Category: 622-95-7

Judge, Neil R.; Chacktas, Geraud; Ma, Ling; Schink, Anke; Buckpesch, Rainer; Schmutzler, Dirk; Machettira, Anu B.; Dietrich, Hansjorg; Asmus, Elisabeth; Bierer, Donald; McLeod, Michael C. published an article in 2021. The article was titled 《Flexible Synthesis and Herbicidal Activity of Fully Substituted 3-Hydroxypyrazoles》, and you may find the article in European Journal of Organic Chemistry.Recommanded Product: 622-95-7 The information in the text is summarized as follows:

The synthesis and herbicidal efficacy of a novel library of fully substituted 3-hydroxypyrazoles I (R1 = H, Me, Et, i-Pr, 2-methoxyethyl; R2 = H, 2,4-F2, 3,4-F2, 3-Cl, etc.; A = O, S, CH2, etc.) is reported. An efficient, divergent approach to introduce Ph, phenoxy, phenylsulfanyl, anilino and benzyl substituents in the 4-position of the pyrazole, alongside a flexible synthesis of N1-alkyl analogs I is described via final step diversification of key intermediates. Herbicidal screening of the prepared compounds against key weed species identified the lead compound I (R1 = Me; R2 = H, 2,4-F2; A = O), which was prepared on a multi-gram scale using an optimized synthetic route. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Recommanded Product: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Yin, Honglu; Chen, Yuepeng; Zhong, Qiu; Zheng, Shilong; Wang, Guangdi; He, Ling published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Design, synthesis, and antitumor study of a series of novel 1-Oxa-4-azaspironenone derivatives》.Electric Literature of C7H6BrCl The author mentioned the following in the article:

A series of 1-oxa-4-azaspiro[4,5]deca-6,9-diene-3,8-dione derivatives containing structural fragments of conjugated dienone have been synthesized previously by authors’ group, however the Michael addition reaction between conjugated dienone and nucleophilic groups in the body may generate harmful and adverse effects. To reduce harmful side effects, the authors started with p-aminophenol to make 1-oxo-4-azaspirodecanedione derivatives I (R1 = 4-MeC6H4, 2-ClC6H4, 4-BrC6H4, etc.) then utilized the Michael addition and cyclopropanation to synthesize target compounds II (R1 = 4-Me, 4-ClC6H4, 3-ClC6H4, 4-BrC6H4; R2 = CH(COOMe)2), III (R1 = 4-MeC6H4, 4-ClC6H4, 2,6-Cl2C6H3; R2 = CH3CH2S) and IV (R1 = 4-O2NC6H4, 2-ClC6H4, 4-BrC6H4, etc.) in order to eliminate α, β unsaturated olefinic bond and lower the Michael reactivity of the compounds in vivo for optimization. At the same time, heteroatoms are put into the mols. in order to improve the hydrophilicity of the mols. and the binding sites of the mols. and the target mols., establishing the groundwork for improved antitumor activity. The majority of the compounds had moderate to potent activity against A549 human lung cancer cells, MDA-MB-231 breast cancer cells, and Hela human cervical cancer cells. Among them, II (R1 = 3-ClC6H4; R2 = CH(COOMe)2) showed the strongest effect on A549 cell line with IC50 of 0.26μM; IV (R1 = 2-ClC6H4) showed the strongest cytotoxicity on MDA-MB-231 cell line with IC50 of 0.10μM; and II (R1 = 3-ClC6H4; R2 = CH(COOMe)2) showed the strongest activity on Hela cell line with IC50 of 0.18μM. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Electric Literature of C7H6BrCl)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Electric Literature of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,European Journal of Organic Chemistry included an article by Cheng, Xinqiang; Shan, Jiankai; Tian, Xinshe; Ren, Yun-Lai; Zhu, Yanyan. Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《Benzylation of Arenes with Benzyl Halides under Promoter-Free and Additive-Free Conditions》. The information in the text is summarized as follows:

It was found that benzyl chlorides and bromides could directly reacted with electron-rich arenes which provided an example of promoter-free and additive-free benzylation of arenes. A variety of benzyl chlorides and bromides were treated with benzene rings to give the targeted products in low to high yields. The present conditions tolerated the vinyl group of the substrates. Preliminary mechanistic investigation suggested that the present reactions possibly proceeded via an autocatalytic mechanism pathway. The results came from multiple reactions, including the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Recommanded Product: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design, synthesis, biological evaluation, and docking study of new acridine-9-carboxamide linked to 1,2,3-triazole derivatives as antidiabetic agents targeting α-glucosidase》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Asgari, Mohammad S.; Tahmasebi, Behnam; Mojtabavi, Somayeh; Faramarzi, Mohammad A.; Rahimi, Rahmatollah; Ranjbar, Parviz R.; Biglar, Mahmood; Larijani, Bagher; Rastegar, Hossein; Mohammadi-Khanaposhtani, Maryam; Mahdavi, Mohammad. Formula: C7H6BrCl The article mentions the following:

A new series of acridine-9-carboxamide-1,2,3-triazole derivatives I [R = H, 2-Me, 4-O2N, etc.] were designed, synthesized and evaluated as novel α-glucosidase inhibitors. Compounds I were designed by combination of effective moieties from potent α-glucosidase inhibitors. Most of the synthesized compounds I were more potent than standard inhibitor acarbose. Among the synthesized compounds, the most potent compounds were I [R = 3-Br, 4-Br, H] with IC50 values of 120.2 ± 1.0, 151.1 ± 1.4, and 157.6 ± 1.6μM, resp. (IC50 value of acarbose = 750.0 ± 10.0μM). Docking study of the most potent compounds I [R = H, 3-Br, 4-Br] reported that these compounds formed stable complexes with α-glucosidase active site. Anti-α-amylase assay of compounds I [R = H, 3-Br, 4-Br] was performed and no activity was observed, meanwhile in-vitro cytotoxicity assay of the latter compounds revealed that these compounds were not cytotoxic toward human normal (HDF) and cancer (MCF-7) cell lines. ADME and toxicity prediction of compounds I [R = H, 3-Br, 4-Br] were also performed. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Shuai; Xiao, Jun-Zhao; Li, Yan-Bo; Shi, Chang-Yun; Yin, Liang published their research in Journal of the American Chemical Society in 2021. The article was titled 《Copper(I)-Catalyzed Asymmetric Alkylation of Unsymmetrical Secondary Phosphines》.Product Details of 622-95-7 The article contains the following contents:

A Cu(I)-catalyzed asym. alkylation of HPAr1Ar2 with alkyl halides is uncovered, which provides an array of P-stereogenic phosphines in generally high yield and enantioselectivity. The electrophilic alkyl halides enjoy a broad substrate scope, including allyl bromides, propargyl bromide, benzyl bromides, and alkyl iodides. Also, 11 unsym. diarylphosphines (HPAr1Ar2) serve as competent pronucleophiles. The present methodol. is also successfully applied to catalytic asym. double and triple alkylation, and the corresponding products were obtained in moderate diastereo- and excellent enantioselectivities. Some 31P NMR experiments indicate that bulky HPPhMes exhibits weak competitively coordinating ability to the Cu(I)-bisphosphine complex, and thus the presence of stoichiometric HPAr1Ar2 does not affect the enantioselectivity significantly. Therefore, the high enantioselectivity in this reaction is attributed to the high performance of the unique Cu(I)-(R,RP)-TANIAPHOS complex in asym. induction. Finally, one monophosphine and two bisphosphines prepared by the present reaction are employed as efficient chiral ligands to afford three structurally diversified Cu(I) complexes, which demonstrates the synthetic utility of the present methodol. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Product Details of 622-95-7) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Product Details of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bamoro, Coulibaly; Bamba, Fante; Dindet Steve-Evanes, Koffi Teki; Aurelie, Vallin; Vincent, Chagnault published an article in 2021. The article was titled 《Design, synthesis and antibacterial activity evaluation of 4,5-diphenyl-1H-imidazoles derivatives》, and you may find the article in Open Journal of Medicinal Chemistry.Formula: C7H6BrCl The information in the text is summarized as follows:

Due to the continuous emergence and rapid spread of drug-resistant strains of bacteria, there is an urgent need for the development of novel antimicrobials. Herein, the synthesis and antibacterial activity of 4,5-diphenylimidazol-2-thiol derivatives I (R = Ph, 4-O2NC6H4, 2,4-Cl2C6H3, 5-R’-benzimidazol-5-yl, etc.; R’ = H, O2N, Me, Cl, F3C) have been reported. The structures of the synthesized compounds were confirmed by NMR and high resolution mass spectrometry (HRMS). All compounds were screened in vitro for their antibacterial activity against Pseudomonas aeuroginosa and Escherichia coli (Gram-neg. bacteria) and also against Staphyloccocus aureus and Eterococcus faecalis (Gram-pos. bacteria). The results showed that most of the synthesized compounds have no antibacterial activity. However, the compound I (R = 5-chloro-2-benzimidazolyl) was two-fold potent than ciprofloxacin against Staphylococcus aureus with Min. Inhibitory Concentration (MIC) of 4μg/mL and compound I (R = 5-trifluoromethyl-2-benzimidazolyl) showed moderate biol. activity against Staphylococcus aureus and Eterococcus faecalis.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design, synthesis, and anticancer evaluation of novel benzopyran 1,3,4-oxadiazole derivatives》 was published in Indian Journal of Heterocyclic Chemistry in 2020. These research results belong to Kumar, Piyush; Rahman, Azizur Md.; Wal, Pranay; Rawat, Pinki; Singh, Kuldeep. SDS of cas: 622-95-7 The article mentions the following:

Some new benzopyran 1,3,4-oxadiazole, derivatives I (R = H, benzyl, 4-chlorobenzyl, 3,4-dichlorobenzyl; R1 = benzyl, 4-chlorobenzyl, 3,4-dichlorobenzyl, 3-chlorobenzyl) were designed by docking, in silico absorption, distribution, metabolism, excretion (ADME) and predicted toxicity studies, and then synthesized by S-alkylation of a benzopyran 1,3,4-oxadiazole derivative with different chloro-substituted benzyl bromides. The synthesized compounds were tested for anticancer activity on the MCF-7 cell line. Docking study showed all compounds to have better docking scores than the standard, Adriamycin. In silico, ADME and toxicity studies were also found as significant for most of the compounds The majority of the compounds displayed good to potent anticancer activity on the MCF-7 cell line. The experimental part of the paper was very detailed, including the reaction process of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7SDS of cas: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.SDS of cas: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Hong, Feng-Lin; Shi, Chong-Yang; Hong, Pan; Zhai, Tong-Yi; Zhu, Xin-Qi; Lu, Xin; Ye, Long-Wu published an article in Angewandte Chemie, International Edition. The title of the article was 《Copper-Catalyzed Asymmetric Diyne Cyclization via [1,2]-Stevens-Type Rearrangement for the Synthesis of Chiral Chromeno[3,4-c]pyrroles》.COA of Formula: C7H6BrCl The author mentioned the following in the article:

Here, authors report a copper-catalyzed asym. cascade cyclization/[1,2]-Stevens-type rearrangement via a non-diazo approach, leading to the practical and atom-economic assembly of various valuable chiral chromeno[3,4-c]pyrroles bearing a quaternary carbon stereocenter in generally moderate to good yields with wide substrate scope and excellent enantioselectivities (up to 99% ee). Importantly, this protocol not only represents the first example of catalytic asym. [1,2]-Stevens-type rearrangement based on alkynes but also constitutes the first asym. formal carbene insertion into the Si-O bond.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7COA of Formula: C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.COA of Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Journal of Heterocyclic Chemistry included an article by Sawkmie, Micky Lanster; Paul, Dipankar; Kalita, Gitumoni; Agarwala, Khushboo; Maji, Pradip K.; Chatterjee, Paresh Nath. Related Products of 622-95-7. The article was titled 《Synthesis and characterization of active cuprous oxide particles and their catalytic application in 1,2,3-triazole synthesis via alkyne-azide cycloaddition reaction in water》. The information in the text is summarized as follows:

Active cuprous oxide materials were synthesized from CuSO4.5H2O using sodium stannite as reducing agent in the presence of various stabilizers, viz., cetyl tri-Me ammonium bromide, sodium dodecyl sulfate and polyvinyl pyrrolidone. The synthesized cuprous oxide materials were well characterized by powder X-ray diffraction and Fourier transform IR spectroscopy to ascertain their identity, while field emission SEM and energy-dispersive spectroscopy anal. were used to study their morphol. and composition, resp. The various cuprous oxide materials were used in the cycloaddition reaction of alkynes, benzyl halides and azides to synthesize 1,4-disubstituted-1,2,3-triazoles I [R = allyl, Bn, 3-ClC6H4CH2, etc.; R1 = CH2OH, Ph, 4-MeC6H4, 4-FC6H4, 4-BrC6H4, 2-pyridyl]. A wide variety of substitutions could nicely be tolerated in our optimized reaction conditions to produce very good to excellent yields of the corresponding triazoles in water at 55 °C. The reactions were carried out in water without any assistance of organic cosolvent or other additives, which renders the catalytic method as economical and environment friendly. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Related Products of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Related Products of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Neerathilingam, Nalladhambi; Bhargava Reddy, Mandapati; Anandhan, Ramasamy published their research in Journal of Organic Chemistry in 2021. The article was titled 《Regioselective Synthesis of 2° Amides Using Visible-Light-Induced Photoredox-Catalyzed Nonaqueous Oxidative C-N Cleavage of N,N-Dibenzylanilines》.Recommanded Product: 622-95-7 The article contains the following contents:

A visible-light-driven photoredox-catalyzed nonaqueous oxidative C-N cleavage of N,N-dibenzylanilines to 2° amides is reported. Further, this protocol is applied on 2-(dibenzylamino)benzamide to afford quinazolinones with (NH4)2S2O8 as an additive has been applied. Mechanistic studies imply that the reaction might underwent in situ generation of α-amino radical to imine by C-N bond cleavage followed by the addition of superoxide ion to form amides. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Recommanded Product: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Recommanded Product: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics