Category: 622-95-7

In 2019,Asian Journal of Organic Chemistry included an article by Tang, Jia-Kang; Yu, Shang-Bo; Liu, Chuan-Zhi; Wang, Hui; Zhang, Dan-Wei; Li, Zhan-Ting. Computed Properties of C7H6BrCl. The article was titled 《A Highly Stable Porous Viologen Polymer for the Catalysis of Debromination Coupling of Benzyl Bromides with High Recyclability》. The information in the text is summarized as follows:

A highly stable porous organic polymer bipy-POP has been prepared from the reaction of 4,4′-bipyridine and tetrakis(4-(bromomethyl)phenyl)methane in N-methylpyrrolidone at 110°. Bipy-POP exhibited high efficiency in catalyzing the reductive debromination of a variety of benzyl bromides in N,N-dimethylformamide with dithionite as reductive reagent. For substrates that bear electron-donating group(s) on the benzene ring, the reactions selectively afforded dibenzyl sulfone derivatives Generally, substrates that bear an electron-withdrawing group on the benzene ring gave rise to coupling products ethane derivatives As exceptions, F, Cl or CF3-contained substrates were found to selectively produce sulfone derivatives The recyclability of bipy-POP for the catalysis of the reaction of (4-fluorophenyl)methyl bromide and diphenylmethyl bromide, which afforded the corresponding sulfone or ethane derivative, revealed that, after 40 times of repeated use, the heterogeneous catalysis did not exhibit important decrease of the activity. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Computed Properties of C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Computed Properties of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Joolakanti, Hima Bindhu; Battu, Satyanarayana; Kamepalli, Ramanjaneyulu; Kolanupaka, Harichandana Reddy; Bobbili, Hasika Reddy published their research in Chemical Data Collections in 2021. The article was titled 《Synthesis, docking and biological activities of novel chromone linked [1,2,3]-triazole derivatives》.Synthetic Route of C7H6BrCl The article contains the following contents:

A series of chromone linked [1,2,3]triazoles I [R = C6H5, 3-MeC6H4, 3-ClC6H4, etc.] were designed based on literature followed by in-silico studies. The in-silico studies indicated good docking score for compounds I when docked into the Human Estrogen Receptor Alpha Ligand-Binding Domain (PDB ID: 1XP6). So compounds I were synthesized, characterized and evaluated for cytotoxicity, antibacterial and antioxidant activities. The compounds I [R = C6H5, 4-ClC6H4] showed promising cytotoxicity with IC50 value of 18.61 and 20.39μg/mL resp. The Compounds I [R = 2-FC6H4, 3-FC6H4, 4-ClC6H4, 2-MeC6H4, 2,4-di-ClC6H3] showed encouraging antioxidant activity with IC50 value of < 30μM i.e. DPPH scavenging activity levels more than that of pos. control, whereas compounds I [R = C6H5, 3-FC6H4, 3-ClC6H4, 4-ClC6H4, 3-MeC6H4, 2,4-di-ClC6H3] exhibited moderate antibacterial activities with the MIC value of <240μM. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Synthetic Route of C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Synthetic Route of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Angewandte Chemie, International Edition included an article by Li, Lu-Lu; Ding, Du; Song, Jin; Han, Zhi-Yong; Gong, Liu-Zhu. Product Details of 622-95-7. The article was titled 《Catalytic Generation of C1 Ammonium Enolates from Halides and CO for Asymmetric Cascade Reactions》. The information in the text is summarized as follows:

A general strategy for the design of asym. cascade reactions using readily available halides and carbon monoxide (CO) as substrates is developed. The key is the catalytic generation of C1-ammonium enolates for the subsequent asym. cascade reactions through the combination of palladium-catalyzed carbonylation and chiral Lewis base catalysis. Utilizing this strategy, we have established asym. formal [1+1+4] and [1+1+2] reactions to afford chiral dihydropyridones and β-lactams with high yields and high enantio- and diastereoselectivities. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Product Details of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Product Details of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Imidazo-Fused Isoindoles by Pd(II)/Ag(I)-Promoted Intramolecular Dehydrogenative Coupling》 was written by Lessi, Marco; Lucci, Antonio; Cuzzola, Angela; Bellina, Fabio. HPLC of Formula: 622-95-7 And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

An effective Pd(II)/Ag(I)-promoted intramol. cross-dehydrogenative coupling (CDC) of substituted 1-benzylimidazoles under air provides, for the first time, a simple access to several functionalized imidazo[2,1-a]isoindoles, an interesting class of polycyclic heteroaromatic compounds The direct involvement of two unactivated carbon-hydrogen bonds, without any directing group, grants an elevated atom economy of the whole process. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7HPLC of Formula: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.HPLC of Formula: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kamala, L.; Kumar, B. Sathish; Lakshmi, P. V. Anantha published their research in Russian Journal of Bioorganic Chemistry in 2021. The article was titled 《Synthesis and Docking Studies of Novel Carbazole-Thiazolidinedione Hybrid Derivatives as Antibacterial Agents》.Name: 1-(Bromomethyl)-4-chlorobenzene The article contains the following contents:

A series of novel carbazole-thiazolidinedione hybrids I (R = Ph, 4-O2NC6H4, 2,4-Cl2C6H3, etc.) was designed, synthesized and screened for antimicrobial activity against Gram-pos. and Gram-neg. bacterial species. All the novel compounds were characterized by 1H, 13C NMR, IR and mass spectral anal. data. The results of antibacterial study indicated that compounds I (R = 2-O2NC6H4, 2-BrC6H4) showed appreciable antibacterial activity. Furthermore, mol. docking of selected compounds was performed to study the interaction between active compound and binding site. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Name: 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Name: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhao, Liyu; Yin, Wenbo; Sun, Yin; Sun, Nannan; Tian, Linfeng; Zheng, Yang; Zhang, Chu; Zhao, Shizhen; Su, Xin; Zhao, Dongmei; Cheng, Maosheng published an article in 2021. The article was titled 《Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives》, and you may find the article in European Journal of Medicinal Chemistry.SDS of cas: 622-95-7 The information in the text is summarized as follows:

L-Amino alc. derivatives exhibited high antifungal activity, but the metabolic stability of human liver microsomes in vitro was poor, and the half-life of optimal compound 5 was less than 5 min. To improve the metabolic properties of the compounds, the scaffold hopping strategy was adopted and a series of antifungal compounds with a dihydrooxazole scaffold was designed and synthesized. Compounds substituted with 4-Ph group on dihydrooxazole ring exhibited excellent antifungal activities against C. albicans, C. tropicalis and C. krusei, with MIC values in the range of 0.03-0.25μg/mL. In addition, the metabolic stability of compounds A33 and A34 (I and II, resp.) in human liver microsomes in vitro was improved significantly, with the half-life greater than 145 min and the half-life of 59.1 min, resp. Moreover, pharmacokinetic studies in SD rats showed that A33 exhibited favorable pharmacokinetic properties, with a bioavailability of 77.69%, and half-life (i.v. administration) of 9.35 h, indicating that A33 is worthy of further study. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7SDS of cas: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.SDS of cas: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Jannapu Reddy, Raju; Waheed, Md.; Haritha Kumari, Arram; Rama Krishna, Gamidi published an article in Advanced Synthesis & Catalysis. The title of the article was 《Interrupted CuAAC-Thiolation for the Construction of 1,2,3-Triazole-Fused Eight-Membered Heterocycles from O-/N-Propargyl derived Benzyl Thiosulfonates with Organic Azides》.COA of Formula: C7H6BrCl The author mentioned the following in the article:

A copper(I)-catalyzed interrupted click-sulfenylation of O-/N-propargyl benzyl thiosulfonates with organic azides has been disclosed. The unified CuAAC-thiolation provides a wide range of triazole-fused eight-membered heterocycles in good to high (51-94%) yields under mild reaction conditions. Moreover, a three-component reaction is also achieved involving O-/N-propargyl benzyl thiosulfonates, benzyl bromide, and sodium azide to deliver fused-triazoles in 61-74% yields. From a synthetic point of view, the present protocol has been demonstrated at gram-scale reactions. A plausible mechanism is also proposed based on exptl. results and control experiments In the experiment, the researchers used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7COA of Formula: C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.COA of Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of C7H6BrClIn 2021 ,《Syntheses and Crystal Structures of Benzyl Substituted Thiazolidin-2-cyanamide Derivatives》 was published in Journal of Chemical Crystallography. The article was written by Wang, Jun-Ling; Ma, Sen; Jia, Ai-Quan; Zhang, Qian-Feng. The article contains the following contents:

Reaction of thiazolidin-2-cyanamide and substituted benzyl bromide compounds 2-R-3-R1-4-R2C6H2CH2Br (R = Me, H, CN, Br; R1 = H, Me, CN, F; R2 = H, Me, CN, F, Cl, t-Bu) in acetonitrile at room temperature afforded the 3-(2′-substituted benzyl)thiazolidin-2-cyanamide derivatives I in good yields. Compounds I were characterized by proton NMR (1H NMR) and IR spectroscopies, of which the structures of the isomeric o-, m-, and p-fluoro derivatives I (R = F, R1 = H, R2 = H; R = H, R1 = F, R2 = H; R = H, R1 = H, R2 = F) were established by single crystal X-ray crystallog. Compound I (R = F, R1 = H, R2 = H) crystallizes in the monoclinic space group P21/n, with a = 9.177(19), b = 8.551(18), c = 14.090(3) Å, β = 98.243(3)°, and Z = 4. The unit cell of I (R = H, R1 = F, R2 = H) has a monoclinic P21/c symmetry with the cell parameters a = 9.289(2), b = 14.057(4), c = 8.574(2) Å, β = 100.350(3)°, and Z = 4. The unit cell of I (R2 = FR = H, R1 = H, R2 = F) also has a monoclinic P21/c symmetry with the cell parameters a = 9.333(4), b = 14.034(5), c = 8.508(3) Å, β = 99.15(5)°, and Z = 4. A series of 3-(2′-substituted benzyl)thiazolidin-2-cyanamide derivatives I was efficiently synthesized via the reaction of benzyl bromide compounds with thiazolidin-2-cyanamide, of which the structures of the isomeric o-, m-, and p-fluoro derivatives were characterized by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Electric Literature of C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Electric Literature of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《CuO-NiO bimetallic nanoparticles supported on graphitic carbon nitride with enhanced catalytic performance for the synthesis of 1,2,3-triazoles, bis-1,2,3-triazoles, and tetrazoles in parts per million level》 was written by Gajurel, Sushmita; Dam, Binoyargha; Bhushan, Mayank; Singh, L. Robindro; Pal, Amarta Kumar. Product Details of 622-95-7This research focused ontriazole preparation green chem; arylboronic acid arylacetylene heterocyclization copper nickel dioxide nanocatalyst; benzylhalide arylacetylene heterocyclization copper nickel dioxide nanocatalyst; epoxide phenyl acetylene heterocyclization copper nickel dioxide nanocatalyst; bistriazolyl methane preparation green chem; diazidomethyl methoxybenzene alkyne heterocyclization copper nickel dioxide nanocatalyst; tetrazole preparation green chem; aromatic nitrile heterocyclization copper nickel dioxide nano catalyst. The article conveys some information:

The unification of CuCl2 ·2H2O and NiCl2·6H2O with the support of graphitic carbon nitride yielded to form an efficient, synergistic, bimetallic nano-catalyst CuO-NiO@g-C3N4. Catalyst with three different molar ratios of Cu and Ni, i.e., Cu75Ni25 (Cu:Ni = 3:1; catalyst-a), Cu50Ni50 (Cu:Ni = 1:1; catalyst-b), and Ni66Cu33 (Ni:Cu = 2:1; catalyst-c), was synthesized, and their catalytic activity was examined The synergistic interaction of one metal with the other on the surface of extremely stable graphitic carbon nitride has enhanced the catalytic performance in the synthesis of triazoles I (R1 = Ph, (4-bromophenyl)methyl, 2-hydroxy-1-phenylethyl, etc.; R2 = H, 4-F, 3-Me, 4-Me, 4-OMe), tetrazoles II (R3 = Ph, pyrazin-2-yl, 4-formylphenyl, etc.), and bis-triazole derivatives III to such a distinguished level (in ppm level), which a monometal fail to possess. The aforementioned statement has been supported by the catalytic activity data provided for both the monometallic and bimetallic catalyst herein. In addition to this, benign reaction conditions, in situ generation of azides, wide reaction scopes, and reusability of the catalyst were also the major advantages leading toward safe and sustainable chem. beyond doubt. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Product Details of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Product Details of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yin, Zheng; Gu, Mingxing; Ma, Huili; Jiang, Xueyan; Zhi, Jiahuan; Wang, Yafei; Yang, Huifang; Zhu, Weiguo; An, Zhongfu published an article in 2021. The article was titled 《Molecular Engineering through Control of Structural Deformation for Highly Efficient Ultralong Organic Phosphorescence》, and you may find the article in Angewandte Chemie, International Edition.Product Details of 622-95-7 The information in the text is summarized as follows:

It is an enormous challenge to achieve highly efficient organic room-temperature phosphorescence (RTP) with a long lifetime. We demonstrate that, by bridging the carbazole and halogenated Ph ring with a methylene linker, RTP phosphors CzBX (X=Cl, Br) present high phosphorescence efficiency (ΦPh). A ΦPh up to 38% was obtained for CzBBr with a lifetime of 220 ms, which is much higher than that of compounds CzPX (X=Cl, Br) with a C-N bond as a linker (ΦPh<1%). Single-crystal anal. and theor. calculations revealed that, in the crystal phase, intermol. π-Br interactions accelerate the intersystem crossing process, while tetrahedron-like structures induced by sp3 methylene linkers restrain the nonradiative decay channel, leading to the high phosphorescence efficiency in CzBBr. This research paves a new road toward highly efficient and long-lived RTP materials with potential applications in anti-counterfeiting or data encryption. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Product Details of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Product Details of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics