C(O)OC2H5) for 72 h at multiple concentrations to determine 50% EDs. Results showed that 14 cell lines were affected by I (X = S; R = CH2C(O)OC2H5) quantities lower than 10 μM. The structure of I (X = S; R = CH2C(O)OC2H5), which is particularly effective on breast cancers, can be used to slow down the progression of tumors. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Visible-light Driven Hydrolysis of Benzyl Halides with Water for Preparation of Benzyl Alcohols》 was written by Xu, Jianbin; Liu, Na; Zou, Lingling; Cheng, Feixiang; Shen, Xianfu; Liu, Teng; Lv, Haiping; Khan, Ruhima; Fan, Baomin. Application of 622-95-7This research focused onwater benzyl halide rhodamine B catalyst photochem hydrolysis; benzyl alc preparation. The article conveys some information:

Visible-light-mediated hydrolysis of benzyl halides were achieved that was efficiently catalyzed by metal-free catalyst rhodamine B. Benzyl bromides and chlorides were smoothly reacted with water to prepare a series of benzyl alc. compounds in good yields. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Application of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Ciccone, Lidia; Nencetti, Susanna; Camodeca, Caterina; Ortore, Gabriella; Cuffaro, Doretta; Socci, Simone; Orlandini, Elisabetta published an article in Pharmaceutical Chemistry Journal. The title of the article was 《Synthesis and Evaluation of Monoaryl Derivatives as Transthyretin Fibril Formation Inhibitors》.HPLC of Formula: 622-95-7 The author mentioned the following in the article:

Here, the synthesis of new 2-((benzyloxy)imino)acetic, -propanoic and -butanoic acid derivatives, RCH2ON=C(R1)C(O)OH (R = 2-chlorophenyl, 4-methoxyphenyl, 2,4-dichlorophenyl, etc.; R1 = H, Me, Et) results of their turbidimetric UV assay and the docking study of new monoaryl compounds were reported. The obtained results suggest that, for this class of compounds, (i) the chlorine atom in ortho position on the aromatic ring is the best substituent; (ii) the linker inversion still allows the interaction with thyroxine binding sites; and (iii) the steric hindrance in R1 position is detrimental for the activity. The results came from multiple reactions, including the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7HPLC of Formula: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.HPLC of Formula: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design, synthesis and antibacterial activity evaluation of novel 2-(4-((1-aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)2-(2-oxoazetidin-1-yl)acetamide derivatives》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Zarei, Samaneh; Komeili, Golzar; Bahadorikhalili, Saeed; Yahya-Meymandi, Azadeh; Karami-Zarandi, Morteza; Larijani, Bagher; Biglar, Mahmood; Sadat Ebrahimi, Seyed Esmaeil; Mahdavi, Mohammad. Reference of 1-(Bromomethyl)-4-chlorobenzene The article mentions the following:

In this paper, a novel series of 2-(4-((1-aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)2-(2-oxoazetidin-1-yl)acetamide derivatives I (R = t-Bu, Cy; R1 = 4-F, 2-Me, 4-NO2, etc.; R2 = H, OMe) are synthesized in two steps. The first step involved Ugi multicomponent reaction of β-alanine, o-(propargyl)benzaldehydes 3-R2-4-(HCCCH2O)C6H3CHO and isocyanide derivatives RN+C-. The product of this step, underwent a click 1,3-dipolar cycloaddition reaction with benzyl azide derivatives R1C6H4CH2N3. The 2-(4-((1-aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)2-(2-oxoazetidin-1-yl)acetamide products I were characterized and their antibacterial activities were evaluated against various G-pos. (Staphylococcus aureus and Bacillus subtilis) and G-neg. (Pseudomonas aeruginosa and Escherichia coli) bacteria, using minimal inhibition concentration The compounds I showed very good antimicrobial activity and a number of products have been more active than ciprofloxacin. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Reference of 1-(Bromomethyl)-4-chlorobenzene) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Reference of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Clustering-Triggered Ultralong Room-Temperature Phosphorescence of Organic Crystals through Halogen-Mediated Molecular Assembly》 was published in Journal of Physical Chemistry Letters in 2020. These research results belong to Sun, Huili; Ding, Riqing; Lv, Shanling; Zhou, Shasha; Guo, Sidan; Qian, Zhaosheng; Feng, Hui. Recommanded Product: 622-95-7 The article mentions the following:

To achieve efficient room-temperature phosphorescence of organic materials with ultralong lifetime, it is imperative to resolve the dilemma that the introduction of heavy atoms simultaneously improves emission efficiencies and shortens the emission lifetimes. Herein, we report a new mol. design approach for halogenated luminogens with a methylene bridge to avoid the lifetime shortening induced by heavy halogens and propose a general mol. engineering strategy to realize efficient and ultralong room-temperature phosphorescence via halogen-mediated mol. clustering. The halogenated N-benzylcarbazole derivatives show distinct photophys. behaviors depending on different phys. states, including single-mol. state and cluster state. Their crystals demonstrate the halogen-dependent emission duration of room-temperature phosphorescence upon excitation. Exptl. data and theor. anal. indicate that halogen-regulated mol. clustering in the crystal is responsible for the generation of efficient ultralong room-temperature phosphorescence, and halogen-dominated mol. engineering favors the promotion of the intersystem crossing process and the following triplet emissions.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 622-95-7) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Recommanded Product: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jin, Xin; Cao, Jianguo; Zhao, Qingjie; Wang, Qi; Guo, Hongmei; Aisa, Haji Akber; Huang, Guozheng published their research in Journal of the Serbian Chemical Society in 2021. The article was titled 《Synthesis of new derivatives of alepterolic acid via click chemistry》.Computed Properties of C7H6BrCl The article contains the following contents:

In this article, 23 new derivatives of alepterolic acid combined with 1,2,3-triazole I (R = Ph, 2-methylphenyl, 4-fluorophenyl, etc.) were designed and synthesized by esterification and click chem. reaction in a fast, conventional and efficient way. All the products were obtained in good yields (72 to 97%). The use of the easily available reactants and the common reaction conditions furnish an efficient method for the synthesis of alepterolic acid derivatives I. The preparation of these compounds would enable further biol. evaluation in the future. In the experimental materials used by the author, we found 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Computed Properties of C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Computed Properties of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics